15,364 results match your criteria reactions include

Precision medicine in Fabry disease.

Nephrol Dial Transplant 2021 Jun;36(Supplement_2):14-23

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, Interdisciplinary Fabry Center Münster, University Hospital Münster, Münster, Germany.

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (GLA) gene, leading to a deficiency in α-galactosidase A. The lysosomal accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3) and its deacylated form, globotriaosylsphingosine (lyso-Gb3), results in progressive renal failure, cardiomyopathy associated with cardiac arrhythmia and recurrent cerebrovascular events, significantly limiting life expectancy in affected patients. In male patients, a definitive diagnosis of FD involves demonstrating a GLA deficiency in leucocytes. Read More

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Massage efficacy in the treatment of autistic children - a literature review.

Int J Dev Disabil 2017 Mar 21;64(4-5):225-229. Epub 2017 Mar 21.

Department of Rehabilitation of the University of Physical Education, Cracow, Poland.

Autism is one of the most serious contemporary medical problems. The causes of this disorder remain unknown however there are many hypotheses on the development of this specific symptom constellation. Autistic children have difficulties with contact establishment, they do not like to be touched and do not react to the external stimuli. Read More

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The Revenge of Unintended Consequences of Anaphylaxis-Risk Overdiagnosis: How Far We've Come and How Far We Have to Go.

J Allergy Clin Immunol Pract 2021 Jun 17. Epub 2021 Jun 17.

Dartmouth-Hitchcok Medical Center, Section of Allergy and Immunology, Lebanon, NH; Geisel School of Medicine at Dartmouth, Hanover, NH. Electronic address:

Overdiagnosis of anaphylaxis-risk is an underappreciated aspect of anaphylaxis prevention. While the benefits of anaphylaxis-risk prevention are well-known, potential harms resulting from pre-emptive approaches to mitigate anaphylaxis-risk are not insignificant. Still, great progress has been made in recent years to avoid the unintended consequences of anaphylaxis-risk overdiagnosis. Read More

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Recent Progress on Perovskite Surfaces and Interfaces in Optoelectronic Devices.

Adv Mater 2021 Jun 17:e2006004. Epub 2021 Jun 17.

Dr. D. Luo, Prof. H. Yu, Prof. Z.-H. Lu, School of Microelectronics, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.

Surfaces and heterojunction interfaces, where defects and energy levels dictate charge-carrier dynamics in optoelectronic devices, are critical for unlocking the full potential of perovskite semiconductors. In this progress report, chemical structures of perovskite surfaces are discussed and basic physical rules for the band alignment are summarized at various perovskite interfaces. Common perovskite surfaces are typically decorated by various compositional and structural defects such as residual surface reactants, discrete nanoclusters, reactions by products, vacancies, interstitials, antisites, etc. Read More

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Stevens-Johnson syndrome and concurrent hand foot syndrome during treatment with capecitabine: A case report.

World J Clin Cases 2021 Jun;9(17):4279-4284

Department of Dermatology, Jeonbuk National University Medical School, Jeonju 54907, South Korea.

Background: Capecitabine is used in combination with lapatinib as palliative treatment for human epidermal growth factor receptor 2 - positive metastatic breast cancer. The most frequently reported adverse events attributed to capecitabine include diarrhea, hyperbilirubinemia, and hand-foot syndrome (HFS). A number of cutaneous adverse events have been attributed to capecitabine, including Stevens-Johnson syndrome (SJS) as a rare and potentially life-threatening mucocutaneous condition. Read More

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Trolls Without Borders: A Cross-Cultural Examination of Victim Reactions to Verbal and Silent Aggression Online.

Front Psychol 2021 1;12:549955. Epub 2021 Jun 1.

Department of American Studies, University of Groningen, Groningen, Netherlands.

Trolling-the online exploitation of website, chat, or game mechanics at another user's expense-can and does take place all over cyberspace. It can take myriad forms, as well-some verbal, like trash-talking an opponent in a game, and some silent, like refusing to include a new player in a team effort during an in-game quest. However, despite this variety, there are few to no studies comparing the effects of these differing trolling types on victims. Read More

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Role of Endolysosome Function in Iron Metabolism and Brain Carcinogenesis.

Semin Cancer Biol 2021 Jun 14. Epub 2021 Jun 14.

Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute, Buffalo, New York, United States. Electronic address:

Iron, the most abundant metal in human brain, is an essential microelement that regulates numerous cellular mechanisms. Some key physiological roles of iron include oxidative phosphorylation and ATP production, embryonic neuronal development, formation of iron-sulfur clusters, and the regulation of enzymes involved in DNA synthesis and repair. Because of its physiological and pathological importance, iron homeostasis must be tightly regulated by balancing its uptake, transport, and storage. Read More

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Inactivation Mechanism of Neuronal Nitric Oxide Synthase by ()-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid: Chemical Conversion of the Inactivator in the Active Site.

Inorg Chem 2021 Jun 17. Epub 2021 Jun 17.

School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Neuronal nitric oxide synthase (nNOS) is one of the three isoforms of nitric oxide synthase (NOS). The other two isoforms include inducible NOS (iNOS) and endothelial NOS (eNOS). These three isoforms of NOS are widely present in both human and other mammals and are responsible for the biosynthesis of NO. Read More

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Toward an Atomic-Level Understanding of Ceria-Based Catalysts: When Experiment and Theory Go Hand in Hand.

Acc Chem Res 2021 Jun 17. Epub 2021 Jun 17.

Eduard-Zintl-Institute of Inorganic and Physical Chemistry, Technical University of Darmstadt, Alarich-Weiss-Str. 8, 64287 Darmstadt, Germany.

ConspectusBecause ceria (CeO) is a key ingredient in the formulation of many catalysts, its catalytic roles have received a great amount of attention from experiment and theory. Its primary function is to enhance the oxidation activity of catalysts, which is largely governed by the low activation barrier for creating lattice O vacancies. Such an important characteristic of ceria has been exploited in CO oxidation, methane partial oxidation, volatile organic compound oxidation, and the water-gas shift (WGS) reaction and in the context of automotive applications. Read More

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Adulterated Traditional-Herbal Medicinal Products and Its Safety Signals in Malaysia.

Drug Healthc Patient Saf 2021 8;13:133-140. Epub 2021 Jun 8.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Cawangan Selangor, Kampus Puncak Alam, Puncak Alam, 42300, Selangor, Malaysia.

Background: Usage of traditional-herbal medicines (THM) for various illnesses has been increased around the world, so does the adulteration of these products with hazardous compounds. There are limited Malaysian data that have been published on the characteristics trend and adverse events associated with adulterated THM products.

Aim: This study described characteristics of adulterated THM products in Malaysia and aimed to quantify THM products' safety signals of adverse reactions (ARs). Read More

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Substitution treatment for opioid dependence with slow-release oral morphine: Retention rate, health status, and substance use after switching to morphine.

J Subst Abuse Treat 2021 Aug 4;127:108350. Epub 2021 Mar 4.

Centre for Interdisciplinary Addiction Research of Hamburg University (CIAR), University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr. 52, 20246 Hamburg, Germany. Electronic address:

Introduction: Since April 2015, slow-release oral morphine (SROM) has been approved for opioid agonist treatment (OAT) in Germany. Experimental studies show that benefits of SROM over methadone include less heroin craving, better tolerability, and higher patient satisfaction and mental stability. The SROMOS study (Efficacy and Tolerability of Slow-Release Oral Morphine in Opioid Substitution Treatment) aims to investigate the long-term effects (effectiveness and safety) of morphine substitution under routine care in Germany. Read More

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Mineral Carbonation of Biomass Ashes in Relation to Their CO Capture and Storage Potential.

ACS Omega 2021 Jun 27;6(22):14598-14611. Epub 2021 May 27.

Institute of Mineralogy and Crystallography, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 107, Sofia 1113, Bulgaria.

Short-term stored, long-term stored, and weathered biomass ashes (BAs) produced from eight biomass varieties were studied to define their composition, mineral carbonation, and CO capture and storage (CCS) potential by a combination of methods. Most of these BAs are highly enriched in alkaline-earth and alkaline oxides, and the minerals responsible for CCS in them include carbonates such as calcite, kalicinite, and fairchildite, and to a lesser extent, butschliite and baylissite. These minerals are a result of reactions between alkaline-earth and alkaline oxyhydroxides in BA and flue CO gas during biomass combustion and atmospheric CO during BA storage and weathering. Read More

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Transfusion Reactions in Pediatric Patients: An Analysis of 5 Years of Hemovigilance Data From a National Center for Children's Health in China.

Front Pediatr 2021 28;9:660297. Epub 2021 May 28.

Department of Transfusion Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

This study aimed to describe transfusion reactions of pediatric patients from a National Center for Children's Health in China and to examine reaction incidents, reaction types by blood transfusion, and the associated blood products resulting in transfusion reactions. We compared transfusion reaction rates, among platelets, plasma, and red blood cells (RBCs) using a retrospective analysis of pediatric patients treated with blood transfusion based on data from the National Center for Children's Health (Beijing, China) by a hemovigilance reporting system from January 2015 to December 2019. Over the past 5 years, 165 reactions were reported, and the overall incidence was 1. Read More

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Metallodrugs are unique: opportunities and challenges of discovery and development.

Chem Sci 2020 Nov 12;11(48):12888-12917. Epub 2020 Nov 12.

Department of Chemistry, University of Warwick Gibbet Hill Road Coventry CV4 7AL UK

Metals play vital roles in nutrients and medicines and provide chemical functionalities that are not accessible to purely organic compounds. At least 10 metals are essential for human life and about 46 other non-essential metals (including radionuclides) are also used in drug therapies and diagnostic agents. These include platinum drugs (in 50% of cancer chemotherapies), lithium (bipolar disorders), silver (antimicrobials), and bismuth (broad-spectrum antibiotics). Read More

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November 2020

Nucleation mechanisms and speciation of metal oxide clusters.

Chem Sci 2020 Aug 3;11(32):8448-8456. Epub 2020 Aug 3.

Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology (BIST) Av. Països Catalans, 16 43007 Tarragona Spain

The self-assembly mechanisms of polyoxometalates (POMs) are still a matter of discussion owing to the difficult task of identifying all the chemical species and reactions involved. We present a new computational methodology that identifies the reaction mechanism for the formation of metal-oxide clusters and provides a speciation model from first-principles and in an automated manner. As a first example, we apply our method to the formation of octamolybdate. Read More

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Selective single-atom electrocatalysts: a review with a focus on metal-doped covalent triazine frameworks.

Kazuhide Kamiya

Chem Sci 2020 Jul 20;11(32):8339-8349. Epub 2020 Jul 20.

Research Center for Solar Energy Chemistry, Osaka University 1-3 Machikaneyama Toyonaka Osaka 560-8531 Japan

Single-atom electrocatalysts (SACs), which comprise singly isolated metal sites supported on heterogeneous substrates, have attracted considerable recent attention as next-generation electrocatalysts for various key reactions from the viewpoint of the environment and energy. Not only electrocatalytic activity but also selectivity can be precisely tuned the construction of SACs with a defined coordination structure, such as homogeneous organometallics. Covalent organic frameworks (COFs) are promising supports for single-atom sites with designed coordination environments due to their unique physicochemical properties, which include porous structures, robustness, a wide range of possible designs, and abundant heteroatoms to coordinate single-metal sites. Read More

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Enlightening advances in polymer bioconjugate chemistry: light-based techniques for grafting to and from biomacromolecules.

Chem Sci 2020 May 6;11(20):5142-5156. Epub 2020 May 6.

George & Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science & Engineering, Department of Chemistry, University of Florida Gainesville Florida USA

Photochemistry has revolutionized the field of polymer-biomacromolecule conjugation. Ligation reactions necessitate biologically benign conditions, and photons have a significant energy advantage over what is available thermally at ambient temperature, allowing for rapid and unique reactivity. Photochemical reactions also afford many degrees of control, specifically, spatio-temporal control, light source tunability, and increased oxygen tolerance. Read More

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Eye movements in real and simulated driving and navigation control - Foreword to the Special Issue.

J Eye Mov Res 2021 Jun 3;12(3). Epub 2021 Jun 3.

University of Tübingen, Tübingen, Germany.

The control of technological systems by human operators has been the object of study for many decades. The increasing complexity in the digital age has made the optimization of the interaction between system and human operator particularly necessary. In the present thematic issue, ten exemplary articles are presented, ranging from observational field studies to experimental work in highly complex navigation simulators. Read More

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COVID Arm: Delayed Hypersensitivity Reactions to SARS-CoV-2 Vaccines Misdiagnosed as Cellulitis.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211024431

Bay Area Cosmetic Dermatology, San Francisco, CA, USA.

The term "COVID arm" has been coined to describe a harmless delayed hypersensitivity reaction occurring approximately a week after administration of the novel SARS-CoV-2 mRNA vaccine. It appears as a red, warm, pruritic, indurated, or swollen area in the vicinity of the vaccine site. These reactions, especially if accompanied by systemic symptoms, have been mistaken for cellulitis. Read More

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WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization.

Genetics 2021 Jun 12. Epub 2021 Jun 12.

Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, 01609, United States of America.

In our group, we aim to understand metabolism in the nematode Caenorhabditis elegans and its relationships with gene expression, physiology and the response to therapeutic drugs. Visualization of the metabolic pathways that comprise the metabolic network is extremely useful for interpreting a wide variety of experiments. Detailed annotated metabolic pathway maps for C. Read More

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Cayley Graphs of Semigroups Applied to Atom Tracking in Chemistry.

J Comput Biol 2021 Jun 11. Epub 2021 Jun 11.

Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.

While atom tracking with isotope-labeled compounds is an essential and sophisticated wet-lab tool to, for example, illuminate reaction mechanisms, there exists only a limited amount of formal methods to approach the problem. Specifically, when large (bio-)chemical networks are considered where reactions are stereospecific, rigorous techniques are inevitable. We present an approach using the right Cayley graph of a monoid to track atoms concurrently through sequences of reactions and predict their potential location in product molecules. Read More

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Efficacy and safety of acupuncture combined with analgesics on lung cancer pain: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26225

Jiangxi University of Chinese Medicine.

Background: Lung cancer (LC) is the malignant tumor with the highest incidence in the world, and treatment methods include surgery, radiotherapy, chemotherapy, and immunotherapy. Cancer pain is a common symptom in patients with LC, and the clinical treatment is to relieve it with analgesics. Acupuncture can relieve cancer pain. Read More

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A Review of Chemical Tools for Studying Small Molecule Persulfides: Detection and Delivery.

ACS Chem Biol 2021 Jun 11. Epub 2021 Jun 11.

Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States.

Hydrogen sulfide (HS) has gained significant attention as a potent bioregulator in the redox metabolome, but it is just one of many reactive sulfur species (RSS). Recently, small molecule persulfides (structure RSSH) have emerged as RSS of particular interest due to their enhanced antioxidant abilities compared to HS and their ability to directly convert protein thiols into protein persulfides, suggesting that persulfides may have distinct physiological functions from HS. However, persulfides exhibit instability and cross-reactivity that hampers the elucidation of their precise biological roles. Read More

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Antirheumatic drugs in older adults and polypharmacy issues.

Z Gerontol Geriatr 2021 Jun 10. Epub 2021 Jun 10.

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Older individuals experience various noninflammatory and autoimmune inflammatory rheumatic diseases. Given the increased incidence of rheumatic conditions in older adults, it is of great importance for healthcare providers to be aware of the potential benefits and risks of antirheumatic drugs. The present article aims to provide a comprehensive review regarding antirheumatic drug use in older patients, particularly by focusing on safety issues and polypharmacy. Read More

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A Fluorescence Assay for Exosome Detection Based on Bivalent Cholesterol Anchor Triggered Target Conversion and Enzyme-Free Signal Amplification.

Anal Chem 2021 Jun 10. Epub 2021 Jun 10.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

Exosomes are emerging as one of the most promising biomarkers for early disease diagnosis and prognosis. The significant challenges facing the available methods include improving the detection specificity and sensitivity in complex biological samples. Herein, a fluorescence assay was established based on a combination of immunomagnetic separation and a two-step signal amplification strategy for direct isolation and subsequent detection of exosomes. Read More

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Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics.

Front Res Metr Anal 2021 24;6:683212. Epub 2021 May 24.

Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, NSW, Australia.

The COVID-19 pandemic constitutes an ongoing worldwide threat to human society and has caused massive impacts on global public health, the economy and the political landscape. The key to gaining control of the disease lies in understanding the genetics of SARS-CoV-2 and the disease spectrum that follows infection. This study leverages traditional and intelligent bibliometric methods to conduct a multi-dimensional analysis on 5,632 COVID-19 genetic research papers, revealing that 1) the key players include research institutions from the United States, China, Britain and Canada; 2) research topics predominantly focus on virus infection mechanisms, virus testing, gene expression related to the immune reactions and patient clinical manifestation; 3) studies originated from the comparison of SARS-CoV-2 to previous human coronaviruses, following which research directions diverge into the analysis of virus molecular structure and genetics, the human immune response, vaccine development and gene expression related to immune responses; and 4) genes that are frequently highlighted include , , , and . Read More

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Side effects of CDK4/6 inhibitors in the treatment of HR+/HER2- advanced breast cancer: a systematic review and meta-analysis of randomized controlled trials.

Ann Palliat Med 2021 May;10(5):5590-5599

Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.

Background: Although combination of cyclin-dependent kinase 4 and 6(CDK4/6) inhibitors with endocrine therapy for advanced breast cancer (ABC) prolongs PFS in patients, but also has associated toxic side effects. However, few previous studies have summarized the toxic and side effects of CDK4/6 inhibitors. Therefore, this study summarized the corresponding toxic and side effects of CDK/6 inhibitors, which is of great importance for doctors and patients to understand how to balance the high survival rate brought by drugs with the decreased quality of life and improve the management of BC. Read More

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Palladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides.

Angew Chem Int Ed Engl 2021 Jun 9. Epub 2021 Jun 9.

East China Normal University, Department of Chemistry, CHINA.

Despite much progress has been made in the asymmetric α-arylation reactions of cyclic ketones, lactones and lactams, the enantioselective α-arylation of acyclic carbonyl compounds lagged much behind due to the in-situ generated Z/E-enolate intermediates leading to opposite enantiomers. Especially, the asymmetric α-arylation of acyclic aldehydes is a long-standing challenge, because of the highest activity among carbonyl compounds leading to various competitive side reactions. Herein we reported an efficient Pd-catalysed asymmetric intermolecular α-arylation reaction of α-branched aldehydes with aryl bromides, which provides a rapid access to chiral aldehydes bearing an α-all-carbon quaternary stereocenter in moderate to good yields with high enantioselectivities. Read More

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Kawasaki like illness due to COVID-19: a review of the literature.

J Infect Dev Ctries 2021 05 31;15(5):630-638. Epub 2021 May 31.

Divisions of Infectious Diseases and Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.

Introduction: Viral infections have been described as triggers for Kawasaki Disease (KD), a medium vessel vasculitis that affects young children. Akin to the H1N1 pandemic in 2009, there is a similar rise in the incidence of KD in children affected with Coronavirus disease 2019 (COVID-19). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been reported to induce an exaggerated systemic inflammatory response resulting in multi-organ involvement, particularly initiated with pulmonary parenchymal damage. Read More

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Efficacy of Xiang-Sha-Liu-Jun-Zi on chemotherapy-induced nausea and vomiting: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(19):e25848

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, PR China.

Background: Cancer is the main cause of death worldwide, and chemotherapy is the basic method of treating cancer. However, chemotherapy-induced nausea and vomiting (CINV) is the most common side effect of chemotherapy, and conventional antiemetics for the treatment of CINV also have side effects. At present, a large number of randomized controlled trials have shown that Xiang-Sha-Liu-Jun-Zi (XSLJZ) can effectively treat CINV, but there is no systematic review. Read More

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