141 results match your criteria reactions bupropion

Exploring the phototransformation and assessing the in vitro and in silico toxicity of a mixture of pharmaceuticals susceptible to photolysis.

Sci Total Environ 2021 Feb 26;756:144079. Epub 2020 Nov 26.

Laboratory of Environmental Pollution Control, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Thessaloniki, GR-57001, Greece. Electronic address:

The present study comprehensively investigates the phototransformation and ecotoxicity of a mixture of twelve pharmaceutically active compounds (PhACs) susceptible to photolysis. Namely, three antibiotics (ciprofloxacin, levofloxacin, moxifloxacin), three antidepressants (bupropion, duloxetine, olanzapine), three anti-inflammatory drugs (diclofenac, ketoprofen, nimesulide), two beta-blockers (propranolol, timolol) and the antihistamine ranitidine were treated under simulated solar irradiation in ultra-pure and river water. A total of 166 different transformation products (TPs) were identified by ultra-high performance liquid chromatography coupled with Orbitrap high resolution mass spectrometry (UHPLC-Orbitrap HRMS), revealing the formation of twelve novel TPs and forty-nine not previously described in photolytic studies. Read More

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February 2021

Drug interactions for elderly people with mental and behavioral disorders: a systematic scoping review.

Arch Gerontol Geriatr 2021 Mar-Apr;93:104283. Epub 2020 Nov 7.

Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil. Electronic address:

Objectives: To identify drug interactions of potentially inappropriate medications and mental and behavioral disorders, according to explicit potentially inappropriate medications criteria-based tools.

Methodology: A systematic scoping review was conducted in February 2020. Study characteristics, potentially inappropriate medications, drug interactions, rationale, and therapeutic management proposed were extracted. Read More

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February 2021

A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine.

Molecules 2020 Nov 10;25(22). Epub 2020 Nov 10.

Sensor Engineering Group, Faculty of Science and Engineering, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

The rapid sensing of drug compounds has traditionally relied on antibodies, enzymes and electrochemical reactions. These technologies can frequently produce false positives/negatives and require specific conditions to operate. Akin to antibodies, molecularly imprinted polymers (MIPs) are a more robust synthetic alternative with the ability to bind a target molecule with an affinity comparable to that of its natural counterparts. Read More

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November 2020

Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis.

PLoS One 2020 21;15(10):e0240584. Epub 2020 Oct 21.

Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Background: Attention deficit hyperactivity disorder (ADHD) affects approximately 3% of adults globally. Many pharmacologic treatments options exist, yet the comparative benefits and harms of individual treatments are largely unknown. We performed a systematic review and network meta-analysis to assess the relative effects of individual pharmacologic treatments for adults with ADHD. Read More

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December 2020

The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases.

CNS Drugs 2020 11;34(11):1133-1147

Department of Psychiatry, Washington University School of Medicine, 4320 Forest Park Avenue, Suite 301, Saint Louis, MO, 63108, USA.

Depression is common in older adults and those with cardiovascular disease. Although selective serotonin reuptake inhibitors generally have been shown to be safe to treat depression in these patients, it is important to identify additional antidepressants when selective serotonin reuptake inhibitors are not effective. This qualitative narrative review summarizes what is known about the cardiovascular side effects of some of the newer antidepressants. Read More

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November 2020

Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database.

BMC Psychiatry 2020 06 16;20(1):308. Epub 2020 Jun 16.

Service de Pharmacologie Médicale et Clinique, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CHU de Toulouse, Faculté de Médecine, Toulouse, France.

Background: Antidepressants-induced movement disorders are rare and imperfectly known adverse drug reactions. The risk may differ between different antidepressants and antidepressants' classes. The objective of this study was to assess the putative association of each antidepressant and antidepressants' classes with movement disorders. Read More

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[Pharmacotherapy for Smoking Cessation During Pregnancy - CNGOF-SFT Expert Report and Guidelines for Smoking Management During Pregnancy].

J Blanc A Koch

Gynecol Obstet Fertil Senol 2020 Jul - Aug;48(7-8):604-611. Epub 2020 Apr 1.

Pôle de gynécologie-obstétrique, CHU de Strasbourg, 69000 Strasbourg, France.

Objective: To review and describe available pharmacotherapy interventions for smoking cessation during pregnancy: nicotine replacement therapy (NRT) and non-nicotine replacement therapy.

Methods: The PubMed, Medline®, and Cochrane databases® (1/01/2003 au 5/04/2019) were accessed to identify relevant studies, using the search terms "tobacco use cessation devices", "nicotine replacement product or therapy", "smoking cessation", "pregnancy", "pregnant women", "varenicline", "bupropion".

Results: There is no data on the impact of NRT on the rate of smoking cessation during pre conception period. Read More

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Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice.

Pharmacol Rep 2020 Dec 27;72(6):1562-1572. Epub 2020 Mar 27.

Laboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland.

Background: Though there are several classes of antidepressant drugs available on the pharmaceutical market, depression that affects globally over 320 million people is still undertreated. Scientists have made attempts to develop novel therapeutical strategies to maximize effectiveness of therapy and minimize undesired reactions. One of the ideas is use of either dual-action agents or combined administration of two substances that affect diverse neurotransmissions. Read More

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December 2020

Association of sleep among 30 antidepressants: a population-wide adverse drug reaction study, 2004-2019.

Andy R Eugene

PeerJ 2020 11;8:e8748. Epub 2020 Mar 11.

Independent Researcher, Kansas, United States of America.

Background: Sleep is one of the most essential processes required to maintain a healthy human life, and patients experiencing psychiatric illness often experience an inability to sleep. The aim of this study is to test the hypothesis that antidepressant compounds with strong binding affinities for the serotonin 5-HT2C receptor, histamine H1 receptors, or norepinephrine transporter (NET) will be associated with the highest odds of somnolence.

Methods: Post-marketing cases of patient adverse drug reactions were obtained from the United States Food and Drug Administration Adverse Events Reporting System (FAERS) during the reporting window of January 2004 to September 2019. Read More

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Antidepressant-induced sexual dysfunction.

Jody Rothmore

Med J Aust 2020 04 15;212(7):329-334. Epub 2020 Mar 15.

Drug and Therapeutics Information Service, Southern Adelaide Local Health Network, Adelaide, SA.

Sexual dysfunction is a frequent, potentially distressing, adverse effect of antidepressants and a leading cause of medication non-adherence. Sexual function should be actively assessed at baseline, at regular intervals during treatment, and after treatment cessation. Trials comparing the risk of sexual dysfunction with individual antidepressants are inadequate, but it is reasonable to conclude that the risk is greatest with selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs), less with tricyclic antidepressants (except clomipramine) and mirtazapine, and least with moclobemide, agomelatine, reboxetine and bupropion. Read More

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Pharmacological interventions for promoting smoking cessation during pregnancy.

Cochrane Database Syst Rev 2020 03 4;3:CD010078. Epub 2020 Mar 4.

University of Nottingham, Division of Primary Care, Room 1502, Tower Building, University Park, Nottingham, Nottinghamshire, UK, NG7 2RD.

Background: Tobacco smoking in pregnancy causes serious health problems for the developing fetus and mother. When used by non-pregnant smokers, pharmacotherapies (nicotine replacement therapy (NRT), bupropion, and varenicline) are effective for increasing smoking cessation, however their efficacy and safety in pregnancy remains unknown. Electronic cigarettes (ECs) are becoming widely used, but their efficacy and safety when used for smoking cessation in pregnancy are also unknown. Read More

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Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders.

Psychiatr Pol 2019 Oct 30;53(5):977-995. Epub 2019 Oct 30.

Uniwersytet Jagielloński Collegium Medicum, Katedra Psychiatrii.

Objectives: To evaluate harmful interactions between antidepressants and medications used in treatment of cardiovascular disorders.

Methods: The analysis of 66 cases of adverse reactions with a clinical picture indicating, to a degree that is probable or certain, that they were the result of the combination of antidepressant with cardiovascular medication.

Results: The most common side effect (n = 25, 37. Read More

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October 2019

Effectiveness and Safety of Bupropion in Children and Adolescents with Depressive Disorders: A Retrospective Chart Review.

Clin Psychopharmacol Neurosci 2019 Nov;17(4):537-541

Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: This study aimed to investigate the effectiveness and safety of bupropion extended-release for the treatment of depressive disorder in children and adolescents.

Methods: This was a 12-week, retrospective chart review of bupropion, which included 127 youth (age, 15.3 ± 2. Read More

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November 2019

Treatment adherence and short-term outcomes of smoking cessation outpatient clinic patients.

Tob Induc Dis 2018 30;16:38. Epub 2018 Aug 30.

Department of Chest Diseases, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.

Introduction: Previous studies have shown that adherence to treatment is fundamental to success in smoking cessation. However, smoking cessation medication regimens are limited significantly by the struggle to adhere to them. This study was conducted to evaluate the factors associated with treatment adherence and quitting success in a group of patients that applied to our smoking cessation outpatient clinic (SCC). Read More

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Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults.

J Am Geriatr Soc 2019 08 29;67(8):1571-1581. Epub 2019 May 29.

University of Connecticut School of Pharmacy, Storrs, Connecticut.

Objectives: To assess adverse effects of pharmacologic antidepressants for treatment of major depressive disorder (MDD) in adults 65 years of age or older.

Design: Systematic review and meta-analysis.

Setting: Specialist or generalist outpatient setting, rehabilitation facility, and nursing facilities. Read More

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Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis.

Evid Based Ment Health 2019 05 17;22(2):61-66. Epub 2019 Apr 17.

Department of Psychiatry, University of Oxford, Oxford, UK.

Introduction: We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol for a network meta-analysis aimed at extending these results, updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of specific adverse events and tolerability in the acute treatment of major depression in adults.

Methods And Analysis: We will include all double-blind randomised controlled trials comparing one active drug with another or with placebo in the acute treatment major depression in adults. Read More

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[Comparative study of acupoint catgut embedding and bupropion hydrochloride sustained-release tablets for tobacco dependence].

Hong-Ying Li Wei He

Zhongguo Zhen Jiu 2019 Apr;39(4):384-8

Area 1 of Acupuncture, Moxibustion and Rehabilitation, Seventh People's Hospital of Nanning, Nanning 530012, Guangxi Zhuang Autonomous Region, China.

Objective: To compare the clinical efficacy of acupoint catgut embedding and bupropion hydrochloride sustained-release tablets in the treatment of tobacco dependence.

Methods: A total of 100 patients with tobacco dependence who met the inclusion criteria were randomly divided into an acupoint catgut embedding group and a drug group, 50 cases in each group. In the acupoint catgut embedding group, acupoint catgut embedding was applied at Xinshu (BL 15), Shenmen (HT 7), Tianmei (Extra), Taichong (LR 3), the treatment was given once every 2 weeks for 4 times; The bupropion hydrochloride sustained-release tablets was orally administered in the drug group for 7 weeks, 150 mg each time, once a day for the first 3 days, twice daily from day 4 to day 7, and once a day after day 8. Read More

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Correlating effluent concentrations and bench-scale experiments to assess the transformation of endocrine active compounds in wastewater by UV or chlorination disinfection.

Chemosphere 2019 Jul 25;226:565-575. Epub 2019 Mar 25.

Department of Chemistry, The College of Wooster, 943 College Mall, Wooster, OH, 44691, USA. Electronic address:

Transformation of endocrine active compounds (EACs) by either chlorination (Cl-D) or UV disinfection (UV-D) was studied by field sampling and bench-scale validation studies. Field testing assessed concentration of 13 EACs in effluent at two Chicago area 250 MGD wastewater reclamation plants (WRP) over two years. One WRP uses chlorination/dechlorination while the other employs UV disinfection. Read More

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Patients in medical treatment for attention deficit/hyperactivity disorder (ADHD): Are they at risk in drug screening?

Atten Defic Hyperact Disord 2019 Sep 7;11(3):333-340. Epub 2018 Dec 7.

Department of Clinical Biochemistry, North Denmark Regional Hospital, Bispensgade 37, Hjørring, DK-9800, Denmark.

The use of medicines to treat attention deficit/hyperactivity disorder (ADHD) has increased worldwide, including the use of amphetamine-based medicines or prodrugs that metabolise to amphetamine in vivo. At the same time, drugs-of-abuse testing by non-specific, point-of-care immunoassay methods ('quick tests') has increased. This article discusses the risk of 'false positive' results or post-analytical misinterpretations of results when immunoassays are used to analyse biological samples from ADHD patients. Read More

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September 2019

A 10-year review of single medication double-dose ingestions in the nation's largest poison control system.

Clin Toxicol (Phila) 2019 01 28;57(1):31-35. Epub 2018 Nov 28.

a Department of Emergency Medicine, University of California San Diego, San Diego, CA, USA.

Background: Most Americans take at least one medication on a daily basis. Inadvertently ingesting a double-dose of a medication with a narrow therapeutic index may lead to adverse effects. When a patient or medical professional contacts the local poison center after an overdose, a poison specialist fields the incoming information and, depending on the caller, provides specific recommendations. Read More

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January 2019

In vivo phenotyping of cytochrome 450 isoforms involved in the metabolism of anti-HIV and anti-tubercular drugs in human using cocktail approach: An LC-MS/MS analysis.

J Pharm Biomed Anal 2019 Feb 16;164:698-705. Epub 2018 Nov 16.

Department of Biochemistry, School of Chemical and Life Science, Jamia Hamdard (Deemed University), Hamdard Nagar, New Delhi, 110062, India. Electronic address:

Purpose: In vivo phenotyping of CYP isoforms involved in the metabolism of anti-HIV and antitubercular drugs is important to determine therapeutic dose levels in HIV/AIDS-TB coinfections. In this study, we used a cocktail of bupropion, losartan and dapsone for in vivo phenotyping of CYP2B6, CYP2C9 and N-acetyltransferase-2 (NAT2) in plasma. CYP2B6 is the main catalyst of anti-HIV efavirenz, while NAT2 is involved in antitubercular drug isoniazid metabolism. Read More

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February 2019

Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen.

Biomed Pharmacother 2018 Dec 13;108:208-215. Epub 2018 Sep 13.

Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address:

Worldwide, aspirin and ibuprofen are the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs). Some adverse reactions, including gastrointestinal reactions, have been concerned extensively. Nevertheless, the mechanism of liver injury remains unclear. Read More

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December 2018

Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review.

Chonnam Med J 2018 May 25;54(2):101-112. Epub 2018 May 25.

Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.

Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs). However, an increasing number of studies, including meta-analyses, naturalistic studies, and longer-term studies suggested that SSRIs and SNRIs are no less safe than TCAs. We focused on comparing the common side effects of TCAs with those of newer generation antidepressants including SSRIs, SNRIs, mirtazapine, and bupropion. Read More

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Is There a Potential of Misuse for Venlafaxine and Bupropion?

Front Pharmacol 2018 21;9:239. Epub 2018 Mar 21.

Psychopharmacology, Drug Misuse, and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

Traditionally, studies on the non-medical use of pharmaceutical products have focused on controlled substances; e.g., opiates/opioids; and benzodiazepines. Read More

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Comparative evaluation of vortioxetine as a switch therapy in patients with major depressive disorder.

Eur Neuropsychopharmacol 2017 08 27;27(8):773-781. Epub 2017 Jun 27.

Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Switching antidepressant therapy is a recommended strategy for depressed patients who neither respond to nor tolerate an initial pharmacotherapy course. This paper reviews the efficacy and tolerability of switching to vortioxetine. All three published studies of patients with major depressive disorder (MDD) switched from SSRI/SNRI therapy to vortioxetine due to lack of efficacy or tolerability were selected. Read More

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[Arterial Hyper- and Hypotension associated with psychiatric medications: a risk assessment based on the summaries of product characteristics (SmPCs)].

Dtsch Med Wochenschr 2017 Aug 23;142(16):e100-e107. Epub 2017 Jun 23.

Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm, Ulm.

 Psychiatric medications are well-known triggers of clinically relevant blood pressure changes. Therefore, we aimed at creating ranking lists for their risk of causing arterial hyper- or hypotension.  We analyzed 784 Summaries of Product characteristics (SmPCs, available online from "Rote Liste" or "Gelbe Liste" websites) from 105 psychiatric medications registered in adult psychiatry in Germany and extracted the standardized reported risks of increasing or decreasing arterial blood pressure. Read More

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How do smoking cessation medicines compare with respect to their neuropsychiatric safety? A protocol for a systematic review, network meta-analysis and cost-effectiveness analysis.

BMJ Open 2017 06 17;7(6):e015414. Epub 2017 Jun 17.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

Introduction: Cigarette smoking is one of the leading causes of early death in the UK and worldwide. Public health guidance recommends the use of varenicline, bupropion and nicotine replacement therapy (NRT) as smoking cessation aids in the UK. Additionally, the first electronic cigarette has been licensed for use as a smoking cessation medicine. Read More

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Bupropion-Induced Acute Dystonia with Dose Escalation and Use of Naranjo Nomogram.

Cureus 2017 Apr 12;9(4):e1157. Epub 2017 Apr 12.

Hematology/Oncology, Tufts Medical Center, Tufts University School of Medicine.

Acute drug-induced dystonia is commonly associated with antipsychotic drugs, antidepressants, antiemetics, and other medications. Bupropion (Wellbutrin and Zyban) is one of the most frequently prescribed antidepressants in the United States and Canada and smoking cessation aid. However, only few reported cases have been published of acute dystonia including dystonia after discontinuation of bupropion and even after a single dose of bupropion. Read More

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Determination of clozapine, and five antidepressants in human plasma, serum and whole blood by gas chromatography-mass spectrometry: A simple tool for clinical and postmortem toxicological analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Dec 21;1038:43-48. Epub 2016 Oct 21.

Psychiatric Clinic, University Hospital of Ioannina, 45110 Ioannina, Greece.

In this study, we describe a simple and rapid method for the determination of the antipsychotic drug clozapine and five commonly co-administered antidepressants - bupropion, mirtazapine, sertraline, clomipramine and citalopram - in serum, plasma and whole blood. Sample preparation includes solid phase extraction of analytes and determination of drug concentrations by gas chromatography-mass spectrometry without any derivatization steps. The method was fully validated according to international criteria and can be successfully applied for routine analyses. Read More

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December 2016

An Evaluation on the Efficacy and Safety of Treatments for Attention Deficit Hyperactivity Disorder in Children and Adolescents: a Comparison of Multiple Treatments.

Mol Neurobiol 2017 11 13;54(9):6655-6669. Epub 2016 Oct 13.

Department of Paediatrics, Huaihe Hospital, Henan University, No. 115 Ximen Street, Kaifeng, Henan, 475000, China.

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders. We carried out this comparison of multiple treatments based on sufficient data in attempt to evaluate the efficacy and safety of ADHD medication for children and adolescents. PubMed, Embase and the Cochrane Database were used to search for relevant articles. Read More

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November 2017