Sci Total Environ 2021 Feb 26;756:144079. Epub 2020 Nov 26.
Laboratory of Environmental Pollution Control, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Thessaloniki, GR-57001, Greece. Electronic address:
The present study comprehensively investigates the phototransformation and ecotoxicity of a mixture of twelve pharmaceutically active compounds (PhACs) susceptible to photolysis. Namely, three antibiotics (ciprofloxacin, levofloxacin, moxifloxacin), three antidepressants (bupropion, duloxetine, olanzapine), three anti-inflammatory drugs (diclofenac, ketoprofen, nimesulide), two beta-blockers (propranolol, timolol) and the antihistamine ranitidine were treated under simulated solar irradiation in ultra-pure and river water. A total of 166 different transformation products (TPs) were identified by ultra-high performance liquid chromatography coupled with Orbitrap high resolution mass spectrometry (UHPLC-Orbitrap HRMS), revealing the formation of twelve novel TPs and forty-nine not previously described in photolytic studies. Read More