4,087 results match your criteria reactions biases


The efficacy and safety of moxibustion for chronic fatigue syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25742

Guizhou University of Traditional Chinese Medicine, Guizhou.

Background: The pathogenesis of chronic fatigue syndrome (CFS) is not clear. The main purpose of treatment is to improve autoimmune function and relieve fatigue symptoms. Moxibustion is often used to treat diseases caused by low autoimmunity, especially in relieving fatigue symptoms. Read More

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Comparing the efficacy of non-invasive physical therapy in improving pain and joint function of knee osteoarthritis: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25671

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: The incidence of knee osteoarthritis is increasing year by year, which seriously affects people's quality of life, especially the elderly, and has become a major public health problem. A lot of evidence shows that physical therapy has advantages in the treatment of knee joints, but there are a number of physical therapy schemes, and the efficacy of each scheme is different. This study will evaluate the clinical efficacy of different physical therapy regimens in the treatment of knee osteoarthritis (KOA) by means of network meta-analysis. Read More

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Global patterns in anaphylaxis due to specific foods: a systematic review.

J Allergy Clin Immunol 2021 Apr 30. Epub 2021 Apr 30.

National Heart & Lung Institute, Imperial College London, London, United Kingdom;; Department of Paediatrics and Child Health, The University of Sydney, Sydney, New South Wales, Australia. Electronic address:

Background: There are increasing global data relating to prevalence of food allergy and food-induced anaphylaxis, however this is often based on surrogate measures of sensitization rather than objective symptoms at food challenge. In terms of protecting food-allergic consumers from reactions, there has been no global survey assessing geographical differences in the proportion of anaphylaxis triggered by specific foods.

Objective: To identify common triggers for food-induced anaphylaxis, and how these vary from country to country. Read More

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Quantitative gold nanorods based photothermal biosensor for glucose using a thermometer as readout.

Talanta 2021 Aug 26;230:122364. Epub 2021 Mar 26.

Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China. Electronic address:

To meet the increasing need for point-of-care testing (POCT), simple and portable readout strategies would be highly desirable. Thermometer with high accuracy and straightforward readout is an ideal tool for the development of new POCT methods. The exploration of new thermometer-based detection methods is of great significance. Read More

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Normalization of DNA encoded library affinity selection results driven by high throughput sequencing and HPLC purification.

Bioorg Med Chem 2021 Apr 27;40:116178. Epub 2021 Apr 27.

Discovery Chemistry Research & Technologies, Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Madrid 28108, Spain. Electronic address:

The output of an affinity selection screening results in a huge amount of valuable data that, after conducting the appropriate analysis, lead to the correct identification of the compounds enriched in the target of interest. The approach chosen to perform these analyses has become a key step in the development of a successful DNA Encoded Library platform. In this paper, we describe the combination of High Performance Liquid Chromatography purification during the library production with the Next Generation Sequencing analysis of the libraries to assess the yield of the chemical reactions prior to the affinity selection. Read More

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Relationship between injection site reactions and different adalimumab formulations. Analysis of the adverse events reported in Italy in the period 2016-2019.

Eur Rev Med Pharmacol Sci 2021 Apr;25(8):3300-3305

Post-graduate School of Hospital Pharmacy, Sapienza University of Rome, Rome, Italy.

Objective: The adalimumab originator Humira® introduced a new citrate-free formulation in 2016, before the patent expiry that occurred in the European Union in October 2018. Some of the adalimumab biosimilars that were subsequently marketed are citrate-free, while others are not. Since citrate as an excipient is associated with pain at the injection site, recent anecdotical reporting in Italy raised the issue of possible prescription biases related to the differences in formulation existing among the various adalimumab products. Read More

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Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection.

Nanomaterials (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

Department of Mechanical Engineering, Advanced Institute of Manufacturing with High Tech Innovations (AIM-HI), Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi 62102, Taiwan.

P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-vis reflectance spectroscopy, and photocurrent response analyses. Read More

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Diagnostic accuracy of the Cepheid Xpert Xpress and the Abbott ID NOW assay for rapid detection of SARS-CoV-2: A systematic review and meta-analysis.

J Med Virol 2021 Apr 29. Epub 2021 Apr 29.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Rapid and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is essential to prevent the spread of the virus. We investigated the diagnostic accuracy of the Xpert Xpress and the ID NOW assays for rapid detection of SARS-CoV-2 using a systemic review and meta-analysis approach. A systematic literature search was performed using PubMed, Embase, and the Cochrane COVID-19 Study Register. Read More

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Safety of COVID-19 vaccines administered in the EU: Should we be concerned?

Toxicol Rep 2021 20;8:871-879. Epub 2021 Apr 20.

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece.

The COVID-19 pandemic has had an unprecedented and devastating impact on public health, society and economics around the world. As a result, the development of vaccines to protect individuals from symptomatic COVID-19 infections has represented the only feasible health tool to combat the spread of the disease. However, at the same time the development and regulatory assessment of different vaccines has challenged pharmaceutical industries and regulatory agencies as this process has occurred in the shorter time ever though. Read More

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Efficacy and safety of azithromycin and amoxicillin/clavulanate for otitis media in children: a systematic review and meta-analysis of randomized controlled trials.

Ann Clin Microbiol Antimicrob 2021 Apr 24;20(1):28. Epub 2021 Apr 24.

Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Resistance, prolonged therapy, and more adverse reactions made amoxicillin less preferred for treating otitis media. This study aimed to compare the efficacy and safety of azithromycin and amoxicillin/clavulanate for the treatment of otitis media in children.

Methodology: This study was a systematic review and meta-analysis. Read More

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Linggui Zhugan Decoction for peripheral vertigo: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25563

Nanchang Hongdu Hospital of Traditional Chinese Medicine.

Background: Vertigo is a sense of movement or rotation of the patient's own or an external object. At present, western medicine treatment such as vestibular suppressant medications commonly used in clinical practice are ineffective and have adverse reactions. In traditional Chinese medicine, Linggui Zhugan Decoction (LZD) was used by doctors to warm yang for resolving fluid retention, strengthen the spleen and clear away dampness, with significant effect. Read More

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Mechanisms That Underly T Cell Immunity in Graves' Orbitopathy.

Front Endocrinol (Lausanne) 2021 1;12:648732. Epub 2021 Apr 1.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is the most common ocular abnormality of Graves' disease. It is a disfiguring, invalidating, and potentially blinding orbital disease mediated by an interlocking and complicated immune network. Self-reactive T cells directly against thyroid-stimulating hormone receptor-bearing orbital fibroblasts contribute to autoimmune inflammation and tissue remodeling in GO orbital connective tissues. Read More

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Anxiety increases sensitivity to errors and negative feedback over time.

Biol Psychol 2021 Apr 15;162:108092. Epub 2021 Apr 15.

Department of Psychology and Neuroscience, University of Colorado Boulder, United States.

Anxiety is characterized by sensitivity to negative external and internal information, apparent both in symptoms (e.g., hypervigilance and worry) and neural performance monitoring measures (i. Read More

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Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis.

J Allergy Clin Immunol 2021 Apr 13. Epub 2021 Apr 13.

National Heart & Lung Institute, Imperial College London, London, UK. Electronic address:

Background: Regulatory bodies recommend all patients at risk of anaphylaxis are prescribed two epinephrine auto-injectors, which they should carry at all times. This is in contrast to some guidelines. The proportion of anaphylaxis reactions which are treated with multiple doses of epinephrine has not been systematically evaluated. Read More

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Sub-second Time-resolved Surface Enhanced Raman Spectroscopy Reveals Dynamic CO Intermediates during Electrochemical CO2 Reduction on Copper.

Angew Chem Int Ed Engl 2021 Apr 14. Epub 2021 Apr 14.

Utrecht University, Dept. of Inorganic Chemistry and Catalysis, Universiteitsweg 99, 3584 CG, Utrecht, NETHERLANDS.

Electrocatalytic reduction of carbon dioxide (CO2) into value-added products (e.g., ethylene) is a promising approach for greenhouse gas mitigation, but many details of electrocatalytic CO2 reduction reactions (CO2RR) remain elusive. Read More

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A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Apr 13;22(1):276. Epub 2021 Apr 13.

Department of Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Hacettepe Mh., 06230, Ankara, Turkey.

Objectives: The primary objective is to evaluate the efficacy of an inactivated and aluminium hydroxide adsorbed SARS-CoV-2 vaccine (Sinovac, China) in voluntary participants after 14 days of the second dose against RT-PCR confirmed symptomatic COVID-19 cases. The secondary objectives include evaluating the efficacy after at least one dose of the vaccine against RT-PCR confirmed symptomatic COVID-19 cases; the efficacy of two doses of the vaccine on the rates of hospitalization and death; the safety of the vaccine including adverse reactions up to one year after the 2 dose of vaccination; and the immunogenicity of the vaccine and its duration up to 120 days.

Trial Design: This is a phase III, randomized, double-blind, placebo-controlled case driven clinical trial to assess the efficacy and safety of the vaccine. Read More

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A Label-Free Diamond Microfluidic DNA Sensor Based on Active Nitrogen-Vacancy Center Charge State Control.

ACS Appl Mater Interfaces 2021 Apr 13;13(16):18500-18510. Epub 2021 Apr 13.

Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Sítna sq. 3105, 27201 Kladno, Czech Republic.

We propose a label-free biosensor concept based on the charge state manipulation of nitrogen-vacancy (NV) quantum color centers in diamond, combined with an electrochemical microfluidic flow cell sensor, constructed on boron-doped diamond. This device can be set at a defined electrochemical potential, locking onto the particular chemical reaction, whilst the NV center provides the sensing function. The NV charge state occupation is initially prepared by applying a bias voltage on a gate electrode and then subsequently altered by exposure to detected charged molecules. Read More

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Troubling Secondary Victimization of Bullying Victims: The Role of Gender and Ethnicity.

J Interpers Violence 2021 Apr 12:8862605211005151. Epub 2021 Apr 12.

University of Vigo, Ourense, Spain.

Bullying is a severe public health problem, and bystanders' reactions are a key variable in its perpetration and maintenance. This study aimed to assess the level of secondary victimization of bullying victims as a function of the student's sex and the victim's category (nonnormative vs. normative) in three experimental conditions (feminine, masculine, and ethnicity) from a socioecological perspective. Read More

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A comparison of non-intubated video-assisted thoracic surgery with spontaneous ventilation and intubated video-assisted thoracic surgery: a meta-analysis based on 14 randomized controlled trials.

J Thorac Dis 2021 Mar;13(3):1624-1640

Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Background: Video-assisted thoracic surgery (VATS) generally involves endotracheal intubation under general anesthesia. However, inevitably, this may cause intubation-related complications and prolong the postoperative recovery process. Gradually, non-intubated video-assisted thoracic surgery (NIVATS) is increasingly being utilized. Read More

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Characterizing Chelation at Surfaces by Charge Tunneling.

J Am Chem Soc 2021 Apr 9;143(15):5967-5977. Epub 2021 Apr 9.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

This paper describes a surface analysis technique that uses the "EGaIn junction" to measure tunneling current densities ((V), amps/cm) through self-assembled monolayers (SAMs) terminated in a chelating group and incorporating different transition metal ions. Comparisons of (V) measurements between bare chelating groups and chelates are used to characterize the composition of the SAM and infer the dissociation constant (, mol/L), as well as kinetic rate constants ( L/mols; 1/s) of the reversible chelate-metal reaction. To demonstrate the concept, SAMs of 11-(4-methyl-2,2'-bipyrid-4'-yl (bpy))undecanethiol (HS(CH)bpy) were incubated within ethanol solutions of metal salts. Read More

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Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic review and meta-analysis.

Eur J Intern Med 2021 Apr 5. Epub 2021 Apr 5.

Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.

Objective: To estimate the incidence rate ratio (IRR) of adverse events (AE) in chloroquine or hydroxychloroquine users.

Methods: We systematically reviewed randomized controlled trials (RCTs), using MEDLINE (2010-2020) and EMBASE (2010-2020) databases, reporting AE in chloroquine or hydroxychloroquine users during treatment for lupus, rheumatoid arthritis, malaria and COVID-19. The protocol for this systematic review is registered at the PROSPERO database (CRD42020197938). Read More

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Efficacy and safety of moxibustion for menstrual irregularities: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(14):e25281

Jiangxi Province Hospital of Integrated Chinese and Western Medicine.

Background: Menstrual irregularities (MI) is 1 of the most common clinical gynaecological diseases, with abnormal menstrual cycles, abnormal bleeding, and abdominal pain before or during menstruation as the main clinical manifestations. In modern medicine, abnormalities in the function of the pituitary gland, hypothalamus, and ovaries can affect menstruation. Currently, hormone levels in the body are mostly regulated by hormonal drugs, but these drugs can lead to hormonal imbalance, which can lead to adverse reactions. Read More

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Risk factors for steroid-induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic leukemia: A systematic review.

Psychooncology 2021 Apr 6. Epub 2021 Apr 6.

Princess Maxima Center, CS Utrecht, The Netherlands.

Objective: Steroids play an essential role in treating pediatric acute lymphoblastic leukemia (ALL). The downside is that these drugs can cause severe side effects, such as adverse psychological reactions (APRs) and sleep problems, which can compromise health-related quality of life. This study aimed to systematically review literature to identify risk factors for steroid-induced APRs and sleep problems in children with ALL. Read More

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The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Front Pharmacol 2020 18;11:630825. Epub 2021 Mar 18.

Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

For advanced non-small cell lung cancer (NSCLC) patients, first-line chemotherapy is the main treatment in the clinic despite its efficacy is limited and adverse effects are always inescapable. Ginsenoside Rg3, an anti-cancer active ingredient by suppressing angiogenesis, has been increasingly widely used as an adjuvant in first-line chemotherapy for advanced NSCLC to optimize treatment in China. However, no comprehensive meta-analyses have been conducted to estimate the efficacy and safety of the therapy combining ginsenoside Rg3 and first-line chemotherapy in advanced NSCLC patients. Read More

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Standard versus high dose of rifampicin in the treatment of pulmonary tuberculosis: a systematic review and meta-analysis.

Clin Microbiol Infect 2021 Apr 1. Epub 2021 Apr 1.

Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy. Electronic address:

Objectives: A growing amount of evidence suggests that the rifampicin dosing currently recommended for tuberculosis treatment could be associated with inadequate exposure and unfavourable outcomes. We aimed to compare clinical and microbiological efficacy and safety outcomes of standard and higher rifampicin dosing.

Methods: Data sources were MEDLINE, Google Scholar and the Cochrane Library. Read More

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Causal Associations between Serum Urea and Cancer: A Mendelian Randomization Study.

Genes (Basel) 2021 Mar 29;12(4). Epub 2021 Mar 29.

Department of Biochemistry and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Urea is largely derived from the urea cycle reactions through hepatic detoxification of free ammonia and cleared by urination, and the serum urea level is a crucial medical indicator for measuring the kidney function in patients with nephropathy; however, investigative revelations pointing to the serum urea level as a risk factor for cancer are very scarce, and relevant studies are restricted by potential biases. We aimed to explore the causal relationships of the serum urea level with cancer development by focusing on renal cell carcinoma (RCC) using the Mendelian randomization (MR) analyses. Summary estimates were collected from the inverse-variance weighted (IVW) method based on six single nucleotide polymorphisms (SNPs). Read More

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Prevalence of anxiety, depression, and psychological distress among the general population during the COVID-19 pandemic: A systematic review and meta-analysis.

Int J Soc Psychiatry 2021 Apr 1:207640211003121. Epub 2021 Apr 1.

Department of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: The COVID-19 pandemic is a worldwide epidemic declared by the world health organization as a public health emergency of concern and consequently inducing huge mental health and psychological reactions.

Aims: This study is aimed to summarize the existing data regarding anxiety, depression, and psychological distress during the covid-19 pandemic among the wider population so that effective intervention strategies will be initiated.

Methods: Pieces of literature that assessed anxiety, depression, and psychological distress among the general population during the COVID pandemic period were systematically gathered. Read More

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[Analysis of RCT outcome indicators of traditional Chinese medicine for essential hypertension in recent two years].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1547-1557

Office of Basic Research in Evidence-based Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.

To find the status of outcome indicators reported in published randomized controlled trial(RCT) of traditional Chinese medicine(TCM) for essential hypertension in the past two years, we searched for relevant information from four Chinese databases, three English databases and two clinical trial registries in this study, from January 2018 to September 2019. The outcome indicators of RCT were extracted and categorized from trials and the risk of bias was assessed by ROB tools from the Cochrane Collaboration. A total of 125 RCTs and 15 RCT protocols were finally included after study screening. Read More

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[Systematic review and Meta-analysis of clinical efficacy and safety of Ginkgo Leaf Tablets in treatment of acute cerebral infarction].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1537-1546

Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700,China Institute for Brain Disorders,Beijing University of Chinese Medicine Beijing 100700,China.

To systematically evaluate the clinical efficacy and safety of Ginkgo Leaf Tablets(GLT) in the treatment of acute cerebral infarction(ACI). Seven databases both at home and abroad were systematically retrieved from their establishment to March 2020. The data of the included studies were extracted after review and screening. Read More

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[Meta-analysis of effect of Qishen Yiqi Dripping Pills combined with Western medicine on adverse cardiovascular events and quality of life after percutaneous coronary intervention].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1498-1510

Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700,China.

To systemically evaluate the effect of Qishen Yiqi Dripping Pills combined with Western medicine on adverse cardiovascular events and quality of life after percutaneous coronary intervention(PCI). A total of 7 Chinese and English databases including CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane Library and Web of Science were searched by computer to collect the randomized controlled trials(RCTs) on Qishen Yiqi Dripping Pills combined with Western medicine in the treatment of patients with coronary heart disease after PCI with the retrieval time from the database establishment to April 1, 2020. Two researchers independently conducted li-terature screening, data extraction and bias risk assessment. Read More

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