Chem Rec 2021 Jun 11. Epub 2021 Jun 11.
Department of Chemistry, Universidade Federal do Paraná, CP 19081, CEP 81531-990, Curitiba, PR, Brazil.
Neutralization of organophosphates is an issue of public health and safety, involving agrochemicals and chemical warfare. A promising approach is the nucleophilic neutralization, scope of this review, which focuses on the molecular nucleophiles: hydroxide, imidazole derivatives, alpha nucleophiles, amines and other nucleophiles. A reactivity mapping is given correlating the pathways and reaction efficiency with structural dependence of the nucleophile (basicity) and the organophosphate (electrophilic centers, P=O/P=S shift, leaving and non-leaving group). Read More