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Differences in SCN1A intronic variants result in diverse aberrant splicing patterns and are related to the phenotypes of epilepsy with febrile seizures.

Epilepsy Res 2021 Jul 7;176:106711. Epub 2021 Jul 7.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, GX, China. Electronic address:

Objective: Intronic variants of the SCN1A gene are detected in patients with epilepsy with febrile seizures (EFS), which includes a series of phenotypes with different severities. However, the pathogenicity of intronic variants and their genotype-phenotype correlation remain under characterized. The purpose of this study was to determine the changes in mRNA splicing caused by SCN1A intronic variants associated with EFS and their association with phenotypes. Read More

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Relationships between the Physicochemical Properties of Dissolved Organic Matter and Its Reaction with Sodium Borohydride.

Environ Sci Technol 2021 Jul 22. Epub 2021 Jul 22.

Zachry Department of Civil & Environmental Engineering, Texas A&M University, College Station, Texas 77845, United States.

The reaction of dissolved organic matter (DOM) with sodium borohydride has been used to understand the geographic origin of DOM and investigate the photophysical model underlying DOM's optical properties. However, the physicochemical properties of DOM (e.g. Read More

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Diverse reactions of a fluorostannylenoid towards ethynes.

Dalton Trans 2021 Jul 22. Epub 2021 Jul 22.

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.

Fluoro(dialkyl)stannylenoid 2 exhibits unique reactivity towards ethynes with acetylenic hydrogen and those with trimethylsilyl groups, though the corresponding free dialkylstannylene 1 is inactive against those ethynes. Stannylenoid 2 reacts smoothly with gaseous ethyne and phenylethyne at room temperature, giving the corresponding diethynylstannanes, di(phenylethynyl)stannane 3 and diethynylstannane 6, respectively, in good yields with the concomitant evolution of H2. Trimethylsilyl-substituted ethynes such as 1-trimethylsilyl-(2-phenyl)ethyne and 1,2-bis(trimethylsilyl)ethyne react similarly to give 3 and bis(trimethylsilylethynyl)stannane 8, respectively. Read More

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Comparative Transcriptome Analyses of the Developmental Stages of .

Front Vet Sci 2021 5;8:677045. Epub 2021 Jul 5.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.

Cerebral coenurosis, caused by the larvae of (, is a fatal central nervous system disease in sheep and other herbivores and occasionally humans. Comparative transcriptomic profiles of the developmental stages of the parasite remain unknown. In this study, RNA sequencing was used to determine the transcriptome profiles of different stages of the life cycle of , including Oncosphere, (Pro with Cyst), and Adult (Adu), as well as scolex-neck proglottids (Snp), immature-mature proglottids (Imp), and gravid proglottids (Grp) of the adult stage. Read More

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Kinetically driven successive sodic and potassic alteration of feldspar.

Nat Commun 2021 Jul 21;12(1):4435. Epub 2021 Jul 21.

School of Earth, Atmosphere and Environment, Monash University, Clayton, Victoria, Australia.

The dynamic evolutions of fluid-mineral systems driving large-scale geochemical transformations in the Earth's crust remain poorly understood. We observed experimentally that successive sodic and potassic alterations of feldspar can occur via a single self-evolved, originally Na-only, hydrothermal fluid. At 600 °C, 2 kbar, sanidine ((KNa)AlSiO) reacted rapidly with a NaCl fluid to form albite (NaAlSiO); over time, some of this albite was replaced by K-feldspar (KAlSiO), in contrast to predictions from equilibrium reaction modelling. Read More

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miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.

Cancer Cell Int 2021 Jul 21;21(1):390. Epub 2021 Jul 21.

Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Hubei Polytechnic University School of Medicine, Xialu District guilin north, road no. 16, Huangshi, 435003, Hubei, China.

Background: miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RCC) remain elusive. Here, we aimed to explore the role of miR198 in RCC. Read More

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Accelerating Selective Oxidation of Biomass-Based Hydroxyl Compounds with Hydrogen Bond Acceptors.

J Phys Chem Lett 2021 Jul 21:7041-7045. Epub 2021 Jul 21.

State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China.

Hydrogen-bonding-initiated self-association makes the valorization of biomass-based hydroxyl compounds a formidable challenge at high concentration. Apart from enhancing the dehydration reaction of hydroxyl compounds with the noncovalent medium effects, insights into how these effects can be exploited to optimize the oxidative reactivity of concentrated hydroxyl compounds remain unclear. Herein, we elucidate that deaggregation of hydroxyl groups with a catalytic number of hydrogen bond acceptors is essential in improving the reactivity of the aerobic oxidation of biomass-based neat aromatic alcohols over the vanadium-based catalyst. Read More

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Microchemical Engineering in a 3D Ordered Channel Enhances Electrocatalysis.

J Am Chem Soc 2021 Jul 21. Epub 2021 Jul 21.

Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, University of Science and Technology of China, Hefei 230026, China.

The kinetics of electrode reactions including mass transfer and surface reaction is essential in electrocatalysis, as it strongly determines the apparent reaction rates, especially on nanostructured electrocatalysts. However, important challenges still remain in optimizing the kinetics of given catalysts with suitable constituents, morphology, and crystalline design to maximize the electrocatalytic performances. We propose a comprehensive kinetic model coupling mass transfer and surface reaction on the nanocatalyst-modified electrode surface to explore and shed light on the kinetic optimization in electrocatalysis. Read More

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Overexpression of the Long Noncoding RNA Inhibits Non-Small Cell Lung Cancer Cell Proliferation and Invasion Through HIF-2a Pathway.

Cancer Biother Radiopharm 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiology, Tuberculosis Hospital of Shaanxi Province, The Fifth People's Hospital of Shaanxi Province, Xi'an, China.

The role and molecular mechanism of long-chain noncoding RNAs (lncRNAs) in lung cancer remain to be elucidated. The aim of this study was to investigate the association between a long coding RNA hypoxia-inducible factor-2α (HIF-2α) promoter upstream transcript () and clinical characteristics of non-small cell lung cancer (NSCLC) and its regulatory role in NSCLC. The correlation between expression and pathological features of NSCLC was analyzed in NSCLC patient samples. Read More

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Short-term high fat diet alters genes associated with metabolic and vascular dysfunction during adolescence in rats: a pilot study.

PeerJ 2021 9;9:e11714. Epub 2021 Jul 9.

College of Health Solutions & School of Life Sciences, Arizona State University, Tempe, AZ, USA.

Background: Diet-induced metabolic dysfunction precedes multiple disease states including diabetes, heart disease, and vascular dysfunction. The critical role of the vasculature in disease progression is established, yet the details of how gene expression changes in early cardiovascular disease remain an enigma. The objective of the current pilot project was to evaluate whether a quantitative assessment of gene expression within the aorta of six-week old healthy male Sprague-Dawley rats compared to those exhibiting symptoms of metabolic dysfunction could reveal potential mediators of vascular dysfunction. Read More

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Effects of Repeated Intracordal Glucocorticoid Injection on the Histology and Gene Expression of Rat Vocal Folds.

J Voice 2021 Jul 17. Epub 2021 Jul 17.

Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objectives: Local injection of glucocorticoids (GCs) into the vocal folds has been used for treating the vocal fold lesions. While the positive effects on vocal fold nodules, polyps, or scarring have been clinically reported, some concern remains around the potential adverse effects such as vocal fold atrophy, and the mechanisms remain unclear. The present study examined the histology and gene expression of locally injected GC into the vocal folds in rats. Read More

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COVID-19 cumulative incidence, asymptomatic infections, and fatality in Long Island, NY, January-August 2020: A cohort of World Trade Center responders.

PLoS One 2021 20;16(7):e0254713. Epub 2021 Jul 20.

World Trade Center Health and Wellness Program, Stony Brook University (SUNY), Stony Brook, New York, United States of America.

Background: New York City and Long Island, NY were early foci of the COVID-19 epidemic in the US. The effects of COVID-19 on different sub-populations, and its key epidemiologic parameters remain unknown or highly uncertain. We investigated the epidemiology of COVID-19 from January to August of 2020 in an established academic monitoring cohort of N = 9,697 middle-aged World Trade Center responders residing in Long Island, NY. Read More

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A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S.

Proc Natl Acad Sci U S A 2021 Jul;118(30)

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;

Blasticidin S is a peptidyl nucleoside antibiotic. Its biosynthesis involves a cryptic leucylation and two leucylated intermediates, LDBS and LBS, have been found in previous studies. Leucylation has been proposed to be a new self-resistance mechanism during blasticidin S biosynthesis, and the leucyl group was found to be important for the methylation of β-amino group of the arginine side chain. Read More

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Direct, Catalytic α-Alkylation of -Heterocycles by Hydroaminoalkylation: Substrate Effects for Regiodivergent Product Formation.

J Am Chem Soc 2021 Jul 19. Epub 2021 Jul 19.

Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.

Saturated -heterocycles are prevalent in pharmaceutical and agrochemical industries, yet remain challenging to catalytically alkylate. Most strategies for C-H activation of these challenging substrates use protected amines or high loadings of precious metal catalysts. We report an early transition-metal system for the broad, robust, and direct alkylation of unprotected amine heterocycles with simple alkenes. Read More

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Type of exercise may influence postural adaptations in chemotherapy-induced peripheral neuropathy.

Ann Clin Transl Neurol 2021 Jul 18. Epub 2021 Jul 18.

Department of Neurology and Neuroscience, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objective: Traditional posturography measurements characterize postural instability in patients with chemotherapy-induced peripheral neuropathy (CIPN), while underlying postural control mechanisms remain unclear. Taking a model-based approach can yield insights into these mechanisms. This study's aim was to characterize the modifications in postural control of CIPN patients associated with exercise in relation to the postural behavior of healthy control participants (hCON) via an exploratory approach. Read More

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Mechanistic Insights into the Dual Directing Group-Mediated C-H Functionalization/Annulation a Hydroxyl Group-Assisted M-M-M Pathway.

ACS Omega 2021 Jul 1;6(27):17642-17650. Epub 2021 Jul 1.

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

The experimental investigations on the catalyst [Cp*Rh(OAc) and Cp*Ir (OAc))]-controlled [3 + 2] and [4 + 2] annulations of oximes with propargyl alcohols have been finished in our previous work and a supposed dual directing group-mediated reaction pathway has been deduced for the chemodivergent product synthesis. However, the detailed interaction modes of the dual directing groups binding with the corresponding metal center to achieve the above observed chemoselectivity remain unclear and even contradict. For instance, the calculational traditional dual direct coupling transition states suggested that both Cp*Rh(OAc)- and Cp*Ir(OAc)-catalyzed reactions would generate five-membered indenamines as the dominant products [3 + 2] annulation. Read More

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Acute effects of high-intensity interval training and moderate-intensity continuous exercise on BDNF and irisin levels and neurocognitive performance in late middle-aged and older adults.

Behav Brain Res 2021 Jul 15;413:113472. Epub 2021 Jul 15.

Institute of Physical Education, Health and Leisure Studies, National Cheng Kung University, Taiwan.

The purposes of the present study were (1) to explore and compare the acute effects of high-intensity interval training (HIIT) and moderate-intensity continuous exercise (MICE) on neurocognitive performance and molecular biomarkers in late middle-aged and older adults, and (2) to examine the relationships of HIIT/MICE exercise-induced neurocognitive changes with changes in circulating irisin and BDNF levels elicited by different acute exercise modes. Using a within-subject design, twenty-one participants completed an acute bout of 30 min of HIIT, MICE, or a non-exercise-intervention (REST) session in a counterbalanced order. The neuropsychological [i. Read More

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Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19.

Int J Infect Dis 2021 Jul 14. Epub 2021 Jul 14.

Nozaki Tokushukai Hospital, 2-10-50 Tanigawa, Daito City, Osaka, 574-0074, Japan.

Background: The effects of high-intensity immunity on coronavirus disease 2019 (COVID-19) remain unclear. While it may be protective, antibodies against SARS-CoV-2 are more preferentially induced in inpatients with COVID-19 than in outpatients with milder disease, and immunosuppression is the standard therapy for severe cases. We studied the relationship between cross-reactive antibody production against seasonal human coronavirus and the clinical course of COVID-19. Read More

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Current Perspectives on Severe Drug Eruption.

Clin Rev Allergy Immunol 2021 Jul 17. Epub 2021 Jul 17.

Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Tianshan District, No. 91, Tianchi Road, Urumqi, 830001, Xinjiang, China.

Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs. Read More

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Structural basis for potassium transport in prokaryotes by KdpFABC.

Proc Natl Acad Sci U S A 2021 Jul;118(29)

Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University Grossman School of Medicine, New York, NY 10016;

KdpFABC is an oligomeric K transport complex in prokaryotes that maintains ionic homeostasis under stress conditions. The complex comprises a channel-like subunit (KdpA) from the superfamily of K transporters and a pump-like subunit (KdpB) from the superfamily of P-type ATPases. Recent structural work has defined the architecture and generated contradictory hypotheses for the transport mechanism. Read More

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Severe acute respiratory syndrome coronavirus 2 reinfection in a coronavirus disease 2019 recovered young adult: a case report.

J Med Case Rep 2021 Jul 16;15(1):382. Epub 2021 Jul 16.

Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Background: Coronavirus disease 2019 has been a public health threat and a worldwide emergency for more than a year. Unfortunately, many questions concerning the pathophysiology, management, and long-term side effects remain unanswered, and novel aspects of the disease keep on emerging. Of concern to healthcare providers are the recent reported cases of reinfection. Read More

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Circ_0011460 up-regulates HTRA1 expression by sponging miR-762 to suppress HTR8/SVneo cell growth, migration and invasion.

Am J Reprod Immunol 2021 Jul 16:e13485. Epub 2021 Jul 16.

Maternal-Fetal Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Aberrant expression of circular RNAs (circRNAs) during placental development could affect fetal growth and contribute to preeclampsia (PE). Circ_0011460 was found to be differentially expressed in placental samples of PE. However, the exact function and mechanism of circ_0011460 in PE process remain largely undefined. Read More

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Distinct retrotransposon evolution profile in the genome of rabbit (Oryctolagus cuniculus).

Genome Biol Evol 2021 Jul 16. Epub 2021 Jul 16.

College of Animal Science & Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.

Although the rabbit genome has already been annotated, it's mobilome remains largely unknown. Here, multiple pipelines were used to de novo mine and annotate the mobilome in rabbit. Four families and 19 subfamilies of LINE1s, two families and nine subfamilies of SINEs, and 12 ERV families were defined in rabbit based on sequence identity, structural organization, and phylogenetic tree. Read More

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Reaction Kinetics Regulated Formation of Short-Range Order in an Amorphous Matrix during Zeolite Crystallization.

J Am Chem Soc 2021 Jul 16. Epub 2021 Jul 16.

Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

The crystallization of zeolites, a disorder-to-order transformation of aluminosilicates, has not been thoroughly understood because the nucleation events in the amorphous matrix are difficult to recognize from the diverse structural changes, especially for the dense hydrogel systems. Therefore, relationships between the synthesis conditions, the generated amorphous species, and the crystallization behavior of zeolites remain unclear. Herein, by comparatively investigating the structural evolution of the aluminosilicate matrix in a dense hydrogel system when different Si reactants (fumed silica and silicate solution) are employed, we demonstrate that the reactivity of the reactants and the kinetics of the condensation reaction is critical to the formation of short-range order in an amorphous matrix, which greatly influences the nucleation frequency of zeolites. Read More

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Characterizing and Improving Reaction Times for Based Cell-Free Protein Synthesis.

ACS Synth Biol 2021 Jul 16. Epub 2021 Jul 16.

Chemistry and Biochemistry Department, California Polytechnic State University, 1 Grand Avenue, San Luis Obispo, California 93407, United States.

Cell-free protein synthesis (CFPS) is a platform biotechnology that has enabled the on-demand synthesis of proteins for a variety of applications. Numerous advances have improved the productivity of the CFPS platform to result in high-yielding reactions; however, many applications remain limited due to long reaction times. To overcome this limitation, we first established the benchmarks reaction times for CFPS across in-house extracts and commercial kits. Read More

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Upregulation of the long noncoding RNA UBOX5 antisense RNA 1 (UBOX5-AS1) under hypoxic conditions promotes epithelial-mesenchymal transition in endometriosis.

Ann Transl Med 2021 May;9(9):790

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Endometriosis is a debilitating gynecological condition that manifests many common malignant features, including migration and invasion. Hypoxia is a hallmark of endometriosis, characterized by endometrial cell metastasis via epithelial-mesenchymal transition (EMT). The long noncoding RNA (lncRNA) UBOX antisense RNA 1 (UBOX5-AS1) has been shown to be upregulated in ovarian endometriosis. Read More

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Sevoflurane pretreatment regulates abnormal expression of MicroRNAs associated with spinal cord ischemia/reperfusion injury in rats.

Ann Transl Med 2021 May;9(9):752

Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, China.

Background: Spinal cord ischemia/reperfusion injury (SCII) is one of the most serious spinal cord complications that stem from varied spine injuries or thoracoabdominal aortic surgery. Nevertheless, the molecular mechanisms underlying the SCII remain unclear.

Methods: Male Sprague-Dawley (SD) rats were randomly divided into 5 groups of sham, SCII 24 h, SCII 72 h, sevoflurane preconditioning SCII 24 h (SCII 24 h+sevo), and sevoflurane preconditioning SCII 72 h (SCII 72 h+sevo) group. Read More

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Hippocampus chronic deep brain stimulation induces reversible transcript changes in a macaque model of mesial temporal lobe epilepsy.

Chin Med J (Engl) 2021 Jul 14. Epub 2021 Jul 14.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing 100070, China Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China Chinese Institute for Brain Research, Beijing 102206, China.

Background: Deep brain stimulation (DBS) has seizure-suppressing effects but the molecular mechanisms underlying its therapeutic action remain unclear. This study aims to systematically elucidate the mechanisms underlying DBS-induced seizure suppression at a molecular level.

Methods: We established a macaque model of mesial temporal lobe epilepsy (mTLE), and continuous high-frequency hippocampus DBS (hip-DBS) was applied for 3 months. Read More

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A neural index of inefficient evidence accumulation in dyslexia underlying slow perceptual decision making.

Cortex 2021 Jun 24;142:122-137. Epub 2021 Jun 24.

Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Vic, Australia; Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.

Visual processing deficits have been widely reported in developmental dyslexia however the locus of cognitive dysfunction remains unclear. Here, we examined the neural correlates of perceptual decision-making using a dot-motion task and electroencephalography (EEG) and investigated whether presenting deficits were unique to children with dyslexia or if they were also evident in other, typically developing children with equally immature reading systems. Sixty-eight children participated: 32 with dyslexia (DD; 16 females); 21 age-matched controls (AM; 11 females) and 15 reading-matched controls (RM; 9 females). Read More

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Clinical and Molecular Findings of Infections Caused by Extended-Spectrum β-Lactamase-Producing in Patients with Solid Tumors: A Single-Center Study.

Microb Drug Resist 2021 Jul 14. Epub 2021 Jul 14.

Department of Surgical Oncology, Nicolaus Copernicus University Ludwik Rydygier's Collegium Medicum, Bydgoszcz, Poland.

Infectious complications caused by multidrug-resistant bacteria are a serious clinical and therapeutic problem. Our study aimed to analyze the genetic characteristics of extended-spectrum β-lactamase-producing (ESBL-E) that cause multidrug-resistant infections in patients with solid tumors. Identification of ESBL-encoding genes was performed by polymerase chain reaction (PCR) and sequencing. Read More

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