9 results match your criteria rdgn genes

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Systemic paralogy and function of retinal determination network homologs in arachnids.

BMC Genomics 2020 Nov 23;21(1):811. Epub 2020 Nov 23.

Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, 53706, USA.

Background: Arachnids are important components of cave ecosystems and display many examples of troglomorphisms, such as blindness, depigmentation, and elongate appendages. Little is known about how the eyes of arachnids are specified genetically, let alone the mechanisms for eye reduction and loss in troglomorphic arachnids. Additionally, duplication of Retinal Determination Gene Network (RDGN) homologs in spiders has convoluted functional inferences extrapolated from single-copy homologs in pancrustacean models. Read More

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November 2020

HerGePred: Heterogeneous Network Embedding Representation for Disease Gene Prediction.

IEEE J Biomed Health Inform 2019 07;23(4):1805-1815

The discovery of disease-causing genes is a critical step towards understanding the nature of a disease and determining a possible cure for it. In recent years, many computational methods to identify disease genes have been proposed. However, making full use of disease-related (e. Read More

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Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.

PLoS One 2017 6;12(11):e0187546. Epub 2017 Nov 6.

Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America.

A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diversify regulatory potential is to combine multiple biochemical activities into the same protein. Exemplifying this principle of modularity, Eyes absent (Eya), originally identified as a transcriptional co-activator within the retinal determination gene network (RDGN), also harbors tyrosine and threonine phosphatase activities. Read More

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November 2017

Eye Development in Embryo: What the Uncommon Gene Expression Profiles Tell Us about Eye Evolution.

Front Physiol 2017 24;8:613. Epub 2017 Aug 24.

UMR Biologie des Organismes et Ecosystèmes Aquatiques, Museum National d'Histoire Naturelle, Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS 7208), Université Pierre et Marie Curie (UPMC), Université de Caen Normandie, Institut de Recherche Pour le Développement (IRD207), Université des AntillesParis, France.

In metazoans, there is a remarkable diversity of photosensitive structures; their shapes, physiology, optical properties, and development are different. To approach the evolution of photosensitive structures and visual function, cephalopods are particularly interesting organisms due to their most highly centralized nervous system and their camerular eyes which constitute a convergence with those of vertebrates. The eye morphogenesis in numerous metazoans is controlled mainly by a conserved Retinal Determination Gene Network (RDGN) including , and playing also key developmental roles in non-retinal structures and tissues of vertebrates and . Read More

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Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.

Dev Biol 2017 Jan 29;421(1):67-76. Epub 2016 Sep 29.

Department of Ophthalmology and Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY, USA; Departments of Neuroscience & Physiology and Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA. Electronic address:

Drosophila has three types of visual organs, the larval eyes or Bolwig's organs (BO), the ocelli (OC) and the compound eyes (CE). In all, the bHLH protein Atonal (Ato) functions as the proneural factor for photoreceptors and effects the transition from progenitor cells to differentiating neurons. In this work, we investigate the regulation of ato expression in the BO primordium (BOP). Read More

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January 2017

The DACH/EYA/SIX gene network and its role in tumor initiation and progression.

Int J Cancer 2016 Mar 12;138(5):1067-75. Epub 2015 Jun 12.

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

The functional abnormality of developmental genes is a common phenomenon in cancer initiation and progression. The retinal determination gene network (RDGN) is a key signal in Drosophila eye specification, and this conservative pathway is also required for the development of multiple organs in mammalian species. Recent studies demonstrated that aberrant expressions of RDGN components in vertebrates, mainly Dach, Six, and Eya, represent a novel tumor signal. Read More

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Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression.

Dev Biol 2014 Jun 12;390(1):14-25. Epub 2014 Mar 12.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A1S6. Electronic address:

Organogenesis is a complex developmental process, which requires tight regulation of selector gene expression to specify individual organ types. The Pax6 homolog Eyeless (Ey) is an example of such a factor and its expression pattern reveals it is dynamically controlled during development. Ey׳s paralog Twin of eyeless (Toy) induces its expression during embryogenesis, and the two genes are expressed in nearly identical patterns during the larval stages of development. Read More

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The "eyes absent" (eya) gene in the eye-bearing hydrozoan jellyfish Cladonema radiatum: conservation of the retinal determination network.

J Exp Zool B Mol Dev Evol 2012 Jun;318(4):257-67

Biozentrum, Basel University, Basel, Switzerland.

Eyes absent (Eya) is a member of the Retinal Determination Gene Network (RDGN), a set of genes responsible for eye specification in Drosophila. Eya is a dual function protein, working as a transcription factor in the nucleus and as a tyrosine phosphatase in the cytoplasm. It had been shown that Pax and Six family genes, main components of the RDGN, are present in the hydrozoan Cladonema radiatum and that they are expressed in the eye. Read More

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Probing the Drosophila retinal determination gene network in Tribolium (II): The Pax6 genes eyeless and twin of eyeless.

Dev Biol 2009 Sep 13;333(1):215-27. Epub 2009 Jun 13.

Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.

The Pax6 genes eyeless (ey) and twin of eyeless (toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in Drosophila. Most animals possess a singleton Pax6 ortholog, but the dependence of eye development on Pax6 is widely conserved. A rare exception is given by the larval eyes of Drosophila, which develop independently of ey and toy. Read More

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September 2009
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