114 results match your criteria rdgn


Systemic paralogy and function of retinal determination network homologs in arachnids.

BMC Genomics 2020 Nov 23;21(1):811. Epub 2020 Nov 23.

Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, 53706, USA.

Background: Arachnids are important components of cave ecosystems and display many examples of troglomorphisms, such as blindness, depigmentation, and elongate appendages. Little is known about how the eyes of arachnids are specified genetically, let alone the mechanisms for eye reduction and loss in troglomorphic arachnids. Additionally, duplication of Retinal Determination Gene Network (RDGN) homologs in spiders has convoluted functional inferences extrapolated from single-copy homologs in pancrustacean models. Read More

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November 2020

RDGN-based predictive model for the prognosis of breast cancer.

Exp Hematol Oncol 2020 15;9:13. Epub 2020 Jun 15.

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 China.

Background: Breast cancer is the most diagnosed malignancy in females in the United States. The members of retinal determination gene network (RDGN) including DACH, EYA, as well as SIX families participate in the proliferation, apoptosis, and metastasis of multiple tumors including breast cancer. A comprehensive predictive model of RDGN might be helpful to herald the prognosis of breast cancer patients. Read More

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SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1.

Front Oncol 2019 20;9:1450. Epub 2019 Dec 20.

Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.

As a critical member of the Retinal Determination Gene Network (RDGN), SIX1 has been regarded as a tumor promoter in various types of cancer. However, its role in papillary thyroid carcinoma (PTC) has never been investigated. In this study, thyroid carcinoma tissue microarray staining was employed to identify the expression patterns of SIX1 and its co-activator EYA1. Read More

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December 2019

HerGePred: Heterogeneous Network Embedding Representation for Disease Gene Prediction.

IEEE J Biomed Health Inform 2019 07;23(4):1805-1815

The discovery of disease-causing genes is a critical step towards understanding the nature of a disease and determining a possible cure for it. In recent years, many computational methods to identify disease genes have been proposed. However, making full use of disease-related (e. Read More

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EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.

Am J Transl Res 2019 15;11(4):2328-2338. Epub 2019 Apr 15.

Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University 169 Donghu Road, Wuhan 430071, P. R. China.

Hepatocellular carcinoma (HCC) patients are at high risk for both local recurrence and distant metastasis and tightly associated with poor prognosis. Exploring the molecular mechanism will provide a new opportunity in developing personal treatment for advanced HCC patients. As a critical member of the Retinal Determination Gene Network (RDGN), EYA1 has been identified as a tumor promoter in various cancers; however, its role in HCC has never been investigated. Read More

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The regulation of cytokine signaling by retinal determination gene network pathway in cancer.

Onco Targets Ther 2018 4;11:6479-6487. Epub 2018 Oct 4.

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,

Tumor environment plays a pivotal role in determining cancer biology characteristics. Cytokine factors, as a critical component in tumor milieu, execute distinct functions in the process of tumorigenesis and progression via the autocrine or paracrine manner. The retinal determination gene network (RDGN), which mainly comprised DACH, SIX, and EYA family members, is required for the organ development in mammalian species. Read More

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October 2018

Homeodomain-interacting protein kinase phosphorylates the Drosophila Paired box protein 6 (Pax6) homologues Twin of eyeless and Eyeless.

Insect Mol Biol 2018 04 4;27(2):198-211. Epub 2017 Dec 4.

Developmental Biology, Saarland University, Homburg, Germany.

Homeodomain-interacting protein kinase (Hipk), the Drosophila homologue of mammalian HIPK2, plays several important roles in regulating differentiation, proliferation, apoptosis, and stress responses and acts as a mediator for signals of diverse pathways, such as Notch or Wingless signalling. The Paired box protein 6 (Pax6) has two Drosophila homologues, Twin of eyeless (Toy) and Eyeless (Ey). Both stand atop the retinal determination gene network (RDGN), which is essential for proper eye development in Drosophila. Read More

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Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network.

Fly (Austin) 2018 01 12;12(1):62-70. Epub 2017 Dec 12.

a Committee on Development, Regeneration, and Stem Cell Biology , University of Chicago , Chicago , IL , USA.

Master regulatory transcription factors cooperate in networks to shepherd cells through organogenesis. In the Drosophila eye, a collection of master control proteins known as the retinal determination gene network (RDGN) switches the direction and targets of its output to choreograph developmental transitions, but the molecular partners that enable such regulatory flexibility are not known. We recently showed that two RDGN members, Eyes absent (Eya) and Sine oculis (So), promote exit from the terminal cell cycle known as the second mitotic wave (SMW) to permit differentiation. Read More

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January 2018

Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.

PLoS One 2017 6;12(11):e0187546. Epub 2017 Nov 6.

Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, United States of America.

A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diversify regulatory potential is to combine multiple biochemical activities into the same protein. Exemplifying this principle of modularity, Eyes absent (Eya), originally identified as a transcriptional co-activator within the retinal determination gene network (RDGN), also harbors tyrosine and threonine phosphatase activities. Read More

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November 2017

Eye Development in Embryo: What the Uncommon Gene Expression Profiles Tell Us about Eye Evolution.

Front Physiol 2017 24;8:613. Epub 2017 Aug 24.

UMR Biologie des Organismes et Ecosystèmes Aquatiques, Museum National d'Histoire Naturelle, Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS 7208), Université Pierre et Marie Curie (UPMC), Université de Caen Normandie, Institut de Recherche Pour le Développement (IRD207), Université des AntillesParis, France.

In metazoans, there is a remarkable diversity of photosensitive structures; their shapes, physiology, optical properties, and development are different. To approach the evolution of photosensitive structures and visual function, cephalopods are particularly interesting organisms due to their most highly centralized nervous system and their camerular eyes which constitute a convergence with those of vertebrates. The eye morphogenesis in numerous metazoans is controlled mainly by a conserved Retinal Determination Gene Network (RDGN) including , and playing also key developmental roles in non-retinal structures and tissues of vertebrates and . Read More

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Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.

Dev Biol 2017 Jan 13;421(2):93-107. Epub 2016 Dec 13.

Committee on Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, IL 60637, USA; Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA. Electronic address:

Among the mechanisms that steer cells to their correct fate during development, master regulatory networks are unique in their sufficiency to trigger a developmental program outside of its normal context. In this review we discuss the key features that underlie master regulatory potency during normal and ectopic development, focusing on two examples, the retinal determination gene network (RDGN) that directs eye development in the fruit fly and the pluripotency gene network (PGN) that maintains cell fate competency in the early mammalian embryo. In addition to the hierarchical transcriptional activation, extensive positive transcriptional feedback, and cooperative protein-protein interactions that enable master regulators to override competing cellular programs, recent evidence suggests that network topology must also be dynamic, with extensive rewiring of the interactions and feedback loops required to navigate the correct sequence of developmental transitions to reach a final fate. Read More

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January 2017

Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.

Dev Biol 2017 Jan 29;421(1):67-76. Epub 2016 Sep 29.

Department of Ophthalmology and Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY, USA; Departments of Neuroscience & Physiology and Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA. Electronic address:

Drosophila has three types of visual organs, the larval eyes or Bolwig's organs (BO), the ocelli (OC) and the compound eyes (CE). In all, the bHLH protein Atonal (Ato) functions as the proneural factor for photoreceptors and effects the transition from progenitor cells to differentiating neurons. In this work, we investigate the regulation of ato expression in the BO primordium (BOP). Read More

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January 2017

The retinal determination gene network: from developmental regulator to cancer therapeutic target.

Oncotarget 2016 Aug;7(31):50755-50765

Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College, Huazhang University of Science and Technology, Wuhan, P.R. China.

Although originally identified for its function in Drosophila melanogaster eye specification, the Retinal Determination Gene Network (RDGN) is essential for the development of multiple organs in mammals. The RDGN regulates proliferation, differentiation and autocrine signaling, and interacts with other key signaling pathways. Aberrant expression of RDGN members such as DACH, EYA and SIX contributes to tumor initiation and progression; indeed, the levels of RDGN members are clinically prognostic factors in various cancer types. Read More

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The DACH/EYA/SIX gene network and its role in tumor initiation and progression.

Int J Cancer 2016 Mar 12;138(5):1067-75. Epub 2015 Jun 12.

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

The functional abnormality of developmental genes is a common phenomenon in cancer initiation and progression. The retinal determination gene network (RDGN) is a key signal in Drosophila eye specification, and this conservative pathway is also required for the development of multiple organs in mammalian species. Recent studies demonstrated that aberrant expressions of RDGN components in vertebrates, mainly Dach, Six, and Eya, represent a novel tumor signal. Read More

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Interplay of retinal determination gene network with TGF-β signaling pathway in epithelial-mesenchymal transition.

Stem Cell Investig 2015 9;2:12. Epub 2015 Jun 9.

1 Department of Geriatrics, 2 Department of Thyroid and Breast Surgery, 3 Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.

As a fundamental event in the generation of tissues and organs during embryogenesis, the epithelial-mesenchymal transition (EMT) has also been implicated in cancer progression by its ability to alter the plasticity of epithelial cells to acquire invasive properties. Evidence is mounting that ectopic activation of transforming growth factors β (TGF-β)/bone morphogenetic protein (BMP) superfamily members to enhance tumorigenesis and metastasis. In this respect, the Retinal Determination Gene Network (RDGN), which was identified to govern the normal initiation of the morphogenetic furrow in Drosophila, has now been found to be de-regulated in various types of cancers, and the key members of this network, DACH, SIX, and EYA, have emerged as novel co-regulators of TGF- signaling during EMT. Read More

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Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression.

Dev Biol 2014 Jun 12;390(1):14-25. Epub 2014 Mar 12.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A1S6. Electronic address:

Organogenesis is a complex developmental process, which requires tight regulation of selector gene expression to specify individual organ types. The Pax6 homolog Eyeless (Ey) is an example of such a factor and its expression pattern reveals it is dynamically controlled during development. Ey׳s paralog Twin of eyeless (Toy) induces its expression during embryogenesis, and the two genes are expressed in nearly identical patterns during the larval stages of development. Read More

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Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative response in human hepatocellular carcinoma.

Hepatology 2013 Dec 21;58(6):2012-22. Epub 2013 Oct 21.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, P.R. China.

Unlabelled: Human dachshund homolog 1 (DACH1) is a major component of the Retinal Determination Gene Network (RDGN) and functions as a tumor suppressor. However, the regulation of DACH1 expression and its function in hepatocellular carcinoma (HCC) remain unclear. In this study, epigenetic changes of DACH1 were analyzed in HCC cell lines and primary cancers. Read More

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December 2013

The "eyes absent" (eya) gene in the eye-bearing hydrozoan jellyfish Cladonema radiatum: conservation of the retinal determination network.

J Exp Zool B Mol Dev Evol 2012 Jun;318(4):257-67

Biozentrum, Basel University, Basel, Switzerland.

Eyes absent (Eya) is a member of the Retinal Determination Gene Network (RDGN), a set of genes responsible for eye specification in Drosophila. Eya is a dual function protein, working as a transcription factor in the nucleus and as a tyrosine phosphatase in the cytoplasm. It had been shown that Pax and Six family genes, main components of the RDGN, are present in the hydrozoan Cladonema radiatum and that they are expressed in the eye. Read More

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Sonographic assessment of the retroperitoneal position of the third portion of the duodenum: an indicator of normal intestinal rotation.

Pediatr Radiol 2012 Aug 9;42(8):941-5. Epub 2012 Jun 9.

Paediatric Radiology Unit, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, Brussels 1200, Belgium.

Background: The diagnosis of intestinal malrotation is based on an upper gastrointestinal contrast series (UGI), which is considered the imaging reference standard. It may however be challenging even for experienced paediatric radiologists.

Objective: The purpose of this study was to demonstrate the agreement between UGI and US in assessing the position of the third portion of the duodenum (D3) and to show that a retroperitoneal duodenum indicates normal forgut rotation. Read More

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DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.

Biochem Biophys Res Commun 2012 Mar 3;420(1):91-5. Epub 2012 Mar 3.

School of Life Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea.

The cell-fate determination factor Dachshund, a component of the Retinal Determination Gene Network (RDGN), has a role in breast tumor proliferation through the repression of cyclin D1 and several key regulators of embryonic stem cell function, such as Nanog and Sox2. However, little is known about the role of DACH1 in a myeloid lineage as a cell cycle regulator. Here, we identified the differential expression levels of extensive cell cycle regulators controlled by DACH1 in myeloid progenitor cells. Read More

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[Breast liposarcoma].

JBR-BTR 2010 Nov-Dec;93(6):299-301

Department of Medical Imaging, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Liposarcoma of the breast constitutes 1% of all malignant breast tumors. We report the case of a 42-year-old woman presented with a 5 cm-mass in the left breast. Mammography, ultrasonography and MRI showed a non-specific appearance and the histological evaluation was necessary for definitive diagnosis. Read More

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Regulation of ocellar specification and size by twin of eyeless and homothorax.

Dev Dyn 2011 Jan;240(1):75-85

Centro Andaluz de Biología del Desarrollo (CABD), CSIC-UPO, Seville, Spain.

The retinal determination gene network (RDGN) constitutes a paradigm of a gene network controlling organ specification and growth. In this study, we probed the RDGN in the Drosophila ocelli, a set of simple eyes located on the fly's dorsal head, by studying the expression, regulation, and function of toy, hth, eya, and so, members of the Pax6, Meis, Eya, and Six gene families. Our results highlight the role of the pax6 gene toy, together with the hh signaling pathway, in the initiation of eya and so expression; the engagement of eya and so in a feedback loop necessary for their full expression; and the interplay between hh signaling and hth as a mechanism of organ size control, as general regulatory steps in the specification of visual organs. Read More

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January 2011

[Answer to July-August e-quid. Breast filariasis].

J Radiol 2010 Sep;91(9 Pt 1):921-2

Département d'imagerie médicale, Cliniques Universitaires Saint-Luc, Avenue Hippocrate, Bruxelles.

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September 2010

Transient elastography in patients with cystic fibrosis.

Pediatr Radiol 2010 Jul 5;40(7):1231-5. Epub 2010 Feb 5.

Radiology, Cliniques Universitaires St Luc, Avenue Hippocrate 10, Brussels 1200, Belgium.

Background: Hepatic involvement is frequent in patients with cystic fibrosis (CF), with focal biliary cirrhosis being the pathognomonic hepatic manifestation. In around one-quarter of CF patients, it results in CF-associated liver disease (CFLD). This occurs as a relatively early complication with the majority of patients presenting in childhood or their early teens. Read More

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The Dachshund gene in development and hormone-responsive tumorigenesis.

Trends Endocrinol Metab 2010 Jan 5;21(1):41-9. Epub 2009 Nov 5.

Department of Cancer Biology, Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Read More

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January 2010

Probing the Drosophila retinal determination gene network in Tribolium (II): The Pax6 genes eyeless and twin of eyeless.

Dev Biol 2009 Sep 13;333(1):215-27. Epub 2009 Jun 13.

Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.

The Pax6 genes eyeless (ey) and twin of eyeless (toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in Drosophila. Most animals possess a singleton Pax6 ortholog, but the dependence of eye development on Pax6 is widely conserved. A rare exception is given by the larval eyes of Drosophila, which develop independently of ey and toy. Read More

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September 2009

[US and dense breasts: where do we stand?].

Authors:
I Leconte L Fellah

J Radiol 2008 Sep;89(9 Pt 2):1169-79

Département d'imagerie médicale, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Bruxelles.

The use of ultrasonography in dense breast remains a controversial topic. It is acknowledged that ultrasound as an adjunct to mammography increases the detection rate of breast cancers. However, the main limitation of US, in addition to its operator dependent nature, is its low specificity, leading to a high rate of false positive results. Read More

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September 2008

Drosophila nemo promotes eye specification directed by the retinal determination gene network.

Genetics 2008 Sep 30;180(1):283-99. Epub 2008 Aug 30.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Drosophila nemo (nmo) is the founding member of the Nemo-like kinase (Nlk) family of serine-threonine kinases. Previous work has characterized nmo's role in planar cell polarity during ommatidial patterning. Here we examine an earlier role for nmo in eye formation through interactions with the retinal determination gene network (RDGN). Read More

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September 2008

[Plain radiography of the knee: the articular surfaces].

J Radiol 2008 May;89(5 Pt 2):692-7; quiz708-10

Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Département d'imagerie médicale, avenue Hippocrate 10, 1200 Bruxelles, Belgique.

Lateral knee radiographs allow recognition of both medial and lateral femoral and tibial surfaces, groove and anterior borders of the trochlea and lateral facet and ridge of the patella. Analysis of these lines allows detection of focal contour abnormalities, femoral trochlear dysplasia and patellar tilt. Qualitative radiological analysis of the osseous surfaces detects the particular aspect of abraded subchondral bone ("drawn with chalk"), preventing the trap of false joint spaces on non weight-bearing views. Read More

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Screening for lung cancer with low-dose CT.

Authors:
E Coche

JBR-BTR 2008 Jan-Feb;91(1):1-5

Department of Medical Imaging, Cliniques Universitaires St-Luc, Brussels, Belgium.

Lung cancer represents the leading cause of cancer-related mortality in the world. In the past, many attempts were made to detect the disease at an early stage and subsequently reduce its mortality. Chest X-ray was abandoned for this purpose. Read More

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