155,149 results match your criteria rats surgical


Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats.

J Pharmacol Sci 2021 Aug 28;146(4):183-191. Epub 2021 Apr 28.

Department of General Medicine, Asahikawa Medical University, Japan.

Short chain fatty acids readily crosses the gut-blood and blood-brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system may play a role in the regulation of intestinal functions. Colonic permeability and visceral sensation was evaluated in rats. Read More

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Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: whole-transcriptome profiling in the rat nucleus of the solitary tract.

Genes Brain Behav 2021 Jun 10:e12759. Epub 2021 Jun 10.

Department of Anesthesiology and Perioperative Medicine, Tohoku University School of Medicine, Sendai, Japan.

The genetic mechanisms of postoperative nausea and vomiting (PONV) and the involvement of the catecholamine system in the brain have not been elucidated. Eating kaolin clay as a type of pica has been examined as an alternative behavior to emesis. Here, we evaluated changes in whole-transcriptome analysis in the nucleus of the solitary tract (NTS) in a rat pica model as a surrogate behavior of PONV to elucidate the molecular genetic mechanisms of the development of PONV and the involvement of the catecholamine system in the NTS. Read More

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Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage.

Bone 2021 Jun 7:116035. Epub 2021 Jun 7.

Division of Pediatric Endocrinology and Center for Molecular Medicine, L8:01, Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Stockholm, Sweden; School of Medical Sciences, Örebro University and University Hospital, Örebro, Sweden. Electronic address:

Objective: Perichondrium autotransplants have been used to reconstruct articular surfaces destroyed by infection or trauma. However, the role of the transplanted perichondrium in the healing of resurfaced joints have not been investigated.

Design: Perichondrial and periosteal tissues were harvested from rats hemizygous for a ubiquitously expressed enhanced green fluorescent protein (EGFP) transgene and transplanted into full-thickness articular cartilage defects at the trochlear groove of distal femur in wild-type littermates. Read More

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Implantation of Neuropixels probes for chronic recording of neuronal activity in freely behaving mice and rats.

Nat Protoc 2021 Jun 9. Epub 2021 Jun 9.

Neuroelectronics Research Flanders, Leuven, Belgium.

How dynamic activity in neural circuits gives rise to behavior is a major area of interest in neuroscience. A key experimental approach for addressing this question involves measuring extracellular neuronal activity in awake, behaving animals. Recently developed Neuropixels probes have provided a step change in recording neural activity in large tissue volumes with high spatiotemporal resolution. Read More

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Extracellular Vesicles Derived from Cardiosphere-Derived Cells (CDC-EVs) as a Potential Anti-Shock Therapeutic.

J Trauma Acute Care Surg 2021 Apr 8. Epub 2021 Apr 8.

Coagulation and Blood Research (Blood), The United States Army Institute of Surgical Research, San Antonio, Texas/ 78234-4504, United States. Capricor Therapeutics Institute, Beverly Hills, California, 90211 Department of Biological Chemistry, Johns Hopkins, Baltimore, Maryland/ 21218, United States. Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, Texas/ 78249, United States.

Background: Extracellular vesicles (EVs) isolated from cardiosphere-derived cells (CDC-EVs) are coming to light as a unique, cell free therapeutic. Due to their novelty, however, there still exist prominent gaps in knowledge regarding their therapeutic potential. Herein the therapeutic potential of CDC-EVs in a rat model of acute traumatic coagulopathy induced by polytrauma and hemorrhagic shock is outlined. Read More

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Bone heating and implant removal using a high-frequency electrosurgical device. An in vivo experimental study.

Clin Oral Implants Res 2021 Jun 9. Epub 2021 Jun 9.

Divisions of Bio-prosthodontics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Objectives: Failed implant removal using a high-frequency electrosurgical device (HFED) has been reported to be less invasive than other surgical techniques. We sought to clarify the mechanism of removal torque reduction of an implant by heating with HFED.

Materials And Methods: Sixty-eight Wistar rats received titanium implants on the maxillary bone 4 weeks after extraction of the first and second molars. Read More

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Self-assembling peptide hydrogel SPG-178 as a pancreatic fistula-preventing agent.

Langenbecks Arch Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.

Purpose: Pancreatic fistula (PF) is a common and challenging complication after pancreatic surgery. The aim of this study was to investigate the efficacy of a new method for preventing PF utilizing self-assembling peptide hydrogel SPG-178 as a preclinical study.

Methods: The degradability of SPG-178 was confirmed by mixing it with protease. Read More

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[Study on the effect of antibiotics application in perioperative period on carotid artery and serum interleukin-6 in periodontitis rats with hyperlipidemia or diabetes].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jun;56(6):557-564

Department of Periodontology, Shanxi Medical University School and Hospital of Stomatology & Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, China.

To investigate the effect of antibiotics application in perioperative period on carotid artery and serum interluekin-6 (IL-6) in chronic periodontitis (CP) rats with hyperlipidemia (HL) or diabetes mellitus (DM). The models of CP rats with HL or DM were established in different batches. The rats were divided into groups as follows: A and A' were normal control groups, =7 in each group; B(HL) and B'(DM) were groups of HL and DM, =7 in each; C(HL+CP) and C'(DM+CP) were groups of CP with HL and CP with DM, =21 in each. Read More

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Biomechanical Effects of Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD), the Major Constituents of Cannabis, in a Sprague Dawley Rat Achilles Tendon Surgical Repair Model: A Pilot Study.

Am J Sports Med 2021 Jun 7:3635465211016840. Epub 2021 Jun 7.

Department of Orthopedics and Rehabilitation, Center for Orthopedic Research and Translational Sciences (CORTS), Penn State Hershey Medical Center, Hershey, Pennsylvania, USA.

Background: The use of cannabis is common among athletes and the US population at large. Cannabinoids are currently being evaluated as alternatives to opioid medications for chronic pain management. However, the effects of recreational and/or medical use of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on musculoskeletal injury and healing remain largely unknown. Read More

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Comparative effects of metformin and Cistus laurifolius L. extract in streptozotocin-induced diabetic rat model: oxidative, inflammatory, apoptotic, and histopathological analyzes.

Environ Sci Pollut Res Int 2021 Jun 7. Epub 2021 Jun 7.

Faculty of Medicin, Department of Medical Biochemistry, Eskisehir Osmangazi University, Eskisehir, Turkey.

Interest in phytochemical therapy methods in the treatment of diabetes is increasing day by day. Although the antidiabetic and antioxidant effects of Cistus laurifolius L. (CL) have been mentioned, the systemic effects remain unknown. Read More

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A pilot of the feasibility and usefulness of an aged obese model for use in stroke research.

Wellcome Open Res 2021 10;6:104. Epub 2021 May 10.

School of Life Science, University of Nottingham, Nottingham, NG7 2UH, UK.

Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model, and then examined the feasibility of modelling stroke in such rats. Twelve-month old male Wistar-Han rats (n=15) were fed a 60% fat diet for 8 months during which monthly serial blood samples were taken to assess the development of metabolic syndrome and pro-inflammatory markers. Read More

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TNF-mimetic peptide mixed with fibrin glue improves peripheral nerve regeneration.

Brain Res Bull 2021 Jun 6;174:53-62. Epub 2021 Jun 6.

Institute of Biomedical Science, Laboratory of Morphology and Cell Culture. Federal University of Uberlandia, UFU, Uberlandia, MG, Brazil. Electronic address:

Surgical intervention is necessary following nerve trauma. Tubular prostheses can guide growing axons and inserting substances within these prostheses can be positive for the regeneration, making it an alternative for the current standard tools for nerve repair. Our aim was to investigate the effects of fibrin glue BthTL when combined with a synthetic TNF mimetic-action peptide on nerve regeneration. Read More

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Extremity trauma exacerbates acute kidney injury following prolonged hemorrhagic hypotension.

J Trauma Acute Care Surg 2021 Jun 4. Epub 2021 Jun 4.

US Army Institute of Surgical Research, JBSA-Fort Sam Houston, TX Uniformed Services University, Bethesda, MD.

Background: The incidence of and mortality due to acute kidney injury (AKI) is high in patients with traumatic shock. However, it is unclear how hemorrhage and trauma synergistically affect renal function, especially when timely volume resuscitation is not available.

Method: We hypothesized that trauma impairs renal tolerance to prolonged hemorrhagic hypotension. Read More

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Segmental branches emanating from saphenous nerve morphing into sympathetic trunks for innervation of saphenous artery and its clinical implication for arterial sympathectomy.

Int Wound J 2021 Jun 4. Epub 2021 Jun 4.

Orthopedic Department, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Sympathectomy of arteries has been adopted for the treatment of peripheral arterial disease and Raynaud's disease. However, the exact route for sympathetic axons to reach peripheral arteries awaits further investigation that could pave the way for development of new surgical strategies. In this study, saphenous neurovascular bundles from 10 neonatal Sprague-Dawley rats first were harvested for whole-mount immunostaining to show sympathetic innervation pattern of the artery. Read More

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The Combined Effect of Photobiomodulation and Curcumin on Acute Skin Wound Healing in Rats.

J Lasers Med Sci 2021 23;12:e9. Epub 2021 Feb 23.

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abnormal wound repair is a cause for considerable expense, as well as patient morbidity and mortality. Here, we investigated the combined impact of photobiomodulation (PBM) and curcumin on a rat experimental model of an acute skin wound. A round full-thickness wound was created on the back of each rat. Read More

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February 2021

Influence of the new formulation based on silver alginate microcapsules loaded with tannic acid on the microcirculation of the experimental periodontitis in rats.

Mater Sci Eng C Mater Biol Appl 2021 Jul 30;126:112144. Epub 2021 Apr 30.

Central Research Laboratory, Saratov State Medical University of V. I. Razumovsky, Ministry of Health of the Russian Federation, 410012 Saratov, Russia.

The microvascular changes caused by disorders of host immune response to oral microorganisms resulting in long-lasting inflammation of gums play a critical role in the periodontal lesion in the pathogenesis of chronic periodontitis. Current strategies of non-surgical periodontal therapy are aimed at the attainment of anti-inflammatory effects. We hypothesized that the usage of the microencapsulated form of anti-inflammatory substances with vasoactive effects could enhance the efficiency of the therapy by the prolonged release of active components. Read More

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Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism.

Front Endocrinol (Lausanne) 2021 17;12:625173. Epub 2021 May 17.

Post Graduate Program in Surgical Sciences, Center of Experimental Surgery, Department of Surgery, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

To verify the viability and functionality of cryopreserved thyroid autotransplantation in rats who underwent total thyroidectomy in the treatment of postoperative hypothyroidism. Thirty-two Wistar rats were randomly assigned into groups (G) with eight animals each: control (CG); simulation (SG); hypothyroidism (HTG) and transplanted (TG). At the beginning and in the 13th week of the experiment, serum levels of total T3, free T4, TSH and calcium were determined. Read More

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Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma.

Onco Targets Ther 2021 24;14:3373-3381. Epub 2021 May 24.

Department of Carcinogenesis and Aging, N.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg, Russia.

Aim: Alterations in circadian rhythms caused by tumor growth are thought to be clinically relevant as they affect the prognosis and treatment response. We aimed to evaluate the chronotherapeutic approach in rats with ovarian cancer receiving cisplatin intravenously (IV) or with hyperthermic intraperitoneal chemoperfusion (HIPEC) and to assess daily variations in tumor and intestinal epithelium proliferation.

Methods: In the pilot study, we used 12 intact rats and 12 rats with transplantable ovarian cancer, which were euthanized at ZT0 (08:00, lights on), ZT6, ZT12 and ZT18. Read More

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Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach.

Int J Mol Sci 2021 May 19;22(10). Epub 2021 May 19.

Experimental Pathology Department, Institute of Biomedical Research of Barcelona (IIBB), CSIC-IDIBAPS, 08036 Barcelona, Spain.

The total damage inflicted on the liver before transplantation is associated with several surgical manipulations, such as organ recovery, washout of the graft, cold conservation in organ preservation solutions (UW, Celsior, HTK, IGL-1), and rinsing of the organ before implantation. Polyethylene glycol 35 (PEG35) is the oncotic agent present in the IGL-1 solution, which is an alternative to UW and Celsior solutions in liver clinical transplantation. In a model of cold preservation in rats (4 °C; 24 h), we evaluated the effects induced by PEG35 on detoxifying enzymes and nitric oxide, comparing IGL-1 to IGL-0 (which is the same as IGL-1 without PEG). Read More

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Oral Administration of Mycelia Promotes Non-Rapid Eye Movement and Rapid Eye Movement Sleep in Rats.

J Fungi (Basel) 2021 May 10;7(5). Epub 2021 May 10.

Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan.

The present study aimed to explore whether water and ethanol extracts of mycelia produce sedative and hypnotic effects in rats. Male Sprague-Dawley rats were surgically implanted with two electroencephalogram electrodes on the skull and an electromyogram electrode on neck muscle to evaluate the alterations in rapid eye movement (REM) and non-REM (NREM) sleep after oral administration of the water and ethanol extracts. Following post-surgical recovery, thirty-six rats were randomly divided into four treatment groups and two control groups. Read More

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What happened to quinacrine non-surgical female sterilization?

Regul Toxicol Pharmacol 2021 May 29;124:104968. Epub 2021 May 29.

International Services Assistance Fund, P.O. Box 13067, Research Triangle Park, NC, 27709, USA. Electronic address:

Quinacrine sterilization (QS) is a nonsurgical female method used by more than 175,000 women in over 50 countries. With FDA approval, QS is expected to be used by hundreds of millions of women. The negative international health consequences of the results of a 2-year rat study in 2010 by Cancel et al. Read More

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Comparison of Vascular Morphometry in Jawbones and Long Bones: Micro-CT Study in a Rat Model Treated with Zoledronic Acid.

Biomed Res Int 2021 12;2021:6651318. Epub 2021 May 12.

Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong.

The study was aimed at investigating the effect of zoledronic acid on vascular morphometry in jawbones and long bones on a rat model. Twenty-four skeletal mature Sprague-Dawley female rats were administered oncologic dose of zoledronic acid (ZA) or normal saline for 4 weeks and then subjected to tooth extraction on the mandible and maxilla and a bone defect creation on the femur. After the surgical procedures, ZA or saline treatment was continued until sacrifice at week 2, week 4, and week 8 postoperatively. Read More

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Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers.

Stem Cell Res Ther 2021 May 29;12(1):312. Epub 2021 May 29.

Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan.

Background: Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified in Ret/PH-treated rat livers transplanted with Thy1 cells derived from D-galactosamine-treated injured livers. Extracellular vesicles (EVs) produced by hepatic Thy1 donor cells activated SHPCs via interleukin (IL)-17 receptor B signaling. Read More

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Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.

Neurochem Int 2021 May 25;148:105078. Epub 2021 May 25.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China. Electronic address:

As a general anesthetic widely used in surgical, sevoflurane has been shown to cause cognitive and memory deficits in the elderly. It's important to find out agents that can counteract sevoflurane-induced cognitive dysfunction. This study is aimed to investigate the effect of lovastatin on sevoflurane-induced cognitive impairment in aged rats and reveal the potential mechanisms. Read More

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Systemic metastasis-targeted nanotherapeutic reinforces tumor surgical resection and chemotherapy.

Nat Commun 2021 05 27;12(1):3187. Epub 2021 May 27.

Shanghai Pudong Hospital & Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.

Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Metastasis consists of three steps: (i) tumor cells extravasate from the primary sites into the circulation system via epithelial-mesenchymal transition (EMT), (ii) the circulating tumor cells (CTCs) form "micro-thrombi" with platelets to evade the immune surveillance in circulation, and (iii) the CTCs colonize in the pre-metastatic niche. Here, we design a systemic metastasis-targeted nanotherapeutic ([email protected]) composed of an anti-inflammatory agent, piceatannol, and an anti-thrombotic agent, low molecular weight heparin, to hinder the multiple steps of tumor metastasis. Read More

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Sustainable Antibacterial Surgical Suture Using a Facile Scalable Silk-Fibroin-Based Berberine Loading System.

ACS Biomater Sci Eng 2021 Jun 27;7(6):2845-2857. Epub 2021 May 27.

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.

Medical sutures with sustainable antibacterial properties can effectively inhibit pathogens, thus avoiding the occurrence of surgical site infection and reducing the recurrence of patients resulting in postoperative death. This paper describes a facile scalable antibacterial surgical suture with sustainable antibacterial function and fair mechanical and biocompatible properties using a simple, efficient, and eco-friendly method. Silk filaments were braided into a core-shell structure using a braiding machine, and then silk fibroin (SF) films loaded with different percentages of berberine (BB) were coated onto the surface of the suture. Read More

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Performance of Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogenic Hydroxyapatite on Bone Regeneration in Rat Calvarial Defects: Histomorphometric, Immunohistochemical and Ultrastructural Analysis.

Int J Nanomedicine 2021 18;16:3473-3485. Epub 2021 May 18.

Biology Department, School of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Synthetic biomaterials have played an increasingly prominent role in the substitution of naturally derived biomaterials in current surgery practice. In vitro and in vivo characterization studies of new synthetic biomaterials are essential to analyze their physicochemical properties and the underlying mechanisms associated with the modulation of the inflammatory process and bone healing.

Purpose: This study compares the in vivo tissue behavior of a synthetic biomaterial nano-hydroxyapatite/beta-tricalcium phosphate (nano-HA/ß-TCP mixture) and deproteinized bovine bone mineral (DBBM) in a rat calvarial defect model. Read More

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ROLE OF ALBUMIN ON ENDOTHELIAL BASEMENT MEMBRANE AND HEMOSTASIS IN A RAT MODEL OF HEMORRHAGIC SHOCK.

J Trauma Acute Care Surg 2021 May 25. Epub 2021 May 25.

United States Army Institute of Surgical Research (USAISR), JBSA Fort Sam Houston, Texas, USA.

Background: We sought to determine the extent of loss of endothelial basement membrane (BM), leukocyte recruitment and changes in coagulation after hemorrhagic shock (HS), followed by limited-volume resuscitation (LVR) with 5% albumin (ALB).

Methods: Anesthetized rats were bled 40% of blood volume and assigned to treatment groups: untreated (n = 6); LVR with normal saline (NS; n = 8); or LVR with ALB (n = 8). Sham rats (n = 6) underwent all procedures except hemorrhage or resuscitation. Read More

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Robot-assisted thoracoscopic enucleation for a large esophageal leiomyoma: a case report.

Surg Case Rep 2021 May 26;7(1):129. Epub 2021 May 26.

Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Background: Video-assisted thoracoscopic surgery (VATS) is being used to treat esophageal submucosal tumors (SMTs) all over the world. However, this technique is difficult when the tumor is large and located on the left side wall of the esophagus, within the upper mediastinum. This is because, with VATS, the surgical forceps have a limited range of motion. Read More

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