36,204 results match your criteria rats randomly


HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content.

Reprod Toxicol 2021 Jun 9. Epub 2021 Jun 9.

Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria; Department of Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Osun State, Nigeria.

Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly, anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have been shown to impair male fertility. Read More

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Investigating the inflammatory cascade effect of basophil activation in children with allergic rhinitis or asthma, via the IgE-FcεRI-NF-κB signaling pathway.

Authors:
Yi Qiao Jie Chen

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Otorhinolaryngology, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, China.

Background: Allergic rhinitis (AR) is a type I allergic reaction mediated by serum immunoglobulin E (IgE).

Objectives: This study aimed to investigate the basophil activation rate and serum expression of inflammatory factors in AR patients and rats. The involvement of the IgE-FcεRI-nuclear factor kappa B (NF-κB) signaling pathway in the pathogenesis of AR was also explored. Read More

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The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats.

Environ Sci Pollut Res Int 2021 Jun 11. Epub 2021 Jun 11.

Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

This study was aimed at elucidating the protective effects of 18β-glycyrrhetinic acid (18βGA) against acrylamide (Acr)-induced cellular damage in diabetic rats. Rats were randomly assigned into eight groups (n = 8) following 12 h of fasting: control group, a single dose of 50 mg/kg streptozotocin (STZ) intraperitoneally (diabetic group), 50 mg/kg 18βGA orally after 2 weeks from STZ injection (18βGA group), 20 mg/kg Acr after 1month from STZ injection (Acr group), STZ plus Acr (STZ-Acr group), STZ plus 18βGA (STZ-18βGA group), Acr plus 18βGA (Acr-18βGA group), or STZ plus Acr plus 18βGA (STZ-Acr-18βGA group). Administration of 18βGA alone increased GSH, GSH-PX, SOD, and CAT in both liver and kidneys. Read More

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Treatment with edaravone improves the structure and functional changes in the hippocampus after chronic cerebral hypoperfusion in rat.

Brain Res Bull 2021 Jun 8. Epub 2021 Jun 8.

Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

This study aimed to find out cellular and electrophysiological effects of the edaravone (EDR) administration following induction of vascular dementia (VaD) via bilateral-carotid vessel occlusion (2VO). The rats were randomly divided into control, sham, 2VO + V (vehicle), and 2VO + EDR groups. EDR was administered once a day from day 0-28 after surgery. Read More

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REVISITING THE ACUTE KIDNEY INJURY IN WISTAR RATS EXPERIMENTALLY ENVENOMATED WITY Bothrops jararacussu VENOM.

Toxicon 2021 Jun 8. Epub 2021 Jun 8.

Programa de Pós-graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

There is no consensus on whether serotherapy prevents acute kidney injury (AKI) and there is no pharmacotherapy to impede the disease. We aimed to elaborate an AKI model induced by the administration of Bothrops jararacussu (Bj) venom for preclinical studies. Male Wistar rats were randomly divided into 3 different groups: (1) Bj-IV: intravenous administration of 0. Read More

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MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway.

Bioengineered 2021 Dec;12(1):2639-2648

Department of Radiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi China.

The purpose of this study was to investigate the impact and mechanism of microRNA miR-126 on brain injury induced by blood-brain barrier (BBB) damage in septic rats. We used cecal ligation and perforation (CLP) to create a rat model of sepsis. The experimental rats were randomly divided into Control group, CLP group, CLP + miR-NC group, CLP + miR-126 group and CLP + miR-126 + NF-κB pathway agonist (PMA) group. Read More

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December 2021

Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model.

Andrologia 2021 Jun 11:e14143. Epub 2021 Jun 11.

Department of Anatomy, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

This study was designed to investigate the effects of separate and combined administration of hypothermia and pentoxifylline to preserve the effects on the testicles in an experimental model of testicular torsion/ detorsion injuries in rats. Forty male adult Wistar rats were randomly divided into five groups, control, torsion/detorsion (TD), torsion/detorsion/hypothermia (TD+ICE), torsion/detorsion received of pentoxifylline (40mg/kg, ip) (TD+PTX) and torsion/detorsion/hypothermia/PTX (TD+ICE+PTX). Left testicular torsion (TT) was performed for 4 and half hours, and ice fragments have been used at the beginning of torsion. Read More

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Bone healing around titanium implants in a preclinical model of bile duct ligation-induced liver injury.

Clin Oral Implants Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Objectives: Chronic liver disease increases the risk for periodontal disease and osteoporotic fractures, but its impacts on bone regeneration remain unknown. Herein we studied the impact of liver cirrhosis on peri-implant bone formation.

Material And Methods: A total of 20 male Wistar rats were randomly divided into two groups; one with the common bile duct ligated (BDL) and the respective sham-treated control group (SHAM). Read More

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Protective effects of acupuncture and LGNHFD on expressions of vascular endothelial growth factor, basic fibroblast growth factor, and cluster of differentiation 34 in rats with cerebral ischemia-reperfusion injury.

J Tradit Chin Med 2021 Jun;41(3):463-470

Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

Objective: To investigate the protective effects of electroacupuncture and LGNHFD on cerebral ischemia-reperfusion injury, and their effects on the expression of cluster of differentiation 34 (CD 34), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in the peripheral tissue of the cerebral ischemic semi-dark zone in rats. The influence and mechanism of expression.

Methods: Healthy male Sprague-Dawley rats were randomly divided into the sham operation group, model group, Traditional Chinese Medicine (TCM) group, electroacupuncture group, and acupuncture group. Read More

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Electroacupuncture Pretreatment at Neiguan (PC6) attenuates autophagy in rats with myocardial ischemia reperfusion through the phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin pathway.

J Tradit Chin Med 2021 Jun;41(3):455-462

Institute of Internal medicine, Huangjiahu Hospital of Hubei University of Traditional Chinese Medicine, Wuhan 430065, China.

Objective: To investigate the protective efficacy of electroacupuncture (EA) pretreatment at Neiguan (PC6) on myocardial ischemia-reperfusion (I/R) in rats.

Methods: Fifty rats were randomly divided into five groups (n = 10): sham operation group, model group (underwent in vivo myocardial I/R), EA pretreatment group [EA at Neiguan (PC 6) 1 week before I/R], wortmannin group (1 week before I/R, the PI3K inhibitor, wortmannin, was injected), EA pretreatment + wortmannin group (both pretreatments were performed simultaneously). After establishing the I/R model, 2,3,5-triphenyltetrazolium chloride (TTC) staining was used to analyze the weight and area of the myocardial infarction tissue. Read More

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Zhuifeng Tougu capsules improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway.

J Tradit Chin Med 2021 Jun;41(3):447-454

Postdoctoral Research Workstation, Hinye Pharmaceutical Co. Ltd., Hinye Pharmaceutical Co., Ltd., Changsha 410331, China.

Objective: To investigate the efficacy of Zhuifeng tougu capsules (, ZFTG) in the treatment of rheumatoid arthritis (RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B (TLR2/4-NF-κB) signaling pathway.

Methods: Type Ⅱ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-, and low-dose ZFTG groups. Read More

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Effect of Rongchang capsule on seizure behavior, cognitive impairment, and hippocampal DNA damage and inflammatory factors in epileptic rat.

J Tradit Chin Med 2021 Jun;41(3):438-446

Department of pediatrics, Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Objective: To observe the behavioral changes and changes in DNA fragments and related inflammatory factors in the hippocampus of epileptic rats pretreated with Rongchang capsule ().

Methods: Eighty Sprague-Dawley rats were randomly divided into the normal group (NG), model group (MG), sodium valproate group (VG), and Rongchang capsule group (RG) (n = 20 in each group). Pentylentetrazol was administered to the MG, VG, and RG to induce epilepsy. Read More

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Full composition granules of Huanglian (Rhizoma Coptidis) decrease the serum monocyte chemotactic protein-1 and connective tissue growth factor levels and inhibit kidney nuclear factor-κB expression in rats with high-fat diet-induced diabete.

J Tradit Chin Med 2021 Jun;41(3):424-431

Department of Traditional Chinese Medicine, the Mongolian Medical and Traditional Chinese Medicine Hospital of Wuhai, Wuhai 016000, China.

Objective: To investigate the efficacy of the full composition granules of Huanglian (Rhizoma Coptidis) (FGC) on the serum monocyte chemotactic protein-1 (MCP-1) and connective tissue growth factor (CTGF) levels and kidney nuclear factor-κB (NF-κB) expression in rats with high-fat diet-induced diabetes.

Methods: Diabetes was induced in rats by feeding a high-fat chow combined with intravenous streptozotocin injection. Forty diabetic Sprague- Dawley rats were randomly assigned to a normal group (NG), model group (MG), irbesartan group (IG), and low-, middle-, and high-dosage FGC groups (LFGC, MFGC, HFGC), with eight rats per group. Read More

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Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure model.

Heart Rhythm O2 2020 Jun 15;1(2):126-135. Epub 2020 Jun 15.

Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.

Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2 may exert therapeutic effects in these conditions.

Objective: The purpose of this study was to investigate the effects of stabilizing RyR2 with chronic dantrolene treatment on HF development and AF inducibility in a myocardial infarction (MI)-induced HF model in rats. Read More

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Effect of pericarp extract on glial NF-κB levels and expression of serum inflammation markers in an obese-type 2 diabetes mellitus animal model.

Biomed Rep 2021 Jul 3;15(1):63. Epub 2021 Jun 3.

Department of Physics, Faculty of Science and Mathematics Diponegoro University, Semarang, Java 50275, Indonesia.

Type 2 diabetes mellitus (T2DM) is an age-related disease associated with cerebral inflammation and Alzheimer's disease. pericarp (GMP) possesses antihyperglycemic, antidiabetic and anti-inflammatory effects. The aim of the present study was to evaluate the effect of GMP extract on cerebral inflammation in Wistar rats with T2DM by examining the expression levels of glial nuclear factor-κB (NF-κB), interleukin (IL)-6, tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD). Read More

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Improving NKCC1 Function Increases the Excitability of DRG Neurons Exacerbating Pain Induced After TRPV1 Activation of Primary Sensory Neurons.

Front Cell Neurosci 2021 25;15:665596. Epub 2021 May 25.

The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Physiology, Shihezi University Medical College, Shihezi, China.

Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action. Male Sprague-Dawley rats were randomly divided into control, capsaicin, and inhibitor groups. The expression and distribution of TRPV1 and NKCC1 in rat DRG were observed by immunofluorescence. Read More

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[Effects of noise, bright light and mechanical stimulation on sleep, blood-brain barrier and cognitive function in septic rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):529-534

Department of Critical Care Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology (Xiaogan Central Hospital), Xiaogan 432000, Hubei, China. Corresponding author: Yao Peng, Email:

Objective: To evaluate the effects of noise, bright light and mechanical stimulation on sleep, blood-brain barrier and cognitive function in septic rats.

Methods: Forty male Sprague-Dawley (SD) rats were selected and intraperitoneal injection of 10 mg/kg lipopolysaccharide (LPS) was used to establish sepsis model. 0, 30, 45, 60, 75 dB noise stimulation or 0, 50, 100, 200, 400 Lux light stimulation were given to rats (all n = 4). Read More

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The protective effects of Anakinra in a neonatal rat model of necrotizing enterocolitis.

Turk J Med Sci 2021 Jun 10. Epub 2021 Jun 10.

Background: Necrotizing enterocolitis (NEC) is a commonly seen life-threatening condition in newborns characterized by ischemic necrosis. This study aimed to investigate anakinra's effects, an interleukin-1 receptor antagonist, on oxidative stress, inflammation, and tissue necrosis in an NEC rat model.

Materials And Methods: Forty Wistar albino pups were divided into four groups randomly as follows; group 1, control group; group 2, anakinra-treated control group; group 3, NEC group, group 4, NEC, and anakinra treatment group. Read More

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50 week ultrasound imaging and ultrastructural abnormalities of bladder after sugar diuresis and diabetes mellitus in rats.

Int Urol Nephrol 2021 Jun 10. Epub 2021 Jun 10.

Department of Urology, First Affiliated Hospital, Shihezi University, Shihezi, 832008, Xinjiang, China.

Purpose: To investigate 50 week ultrasound imaging and ultrastructure changes of bladder in diuresis and diabetes rats.

Methods: Forty-two healthy male Sprague-Dawley rats were randomly divided into control group, sugar-induced diuresis group and streptozotocin-induced diabetes group. The 24 h drinking and urine volume were calculated from 21 to 31 weeks. Read More

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Silicon, an important exposure marker in vivo in silicosis research.

Int Arch Occup Environ Health 2021 Jun 10. Epub 2021 Jun 10.

School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.

Purpose: The degree of silicosis exposure is closely related to the progress of silicosis. At present, we use animal and human studies to explore whether silicon can be an important exposure marker in the development of silicosis.

Methods: Rats were randomly divided into 2 groups: (1) controls; and (2) silicosis. Read More

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The effect of dexmedetomidine on liver injury secondary to lower extremity ischemia-reperfusion in a diabetic rat model.

Clin Exp Hypertens 2021 Jun 10:1-6. Epub 2021 Jun 10.

Department of Basic Sciences Biochemistry, Faculty of Medicine, University of Recep Tayyip Erdoğan, Rize, Turkey.

In this study, we aimed to evaluate the hepatic protective effects of dexmedetomidine in the lower extremity ischemia-reperfusion model in diabetic rats biochemically and histopathologically. Rats were randomly divided into 4 equal groups (n = 6); Control (C) group, diabetic control group (DM), diabetic ischemia-reperfusion group (IR), group with diabetic IR and dexmedetomidine (DEX). In the IR and DEX groups were performed 120 min reperfusion after 120 min ischemia. Read More

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Rehabilitation training improves cognitive disorder after cerebrovascular accident by improving BDNF Bcl-2 and Bax expressions in regulating the JMK pathway.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3807-3821

Department of Rehabilitation Medicine, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, P.R. China.

Objective: To explore the effect of rehabilitation training on cognitive impairment after cerebrovascular accident and its potential mechanism.

Patients And Methods: 100 patients of cerebrovascular accident treated in our hospital from August 2018 to August 2019 were selected as the subjects, and 50 patients with physical examination were selected as healthy control group. The patients with cerebrovascular accident were randomly divided into control group (50 patients) and research group (50 patients). Read More

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Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.

Front Pharmacol 2021 24;12:669782. Epub 2021 May 24.

Department of Physiology, School of Basic Medical Sciences, Hebei University of Chinese Medicine, Shijiazhuang, China.

Astragaloside IV (ASIV) is the main active component of , and can ameliorate cardiomyocyte hypertrophy, apoptosis and fibrosis. In this experiment, we studied how ASIV reduces the cardiotoxicity caused by adriamycin and protects the heart. To this end, rats were randomly divided into the control, ADR, ADR + ASIV and ASIV groups ( = 6). Read More

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CORM-2 inhibits intracerebral hemorrhage-mediated inflammation.

Neurol Res 2021 Jun 10:1-8. Epub 2021 Jun 10.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

: Low-dose of carbon monoxide delivered by CO-releasing molecule-2 (CORM-2) had been confirmed having anti-inflammatory efficacy in some inflammatory diseases. Herein, we assessed the usefulness of CORM-2 in correcting intracerebral hemorrhage (ICH)-mediated inflammation.: Healthy male Sprague Dawley (SD) rats randomly entered into four groups: sham-ICH, ICH, ICH+CORM-2, and ICH+ inactive carbon monoxide releasing molecule 2 (iCORM-2). Read More

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Potentiating response of D- Ribose-L-Cysteine on Sodium arsenateinduced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat.

JBRA Assist Reprod 2021 Jun 9. Epub 2021 Jun 9.

Human Anatomy Department, Federal University of Technology Akure, Ondo State.

Objective: Reproductive toxicity is an important health challenge, mostly associated with exposure to several environmental toxicants. Arsenic is a ubiquitous toxic compound naturally present in the environment. This study was carried out to evaluate the dietary supplements of D-Ribose-L-Cysteine against sodium arsenate-induced testicular toxicity in adult male Wistar rats. Read More

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[The Comparison of Iron Deficiency Anemia Rat Treated with Hydroxypropyl Chitosan Ferrous Ion Complex and Ferrous Sulfate].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):853-859

Medical Center of Children, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province,

Objective: To observe and compare the therapeutic effects of hydroxypropyl chitosan ferrous ion complex solution and ferrous sulfate solution in iron deficiency anemia rats and their effects on gastric mucosa.

Methods: Seven rats were randomly selected from thirty five SPF grade SD rats as control group, and were fed with normal diet, distilled water (E). The rest of SD rats were fed with low iron feed and distilled water plus continuous tail vein bloodletting to establish the iron deficiency anemia model. Read More

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Long-Term Outcome of Sciatic Nerve Regeneration Using Bio3D Conduit Fabricated from Human Fibroblasts in a Rat Sciatic Nerve Model.

Cell Transplant 2021 Jan-Dec;30:9636897211021357

Department of Orthopaedic Surgery, 12918Kyoto University Graduate School of Medicine, Kyoto, Japan.

Previously, we developed a Bio3D conduit fabricated from human fibroblasts and reported a significantly better outcome compared with artificial nerve conduit in the treatment of rat sciatic nerve defect. The purpose of this study is to investigate the long-term safety and nerve regeneration of Bio3D conduit compared with treatments using artificial nerve conduit and autologous nerve transplantation.We used 15 immunodeficient rats and randomly divided them into three groups treated with Bio3D ( = 5) conduit, silicon tube ( = 5), and autologous nerve transplantation ( = 5). Read More

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Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation.

Biomed Res Int 2021 19;2021:6687551. Epub 2021 May 19.

Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

In the present study, we examined the synergetic effect of forskolin and mevastatin administration on lipid profile and lipid metabolism in omental adipose tissue in dyslipidemic rats. The study was conducted on forty male albino rats. The rats were randomly classified into four main groups of ten animals in each group as follows: , served as control nontreated; , rats that received Triton WR 1339 (500 mg/kg); , rats that received Triton WR 1339 with forskolin (100% FSK extract 0. Read More

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Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress, lipid disorders, and NLRP3 inflammasome in mother rats and offspring.

Food Nutr Res 2019 23;63. Epub 2019 Aug 23.

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Objective: This study aimed to evaluate the effects of microbe-derived antioxidant (MA) on high-fat diet (HFD)-induced hepatic lipid disorders in mother rats and offspring.

Methods: A total of 36 female rats were randomly divided into three groups at the beginning of pregnancy: the control group (CG), HFD, and HFD with 2% MA. Mother rats were slaughtered at the first and 10th day of lactation (L1 and L10) and offspring were slaughtered at L10. Read More

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L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage.

Int J Med Sci 2021 29;18(12):2607-2614. Epub 2021 Apr 29.

Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Intracerebral hemorrhage (ICH) is a devastating type of stroke with high morbidity and mortality, and the effective therapies for ICH remain to be explored. L-3-n-butylphthalide (NBP) is widely used in the treatment of ischemic stroke. However, few studies evaluated the therapeutic effects of NBP on ICH. Read More

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