Chemosphere 2021 Jan 14;263:128307. Epub 2020 Sep 14.
Biomedical Health Sciences Institute, Neuroscience Program, University of Georgia, Athens, GA, 30602, USA; Department of Veterinary Biosciences and Diagnostic Imaging, Neuroscience Program, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA; Department of Pharmacology and Toxicology, Michigan State University, E. Lansing, MI, 48824, USA. Electronic address:
Bisphenol A (BPA) and Diethylhexyl Phthalate (DEHP) are well-studied endocrine disrupting chemicals (EDCs), however, the effects of mixtures of these EDCs are not. To assess the consequences of prenatal exposure to a mixture of these EDCs, dams were orally administered either saline (control), BPA (5 μg/kg BW/day), high dose DEHP (HD-D; 7.5 mg/kg BW/day), or a combination of BPA with HD-D in experiment 1; saline, BPA (5 μg/kg BW/day), low-dose DEHP (LD-D; 5 μg/kg BW/day) or a combination of BPA with LD-D in experiment 2. Read More