53,407 results match your criteria rats orally


Evaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies.

Regul Toxicol Pharmacol 2022 Jan 14:105118. Epub 2022 Jan 14.

Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista - Botucatu, São Paulo State, Brazil. Electronic address:

Piper amalago L. (Piperaceae) is traditionally used due to its anti-inflammatory, analgesic, diuretic, and antiparasitic properties. However, few studies have focused on its adverse effects, compromising its safe use. Read More

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January 2022

Anti-obesity and Anti-diabetic Effect of Ursolic Acid against Streptozotocin/High Fat Induced Obese in Diabetic Rats.

J Oleo Sci 2022 Jan 14. Epub 2022 Jan 14.

Department Endocrinology, Ninth People's Hospital of Chongqing.

Obesity is occurring due to continue taken high fat diet; this is the fast-growing problem reaching epidemic proportion globally. Ursolic acid altered the abnormal glucose metabolism in diabetic rats. In this experimental protocol, we examine ursolic acid (UA) anti-obesity effect against streptozotocin (STZ) and high-fat diet-induced obesity in rats. Read More

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January 2022

Platycodon grandiflorum extract attenuates lipopolysaccharide-induced acute lung injury via TLR4/NF-κBp65 pathway in rats.

Pak J Pharm Sci 2021 Nov;34(6):2213-2218

Aba Teachers University, Wenchuan, PR China.

The traditional Chinese medicine Platycodon grandiflorum (PG) is often used for the treatment of a number of chronic inflammatory diseases. In Chinese veterinary clinic, PG is always extracted by decoction and taken orally, however, the molecular mechanism of PG extract (PE) to reduce LPS-induced inflammation, especially acute lung injury (ALI) in vivo, are not known. Thus, we have studied the anti-inflammatory effects of PE on lipopolysaccharide (LPS)-induced acute lung injury via TLR4/NF-κBp65 pathway in rat. Read More

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November 2021

Discovery of Gut-Restricted Small-Molecule Inhibitors of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia.

J Med Chem 2022 Jan 17. Epub 2022 Jan 17.

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo-shi, Hokkaido 060-0812, Japan.

NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. The inhibition of NaPi2b, responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia. Using a novel phosphate uptake inhibitor (IC = 87 nM), identified from an in-house compound collection in human NaPi2b-transfected cells as a prototype compound, we conducted its derivatization based on a Ro5-deviated strategy to develop orally administrable small-molecule NaPi2b inhibitors with nonsystemic exposure. Read More

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January 2022

Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome.

BMC Pharmacol Toxicol 2022 Jan 15;23(1). Epub 2022 Jan 15.

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Bergische Landstraße 2, 40629, Düsseldorf, Germany.

Background: Patients with liver diseases often have some form of anemia. Hematological dyscrasias are known side effects of antipsychotic drug medication and the occurrence of agranulocytosis under clozapine is well described. However, the sex-dependent impact of clozapine and haloperidol on erythrocytes and symptoms like anemia, and its association with hepatic iron metabolism has not yet been completely clarified. Read More

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January 2022

Cajanus cajan ameliorated CCl-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibition.

J Ethnopharmacol 2022 Jan 12:114920. Epub 2022 Jan 12.

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Ethnopharmacological Relevance: Liver diseases is a public health issue in sub-saharan Africa and has been reported major cause of many hospital admissions. Oxidative stress, mitochondrial dysfunction and inflammation play important role in several diseases including liver injury. Cajanus cajan is an indigenous medicinal plant useful in the traditional treatment of jaundice, inflammation and liver injury. Read More

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January 2022

Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats.

Heliyon 2022 Jan 16;8(1):e08622. Epub 2021 Dec 16.

Hormones Department, Research Division, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.

The goal of the current study was to investigate the therapeutic effects of exosomes derived from mesenchymal stem cells (MSCs-Exo) and copper sulfide nanoparticles (CuSNPs) as biomaterials in order to understand the mechanisms that contribute to overcoming cadmium (Cad) induced neurological disorders in rats. Animals were divided into five groups (n = 10): group 1 was served as a negative control and receive vehicle saline (Con), group 2 Positive control groups were received Cad as cadmium chloride at a dose of 20 mg/kg/day for six weeks (Cad group), group 3 was received Cad plus MSCs-Exo as a single dose of 100 μLi. v. Read More

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January 2022

Nasal obstruction promotes alveolar bone destruction in the juvenile rat model.

J Dent Sci 2022 Jan 11;17(1):176-183. Epub 2021 Jun 11.

Departments of Oral Biochemistry, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju, South Korea.

Background/purpose: Nasal obstruction leads to oral breathing and consequently hypoxia. The purpose of this study was to determine the influence of hypoxia on inflammatory response and the effect on alveolar bone development in a rat model in which mouth breathing was induced by nasal obstruction.

Materials And Methods: Unilateral nasal obstruction was performed by injecting a Merocel sponge into the nasal cavity of 8-week-old Sprague Dawley (SD) rats. Read More

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January 2022

Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation.

Biotech Histochem 2022 Jan 14:1-14. Epub 2022 Jan 14.

Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.

We investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats. We used six groups of animals: control; indomethacin (Indo); reference (Ulcuran®); indomethacin + 25 mg/kg chrysin (Indo + CHR25); indomethacin + 50 mg/kg chrysin (Indo + CHR50); indomethacin + 100 mg/kg chrysin (Indo + CHR100). All doses of chrysin were given orally to rats before indomethacin. Read More

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January 2022

Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process.

Phytomedicine 2021 Dec 31;97:153920. Epub 2021 Dec 31.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu 730070, China. Electronic address:

Background: Liver damage is one of the most common complications in humans and animals after heat stress (HS). Sheng Mai San (SMS), a traditional Chinese medicine prescription that originated in the Jin Dynasty, exert a therapeutic effect on HS. However, how SMS prevents liver injury after heat exposure remains unknown. Read More

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December 2021

Multi modular toxicity assessment of nephrotoxicity in podophyllotoxin exposure rats on account of toxicological evidence chain (TEC) concept.

Ecotoxicol Environ Saf 2022 Jan 10;231:113157. Epub 2022 Jan 10.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District, Beijing 102488, China. Electronic address:

Early diagnosis of kidney injuries caused by herbs is necessary to enable effective treatments, prevent kidney failure and promote the internationalization and modernization of herbal medicine. Whereas the toxic assessment evidence has not integrated yet, and the evaluation method has not been unanimously agreed. For example, the gold standard assessing toxicity in animals remains to be histopathology, but serum biochemical indexes are the primary measures for monitoring organs dysfunction in humans. Read More

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January 2022

Enhanced Oral NO Delivery through Bioinorganic Engineering of Acid-Sensitive Prodrug into a Transformer-like [email protected] Microrod.

ACS Appl Mater Interfaces 2022 Jan 12. Epub 2022 Jan 12.

Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.

Nitric oxide (NO) is an endogenous gasotransmitter regulating alternative physiological processes in the cardiovascular system. To achieve translational application of NO, continued efforts are made on the development of orally active NO prodrugs for long-term treatment of chronic cardiovascular diseases. Herein, immobilization of NO-delivery [Fe(μ-SCHCHCOOH)(NO)] () onto MIL-88B, a metal-organic framework (MOF) consisting of biocompatible Fe and 1,4-benzenedicarboxylate (BDC), was performed to prepare a [email protected] microrod for enhanced oral delivery of NO. Read More

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January 2022

Association of Early Pubertal Onset in Female Rats With Inhalation of Lavender Oil.

J Korean Med Sci 2022 Jan 10;37(2):e9. Epub 2022 Jan 10.

Department of Pediatrics, College of Medicine, Chungnam National University, Daejeon, Korea.

Background: Central precocious puberty (CPP) is caused by early activation of the hypothalamic-pituitary-gonadal axis but its major cause remains unclear. Studies have indicated an association between chronic environmental exposure to endocrine-disrupting chemicals and pubertal onset. Essential oil is widely used in homes worldwide for relief of respiratory symptoms, stress, and/or sleep disturbance. Read More

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January 2022

Protective effects of chrysin against cyclophosphamide-induced cardiotoxicity in rats: A biochemical and histopathological approach.

Chem Biodivers 2022 Jan 10. Epub 2022 Jan 10.

Prince of Songkla University, Traditional Thai Medicine, Hat Yai, 90112, Hat Yai, THAILAND.

Mounting evidences have indicated that cyclophosphamide (CyC)a potent anticancer and cytotoxic agent is associated with various organ and systemic toxicities and the cytotoxic effects observed after administration of CyC still challenges its clinical use. Chrysin (Chy) is a dietary flavonoid with prevailing antioxidant and anti-inflammatory properties. This study evaluated the protective properties of Chy against CyC-induced cardiotoxicity in rats. Read More

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January 2022

Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters.

J Food Biochem 2022 Jan 10:e14073. Epub 2022 Jan 10.

School of Life Science, Zhengzhou University, Zhengzhou, China.

Colorectal cancer is considered as a major cancer among all types of cancers, especially in developed countries. The colorectal cancer has few to no symptoms and mostly the tumor is often diagnosed in the later stage of cancer. Oxidative stress and inflammatory reaction play an important role in the expansion and the progression of colorectal cancer. Read More

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January 2022

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy.

Heart Vessels 2022 Jan 11. Epub 2022 Jan 11.

Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido University, Kita 15, Nishi 7, Kitaku, Sapporo, 060-8638, Japan.

Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. Read More

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January 2022

Development of Sustained Release Baricitinib Loaded Lipid-Polymer Hybrid Nanoparticles with Improved Oral Bioavailability.

Molecules 2021 Dec 28;27(1). Epub 2021 Dec 28.

CNRS, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux, University Pau & Pays Adour, E2S UPPA, IPREM, UMR5254, 64000 Pau, France.

Baricitinib (BTB) is an orally administered Janus kinase inhibitor, therapeutically used for the treatment of rheumatoid arthritis. Recently it has also been approved for the treatment of COVID-19 infection. In this study, four different BTB-loaded lipids (stearin)-polymer (Poly(d,l-lactide-co-glycolide)) hybrid nanoparticles (B-PLN1 to B-PLN4) were prepared by the single-step nanoprecipitation method. Read More

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December 2021

Increases Intestinal Melatonin Level by Activating p-CREB-AANAT Pathway.

Nutrients 2021 Dec 28;14(1). Epub 2021 Dec 28.

Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.

Intestinal melatonin exerts diverse biological effects on the body. Our previous research showed that the abundance of the butyrate-producing bacteria, , is positively related to the expression of colonic mucosal melatonin. However, the detailed relationship is unclear. Read More

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December 2021

Ipidacrine (Axamon), A Reversible Cholinesterase Inhibitor, Improves Erectile Function in Male Rats With Diabetes Mellitus-Induced Erectile Dysfunction.

Sex Med 2022 Jan 7;10(1):100477. Epub 2022 Jan 7.

Institute of Pre-clinical Research Ltd, Leningradskaya Region, Russia.

Background: Management of diabetes mellitus-induced erectile dysfunction (DMED) is challenging because of its insufficient responses to phosphodiesterase type 5 inhibitors.

Aim: To compare the effects of ipidacrine, a reversible cholinesterase inhibitor, and sildenafil on DMED in a rat model of streptozotocin (STZ)-induced diabetes.

Methods: Erectile dysfunction (ED) caused by STZ-induced diabetes mellitus was modeled in adult male Wistar rats, which were randomized to 4 groups: untreated diabetic rats, sildenafil (5 mg/kg), ipidacrine (3. Read More

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January 2022

Ficus natalensis extract alleviates Cadmium chloride-induced testicular disruptions in albino rats.

J Trace Elem Med Biol 2022 Jan 5;70:126924. Epub 2022 Jan 5.

National Organization for Drug Control and Research, Dokki, Cairo, Egypt. Electronic address:

Background: Cadmium is a potential environmental pollutant with worldwide health problems. Many Ficus species are reported to have an extensive diversity of traditional uses, among them the treatment of reproductive toxicity.

Objectives: This study set out to evaluate the effect of Ficus natalensis extract on the testicular impairments induced by cadmium chloride (CdCl) and investigated the potential mechanisms associated with its treatment. Read More

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January 2022

Ascorbic Acid Significantly Decreases Creatine Kinase Plasma Levels in an Animal Model of Statin/Fibrate-Induced Myopathy.

Adv Pharmacol Pharm Sci 2021 29;2021:5539595. Epub 2021 Dec 29.

Department of Clinical Pharmacy, Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Myopathy is one of the side effects of lipid-lowering drugs, especially statins and particularly when combined with a fibrate. To diagnose myopathy and determine its severity, the plasma levels of three enzymes, creatine kinase (CK), aldolase, and lactate dehydrogenase (LDH), are routinely measured. Physical exercise can aggravate the statin-associated muscular disease. Read More

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December 2021

Assessment of the acute and sub-acute toxicity of the ethanolic extract of the aerial parts of (Asteraceae) in rats.

Toxicol Rep 2022 16;9:58-63. Epub 2021 Dec 16.

Greenyn Biotechnology Co., Ltd., Taichung City, 42881, Taiwan.

This pioneering study was to assess the acute and sub-acute toxicity of the ethanolic extract of the aerial parts of (Asteraceae) in rats. is a common vegetable and herb for treating inflammation-related syndromes in Taiwan. Pharmacological studies have unveiled that the extracts of have potential to become hepatoprotective, anti-inflammatory, or anti-cancer agents. Read More

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December 2021

Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats.

Saudi J Biol Sci 2022 Jan 16;29(1):564-573. Epub 2021 Sep 16.

Department of Medical Microbiology, College of Science, Cihan University-Erbil, Erbil, Kurdistan Region, Iraq.

Ethnopharmacological Relevance: Since ancient times, herbal medicines have been applied in the treatment of cancer. Tea, derivative from the dried leaves of Camellia sinensis (L.) Kuntze plant is the most popular beverage globally after water and is available in various forms. Read More

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January 2022

Antihypertensive and cardioprotective effects of different monotherapies and combination therapies in young spontaneously hypertensive rats - A pilot study.

Saudi J Biol Sci 2022 Jan 8;29(1):339-345. Epub 2021 Sep 8.

University of Leipzig, Faculty of Medicine, Carl-Ludwig-Institute of Physiology, Liebigstrasse 27, Leipzig, Germany.

Spontaneously hypertensive rats (SHR) are an established animal model for antihypertensive treatment. The aim of this pilot study was a systematic search for two lines of antihypertensive treatment - a monotherapy and a combination of two drugs - to be applied in a future study on old SHR. Originally, representatives of three drug classes recommended for antihypertensive therapy in humans should be applied, namely captopril (CAP) as an antagonist of the renin-angiotensin-aldosterone system, nifedipine (NIF) as calcium channel blocker and propranolol (PROP) as β-adrenergic blocker. Read More

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January 2022

Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes.

J Inflamm Res 2021 30;14:7467-7486. Epub 2021 Dec 30.

Xin'an Medicine Research Center, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, 241000, People's Republic of China.

Background: Qing-Luo-Yin (QLY) is an anti-rheumatic herbal formula. Despite the well-investigated therapeutic efficacy of QLY, its immune regulatory properties are largely unknown. CD4 T cells and monocytes are two key parameters in rheumatoid arthritis (RA). Read More

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December 2021

Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Inflammatory, Anti-Apoptotic, and Neuromodulatory Activities.

Int J Nanomedicine 2021 30;16:8447-8464. Epub 2021 Dec 30.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

Purpose: Depression is a mood disorder accompanied by intensive molecular and neurochemical alterations. Currently, available antidepressant therapies are not fully effective and are often accompanied by several adverse impacts. Accordingly, the ultimate goal of this investigation was to clarify the possible antidepressant effects of prodigiosins (PDGs) loaded with selenium nanoparticles (PDGs-SeNPs) in chronic unpredictable mild stress (CUMS)-induced depression-like behavior in rats. Read More

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January 2022

Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats.

Pharm Biol 2022 Dec;60(1):163-174

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.

Context: Yi Shen An (YSA) is an investigational composite of traditional Chinese medicine (Reference: 2010L000974) for the treatment of renal disease.

Objective: To investigate the protective effects of YSA against membranous glomerulonephritis (MGN).

Materials And Methods: Male Sprague-Dawley rats were injected with cationic bovine serum albumin (C-BSA) to create a model of MGN. Read More

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December 2022

QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats.

Pharm Biol 2022 Dec;60(1):185-194

National Clinical Drug Monitoring Center, Hebei General Hospital, Shijiazhuang, China.

Context: Atorvastatin (ATV) and QiShenYiQi pills (QSYQ), a Chinese patent medicine, are often co-prescribed to Chinese cardiovascular patients. The effects of QSYQ on the pharmacokinetics of ATV have not been studied.

Objective: We investigated the influence of QSYQ on the pharmacokinetics of ATV and its metabolites upon oral or intravenous administration of ATV to rats. Read More

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December 2022

An in vivo acute toxicity and anti-shigellosis effect of designed formulation on rat.

J Ayurveda Integr Med 2022 Jan 5:100536. Epub 2022 Jan 5.

Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, Uttar Pradesh, India. Electronic address:

Introduction: Shigellosis is an intestinal disease and is one of the main causes of morbidity and mortality among children in India. The study aims to analyze the effect of the designed formulation on the hematological parameters in shigellosis-induced rats and assess the in vivo toxicity of this formulation.

Methods: Male Wistar rats were housed in different groups. Read More

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January 2022

Anti-atherosclerotic Activity of Para Methoxy Cinnamic Acid in High Fat Diet Induced Hyperlipidemia Model Rats.

Authors:
Cheng Chen

Appl Biochem Biotechnol 2022 Jan 8. Epub 2022 Jan 8.

Vascular Surgery, Yunnan Fuwai Cardiovascular Hospital, Kunming, 650000, Yunnan, China.

Hypercholesterolemia is a well-known etiological feature for cardiovascular diseases and a common indication of maximum categories of metabolic disorders. Para methoxy cinnamic acid is one of the cinnamic acid derivatives as a natural product obtained from the rice bran oil as an active constituent and has the antioxidant property. The present study was designed to evaluate the hypolipidemic activity of P-methoxy cinnamic acid against high fat diet induced hyperlipidemia in experimental rats. Read More

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January 2022