145,018 results match your criteria rats demonstrated

[Animal Experimental Study of the Role of Menthol and Cineole, Two Tobacco Additives, on Nicotine Dependence].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):649-654

Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To establish a nicotine intravenous self-administration rat model, and to examine, with this model, the effects of two flavoring additives, menthol and cineole, on nicotine dependence.

Methods: Thirty male Sprague-Dawley (SD) rats were included in the study. After jugular venous catheterization was performed, fixed concentration of nicotine was administered in order to train the rats and establish the rat model of intravenous self-administration groups, receiving intraperitoneal injection of menthol, cineole, and dimethyl sulfoxide (DMSO), the vehicle that was used for the control group. Read More

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Mesenchymal stem cells from different sources show distinct therapeutic effects in hyperoxia-induced bronchopulmonary dysplasia in rats.

J Cell Mol Med 2021 Jul 29. Epub 2021 Jul 29.

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Mesenchymal stem cells (MSCs) have been shown as an effective medicinal means to treat bronchopulmonary dysplasia (BPD). The widely used MSCs were from Wharton's jelly of umbilical cord (UC-MSCs) and bone marrow (BM-MSCs). Amniotic fluid MSCs (AF-MSCs) may be produced before an individual is born to treat foetal diseases by autoplastic transplantation. Read More

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Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey.

Doxorubicin (DOX) is a well-known chemotherapeutic drug for most malignancies including breast cancer and leukemia whilst the usage of DOX is limited owing to its cardiotoxicity. In the present study, we aimed to investigate the effects of crocin on doxorubicin-induced cardiotoxicity in rats. Forty rats were randomly divided into four groups: (a) control [received normal saline as a dose of 1 ml/kg by intraperitoneal injection (ip) for 15 days], (b) crocin (received crocin as a dose of 40 mg/kg/24h by ip for 15 days), (c) DOX (received DOX as a dose of 2 mg/kg/48h by ip in six injection, cumulative dose 12 mg/kg), and (d) DOX+crocin (received DOX as a dose of 2 mg/kg/48h by ip in six injection, and crocin as a dose of 40 mg/kg/24h i. Read More

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Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study.

Front Cardiovasc Med 2021 12;8:688586. Epub 2021 Jul 12.

Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect of ADR on myocardial fibrosis in DCM rats. Read More

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Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat.

Sci Rep 2021 Jul 28;11(1):15375. Epub 2021 Jul 28.

Nephrological Department P 2131, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, 2100, Copenhagen, Denmark.

The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats. α-Klotho (klotho) is an aging-suppressor gene, and overexpression of klotho is associated with extended lifespan in mice. Klotho is predominantly expressed in the kidney. Read More

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Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant IDH1 for Treatment of -Mutant Malignancies.

Drug Metab Dispos 2021 Jul 28. Epub 2021 Jul 28.

Agios Pharmaceuticals, Inc., United States.

Point mutations in isocitrate dehydrogenase 1 () result in conversion of α-ketoglutarate to the oncometabolite, D-2-hydroxyglutarate (2-HG). Ivosidenib is a once daily (q.d. Read More

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Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney.

Biomed Pharmacother 2020 Oct 28;130:110627. Epub 2020 Aug 28.

Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Shebin Elkoum 32514, Egypt.

Piroxicam (PM) is an oxicam-NSAID commonly recommended for various pain and associated inflammatory disorders. However, it is reported to have a gastric and hepato-renal toxic effect. Therefore, the current research was planned to investigate the possible mechanisms behind the mitigating action of the coenzyme (CoQ10), a natural, free radical scavenger, against PM tissue injury. Read More

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October 2020

Escalating morphine dosage fails to elicit conditioned analgesia in a preclinical chronic neuropathic pain model.

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

School of Medical Sciences (Neuroscience) and the Brain and Mind Centre, The University of Sydney, New South Wales, Australia.

Many people with chronic pain escalate their opioid dosage to counteract tolerance effects. A treatment regimen consisting of placebos admixed with opioids has been suggested as a possible therapeutic option that could reduce the harm of long-term opioid use. However, the analgesic efficacy of such a regimen requires further investigation before widespread adoption. Read More

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Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages.

Braz J Med Biol Res 2021 23;54(8):e11184. Epub 2021 Jul 23.

Department of Plastic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Hypertrophic scar (HS) formation is a common complication that develops after skin injury; however, there are few effective and specific therapeutic approaches for HS. Emodin has previously been reported to inhibit mechanical stress-induced HS inflammation. Here, we investigated the molecular mechanisms underlying the inhibitory effects of emodin on HS formation. Read More

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Machine Learning-Enabled High-Resolution Dynamic Deuterium MR Spectroscopic Imaging.

IEEE Trans Med Imaging 2021 Jul 28;PP. Epub 2021 Jul 28.

Deuterium magnetic resonance spectroscopic imaging (DMRSI) has recently been recognized as a potentially powerful tool for noninvasive imaging of brain energy metabolism and tumor. However, the low sensitivity of DMRSI has significantly limited its utility for both research and clinical applications. This work presents a novel machine learning-based method to address this limitation. Read More

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Betaine downregulates microRNA 34a expression via a p53-dependent manner in cisplatin-induced nephrotoxicity in rats.

J Biochem Mol Toxicol 2021 Jul 28:e22856. Epub 2021 Jul 28.

Department of Pharmacology, Faculty of Medicine, Mutah University, Al-Karak, Jordan.

Cisplatin-induced nephrotoxicity limits its wide application as a chemotherapeutic drug. Betaine is a natural trimethylglycine compound involved in several biological reactions. In this study, the protective effect of betaine against cisplatin-induced nephrotoxicity through modulating the expression of microRNA 34a (miRNA 34a), p53, apoptosis, and inflammation was investigated. Read More

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Chios Mastic Gum Consumption Has a Protective Effect on Ovariectomy-Induced Bone Loss in Rats.

Prev Nutr Food Sci 2021 Jun;26(2):166-176

Laboratory for Research of the Musculoskeletal System, School of Medicine, National & Kapodistrian University of Athens, KAT Hospital, Kifissia 14561, Greece.

The purpose of this study was to examine the potential effect of Chios Mastic Gum (CMG) consumption on bone mineral density (BMD) and strength of ovariectomized rats. CMG is a known resin used from ancient times for its beneficial biological properties. Thirty mature female Wistar rats were randomized into three equal groups: sham-operated (control), ovariectomized (OVX), and ovariectomized and administered CMG (OVX+CMG). Read More

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ethanol extract prevents monosodium glutamate adverse effects on the serum levels of reproductive hormones, sperm quality, and testis histology in male rats.

Vet World 2021 Jun 15;14(6):1529-1536. Epub 2021 Jun 15.

Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia.

Background And Aim: is an aquatic plant that contains high antioxidants level and could prevent cell damages caused by free radicals. The present study aimed to investigate the effect of . ethanol extract on luteinizing hormone (LH), testosterone levels, sperm quality, and testis histology of adult male rats induced by monosodium glutamate (MSG). Read More

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Melatonin Abates TMJOA Chronic Pain by MTR in Trigeminal Ganglion Neurons.

J Dent Res 2021 Jul 27:220345211026551. Epub 2021 Jul 27.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.

Temporomandibular joint osteoarthritis (TMJOA) is one of the most common diseases causing chronic pain in the oral and maxillofacial region. So far, there are few ways to relieve the pain of TMJOA. Melatonin (MT) has a good analgesic effect in many diseases, including fibromyalgia, neuropathic pain, chronic headache, and burn pain, with very low acute toxicity and side effects. Read More

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Effect of ginger extract ingestion on skeletal muscle glycogen contents and endurance exercise in male rats.

Phys Act Nutr 2021 Jun 30;25(2):15-19. Epub 2021 Jun 30.

Ikeda Food Research Co., Ltd, Fukuyama, Hiroshima, Japan.

Purpose: Skeletal muscle glycogen is a determinant of endurance capacity for some athletes. Ginger is well known to possess nutritional effects, such as anti-diabetic effects. We hypothesized that ginger extract (GE) ingestion increases skeletal muscle glycogen by enhancing fat oxidation. Read More

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Sensitivity to interaural time differences in the inferior colliculus of cochlear implanted rats with or without hearing experience.

Hear Res 2021 Jul 9;408:108305. Epub 2021 Jul 9.

Department of Neouroscience, City University of Hong Kong, 31 To Yuen Street, Kowloon, Hong Kong SAR, China; City University of Hong Kong Shenzhen Research Institute, Shenzhen, China. Electronic address:

For deaf patients cochlear implants (CIs) can restore substantial amounts of functional hearing. However, binaural hearing, and in particular, the perception of interaural time differences (ITDs) with current CIs has been found to be notoriously poor, especially in the event of early hearing loss. One popular hypothesis for these deficits posits that a lack of early binaural experience may be a principal cause of poor ITD perception in pre-lingually deaf CI patients. Read More

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Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats.

J Chem Neuroanat 2021 Jul 24:102008. Epub 2021 Jul 24.

Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand 9717853577, Iran. Electronic address:

It has been recently demonstrated that rosmarinic acid (RA) through modulation in the amyloidogenic pathway exhibit neuroprotective potential in Alzheimer's disease. However, its effects on non-amyloidogenic pathways such as neuroinflammation (NI) and oxidative stress have not been elucidated carefully. Hence, this study aimed to investigate the effect of RA on cognitive function, cortical and hippocampal oxidant-antioxidant balance, and proinflammatory cytokines production in lipopolysaccharide (LPS)-induced NI in rats. Read More

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TRIM25 Rescues Against Doxorubicin-Induced Pyroptosis Through Promoting NLRP1 Ubiquitination.

Cardiovasc Toxicol 2021 Jul 27. Epub 2021 Jul 27.

Department of Cardiology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266003, Shandong, China.

Doxorubicin (DOX) is an antineoplastic agent that is widely employed in carcinomas, but it can cause cardiotoxicity in clinic. TRIM25 has E3 ubiquitin ligase activities and can ubiquitinate its target proteins. The role of TRIM25 in DOX-induced cardiotoxicity remains unknown. Read More

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The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury.

Shock 2021 Jul 26. Epub 2021 Jul 26.

Institute of Disaster Medicine, Tianjin University, Tianjin, China Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, China Department of Intensive Care Medicine, Taida hospital of Tianjin University, Tianjin, China Department of Intensive Care Medicine, Shijiazhuang Circulating Chemical Industry Park Hospital, Hebei, China Department of Emergency Medicine, General Hospital of Tianjin Medical University, Tianjin, China Department of Nephrology, Characteristic Medical Center of Chinese People's Armed Police Forces, Tianjin, China Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.

Background: Crush syndrome (CS) is the most common cause of deaths following earthquakes and other disasters. The pathogenesis of CS has yet to be fully elucidated. Thus, clinical choice of ideal drug treatments for CS remains deficient. Read More

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Curr Probl Cardiol 2021 Jul 23:100943. Epub 2021 Jul 23.

Head of Molecular Biology Department, Kuban State Medical University, Krasnodar, Russian Federation.

Introduction: Today, cardiovascular diseases, due to their widespread prevalence, are among the most relevant biomedical problems in the modern world. The development of cardiovascular comorbidity among patients with diabetes mellitus is of high clinical urgency. Therefore, the study of cardiovascular risk modification among patients with diabetes mellitus is of paramount importance. Read More

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Improved intestinal absorption and oral bioavailability of astaxanthin via poly (ethylene glycol)-graft-chitosan nanoparticle: preparation, in vitro evaluation and pharmacokinetics in rats.

J Sci Food Agric 2021 Jul 26. Epub 2021 Jul 26.

Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, 212013, China.

Background: Astaxanthin (ASTA) is a kind of food-derived active ingredients (FDAI) with functions of antioxidant, antidiabetic, and nontoxicity, but its poor solubility and low bioavailability hinder further application in food industry. In this study, a novel carrier, polyethylene glycol grafted chitosan (PEG-g-CS), was applied in enhancing bioavailability of astaxanthin firstly. It encapsulated astaxanthin completely by solvent evaporation to manufacture ASTA-PEG-g-CS nanoparticle for improving absorption. Read More

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Donepezil Protects Against Doxorubicin-Induced Chemobrain in Rats via Attenuation of Inflammation and Oxidative Stress Without Interfering With Doxorubicin Efficacy.

Neurotherapeutics 2021 Jul 26. Epub 2021 Jul 26.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Neuroelectrophysiology Unit, Chiang Mai University, 50200, Chiang Mai, Thailand.

Although doxorubicin (Dox) is an effective chemotherapy medication used extensively in the treatment of breast cancer, it frequently causes debilitating neurological deficits known as chemobrain. Donepezil (DPZ), an acetylcholinesterase inhibitor, provides therapeutic benefits in various neuropathological conditions. However, comprehensive mechanistic insights regarding the neuroprotection of DPZ on cognition and brain pathologies in a Dox-induced chemobrain model remain obscure. Read More

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Morin alleviates hepatic ischemia/reperfusion-induced mischief: In vivo and in silico contribution of Nrf2, TLR4, and NLRP3.

Biomed Pharmacother 2021 Jun 31;138:111539. Epub 2021 Mar 31.

Biochemistry and molecular Biology Department, Faculty of Pharmacy, Helwan University, Helwan 11790, Egypt.

Objective: Morin (MRN), a known natural flavonol, has demonstrated its shielding aptitude against ischemia/reperfusion (I/Re) lesion in various organs. Nonetheless, its potential influence on hepatic I/Re-induced injury modulation has not been fully elucidated. Consequently, the current study strived to investigate the mechanistic maneuvering of MRN against hepatic I/Re. Read More

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Quantifying muscle alterations in a Parkinson's disease animal model using electromyographic biomarkers.

Med Biol Eng Comput 2021 Jul 23. Epub 2021 Jul 23.

Laboratorio de Investigaciones en Neurociencias Y Tecnologías Aplicadas (LINTEC), Departamento de Bioingeniería, Facultad de Ciencias Exactas Y Tecnología, Universidad Nacional de Tucumán, Av. Independencia 1800, (4000) San Miguel de Tucumán, Tucumán, Argentina.

Parkinson's disease (PD) is a neurodegenerative disease currently diagnosed based on characteristic motor dysfunctions. The most common Parkinson's disease animal model induces massive nigrostriatal degeneration by intracerebral infusion of 6-hydroxydopamine (6-OHDA). Motor deficits in rat models of Parkinson's disease were previously addressed in other works. Read More

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CD14 Involvement in Third-degree Skin Burn-induced Myocardial Injury via the MAPK Signaling Pathway.

Cell Biochem Biophys 2021 Jul 23. Epub 2021 Jul 23.

The Department of Plastic and Burn Surgery, Shenzhen Hospital, Southern Medical University, Shenzhen, China.

This study investigated the potential genes and related pathways in burn-induced myocardial injury. Rat myocardial injury induced by third-degree burn and the histopathological structures, apoptosis, and cardiac injury markers were then identified using hematoxylin & eosin staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, and enzyme-linked immunosorbent assay. Next, differentially expressed mRNAs were screened through next-generation sequencing (NGS), followed by functional annotation and key gene validation through quantitative reverse transcription-polymerase chain reaction. Read More

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Depression of Pyroptosis by Inhibiting Caspase-1 Activation Improves Neurological Outcomes of Kernicterus Model Rats.

ACS Chem Neurosci 2021 Jul 23. Epub 2021 Jul 23.

Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.

Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged exposure to high-level unconjugated bilirubin (UCB) directly damages brain tissue. Neuroinflammation is believed to contribute to UCB-induced neurotoxicity. Read More

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MiR-214-3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4.

Cell Biol Int 2021 Jul 23. Epub 2021 Jul 23.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

This study aimed to investigate the functions of miR-214-3p in diabetic neuropathic rodents. The diabetic neuropathy was induced by intraperitoneal injection of streptozotocin (STZ) in rats, and miR-214-3p was delivered via tail vein injection of lentivirus. Hot or cold stimulus tests demonstrated that STZ induced thermal hyperalgesia. Read More

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miR‑34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression.

Mol Med Rep 2021 Sep 23;24(3). Epub 2021 Jul 23.

Department of NICU, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.

The miR‑34a/SIRT1 signaling axis is an important signaling axis in tumors and diseases. Notably, low SIRT1 expression in the intestinal tissues of patients with necrotizing enterocolitis (NEC) has been reported. However, whether miR‑34a/SIRT1 signaling as a target to protect the intestines during the NEC process is unclear and remains to be elucidated. Read More

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September 2021

Morphological Changes in the Motor Endplate and in the Belly Muscle Induced by Previous Static Stretching to the Climbing Protocol.

Microsc Microanal 2021 Jul 23:1-9. Epub 2021 Jul 23.

Department of Physical Activity, Laboratory of Morphology and Physical Activity - LAMAF, Institute of Biosciences (IB), São Paulo State University - UNESP, Rio Claro13506-900, SP, Brazil.

Static stretching provides benefits to the range of motion, modulates intramuscular connective tissue, and is incorporated into warm-up exercises. In this study, we present the effects in the motor endplate and belly muscle resulting from previous static stretching to climbing training. Twenty-four adult male Wistar rats were divided into four groups (n = 6 each): Sedentary (Sed), Climbing (Clb), Static stretching (Ss), and Static stretching prior to climbing (Ssc). Read More

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Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue.

ACS Appl Mater Interfaces 2021 Jul 26. Epub 2021 Jul 26.

Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom.

The lack of clinical response to the alkylating agent temozolomide (TMZ) in pediatric diffuse midline/intrinsic pontine glioma (DIPG) has been associated with -methylguanine-DNA-methyltransferase (MGMT) expression and mismatch repair deficiency. Hence, a potent N(3)-propargyl analogue (N3P) was derived, which not only evades MGMT but also remains effective in mismatch repair deficient cells. Due to the poor pharmacokinetic profile of N3P ( < 1 h) and to bypass the blood-brain barrier, we proposed convection enhanced delivery (CED) as a method of administration to decrease dose and systemic toxicity. Read More

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