279,016 results match your criteria rats compared


Local RANKL delivery improves socket healing in bisphosphonate treated rats.

Bone 2021 Apr 6:115945. Epub 2021 Apr 6.

Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA. Electronic address:

Medication related osteonecrosis of the Jaws (MRONJ) is a severe complication of antiresorptive and anti-angiogenic medications. Osteoclast inhibition is central in MRONJ pathogenesis. Here, we investigated if local application of RANKL (a key molecule in osteoclast activation) could enhance osteoclast generation and improve extraction socket healing in the presence of bisphosphonates. Read More

View Article and Full-Text PDF

Alendronate/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillae.

Bone 2021 Apr 6:115942. Epub 2021 Apr 6.

Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan.

Dental implant treatment in patients prescribed medications is associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ) around the implants. However, there is no scientific information on how bisphosphonate and/or steroid therapies affect wound healing around implants after implant placement. The aim of this study was to histopathologically and immunopathologically investigate the effects of bisphosphonate and/or steroid therapy on the early stages of soft and hard tissue wound healing around implants in rat maxillae. Read More

View Article and Full-Text PDF

PERINATAL EXPOSURE TO PARACETAMOL: DOSE AND SEX-DEPENDENT EFFECTS IN BEHAVIOUR AND BRAIN'S OXIDATIVE STRESS MARKERS IN PROGENY.

Behav Brain Res 2021 Apr 6:113294. Epub 2021 Apr 6.

Graduation Program in Health Sciences, State University of Londrina, 86038-350, Londrina, PR, Brazil; Departament of Physiological Sciences, State University of Londrina, 86057-970, Londrina, PR, Brazil. Electronic address:

Paracetamol (PAR) has been employed worldwide for pain and fever treatment during pregnancy and lactation. Epidemiologic studies have shown that exposure to PAR can increase the risk for developmental disorders, such as attention-deficit hyperactive disorder and autism spectrum disorder. This study aimed to investigate if gestational and lactational exposure to human-relevant doses of PAR could alter behavioural and brain oxidative stress parameters in the rat`s offspring. Read More

View Article and Full-Text PDF

H NMR Metabolomics and Full-Length RNA-Seq Reveal Effects of Acylated and Nonacylated Anthocyanins on Hepatic Metabolites and Gene Expression in Zucker Diabetic Fatty Rats.

J Agric Food Chem 2021 Apr 9. Epub 2021 Apr 9.

Food Chemistry and Food Development, Department of Life Technologies, University of Turku, FI-20014 Turun yliopisto, Finland.

Anthocyanins have been reported to possess antidiabetic effects. Recent studies indicate acylated anthocyanins have better stability and antioxidative activity compared to their nonacylated counterparts. This study compared the effects of nonacylated and acylated anthocyanins on hepatic gene expression and metabolic profile in diabetic rats, using full-length transcriptomics and H NMR metabolomics. Read More

View Article and Full-Text PDF

Extracellular vesicle-derived microRNA-18b ameliorates preeclampsia by enhancing trophoblast proliferation and migration via Notch2/TIM3/mTORC1 axis.

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

Preeclampsia (PE), a common disorder of pregnancy, is characterized by insufficient trophoblast migration and inadequate vascular remodelling, such that promotion of trophoblast proliferation might ameliorate PE. In the current study, we sought to study the underlying mechanism of extracellular vesicle (EV)-derived microRNA-18 (miR-18b) in PE. Human umbilical cord mesenchymal stem cells (HUCMSCs) isolated from placental tissues were verified through osteogenic, adipogenic and chondrogenic differentiation assays. Read More

View Article and Full-Text PDF

The ameliorative role of Physalis pubescens L. against neurological impairment associated with streptozotocin induced diabetes in rats.

Metab Brain Dis 2021 Apr 9. Epub 2021 Apr 9.

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.

Neuropathy is considered a critical complication of diabetes mellitus (DM). Scientific studies are needed to relieve these painful complications. The current study aims to estimate the ameliorative role of Physalis juice (PJ) against neurological impairment in streptozotocin (STZ)-induced diabetic rats. Read More

View Article and Full-Text PDF

Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation-a Potential Approach for HIV Therapy.

AAPS PharmSciTech 2021 Apr 9;22(3):127. Epub 2021 Apr 9.

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, India.

Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral drug, possesses solubility issues. The current research was aimed to improve the solubility of the DTG and thereby enhance its efficacy using the solid dispersion technique. In due course, the miscibility study of the drug was performed with different polymers, where Poloxamer 407 (P407) was found suitable to move forward. Read More

View Article and Full-Text PDF

Nerve autofluorescence in near-ultraviolet light markedly enhances nerve visualization in vivo.

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Cleveland Clinic Florida, Weston, FL, 33325, USA.

Background: During surgery, surgeons must accurately localize nerves to avoid injuring them. Recently, we have discovered that nerves fluoresce in near-ultraviolet light (NUV) light. The aims of the current study were to determine the extent to which nerves fluoresce more brightly than background and vascular structures in NUV light, and identify the NUV intensity at which nerves are most distinguishable from other tissues. Read More

View Article and Full-Text PDF

The Intra.Ox Near-Infrared Spectrometer Measures Variations in Flap Oxygenation That Correlate to Flap Necrosis in a Preclinical Rodent Model.

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine.

Background: Mastectomy flap necrosis affects 7 to 40 percent of patients undergoing immediate breast reconstruction, with many cases resulting in infection and/or explantation. The Intra.Ox near-infrared spectrometer is one of several novel devices that assesses tissue perfusion by measuring the interactions of light with oxygenated and deoxygenated hemoglobin. Read More

View Article and Full-Text PDF

IgG modulation in male mice with reproductive failure after prenatal inflammation.

Reproduction 2021 Apr 1. Epub 2021 Apr 1.

L Zakharova, biochemistry of ontogenesis, Koltzov Institute of Development Biology RAS, Moskva, Russian Federation.

Sexual performance in adult male rats is highly sensitive to prenatal stress which can affect the functionality of the reproductive system and various brain structures involved in modulating sexual behavior. The immunomodulatory effect of mouse IgG on reproductive maturity in male offspring after LPS exposure in vivo and in vitro was studied. Prenatal IgG injection (20 µg / mouse) had a positive impact on the puberty of male mice whose mothers were exposed to LPS (100 µg / kg) on the 12th day of pregnancy. Read More

View Article and Full-Text PDF

Estrogen modulates epithelial progenitor cells in rat vagina.

Investig Clin Urol 2021 Apr 2. Epub 2021 Apr 2.

Department of Urology, Chonnam National University Medical School, Gwangju, Korea.

Purpose: The expression of epithelial progenitor cells (EPCs) in rat vagina was recently reported. The aims were to investigate the effects of estrogen on vaginal EPCs in the oophorectomized female rat model.

Materials And Methods: Female Sprague-Dawley rats (230-240 g, n=30) were divided into 3 groups: control (n=10), bilateral oophorectomy (OVX, n=10), and bilateral OVX followed by subcutaneous injections of 17β-estradiol (50 μg/kg/day, n=10). Read More

View Article and Full-Text PDF

Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats.

Environ Sci Pollut Res Int 2021 Apr 9. Epub 2021 Apr 9.

Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Salah Salem St, 62511, Beni-Suef, Egypt.

The study examines the prophylactic action of artichoke leaf hydroethanolic extract (ALE) and artichoke flower head hydroethanolic extract (AFE) against diethylnitrosamine (DEN)/acetylaminofluorene (AAF)-induced lung cancer in Wistar rats. To chemically induce lung cancer, DEN was injected intraperitoneally twice a week for a fortnight at a dose of 150 mg/kg body weight (b.w. Read More

View Article and Full-Text PDF

Effects of High-Fructose Diet . Teklad Diet in the MNU-Induced Rat Mammary Cancer Model: Altered Tumorigenesis, Metabolomics and Tumor RNA Expression.

J Obes Chronic Dis 2021 11;5(1):67-78. Epub 2021 Jan 11.

Chemopreventive Agent Development Research Group, Division of Cancer Prevention, Rockville, MD.

Epidemiology, clinical and experimental animal studies suggest high fructose diets are detrimental to metabolic status and may contribute to tumor development. This due to increased obesity and metabolic syndrome, known risk factors for many types of cancer. We compared tumor development in N-methyl-N-nitrosourea (MNU)-treated rats fed either a high (60%)-fructose diet (HFD) or a standard diet (SD). Read More

View Article and Full-Text PDF
January 2021

Efficacy of Combined Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study.

Front Surg 2021 23;8:639661. Epub 2021 Mar 23.

Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Preventing surgical flaps necrosis remains challenging. Laser Doppler imaging and ultrasound can monitor blood flow in flap regions, but they do not directly measure the cellular response to ischemia. The study aimed to investigate the efficacy of synergistic electroporation-mediated gene transfer of interleukin 10 (IL-10) with either hepatocyte growth factor (HGF) or vascular endothelial growth factor (VEGF) on the survival of a modified McFarlane flap, and to evaluate the effect of the treatment on cell metabolism, using label-free fluorescence lifetime imaging. Read More

View Article and Full-Text PDF

The Comparison of Clinical and Histopathological Effects of Topical Psyllium () Powder and Silver Sulfadiazine on Second-Degree Burn Wound Healing in Rats.

World J Plast Surg 2021 Jan;10(1):96-103

Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Burn wounds are a worldwide health problem, leading to physical and psychological disabilities in all age's groups. With regard to absorbent properties of mucilage which can decrease wound moisture, we aimed to compare the effect of silver sulfadiazine (SSD) 1% and powdered on second-degree burn wound healing in rats.

Methods: This experimental study was conducted on 30 male Wistar rats with second-degree burn in three groups. Read More

View Article and Full-Text PDF
January 2021

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats.

Evid Based Complement Alternat Med 2021 26;2021:5570356. Epub 2021 Mar 26.

Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

This study aimed to investigate the therapeutic effects of candesartan combined with music therapy on diabetic retinopathy with depression and to assess the molecular mechanisms. Associated animal model of diabetes mellitus and depression was established in rats. Pathological changes in the hippocampus were detected by haematoxylin eosin (H&E) staining. Read More

View Article and Full-Text PDF

The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation.

Int J Chron Obstruct Pulmon Dis 2021 31;16:877-885. Epub 2021 Mar 31.

Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People's Republic of China.

Background: Penehyclidine hydrochloride is a selective antagonist of M1 and M3 receptors. Clinical studies suggest that it is a potential drug for the treatment of chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of penehyclidine hydrochloride on the inflammatory response of lung tissue during mechanical ventilation in rats with COPD and explore the role of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway. Read More

View Article and Full-Text PDF

Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Lepr) rats.

Sci Rep 2021 Apr 8;11(1):7774. Epub 2021 Apr 8.

Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.

We studied the long-term effect of ileal transposition (IT) metabolic surgery on the hepatokines: retinol-binding protein-4 (RBP4), α-2-HS-glycoprotein (aHSG/fetuin-A), and fibroblast growth factor 21 (FGF21), C-reactive protein (CRP) plasma levels, glucose metabolism, body weight, liver histology, as well as total lipids concentration in muscle, liver, and fat tissue of obese Zucker (Crl:ZUC(ORL)-Lepr) rats. 14 adult males were randomly submitted either to IT or SHAM (control) surgery. Pre-operative hepatokines plasma levels were not significantly different in rats submitted to IT or SHAM protocol. Read More

View Article and Full-Text PDF

Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2371-2377

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan/Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.

Seizure are basic characteristic of epilepsy; these initiate due to irregular, excessive and synchronous electrical discharges. We aimed to determine the antiepileptic potential of phyto-flavonoids on the evaluation of the mRNA expression of TNF-α, IL-6, IL-1 Beta, IL-10, IL-1Ra, IL 4 and NF-κB. We induced chronic epilepsy in rats by administering sub-convulsive dose of pentylenetetrazole (25 mg/kg/day for 28 days). Read More

View Article and Full-Text PDF
September 2020

Therapeutic Angiogenesis for Ovarian Transplantation through Ultrasound-Targeted Microbubble Destruction.

Ultrasound Med Biol 2021 Apr 5. Epub 2021 Apr 5.

Department of Echocardiography, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address:

Timely angiogenesis and effective microcirculation perfusion are essential for the survival and functional recovery of transplanted ovaries. Ultrasound-targeted microbubble destruction (UTMD) can lead to angiogenesis and increase flow perfusion by causing transient inflammation. The purpose of this study was to evaluate the effects of UTMD on transplanted ovarian revascularization and survival. Read More

View Article and Full-Text PDF

Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.

Biochemistry (Mosc) 2021 Feb;86(2):179-189

Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt.

Polydatin (PD) has a broad range of pharmacological activities; however, its effects on diabetic liver damage are poorly studies. This work is aimed to explore possible protective effects of polydatin-loaded chitosan nanoparticles (PD-CSNPs) or PD against liver damage associated with diabetes. Diabetes was induced in rats using nicotinamide/streptozotocin treatment. Read More

View Article and Full-Text PDF
February 2021

Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats.

Drug Chem Toxicol 2021 Apr 8:1-9. Epub 2021 Apr 8.

Bucak School of Health, Department of Nursing, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.

This study sought to assess the protective effects of resveratrol and avocado oil in relation to paracetamol-induced hepatotoxicity in rats. The rats were divided into five groups, namely the control, paracetamol (600 mg/kg), resveratrol (RES; 10 mg/kg) + paracetamol, avocado oil (AVO; 200 mg/kg) + paracetamol, and RES + AVO + paracetamol groups. The hepatoprotective activity was evaluated by measuring biochemical parameters such as the total antioxidant status (TAS) and the total oxidant status (TOS) in each rat's liver homogenates. Read More

View Article and Full-Text PDF

Antioxidant properties of Klunzinger's mullet () protein hydrolysates prepared with enzymatic hydrolysis using a commercial protease and microbial hydrolysis with .

Food Sci Technol Int 2021 Apr 8:10820132211005297. Epub 2021 Apr 8.

Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Antioxidant activity of Klunzinger's mullet () muscle hydrolysates obtained using fermentation and enzymatic hydrolysis was determined. Hydrolysates obtained after 6 days of fermentation with showed the highest free radical scavenging activity, metal chelating ability and ferric reducing antioxidant power (FRAP) (P ≤ 0.05). Read More

View Article and Full-Text PDF

[Effect of amoxicillin on the enamel mineralization of SD rats].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Apr;56(4):355-361

Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases & Department of Preventive Dentistry, College of Stomatology, Xi' an Jiaotong University, Xi'an 710004, China.

To determine whether amoxicillin had an effect on the enamel mineralization of SD rats. Eighteen SD rats were randomly divided into three groups. The rats in the control group were given distilled water. Read More

View Article and Full-Text PDF

leaf extract ameliorates phenylhydrazine-induced anaemia and toxicity in Wistar rats.

Drug Metab Pers Ther 2021 Apr 9. Epub 2021 Apr 9.

Department of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu, Abia, Nigeria.

Objectives: L. is used in traditional medicine for the treatment of bacterial infections and anaemia. This study was designed to evaluate the effect of leaf extract on phenylhydrazine (PHZ)-induced anaemia and toxicity in rats. Read More

View Article and Full-Text PDF

Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats.

Biomed Pharmacother 2021 Apr 5;139:111540. Epub 2021 Apr 5.

Department of Medical Biochemistry, University of Gaziantep, Faculty of Medicine, Gaziantep, Turkey.

Ionizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. Read More

View Article and Full-Text PDF

Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats.

Phytomedicine 2021 Mar 17;85:153550. Epub 2021 Mar 17.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, PR China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, PR China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou 510120, PR China. Electronic address:

Background: Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD). The metabolites of BBR were believed to contribute significantly to its pharmacological effects. Oxyberberine (OBB), a gut microbiota-mediated oxidative metabolite of BBR, has been firstly identified in our recent work. Read More

View Article and Full-Text PDF

Anti-inflammatory activity of 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid in LPS-induced rat model.

Prostaglandins Other Lipid Mediat 2021 Apr 5:106549. Epub 2021 Apr 5.

Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jalan Kalisari Selatan 1, Surabaya, 60237, East Java, Indonesia. Electronic address:

Introduction: Salicylic acid derivate is very popular for its activity to suppress pain, fever, and inflammation. One of its derivatives is acetylsalicylic acid (ASA) which has been reported repeatedly that, as a non-steroidal anti-inflammatory drug (NSAID), it has a cardioprotective effect. Although ASA has various advantages, several studies have reported that it may induce severe peptic ulcer disease. Read More

View Article and Full-Text PDF

Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model.

Acta Biomater 2021 Apr 5. Epub 2021 Apr 5.

Simpson Querrey Institute (SQI), Northwestern University 303 E. Superior, Chicago, IL 60611, United States of America; Department of Orthopaedic Surgery, Northwestern University, 676 N. Saint Clair, Chicago, IL 60611, United States of America. Electronic address:

We recently developed a recombinant growth factor-free bone regenerative scaffold composed of stoichiometric hydroxyapatite (HA) ceramic particles and human demineralized bone matrix (DBM) particles (HA-DBM). Here, we performed the first pre-clinical comparative evaluation of HA-DBM relative to the industry standard and established positive control, recombinant human bone morphogenetic protein-2 (rhBMP-2), using a rat posterolateral spinal fusion model (PLF). Female Sprague-Dawley rats underwent bilateral L4-L5 PLF with implantation of the HA-DBM scaffold or rhBMP-2. Read More

View Article and Full-Text PDF

Platelet enhancement by Carica papaya L. leaf fractions in cyclophosphamide induced thrombocytopenic rats is due to elevated expression of CD110 receptor on megakaryocytes.

J Ethnopharmacol 2021 Apr 5:114074. Epub 2021 Apr 5.

Department of Pathology, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

Ethnopharmacological Relevance: Carica papaya leaf juice/decoction has been in use in folk medicine in Srilanka, Malaysia and in few parts of India for enhancing the platelet counts in dengue. In Siddha medicine, a traditional form of medicine in India, papaya leaf juice has been used for increasing the platelet counts. Papaya leaf has been reported to enhance blood volume in ancient Ayurveda books in India. Read More

View Article and Full-Text PDF