J Trauma Acute Care Surg 2021 Apr 8. Epub 2021 Apr 8.
Coagulation and Blood Research (Blood), The United States Army Institute of Surgical Research, San Antonio, Texas/ 78234-4504, United States. Capricor Therapeutics Institute, Beverly Hills, California, 90211 Department of Biological Chemistry, Johns Hopkins, Baltimore, Maryland/ 21218, United States. Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, Texas/ 78249, United States.
Background: Extracellular vesicles (EVs) isolated from cardiosphere-derived cells (CDC-EVs) are coming to light as a unique, cell free therapeutic. Due to their novelty, however, there still exist prominent gaps in knowledge regarding their therapeutic potential. Herein the therapeutic potential of CDC-EVs in a rat model of acute traumatic coagulopathy induced by polytrauma and hemorrhagic shock is outlined. Read More