136,678 results match your criteria ratio decreased


CORRELATION OF CD4+Т LYMPHOCYTES ACTIVATION WITH INTERLEUKIN IL-9, IL-17, IL- 22 PROFILES IN THE PERIPHERAL BLOOD OF PATIENTS WITH PLAQUE PSORIASIS.

Georgian Med News 2021 Mar(312):75-78

3Ilia State University, School of Natural Sciences and Medicine, Tbilisi, Georgia.

Psoriasis is a T cell mediated chronic inflammatory skin disease affecting about 2% of the population worldwide. Recently has established the central role of IL-23/Th17 immune axis in the pathogenesis of psoriasis and different subclasses of T cells including Th1 and Th17 cells are involved in initiation and amplification of the skin inflammation process, in addition, in cases of recurrent psoriasis, Th22 cells play the role of memory cells with the help of Th9 cells, which are also important in this process. The main goal was to evaluate the ratio of T cell profile and IL23/Th17 axis by evaluating IL17A, IL22, IL9 in peripheral blood of persons with moderate to severe plaque psoriasis. Read More

View Article and Full-Text PDF

Estrogen receptor α in mature osteoblasts regulates the late stage of bone regeneration.

Biochem Biophys Res Commun 2021 May 5;559:238-244. Epub 2021 May 5.

Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Ehime, Japan; Department of Pathophysiology, Ehime University Graduate School of Medicine, Ehime, Japan. Electronic address:

Estrogen deficiency impairs fracture healing and homeostasis of bone tissue. OVX-induced estrogen deficiency in mice attenuates fracture healing and changes the expression ratio of estrogen receptor (ER) α and ERβ in callus during the process of fracture healing. Therefore, ERs may be involved in the regulation of fracture healing. Read More

View Article and Full-Text PDF

The Fate of Sutures Post Rotator Cuff Repair.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Department/ Institution: Orthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Ultrasound imaging has been widely used as a diagnostic tool for rotator cuff tears. Several studies have explored the changes in rotator cuff tendon morphology after arthroscopic cuff repair, however none have addressed the fate of sutures. The aim of this study was to determine: (1) if the sutures migrate through the tendon during the postoperative healing period in patients who have had arthroscopic rotator cuff repair, (2) if the sutures do migrate, the time point at which it does and, (3) if the quality of the tendon, in terms of tendon stiffness, modulus of elasticity, bursal thickness and anatomical footprint, affects suture migration. Read More

View Article and Full-Text PDF

Microbiome analysis reveals gut microbiota alteration in mice with the effect of matrine.

Microb Pathog 2021 May 5:104926. Epub 2021 May 5.

College of Animal Science and VeterinaryMedicine, Xinyang Agriculture And Forestry University, Xinyang, China.

Mounting evidence revealed the negative effects of abuse of antibiotic including the induction of decreased immunity and dysbacteriosis. Matrine displayed multiple beneficial effects such as anti-inflammatory, antiviral and antibacterial, but studies of its influence on gut microbiota are still insufficient to report. Here, the present study was conducted to investigate the influence of matrine on the gut microbiota of mice and amoxicillin was used as a positive control. Read More

View Article and Full-Text PDF

Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F.

J Ethnopharmacol 2021 May 5:114190. Epub 2021 May 5.

Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Ethnopharmacological Relevance: Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear. Read More

View Article and Full-Text PDF

Voluntary wheel-running exercise attenuates brain aging of rats through activating miR-130a-mediated autophagy.

Brain Res Bull 2021 May 5. Epub 2021 May 5.

Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan, 430079, China. Electronic address:

Autophagy is a highly regulated intracellular process for the degradation of protein aggregates and damaged organelles. Recently, autophagy has been implicated in Alzheimer's disease (AD) and aging. Autophagy process is regulated by the recruitment and assembly of several autophagy-related genes (Atgs) such as, Atg7 and LC3, as the highly conserved and important markers involved in the regulation of autophagy. Read More

View Article and Full-Text PDF

Energy management and mitochondrial dynamics in cerebral cortex during endotoxemia.

Arch Biochem Biophys 2021 May 5:108900. Epub 2021 May 5.

Universidad de Buenos Aires, CONICET, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Junín 946, C1113AAD, CABA, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Fisicoquímica, Junín 946, C1113AAD, CABA, Argentina. Electronic address:

Mitochondria play an essential role in inflammatory processes such as sepsis or endotoxemia, contributing to organ-cellular redox metabolism, emerging as the energy hub of the cell, and as an important center of action of second messengers. In this work, we aimed to elucidate the energy state, redox balance, and mitochondrial remodeling status in cerebral cortex in an experimental model of endotoxemia. Female Sprague-Dawley rats were subjected to a single dose of LPS (ip 8 mg kg body weight) for 6 h. Read More

View Article and Full-Text PDF

Association of Preoperative Infections, Nasal Staphylococcus Aureus Colonization and Gut Microbiota With Left Ventricular Assist Device Outcomes.

Eur J Heart Fail 2021 May 8. Epub 2021 May 8.

Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.

Aims: Infections are common following left ventricular assist device (LVAD) and predict adverse events. Infections are frequent prior to LVAD although their impact on postoperative outcomes remains unknown. Gut and nasal microbial imbalance may predispose to mucosal colonization with pathogens. Read More

View Article and Full-Text PDF

Mechanical and in vitro biological properties of uniform and graded Cobalt-chrome lattice structures in orthopedic implants.

J Biomed Mater Res B Appl Biomater 2021 May 8. Epub 2021 May 8.

Movement Analysis Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Human bones are biological examples of functionally graded lattice capable to withstand large in vivo loading and allowing optimal stress distribution. Disruption of bone integrity may require biocompatible implants capable to restore the original bone structure and properties. This study aimed at comparing mechanical properties and biological behavior in vitro of uniform (POR-FIX) and graded (POR-VAR) Cobalt-chrome alloy lattice structures manufactured via Selective Laser Melting. Read More

View Article and Full-Text PDF

Elevated serum tyrosine concentration is associated with a poor prognosis among patients with liver cirrhosis.

Hepatol Res 2021 May 8. Epub 2021 May 8.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.

Aim: Chronic liver insufficiency is often associated with changes in amino acid metabolism. We evaluated whether change in serum amino acid concentrations had prognostic value among patients with liver cirrhosis.

Methods: This retrospective study evaluated 158 patients who had been hospitalized with cirrhosis. Read More

View Article and Full-Text PDF

Effects of air discharge on surface charges and cell walls of Fusarium oxysporum.

Int Microbiol 2021 May 8. Epub 2021 May 8.

College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.

Air discharge showed significant inhibition on mycelial growth and spore germination of Fusarium oxysporum, one of the main spoilage fungi in post-harvest lotus roots which is an important economic aquatic vegetable in China. However, the antimicrobial mechanism of air discharge is not clear yet. In the present study, the effects of air discharge on F. Read More

View Article and Full-Text PDF

Using Pressure Mapping to Optimize Hospital-Acquired Pressure Injury Prevention Strategies in the Burn Intensive Care Unit.

J Burn Care Res 2021 May 8. Epub 2021 May 8.

Department of Plastic & Reconstructive Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Although prior studies have demonstrated the utility of real-time pressure mapping devices in preventing pressure ulcers, there has been little investigation of their efficacy in burn intensive care unit (BICU) patients, who are at especially high risk for these hospital-acquired injuries. This study retrospectively reviewed clinical records of BICU patients to investigate the utility of pressure mapping data in determining the incidence, predictors and associated costs of hospital-acquired pressure injuries. Of 122 patients, 57 (47%) were studied prior to implementation of pressure mapping and 65 (53%) were studied after implementation. Read More

View Article and Full-Text PDF

[Energy metabolism disorder and functional magnetic resonance imaging of the medial prefrontal cortex in mice with chronic unpredictable mild stress].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):521-528

Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To analyze spontaneous activities and energy metabolism in the medial prefrontal cortex (mPFC) of mice with chronic unpredictable mild stress (CUMS) and explore the correlation of these changes with the mTORC1 signaling pathway.

Objective: Normal C57Bl/6 mice were randomly divided into control group (=16) and depression model group (= 16), and the mice in the latter group were subjected to 8 weeks of modeling with CUMS. Behavioral tests including open field test, sucrose consumption test, tail suspension test and forced swimming test were performed, and the changes in prefrontal gray matter volume and the amplitude of low frequency fluctuation (ALFF) in the mice were detected with functional magnetic resonance imaging. Read More

View Article and Full-Text PDF

[Effect of protein C activator from venom on early adaptive immune response of septic rats].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):514-520

School of Pharmacy, Wannan Medical College, Wuhu 241002, China.

Objective: To investigate the effect of protein C activator (PCA) from venom (AAV) in modulating early adaptive immune response of septic rats.

Objective: Rat models of sepsis were established by intraperitoneal injection of lipopolysaccharide (LPS; 10 mg/kg) in 36 SD rats, which were divided into 6 groups (=6) for sample collection at 4, 6, 8, 12, 16 and 24 h after LPS injection, with 6 rats injected with saline as the control group. Another 36 rats were divided into two groups, and 30 min after LPS injection, the rats were treated with SEW2871 (a sphingosine-1-phosphate receptor 1 agonist; 0. Read More

View Article and Full-Text PDF

Hepatitis C virus eradication decreases the risks of liver cirrhosis and cirrhosis-related complications (T-COACH).

J Gastroenterol Hepatol 2021 May 7. Epub 2021 May 7.

Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background And Aims: It is currently unknown how hepatitis C virus (HCV) eradication with pegylated interferon and ribavirin (PR) therapy affects the incidence of new-onset liver cirrhosis (LC) in patients without cirrhosis and the incidence of decompensated liver disease (DLD) or hepatocellular carcinoma (HCC) in patients with cirrhosis.

Methods: Taiwanese chronic hepatitis C cohort (T-COACH) is a nationwide HCV registry cohort from 23 hospitals in Taiwan recruited between 2003 and 2015. This study enrolled 10,693 patients with chronic hepatitis C (CHC), linked to the Taiwan National Health Insurance Research Database, receiving PR therapy for at least 4 weeks for new-onset LC and liver-related complications (DLD or HCC). Read More

View Article and Full-Text PDF

Fatty acid composition, oxidative stability, and sensory evaluation of the sausages produced from the meat of pigs fed a diet enriched with 8% of fish oil.

J Food Sci 2021 May 7. Epub 2021 May 7.

Department of infection diseases and preventive medicine, Veterinary Research Institute, Brno, Czech Republic.

The objective of the present study was to increase by dietary means the long-chain polyunsaturated fatty acid (LC-PUFA) n-3 content in selected meat products. Fatty acid (FA) composition, texture, sensory characteristics, and oxidative stability were determined in the Vienna sausages (V-sausages) and Bologna-type salami (B-salami) produced from the meat of six pigs fed a standard feed (control, C) and six pigs fed a standard feed enriched with 8% of fish oil (F), respectively. The saturated FA content in the unheated FV and FB products was decreased (p < 0. Read More

View Article and Full-Text PDF

Comparison of analyte identification criteria and other aspects in triple quadrupole tandem mass spectrometry: Case study using UHPLC-MS/MS for regulatory analysis of veterinary drug residues in liquid and powdered eggs.

Authors:
Steven J Lehotay

Anal Bioanal Chem 2021 May 7. Epub 2021 May 7.

U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, PA, 19038, USA.

Ultrahigh-performance liquid chromatography (UHPLC) coupled with triple quadrupole tandem mass spectrometry (MS/MS) is one of the most powerful tools for the multiclass, multiresidue analysis of veterinary drugs, pesticides, mycotoxins, and other chemical contaminants in foods and other sample types. Until approximately 2010, commercial MS/MS instruments using multiple reaction monitoring (MRM) were generally limited to minimum dwell (and inter-dwell) times of 10 ms per ion transition. To achieve the needed accuracy and detection limits for hundreds of targeted analytes, older UHPLC-MS/MS methods typically acquired only two ion transitions per analyte (yielding only one ion ratio for qualitative identification purposes), which is still the norm despite technological advancements. Read More

View Article and Full-Text PDF

.

J Pharmacol Exp Ther 2021 May 7. Epub 2021 May 7.

Pharmaceutical Sciences, University at Buffalo, United States

The drug of abuse, γ-hydroxybutyric acid (GHB), is commonly co-ingested with ethanol, resulting in a high incidence of toxicity and death. Our laboratory has previously reported that GHB is a substrate for the monocarboxylate transporters (MCT), necessary for its absorption, renal clearance, and tissue distribution, including across the blood-brain barrier. Our goal was to investigate the drug-drug interaction (DDI) between GHB-ethanol and evaluate MCT1 inhibition as a strategy to reverse toxicity. Read More

View Article and Full-Text PDF

Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks.

J Orthop Surg Res 2021 May 7;16(1):300. Epub 2021 May 7.

Department of Joint Surgery, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, No. 158 Wuyang Avenue, Enshi City, 445000, Hubei Province, China.

Background: CircRNA CNST (circ-CNST) is a newly identified biomarker for prognosis of osteosarcoma (OS). However, its role in OS progression remains to be well documented.

Methods: Expression of circ-CNST, microRNA (miR)-578, lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1 (PDK1) was detected by quantitative real-time polymerase chain reaction and Western blotting. Read More

View Article and Full-Text PDF

Mathematical model of modified hybrid pump mechanism for cardiopulmonary resuscitation.

Comput Methods Programs Biomed 2021 Apr 18;206:106106. Epub 2021 Apr 18.

Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea; Institute of BioEngineering, Bio-MAX Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Background And Objective: The "Cardiac pump theory" and "Thoracic pump theory" are representative theories of cardiopulmonary resuscitation (CPR) mechanisms. Based on these theories, many studies on mathematical modeling have been performed to help understand hemodynamics during CPR. However, there are parts that do not yet properly reflect the physiology of CPR. Read More

View Article and Full-Text PDF

Internal loading of phosphate in rivers reduces at higher flow velocity and is reduced by iron rich sand application: an experimental study in flumes.

Water Res 2021 Apr 18;198:117160. Epub 2021 Apr 18.

Division of Soil and Water Management, Department of Earth and Environmental Sciences, KU Leuven, Kasteelpark Arenberg 20 bus 2459, 3001 Leuven, Belgium.

Many lowland regions are afflicted with high phosphorus (P) peaks in rivers during the summer months. Static incubations of sediments have shown that reductive dissolution of ferric iron (Fe(III)) minerals in the sediment explain these P peaks. This study was set up to identify if that mechanism also dominates in a dynamic system, thereby testing the roles of water flow velocity and sediment Fe/P ratio. Read More

View Article and Full-Text PDF

The effect of xenon on fetal neurodevelopment following maternal sevoflurane anesthesia and laparotomy in rabbits.

Neurotoxicol Teratol 2021 May 4:106994. Epub 2021 May 4.

Department of Anesthesiology, University Hospitals of the KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Background: There is concern that maternal anesthesia during pregnancy impairs brain development of the human fetus. Xenon is neuroprotective in pre-clinical models of anesthesia-induced neurotoxicity in neonates. It is not known if xenon also protects the developing fetal brain when administered in addition to maternal sevoflurane-anesthesia during pregnancy. Read More

View Article and Full-Text PDF

A novel non-destructive technique for qualitative and quantitative measurement of dental erosion in its entirety by porosity and bulk tissue-loss.

J Dent 2021 May 4:103688. Epub 2021 May 4.

School of Life Science, Pharmacy and Chemistry, Kingston University London, United Kingdom.

Objective: To explore the potential of combining non-contact profilometry(NCP) and confocal laser scanning microscopy(CLSM) data to measure the entire erosive process non-destructively and to validate findings using inductively coupled plasma-atomic emission spectroscopy(ICP-AES), scanning electron microscopy(SEM) and surface microhardness(SMH) using the same samples throughout.

Methods: Polished bovine enamel samples(n = 35) were divided into groups(7/group) with similar SMH values. Samples underwent individual erosive challenges(1% citric acid,pH3. Read More

View Article and Full-Text PDF

Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3β/NF-κB/CREB pathway.

Life Sci 2021 May 4:119584. Epub 2021 May 4.

Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, PR China. Electronic address:

Aims: Ferulic acid (FA) is a component found in plants that has free radical scavenging and liver-protective properties. Acute liver injury (ALI) is a serious complication of sepsis and is closely associated with changes in the levels of inflammatory factors. This study was taken to examine the role of FA in cecal ligation and perforation (CLP)-induced murine ALI and lipopolysaccharide (LPS)-induced cellular ALI models. Read More

View Article and Full-Text PDF

Low dose of methylprednisolone for pain and immune function after thoracic surgery.

Ann Thorac Surg 2021 May 4. Epub 2021 May 4.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China. Electronic address:

Background: The purpose of this study was to evaluate the effects of single low-dose preoperative methylprednisolone (MP) on the immunological function and postoperative pain of patients undergoing elective video-assisted thoracoscopic surgery under general anesthesia.

Methods: Eighty-one patients who underwent elective video-assisted thoracoscopic surgery were randomly assigned to the MP Group or the Control Group. The T lymphocyte subsets of CD3, CD4, and CD8, the CD4/CD8 ratio at T (before anesthesia), T (after surgery), and T (24 h after surgery) were all recorded. Read More

View Article and Full-Text PDF

Cognitive deficit is correlated with sleep stability in insomnia: A cardiopulmonary coupling study.

Brain Behav 2021 May 7:e02068. Epub 2021 May 7.

Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.

Objectives: To assess the correlation of cognitive function with sleep stability and depressive-anxious symptoms in insomnia patients.

Methods: Twenty-two insomnia patients with cognitive impairment (insomnia-CI), 21 insomnia patients with normal cognition (insomnia-CN), and 15 matched healthy control subjects (HCs) were enrolled and completed neuropsychological tests, the Hamilton Depression and Anxiety Scales (HAMD and HAMA), the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index (PSQI),the Insomnia Severity Index (ISI), and the cardiopulmonary coupling (CPC) examination. Ratios of high-frequency coupling (HFC), low-frequency coupling (LFC), and very low-frequency coupling (VLFC) measured by CPC analysis represent stable sleep, unstable sleep, and wake/rapid eye movement (REM) sleep, respectively. Read More

View Article and Full-Text PDF

Benefits of Early Ambulation in Elderly Patients Undergoing Lumbar Decompression and Fusion Surgery: A Prospective Cohort Study.

Orthop Surg 2021 May 7. Epub 2021 May 7.

Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing, China.

Objective: To evaluate the effects of early ambulation on elderly patients' postoperative physical functional outcomes, complications, 90-day readmission rate, and the length of postoperative hospital stay.

Methods: This is a prospective cohort study conducted between June 2019 and December 2019. The study enrolled 86 elderly patients (39 males) with newly diagnosed lumbar degenerative disease undergoing single-segment decompression and fusion surgerywere enrolled. Read More

View Article and Full-Text PDF

Capillary blood sampling increases the risk of preanalytical errors in pediatric hospital care: Observational clinical study.

J Spec Pediatr Nurs 2021 May 7:e12337. Epub 2021 May 7.

Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.

Purpose: The blood sampling procedure is complex and prone to failure, as reflected by preanalytical errors in pediatric hospital care. The primary aim was to evaluate if the risk of preanalytical errors was higher with capillary blood sampling than with venous blood sampling, and secondary, explore specific factors associated with preanalytical errors, both overall and stratified by capillary and venous blood sampling.

Design And Methods: This observational pediatric hospital study collected outcomes from medical records and blood sampling surveys from year 2014 to 2016. Read More

View Article and Full-Text PDF

Dentist-administered cognitive behavioural therapy versus four habits/midazolam: An RCT study of dental anxiety treatment in primary dental care.

Eur J Oral Sci 2021 May 7:e12794. Epub 2021 May 7.

Faculty of Dentistry, University of Oslo, Oslo, Norway.

The study aimed to test the effectiveness of cognitive behavioural therapy (CBT) administered by a general dental practitioner (GDP) in a general dental practice. In a two-arm parallel randomised controlled trial, the experimental group received a short dentist-administered CBT-intervention (D-CBT). A best-practice control group (FHM) received dental treatment during sedation with midazolam combined with an evidence-based communication model (The Four Habits Model). Read More

View Article and Full-Text PDF

Role of central kisspeptin and RFRP-3 in energy metabolism in the male Wistar rat.

J Neuroendocrinol 2021 May 7:e12973. Epub 2021 May 7.

Netherlands Institute for Neuroscience (NIN), Amsterdam, The Netherlands.

Kisspeptin (Kp) and (Arg)(Phe) related peptide 3 (RFRP-3) are two RF-amides acting in the hypothalamus to control reproduction. In the past 10 years, it has become clear that, apart from their role in reproductive physiology, both neuropeptides are also involved in the control of food intake, as well as glucose and energy metabolism. To investigate further the neural mechanisms responsible for these metabolic actions, we assessed the effect of acute i. Read More

View Article and Full-Text PDF