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Evaluation of the Association of Polymorphisms With Palbociclib-Induced Neutropenia: Pharmacogenetic Analysis of PALOMA-2/-3.

Oncologist 2021 May 5. Epub 2021 May 5.

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: The most frequently reported treatment-related adverse event in clinical trials with the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor palbociclib is neutropenia. Allelic variants in ABCB1 and ERCC1 might be associated with early occurrence (ie, end of Week 2 treatment) of grade 3/4 neutropenia. Pharmacogenetic analyses were performed to uncover associations between single nucleotide polymorphisms (SNPs) in these genes, patient baseline characteristics, and early occurrence of grade 3/4 neutropenia. Read More

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Sleep disorders during pregnancy and post-partum depression: A systematic review and meta-analysis.

Int J Dev Neurosci 2021 May 3. Epub 2021 May 3.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Postpartum depression (PPD) is one of the most important mental disorders in recent years. However, the effects of prenatal sleep disorders on the development of postpartum depression among pregnant women have not been elucidated. . Read More

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Role of dyslipidemia in ischemic stroke patients treated in the telestroke network.

Adv Med Sci 2021 Apr 30;66(2):254-261. Epub 2021 Apr 30.

University of South Carolina, School of Medicine-Greenville, 607 Grove Rd, Greenville, SC, USA. Electronic address:

Purpose: The relationship between the telestroke technology and clinical risk factors in a dysplipidemic ischemic stroke population and neurologic outcomes is not fully understood. This issue was investigated in this study.

Patients And Methods: We analyzed retrospective data collected from a regional stroke registry to identify demographic and clinical risk factors in patients with improving (NIHSS ​≤ ​7) or worsening (NIHSS ​> ​7) neurologic outcome in dyslipidemic ischemic stroke population. Read More

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Factors Associated with Loss to Follow-up among Patients Receiving HIV Treatment in Nairobi, Kenya.

AIDS Res Hum Retroviruses 2021 Apr 29. Epub 2021 Apr 29.

Center for International Health, Education, and Biosecurity Kenya, Nairobi, Kenya.

Objective: We investigated factors associated with loss to follow-up in 24 urban health facilities in Nairobi, Kenya.

Materials And Methods: We conducted a retrospective analysis of routinely collected data to assess factors associated with lost to follow-up (LTFU) in the period October 1, 2016 to June 30, 2017. LTFU was defined as no antiretroviral therapy (ART) refill for ≥90 days and no documentation of transfer, death, or treatment cessation in the patient chart, and if no lapse of ≥90 days between ART refills, patients were considered retained in care. Read More

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The characteristics and optimal treatment of urolithiasis associated with tuberous sclerosis complex.

Int Urol Nephrol 2021 Apr 25. Epub 2021 Apr 25.

Department of Urology, JR Tokyo General Hospital, Tokyo, Japan.

Purpose: The most common renal symptoms of tuberous sclerosis complex (TSC) are angiomyolipomas (AMLs) and renal cysts; however, some patients with TSC also develop urolithiasis. We retrospectively investigated the characteristics and treatment of urolithiasis associated with TSC.

Methods: We analyzed 142 patients who met the diagnostic criteria for TSC, of whom 20 (14. Read More

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Assessment of the Safety and Therapeutic Benefits of Convalescent Plasma in COVID-19 Treatment: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2021 6;8:660688. Epub 2021 Apr 6.

Department of Life Sciences, Applied Molecular Biosciences Unit, Faculdade de Ciências e Tecnologia da Universidade Nova De Lisboa, Caparica, Portugal.

The coronavirus disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), prompted a global health crisis, with no available specific treatments. Convalescent plasma (CP) with neutralizing antibodies could be a promising therapeutic approach to reduce mortality. To evaluate the therapeutic potential of CP for COVID-19 and to assess its safety and efficacy in reducing the patients' mortality. Read More

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Severe acute graft-versus-host disease increases the incidence of blood stream infection and mortality after allogeneic hematopoietic cell transplantation: Japanese transplant registry study.

Bone Marrow Transplant 2021 Apr 19. Epub 2021 Apr 19.

Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan.

This study aimed to clarify the risk factors and prognosis associated with blood stream infection (BSI) in allogeneic hematopoietic cell transplantation (allo-HCT), and the relationship between BSI and acute graft-versus-host disease (aGVHD). This retrospective analysis included 11,098 patients in the Japanese national transplant registry. A total of 2172 patients developed BSI after allo-HCT, with 2332 identified pathogens. Read More

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Association of Trimethylamine N-Oxide and Its Precursor With Cerebral Small Vessel Imaging Markers.

Front Neurol 2021 1;12:648702. Epub 2021 Apr 1.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds. We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. Read More

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Associations of D-dimer with CT Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study.

Ann Am Thorac Soc 2021 Apr 16. Epub 2021 Apr 16.

Weill Cornell Medical College, 12295, Department of Medicine, New York, New York, United States.

Rationale: The coagulation cascade may play a role in the pathogenesis of interstitial lung disease through increased production of thrombin and fibrin deposition. Whether circulating coagulation cascade factors are linked to lung inflammation and scarring among community-dwelling adults is unknown.

Objective: To test the hypothesis that higher baseline D-dimer levels are associated with markers of early lung injury and scarring. Read More

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Paris II and Rotterdam criteria are the best predictors of outcomes in patients with primary biliary cholangitis in Japan.

Hepatol Int 2021 Apr 16. Epub 2021 Apr 16.

Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

Background: Biochemical response to treatment in patients with primary biliary cholangitis (PBC) reflects prognosis. However, the best predictive criteria to detect biochemical response remain undetermined. In addition, because these criteria need > 6 months until definition, parameters that can estimate its results before initiating treatment are needed. Read More

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Development and validation of a cellular host response test as an early diagnostic for sepsis.

PLoS One 2021 15;16(4):e0246980. Epub 2021 Apr 15.

Louisiana State University Health Sciences Center, Baton Rouge, Louisiana, United States of America.

Sepsis must be diagnosed quickly to avoid morbidity and mortality. However, the clinical manifestations of sepsis are highly variable and emergency department (ED) clinicians often must make rapid, impactful decisions before laboratory results are known. We previously developed a technique that allows the measurement of the biophysical properties of white blood cells as they are stretched through a microfluidic channel. Read More

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Economic evaluation of remdesivir for the treatment of severe COVID-19 patients in China under different scenarios.

Br J Clin Pharmacol 2021 Apr 14. Epub 2021 Apr 14.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Aims: The present study aimed to evaluate the cost-effectiveness of the 5-day remdesivir regimen compared with standard of care among severe COVID-19 patients in China, the evidence on which is essential to inform the necessity of securing access to remdesivir.

Methods: A dynamic transmission model that extended the susceptible-exposed-infected-recovered framework by incorporating asymptomatic, presymptomatic and waiting-to-be-diagnosed patients was constructed to conduct the cost-effectiveness analysis from the healthcare system perspective. To estimate epidemic parameters, the model was first calibrated to the observed epidemic curve in Wuhan from 23 January to 19 March 2020. Read More

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Performance assessment of intravenous catheters for massive transfusion: A pragmatic in vitro study.

Transfusion 2021 Apr 13. Epub 2021 Apr 13.

Veterens Affairs Portland Health Care System, Portland, Oregon, USA.

Background: Rapid infusion of warmed blood products is the cornerstone of trauma resuscitation and treatment of surgical and obstetric massive hemorrhage. Integral to optimizing this delivery is selection of an intravenous (IV) catheter and use of a rapid infusion device (RID). We investigated which IV catheter and RID system enabled the greatest infusion rate of blood products and the governing catheter characteristics. Read More

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Treatment Satisfaction of Galcanezumab in Japanese Patients with Episodic Migraine: A Phase 2 Randomized Controlled Study.

Neurol Ther 2021 Apr 9. Epub 2021 Apr 9.

Eli Lilly Japan K.K., Kobe, Japan.

Introduction: This analysis evaluated the treatment satisfaction of Japanese patients receiving galcanezumab (GMB) as a preventive medication for episodic migraine (4-14 monthly migraine headache days).

Methods: This phase 2, randomized, double-blind, placebo-controlled study enrolled patients aged 18-65 years at 40 centers in Japan. Patients were randomized 2:1:1 to receive monthly subcutaneous injections of placebo (PBO, n = 230), GMB 120 mg (n = 115), or GMB 240 mg (n = 114) for 6 months. Read More

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[A 180-day mortality predictive score based on frailty syndrome in elderly patients with sepsis: a Logistic regression analysis model].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):257-262

Department of Medical Intensive Care Unit, General Hospital of Southern Theatre Command; Guangzhou Key Laboratory of Geriatric Infection and Organ Function Support, Branch of National Clinical Research Center for Geriatric Diseases (Chinese PLA General Hospital), Guangzhou 510010, Guangdong, China.

Objective: To establish a 180-day mortality predictive score based on frailty syndrome in elderly sepsis patients [elderly sepsis score (ESS)].

Methods: A prospective study for sepsis patients aged 60 years and above who were admitted to a medical intensive care unit of the General Hospital of Southern Theatre Command from January 1st, 2018 to December 31st, 2018 was conducted. Univariate analysis was performed on 19 independent variables including gender, age, body mass index (BMI), tumor, charlson comorbidity index (CCI), activity of daily living (ADL), instrumental activity of daily living (IADL), mini-mental state examination (MMSE), geriatric depression scale (GDS), clinical frail scale (CFS), sequential organ failure assessment (SOFA), Glasgow coma scale (GCS), acute physiology and chronic health evaluation (APACHE II, APACHE IV), modified NUTRIC score (MNS), multiple drug resistance (MDR), mechanical ventilation (MV), continuous renal replacement therapy (CRRT) and palliative care. Read More

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Rabies vaccination and multiple sclerosis relapse: A retrospective cohort study.

Mult Scler Relat Disord 2021 Mar 18;51:102906. Epub 2021 Mar 18.

Department of Neurosciences, Division of Neurology, Unit of Neuroimmunology and Neuromuscular Diseases, Geneva University Hospitals, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Division of Laboratory Medicine, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. Electronic address:

Background: No studies assessing rabies vaccine (RV) tolerability in persons with multiple sclerosis (MS) have been conducted. Given the lack of safety data, RV is recommended essentially only for post-exposure prophylaxis, which is difficult to administer effectively in many rabies-endemic countries. We sought to determine whether RV administration as pre-exposure prophylaxis was associated with MS relapse. Read More

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Effects of Different Exposure Days to Gonadotropin-Releasing Hormone Agonist (GnRH-a) on Live Birth Rates in the Depot GnRH-a Protocol: A Retrospective Analysis of 7007 Cycles.

Med Sci Monit 2021 Apr 5;27:e929854. Epub 2021 Apr 5.

Reproductive Medicine Center, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland).

BACKGROUND In controlled ovarian hyperstimulation protocols worldwide, depot gonadotropin-releasing hormone agonist (GnRH-a) pretreatment is generally used for pituitary desensitization. The delay between the GnRH-a administration and starting gonadotropin treatment varies greatly, from 25 to 60 days. However, the association between exposure days to GnRH-a before the onset of gonadotropin administration and the clinical outcomes remains unknown. Read More

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Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data.

EBioMedicine 2021 Apr 1;66:103318. Epub 2021 Apr 1.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background: Biomarker-disease relationships are extensively investigated. However, associations between common clinical biomarkers and healthspan, the disease-free lifespan, are largely unknown. We aimed to explore the predictive values of ten biomarkers on healthspan and lifespan, and to identify putative causal mechanisms. Read More

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Amelioration of Tumor Targeting and In Vivo Biodistribution of Tc-Methotrexate-Gold Nanoparticles (Tc-Mex-AuNPs).

J Pharm Sci 2021 Apr 2. Epub 2021 Apr 2.

Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority, Cairo 13759, Egypt; Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt. Electronic address:

Gold nanoparticles (AuNPs) represent very attractive and promising drug delivery carriers due to their unique dimensions, adjustable surface functions, and controllable drug release. Therefore, AuNPs are used to overcome the limitations of conventional chemotherapy, for example methotrexate (Mex), one of the first-generation chemotherapy drugs for cancer treatment, whose usefulness has been restricted due to drug resistance and dose-dependent side effects. In the present study, the AuNPs drug delivery system was synthesized and loaded with technetium-99 m radiolabeled Methotrexate (Tc-Mex) to produce new potential nanoradiopharmaceutical for tumor targeting and further imaging. Read More

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Use of gastric acid-suppressive agents increases the risk of dementia in patients with upper gastrointestinal disease: A population-based retrospective cohort study.

PLoS One 2021 25;16(3):e0249050. Epub 2021 Mar 25.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.

Background: Prescriptions for gastric acid-suppressive agents, including proton-pump inhibitors (PPIs) and histamine type-2 receptor antagonists (H2RAs), are rising. However, little data exist regarding their association with dementia in the Asian population. The objective of this study was thus to investigate the impact of the use of PPIs and H2RAs on the risk of dementia in an Asian population with upper gastrointestinal disease (UGID). Read More

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Mortality and morbidity of curative and palliative anticancer treatments during the COVID-19 pandemic: A multicenter population-based retrospective study.

Mol Clin Oncol 2021 Apr 26;14(4):82. Epub 2021 Feb 26.

Community Medicine Department, Umm Al-Qura University, Makkah 21421, Saudi Arabia.

Administration of effective anticancer treatments should continue during pandemics. However, the outcomes of curative and palliative anticancer treatments during the coronavirus disease (COVID-19) pandemic remain unclear. The present retrospective observational study aimed to determine the 30-day mortality and morbidity of curative and palliative anticancer treatments during the COVID-19 pandemic. Read More

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Relationships between circulating galectin-3, extracellular matrix fibrosis and outcomes in dilated cardiomyopathy.

Adv Clin Exp Med 2021 Mar;30(3):245-253

Department of Cardiac and Vascular Disease, John Paul II Hospital, Jagiellonian University Medical College, Kraków, Poland.

Background: Galectin-3 is an emerging biomarker in cardiovascular disease. Myocardial galectin-3 is involved in the pathology of cardiac fibrosis; however, the role of circulating galectin-3 is not yet established.

Objectives: To assess the relationships between circulating galectin-3, fibrosis and outcomes in dilated cardiomyopathy (DCM). Read More

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Interplay of Mineralocorticoid Receptor Antagonists and Empagliflozin in Heart Failure: EMPEROR-Reduced.

J Am Coll Cardiol 2021 Mar;77(11):1397-1407

Baylor University Medical Center, Dallas, Texas, USA; Imperial College, London, United Kingdom.

Background: Mineralocorticoid receptor antagonists (MRAs) and sodium glucose co-transporter 2 inhibitors favorably influence the clinical course of patients with heart failure and reduced ejection fraction.

Objectives: This study sought to study the mutual influence of empagliflozin and MRAs in EMPEROR-Reduced (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Reduced Ejection Fraction).

Methods: Secondary analysis that compared the effects of empagliflozin versus placebo in 3,730 patients with heart failure and a reduced ejection fraction, of whom 71% used MRAs at randomization. Read More

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[Risk factors for citrate accumulation in patients with liver failure undergoing continuous renal replacement therapy with regional citrate anticoagulation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Feb;33(2):211-215

Department of Critical Care Medicine, Nantong Third People's Hospital, Nantong 226000, Jiangsu, China. Corresponding author: Zhang Suyan, Email:

Objective: To investigate the risk factors of citrate accumulation in patients with liver failure treated with regional citrate anticoagulated continuous renal replacement therapy (RCA-CRRT).

Methods: The clinical data of liver failure patients with RCA-CRRT admitted to department of intensive care unit (ICU) of Nantong Third People's Hospital from January 2017 to June 2020 were retrospectively analyzed. The selected patients were divided into citrate accumulation group and control group according to whether there was citrate accumulation (serum total calcium/free calcium ratio ≥ 2. Read More

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February 2021

A comparative cost analysis between two quick diagnosis units of different levels of complexity.

J Comp Eff Res 2021 Apr 12;10(5):381-392. Epub 2021 Mar 12.

Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Hospital Clínic, Barcelona 08036, Spain.

To compare by micro-costing the costs incurred by quick diagnosis units of tertiary and second-level hospitals. We included 407 patients from a tertiary and secondary hospital unit. A bottom-up approach was applied. Read More

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Acupuncture Treatment of Delirium in Older Adults Hospitalized in Internal Medicine Departments: An Open-Label Pragmatic Randomized-Controlled Trial.

J Geriatr Psychiatry Neurol 2021 Mar 9:891988721996804. Epub 2021 Mar 9.

Internal Medicine B Department, 37772Bnai Zion Medical Center, Haifa, Israel.

Background: Acupuncture seems to improve cognitive function in experimental models and to reduce agitation in dementia. The addition of acupuncture to standard-of-care (SOC) may improve clinical outcomes related to delirium in hospitalized older adults.

Methods: This pragmatic open-label randomized-controlled trial evaluated 81 older adults hospitalized in an internal medicine ward and diagnosed with delirium. Read More

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Protective effect of fermented Diospyros lotus L. extracts against the high glucose-induced apoptosis of MIN6 cells.

J Food Biochem 2021 Apr 7;45(4):e13685. Epub 2021 Mar 7.

Beijing Key Laboratory of Forest Food Process and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, People's Republic of China.

Date plum persimmon (Diospyros lotus L.) is a fruit crop from the Ebenaceae family. Its microorganism-fermented extract (DPEML) was shown to exhibit a hypoglycemic effect in our previous work. Read More

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Establishing a proof of concept for the effects of low-carbohydrate, high-fat diet (LCHFD) and physical activity on body composition in type 2 diabetes.

Heliyon 2021 Feb 16;7(2):e06266. Epub 2021 Feb 16.

Department of Human Movement Science, University of Zululand, KwaDlangezwa, 3886, South Africa.

Overweight and obesity are both a risk factor for developing and exacerbating type 2 diabetes (T2D). While the most common diet used to treat overweight and obesity focus on high-carbohydrate, low-fat, energy deficit diets, recently, low-carbohydrate, high-fat diets (LCHFD) have become popular in targeting obesity. This proof-of-concept study attempted to determine if an LCHFD could improve body composition variables, or if a concurrent treatment of LCHFD and physical activity would create an interference effect in individuals with T2D. Read More

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February 2021

Subthreshold Nanosecond Laser in Age-Related Macular Degeneration: Observational Extension Study of the LEAD Clinical Trial.

Ophthalmol Retina 2021 Mar 1. Epub 2021 Mar 1.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.

Purpose: To evaluate the long-term effect of subthreshold nanosecond laser (SNL) treatment on progression to late age-related macular degeneration (AMD).

Design: Observational extension study of a randomized, sham-controlled trial.

Participants: Two hundred twelve participants with bilateral large drusen. Read More

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Opportunities for Prevention of Gestational Diabetes Before 24 Weeks of Gestation.

Diabetes Metab Syndr Obes 2021 24;14:813-819. Epub 2021 Feb 24.

Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai, 201600, People's Republic of China.

Background: Gestational diabetes (GDM), increasingly prevalent worldwide, is related to growing pregnancy complications and long-term metabolic risks for the woman and the descendants. The aim of this study is to determine the optimal BMI ranges specific for age group and optimal gestational weight gain (GWG) at 24 weeks specific for different pre-BMI (pre-pregnancy body mass index) groups to avoid or reduce the incidence of GDM.

Methods: A retrospective cohort study of 3104 pregnant women was conducted in Song Jiang district, Shanghai, China. Read More

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February 2021