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Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy.

Can J Gastroenterol Hepatol 2021 14;2021:8875564. Epub 2021 Apr 14.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Introduction: Ischemic enteritis (IE) is a relatively rare small bowel disease that is diagnosed via double-balloon endoscopy (DBE), although the lack of established diagnostic criteria can make it difficult to confirm the diagnosis. This study aimed to describe the clinical characteristics, endoscopic imaging features, and treatments for IE at our center. . Read More

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Proliferative Glomerulonephritis: Risk Factor for Hypertension in Lupus.

Int J Hypertens 2021 15;2021:6691821. Epub 2021 Apr 15.

Department of Nephrology, Dalal Jamm University Hospital, Dakar, Senegal.

Studies report a high prevalence of hypertension in lupus, reaching up to 74%. The incidence of hypertension in SLE patients is increased with the severity of the kidney damage. This work was carried out with the objective of determining the prevalence of hypertension in lupus nephritis and to seek the existence of an association between the presence of a proliferative glomerulonephritis and hypertension. Read More

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HIV-1 Infection Alters the Viral Composition of Plasma in Men Who Have Sex with Men.

mSphere 2021 May 5;6(3). Epub 2021 May 5.

Shanghai Clinical Research Center for Infectious Disease (HIV/AIDS), Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

Altered gut virome and expanded abundance of certain viruses were found in HIV-1-infected individuals. It remains largely unknown how plasma virus composition changes during HIV-1 infection and antiretroviral therapy (ART). We performed viral metagenomic analysis on viral particles enriched from human plasma from 101 men who have sex with men (MSM) with or without HIV-1 infection and whether or not on ART and compared the differences in the plasma virome. Read More

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Victimisation of individuals with serious mental illness living in sheltered housing: differential impact of risk factors related to clinical and demographic characteristics.

BJPsych Open 2021 May 6;7(3):e97. Epub 2021 May 6.

Department of Psychiatry, Erasmus University Medical Center, The Netherlands.

Background: Sheltered housing is associated with quality-of-life improvements for individuals with serious mental illness (SMI). However, there are equivocal findings around safety outcomes related to this type of living condition.

Aims: We aimed to investigate raw differences in prevalence and incidence of crime victimisation in sheltered housing compared with living alone or with family; and to identify groups at high risk for victimisation, using demographic and clinical factors. Read More

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A systematic review of the incidence, risk factors and prognosis of acute exacerbation of systemic autoimmune disease-associated interstitial lung disease.

BMC Pulm Med 2021 May 5;21(1):150. Epub 2021 May 5.

Department of Intensive Care Medicine, Northern Hospital, Melbourne, Australia.

Introduction: Acute exacerbation (AE) is a devastating phenomenon and reported to be complicated with systemic autoimmune disease-associated interstitial lung disease (ILD). The aim of this study was to investigate the incidence and prognosis of AE of systemic autoimmune disease-ILD and clarify relevant clinical information predictive of these outcomes.

Method: This study was designed as a systematic review and meta-analysis. Read More

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Sarcopenia as a predictor of initial administration dose of afatinib in patients with advanced non-small cell lung cancer.

Thorac Cancer 2021 May 5. Epub 2021 May 5.

Department of Medical Oncology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Background: Sarcopenia has recently emerged as a new condition with increasing importance in lung cancer patients. The aim of this study was to investigate the influence of sarcopenia on tolerance and efficacy of afatinib.

Methods: We retrospectively evaluated 35 patients with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC) treated with first-line afatinib. Read More

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Risk factors for critical illness and death among adult Brazilians with COVID-19.

Rev Soc Bras Med Trop 2021 28;54:e0014 2021. Epub 2021 Apr 28.

Universidade Federal de Lavras, Departamento de Nutrição, Programa de Pós-Graduação em Nutrição e Saúde, Lavras, MG, Brasil.

Introduction: Severe acute respiratory syndrome coronavirus 2 has infected more than 9,834,513 Brazilians up to February 2021. Knowledge of risk factors of coronavirus disease among Brazilians remains scarce, especially in the adult population. This study verified the risk factors for intensive care unit admission and mortality for coronavirus disease among 20-59-year-old Brazilians. Read More

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Correlation between Sarcopenia and Arteriosclerosis in Elderly Community Dwellers: A Multicenter Study.

J Nutr Health Aging 2021 ;25(5):692-697

Hui Xie; School of Nursing, Bengbu Medical College, 2600# Donghai Road, Bengbu, Anhui, 233030, China, e-mail:

Background: Evidence suggests that arteriosclerosis and sarcopenia (decreased muscle mass) share some of their many causes. However, after controlling for confounding factors, it is unclear whether the presence of arteriosclerosis correlates with sarcopenia.

Objectives: The aim of this paper is to explore whether sarcopenia is associated with arteriosclerosis. Read More

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January 2021

Predictors of reoperation for perianal fistula in Crohn's disease.

J Dig Dis 2021 May 4. Epub 2021 May 4.

Department of Gastroenterology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Aims: Treatment of perianal fistula in cases of Crohn's disease remains challenging and the postoperative recurrence rate is reportedly 22-28%. This study aimed to identify factors that predict the reoperation for perianal fistula in Korean patients with Crohn's disease.

Methods: A total of 51 patients (42 men, mean age: 22±9 years) with clinically and pathologically confirmed Crohn's disease underwent surgical treatment for perianal fistula at four referral centers between March 2010 and February 2020. Read More

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Depression, Chronic obstructive pulmonary disease, and Healthcare Utilization: Results from the Korean Longitudinal Study of Aging (KLoSA).

Clin Respir J 2021 May 5. Epub 2021 May 5.

Department of Neurology, International St. Mary`s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.

Background: Depression is a common comorbidity among people with chronic obstructive pulmonary disease (COPD), but the health effects of depression in this group of patients remains poorly understood. The purpose of the present study was to investigate the association between COPD and depression, and the effects of comorbid COPD and depression on health care utilization.

Methods: Our study sample included 10,180 Korean adults (4,437 men and 5,743 women; all aged ≥ 45 years) who participated in the cross-sectional Korean Longitudinal Study of Aging (KLoSA). Read More

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The association between use of chemsex drugs and HIV clinic attendance among gay and bisexual men living with HIV in London.

HIV Med 2021 May 5. Epub 2021 May 5.

Institute for Global Health, University College London, London, UK.

Objectives: To investigate the association between chemsex drug use and HIV clinic attendance among gay and bisexual men in London.

Methods: A cross-sectional survey of adults (> 18 years) diagnosed with HIV for > 4 months, attending seven London HIV clinics (May 2014 to August 2015). Participants self-completed an anonymous questionnaire linked to clinical data. Read More

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Comparisons of Serologic Responses of Early Syphilis to Treatment with a Single-Dose Benzathine Penicillin G Between HIV-Positive and HIV-Negative Patients.

Infect Dis Ther 2021 May 4. Epub 2021 May 4.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan.

Introduction: Poorer serologic responses of early syphilis to treatment have been inconsistently reported in HIV-positive patients compared with HIV-negative patients, but the interpretation of previous studies is limited by discrepant study designs. The present study aimed to evaluate the effect of HIV infection on the treatment response to a single dose of benzathine penicillin G (BPG) for early syphilis.

Methods: From January 2015 to March 2020, adult patients with early syphilis who received a single dose of BPG were enrolled and rapid plasma reagin (RPR) titers were periodically determined. Read More

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Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden.

BMJ 2021 05 4;373:n877. Epub 2021 May 4.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 171 77 Stockholm, Sweden

Objective: To assess the risk of colorectal cancer (CRC) in first degree relatives (parents and full siblings) of patients with precursor lesions (polyps) for CRC.

Design: Case-control study.

Setting: Linkage to the multi-generation register and gastrointestinal ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) histopathology cohort in Sweden. Read More

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Knowledge, Attitudes and Practices Regarding Pre-Exposure Prophylaxis (PrEP) in a Sample of Italian Men Who Have SEX with MEN (MSM).

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Turin, Italy.

Background: Pre-exposure prophylaxis (PrEP) is suitable for high human immunodeficiency virus (HIV)-infection risk people, foremost among whom are males who have sex with other males (MSM). This study evaluated knowledge, attitudes and practices regarding PrEP in a sample of Italian MSM, in order to hypothesize strategies to implement PrEP awareness and use. No previous study has assessed this issue; Methods: An online survey was given to an opportunistic sample of Italian MSM. Read More

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Autism spectrum disorder and new perspectives on the reliability of second to fourth digit ratio.

Dev Psychobiol 2021 May 4. Epub 2021 May 4.

Institute of Physiology, Academic Research Center for Autism, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

The second to fourth digit ratio (2D:4D) is according to previous studies a likely biomarker for prenatal testosterone exposure and its effect on the human brain. It was found to be linked to autism spectrum disorders (ASD). Recently, 2D:4D raised a lot of questions with regard to its stability and autism-related behaviors. Read More

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Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study.

Med Gas Res 2021 Jul-Sep;11(3):104-109

Faculty of Environment and Information Studies, Keio University, Fujisawa, Japan.

Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, reducing bone marrow damage is limited. Thus, a novel technology is needed to further mitigate IMRT-induced bone marrow damage. Molecular hydrogen (H) was recently reported as a preventive and therapeutic antioxidant that selectively scavenges hydroxyl radical (·OH) and peroxynitrite (ONOO). Read More

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SARS-CoV-2 outbreak in immune-mediated inflammatory diseases: the Euro-COVIMID multicentre cross-sectional study.

Lancet Rheumatol 2021 Apr 28. Epub 2021 Apr 28.

Sorbonne Université, Pierre Louis Institute of Epidemiology and Public Health, Inserm UMR 1136, Paris, France.

Background: The COVID-19 pandemic has raised numerous questions among patients with immune-mediated inflammatory diseases regarding potential reciprocal effects of COVID-19 and their underlying disease, and potential effects of immunomodulatory therapy on outcomes related to COVID-19. The seroprevalence of SARS-CoV-2 and factors associated with symptomatic COVID-19 in patients with immune-mediated inflammatory diseases are still unclear. The Euro-COVIMID study aimed to determine the serological and clinical prevalence of COVID-19 among patients with immune-mediated inflammatory diseases, as well as factors associated with COVID-19 occurrence and the impact of the pandemic in its management. Read More

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Anatomic study of carpal tunnel in adults using monoenergetic reconstruction of dual-energy computed tomography.

J Pak Med Assoc 2021 Feb;71(2(B)):663-671

Department of Radiology, Shengjing Hospital of China Medical University, Heping, Shenyang, China.

Objective: To seek optimal keV settings for imaging carpal tunnel in adults by dual-energy computed tomography (DECT) monoenergetic technique; to describe anatomic characteristics of carpal tunnel and to observe correlation between carpal bony and soft tissue structures.

Methods: DECT images of 20 wrists (11 left and 9 right wrists; 14 men, mean age 26.93±1. Read More

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February 2021

Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis.

Sci Rep 2021 May 3;11(1):9424. Epub 2021 May 3.

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Systemic sclerosis (SSc) is recognized as a chronic inflammatory disease and several SSc-associated factors may increase the risk of osteoporosis and its related fractures. To determine the prevalence and predictive factors of osteoporosis in Thai SSc, a cross-sectional study was designed in adult SSc patients at Scleroderma clinic, Khon Kaen University Hospital. The prevalence of osteoporosis with the 95% confidence interval (CI) were determined and the odds ratio (OR) with 95%CI were assessed the clinical association with osteoporosis. Read More

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Coronal Plane Gap Increases Postoperative Pseudoarthrosis after Lateral Interbody Fusion for Adult Spinal Deformity.

Asian Spine J 2021 May 6. Epub 2021 May 6.

Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Japan.

Study Design: This is a retrospective study.

Purpose: This study aims to evaluate the risk factor associated with pseudoarthrosis after placement of lateral interbody fusion (LIF) cages for adult spinal deformity (ASD) treatment.

Overview Of Literature: LIF technique is widely used for ASD correction. Read More

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Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens.

Am J Clin Pathol 2021 May 3. Epub 2021 May 3.

Department of Urology, University of Illinois at Chicago, Chicago, IL, USA.

Objectives: To the best of our knowledge, no study has analyzed the association between cigarette smoking and prostate basal cell proliferation. Therefore, we sought to evaluate whether smoking status is associated with the presence of basal cell hyperplasia (BCH).

Methods: We performed a retrospective analysis of 8,196 men aged 50 to 75 years with prostate-specific antigen values between 2. Read More

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Tranexamic acid and bleeding in patients treated with non-vitamin K oral anticoagulants undergoing dental extraction: The EXTRACT-NOAC randomized clinical trial.

PLoS Med 2021 May 3;18(5):e1003601. Epub 2021 May 3.

Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium.

Background: Oral bleeding after dental extraction in patients on non-vitamin K oral anticoagulants (NOACs) is a frequent problem. We investigated whether 10% tranexamic acid (TXA) mouthwash decreases post-extraction bleeding in patients treated with NOACs.

Methods And Findings: The EXTRACT-NOAC study is a randomized, double-blind, placebo-controlled, multicenter, clinical trial. Read More

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A Low Total Psoas Muscle Area Index Is a Strong Prognostic Factor in Metastatic Pancreatic Cancer.

Pancreas 2021 Apr;50(4):579-586

Department of Radiology, University Hospital of Saint-Etienne, Saint-Priest-en-Jarez.

Objectives: The total psoas area index (TPI) is an emerging alternative to the total skeletal muscle area index as a prognostic factor but has never been evaluated in metastatic pancreatic cancer (mPC).

Methods: Areas were manually recorded, as previously described. Sex-specific cutoffs were identified by optimum stratification of TPI using log-rank χ2 statistic associated with mortality to define sarcopenic psoas. Read More

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Prognostic impact of muscle and fat mass in patients with heart failure.

J Cachexia Sarcopenia Muscle 2021 May 3. Epub 2021 May 3.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Background: Cachexia, characterized by loss of muscle with or without loss of fat mass, is a poor prognostic factor in patients with heart failure (HF). However, there is limited investigation on the prognostic impact of muscle and fat mass separately in HF. We hypothesized that muscle and fat mass have different effects on the prognosis of HF. Read More

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Time-varying effect of sex on prognosis of lung adenocarcinoma surgical patients in China.

Thorac Cancer 2021 May 3. Epub 2021 May 3.

Department of Cancer Prevention, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Little is known about the prognostic advantage of sex for pulmonary adenocarcinoma among Chinese patients. In this study, we aimed to investigate the true sex differences in prognosis by adjusting for confounders and to explore whether the differences were time-varying.

Methods: We identified 4438 lung adenocarcinoma patients who underwent surgery at a regional Cancer Center of China from 2008 to 2016, retrospectively. Read More

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Visceral adiposity, muscle composition, and exercise tolerance in heart failure with preserved ejection fraction.

ESC Heart Fail 2021 May 3. Epub 2021 May 3.

School of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.

Aims: Visceral adipose tissue (AT) promotes inflammation and may be associated with disease progression in heart failure with preserved ejection fraction (HFpEF). We characterized regional AT distribution in HFpEF patients and controls and analysed associations with co-morbidities and exercise tolerance.

Methods And Results: Magnetic resonance imaging was performed to quantify epicardial, liver, abdominal, and thigh skeletal muscle AT. Read More

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Risk Factors for Late Rebleeding of Colonic Diverticular Bleeding in Elderly Individuals.

J Anus Rectum Colon 2021 28;5(2):148-157. Epub 2021 Apr 28.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University School of Medicine, Kanagawa, Japan.

Objectives: This study aimed to examine the clinical characteristics of colonic diverticular bleeding (CDB) in elderly individuals.

Methods: This retrospective case-control study was conducted at a single tertiary center. A total of 519 patients (356 men and 163 women; mean age of 73. Read More

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Test-Retest Reliability of the Assessment of Fatty Liver Disease Using Low-Dose Computed Tomography in Cardiac Patients.

Front Med (Lausanne) 2021 15;8:656658. Epub 2021 Apr 15.

Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.

Non-alcoholic fatty liver disease (NAFLD) is a common disorder that is associated with the risk of cardiovascular diseases. Therefore, its prevalence is high in patients with coronary artery disease. In myocardial perfusion imaging (MPI), low-dose computed tomography (CT) scans are used for attenuation correction in separate stress and rest studies. Read More

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Risk Factors for Revision After Early and Delayed Total Hip Arthroplasty Dislocation. An Analysis of Lithuanian Arthroplasty Register.

Cureus 2021 Mar 28;13(3):e14155. Epub 2021 Mar 28.

Centre of Orthopedics and Traumatology, Republican Vilnius University Hospital, Vilnius, LTU.

Introduction: Despite relatively low incidence, dislocation remains one of the main reasons for total hip arthroplasty (THA) revision. It is a devastating complication for a patient and a surgeon, and has high burden on the healthcare system. The aim of the present study was to assess and compare the risk factors for revision after early and delayed THA dislocations. Read More

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