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Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study.

Neurosurgery 2021 Jul 29. Epub 2021 Jul 29.

Seikei-kai Chiba Medical Center, Chiba, Japan.

Background: Microvascular decompression (MVD) is the most effective procedure for the long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, and there are currently no prospective, multicenter studies.

Objective: To evaluate the short- and long-term outcomes and complications in patients with TGN who underwent MVD at specialized Japanese institutions. Read More

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Factors That Drive Annual Variation in Pediatric Elbow Fracture Occurrence, Severity, and Resource Utilization.

J Pediatr Orthop 2021 Jul 29. Epub 2021 Jul 29.

Vanderbilt University School of Medicine Division of Pediatric Orthopaedics, Monroe Carell Jr. Children's Hospital at Vanderbilt Department of Orthopaedics, Vanderbilt University Medical Center Departments of Pharmacology Pediatrics Pathology, Microbiology, and Immunology Center for Bone Biology, Nashville, TN The Wharton School at the University of Pennsylvania, Philadelphia, PA.

Background: Elbow fractures are the most common pediatric fractures requiring operative treatment. To date, few studies have examined what annual factors drive pediatric elbow fracture incidence and no studies have examined which annual factors drive elbow fracture severity or resource utilization. The goal of this study was to not only document the annual patterns of pediatric elbow fracture incidence and severity but also the impact of these patterns on resource utilization in the emergency department, emergency medical service transportation, and the operating room (OR). Read More

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Association of Organizational Factors with the Proportion of Healthy Behaviors and Control of Blood Pressure at a Company Level.

J Occup Environ Med 2021 Jul 27. Epub 2021 Jul 27.

Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.

Objectives: The study examined a relationship between organizational factors and the health outcomes (health behaviors and blood pressure control) at a company level.

Methods: This cross-sectional study using data from listed corporations on a stock exchange with 1,000-30,000 employees that completed the health and productivity management survey of Japan in 2019.

Results: We analyzed 886 companies. Read More

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Pediatric Tuberculosis Disease during Years of High Refugee Arrivals: A 6-Year National Prospective Surveillance Study.

Respiration 2021 Jul 29:1-10. Epub 2021 Jul 29.

Department of Clinical Research, Mycobacterial and Migrant Health Research Group, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

Background: In Europe, surveillance and monitoring of pediatric tuberculosis (TB) remains important, particularly in the light of migration in recent years. The aim of the study was to evaluate incidence rates of childhood TB and detailed diagnostic pathways and treatment.

Methods: Data were collected through the Swiss Pediatric Surveillance Unit (SPSU) from December 2013 to November 2019. Read More

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Do Editorialists With Industry-Related Conflicts of Interest Write Unduly Favorable Editorials for Cancer Drugs in Top Journals?

J Natl Compr Canc Netw 2021 Jul 29. Epub 2021 Jul 29.

2Department of Oncology.

Background: Editorials accompanying the publication of trials in major oncology journals can have a substantial influence on clinical practice. We describe the prevalence of financial conflicts of interest (FCOIs) of authors writing such editorials and the extent to which FCOIs may shape the interpretation of clinical trials.

Methods: We examined editorials published in 2018 alongside trial reports in the top 5 journals that publish cancer drug trials (New England Journal of Medicine, Lancet, Lancet Oncology, JAMA Oncology, and Journal of Clinical Oncology). Read More

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COVID-19 vaccine hesitancy in adults with multiple sclerosis in the United States: A follow up survey during the initial vaccine rollout in 2021.

Mult Scler Relat Disord 2021 Jul 22;54:103163. Epub 2021 Jul 22.

Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States; Department of Neurology, University of Washington, Seattle, WA, United States.

Background: Multiple sclerosis (MS) organizations have recommended that adults with MS obtain the COVID-19 vaccination. Vaccine hesitancy is a barrier to full COVID-19 inoculation in the general population. Whether vaccine hesitancy is also a barrier towards optimizing vaccination rates in the MS community is unknown. Read More

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Simultaneous removal of phosphorous and nitrogen by ammonium assimilation and aerobic denitrification of novel phosphate-accumulating organism Pseudomonas chloritidismutans K14.

Bioresour Technol 2021 Jul 21;340:125621. Epub 2021 Jul 21.

Tianjin Key Laboratory of Aqua-Ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin 300384, China. Electronic address:

Pseudomonas chloritidismutans K14, a novel phosphate-accumulating organism with the capacity to perform ammonium assimilation, aerobic denitrification, and phosphorus removal, was isolated from aquaculture sediments. It produced no hemolysin, and showed susceptibility to most antibiotics. Optimum conditions were achieved with sodium pyruvate as a carbon source, a C/N ratio of 10, pH of 7. Read More

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Survey of the operational status of twenty-six urban stormwater biofilter facilities in Sweden.

J Environ Manage 2021 Jul 26;297:113375. Epub 2021 Jul 26.

Dept. of Civil, Environmental, and Natural Resources Engineering, Luleå Univ. of Technology, 97187, Luleå, Sweden. Electronic address:

This study evaluates the operational status of twenty-six biofilter facilities across nine cities in Sweden, with respect to their functional design criteria, engineered design features (filter media composition, hydraulic conductivity, and drawdown time), and includes a visual inspection of the biofilter components (pre-treatment, in/outlet structures, filter media, and vegetation). These indicators were used to examine the performance level of each biofilter in achieving their design objectives set by the operators. Furthermore, it was investigated whether the biofilter facilities had been properly maintained to meet the objectives. Read More

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PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1.

Neoplasia 2021 Jul 26;23(9):912-928. Epub 2021 Jul 26.

Department of Pathophysiology, Zhengzhou University, Zhengzhou, China.

Protein Disulfide Isomerase Family A Member 6 (PDIA6) is an endoplasmic reticulum protein that is capable of catalyzing protein folding and disulfide bond formation. Abnormally elevated expression of PDIA6 has been reported to predict poor outcomes in various cancers. Herein, gain-of- and loss-of-function experiments were performed to investigate how PDIA6 participated in the carcinogenesis of pancreatic cancer (PC). Read More

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Foraging of the sea urchin Paracentrotus lividus (Lamarck, 1816) on invasive allochthonous and autochthonous algae.

Mar Environ Res 2021 Jul 23;170:105428. Epub 2021 Jul 23.

Department of Life and Environmental Sciences, University of Cagliari, Via T. Fiorelli, 1, 09126, Cagliari, Italy.

Attempts to control marine invasive alien species (IAS) with native predators gained contrasting results, so far. To explore the feasibility of this approach to control the invasive marine alga Caulerpa cylindracea, we investigated the foraging behaviour of the sea urchin Paracentrotus lividus on three native macroalgae (Ulva sp., Penicillus capitatus and Cystoseira compressa) and on C. Read More

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The link between COVID-19 mortality and PM emissions in rural and medium-size municipalities considering population density, dust events, and wind speed.

Chemosphere 2021 Jul 22;286(Pt 1):131634. Epub 2021 Jul 22.

Universidad Nacional Autónoma de México, Instituto de Ciencias del Mar y Limnología, Unidad Académica Mazatlán, P.O. Box 811, Mazatlán, 82000, Sinaloa, Mexico.

One contemporary issue is how environmental pollution and climate can affect the dissemination and severity of COVID-19 in humans. We documented the first case of association between particulate matter ≤2.5 μm (PM) and COVID-19 mortality rates that involved rural and medium-sized municipalities in northwestern Mexico, where direct air quality monitoring is absent. Read More

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Assessing main process mechanism and rates of sulfate reduction by granular biomass fed with glycerol under sulfidogenic conditions.

Chemosphere 2021 Jul 23;286(Pt 1):131649. Epub 2021 Jul 23.

GENOCOV Research Group, Department of Chemical, Biological and Environmental Engineering, Escola d'enginyeria, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Electronic address:

Sulfate-reducing bioreactors for sulfide production are the initial stage of processes targeting elemental sulfur recovery from sulfate-rich effluents. In this work, the principal reactions involved in glycerol fermentation and sulfate reduction using glycerol and its fermentation products as electron donors were assessed together with their specific consumption/production rates. A battery of batch activity tests with and without sulfate were performed with glycerol and with each fermentation product using a non-methanogenic but sulfidogenic granular sludge from an up-flow anaerobic sludge blanket (UASB) reactor operated under long-term while fed with crude glycerol. Read More

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Novel label-free fluorescence aptasensor for chloramphenicol detection based on a DNA four-arm junction-assisted signal amplification strategy.

Food Chem 2021 Jul 21;366:130648. Epub 2021 Jul 21.

Key Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Science, Shandong Normal University, Jinan 250014, PR China. Electronic address:

A novel label-free fluorescence aptasensor was established for chloramphenicol (CAP) detection by DNA four-arm junction-assisted target recycling and SYBR Green I dye-aided fluorescence-signal amplification. The CAP aptamer was hybridized to its complementary strand (primer) to form a double-stranded primer/aptamer complex. In the presence of CAP, aptamers can specifically bind with CAP to dissociate primers, which can trigger the self-assembly of four hairpins to continuously generate DNA four-arm junctions. Read More

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Rapid personalized AMR diagnostics using two-dimensional antibiotic resistance profiling strategy employing a thermometric NDM-1 biosensor.

Biosens Bioelectron 2021 Jul 21;193:113526. Epub 2021 Jul 21.

Pure and Applied Biochemistry, Department of Chemistry, Lund University, SE, 22100, Lund, Sweden. Electronic address:

Antimicrobial resistance (AMR) threatens global public health and modern surgical medicine. Expression of β-lactamase genes is the major mechanism by which pathogens become antibiotic resistant. Pathogens expressing extended spectrum β-lactamases (ESBL) and carbapenemases (CP) are especially difficult to treat and are associated with increased hospitalization and mortality rates. Read More

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The effect of dispatch of national medical teams to Wuhan on its control and prevention of COVID-19.

X Fan Y Gu B Guan

Public Health 2021 Apr 27;198:1-5. Epub 2021 Apr 27.

Institute of Social Development, Chinese Academy of Macroeconomic Research, Beijing, 100038, China.

Objectives: As a unique prevention and control measure, the dispatch of national medical teams to Wuhan has played a key role in protecting Wuhan against COVID-19. This study aimed to quantitatively evaluate the effect of this key measure in reducing infections and fatalities.

Study Design: A scenario analysis is used in this study, where the forming of scenarios is on the basis of the stages of medical to Wuhan. Read More

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Indirect effects of HPA axis dysregulation in the association between peer victimization and depressed affect during early adolescence.

Psychoneuroendocrinology 2021 Jul 14;132:105356. Epub 2021 Jul 14.

Concordia University, Department of Psychology, Center for Research in Human Development, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.

Objective: Previous research has identified a link between peer victimization and depressive symptoms during adolescence. The goal of the current study is to examine the possible indirect effects of HPA axis dysregulation in the link between adolescent peer victimization and depressive symptoms.

Method: A total of 113 boys (n = 61) and girls (n = 52) participants from grade 5 (M age = 10. Read More

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Age-specific rates of onset of cannabis use in Mexico.

Addict Behav 2021 Jul 1;122:107038. Epub 2021 Jul 1.

Drug Policy Program, Center for Research and Teaching in Economics (CIDE), Aguascalientes, Mexico; Division of Public Administration, Center for Research and Teaching in Economics (CIDE), Aguascalientes, Mexico. Electronic address:

Background: Over the previous two decades, the lifetime prevalence of cannabis use has risen among Mexico's population.

Aims: Estimate the sex- and age-specific rates of onset of cannabis use over time.

Design: Five nationally representative cross-sectional surveys, the Mexican National Surveys of Addictions (1998, 2002, 2008, 2012) and the Mexican National Survey on Drugs, Alcohol, and Tobacco Consumption (2016). Read More

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Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events.

Ecotoxicol Environ Saf 2021 Jul 26;222:112544. Epub 2021 Jul 26.

Department of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Integrative Biology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:

Toxicological studies of O-ethyl-O-(4-nitrophenyl) phenylphosphonothioate (EPN) to aquatic vertebrates have been reported, but no reports on toxic mechanism was reported. As zebrafish (Danio rerio) embryos were exposed to EPN, no changes in their survival and hatching rates were observed until 96 h post fertilization (hpf), even at the highest treated concentration of 500 μg/L. In both 250 μg/L and 500 μg/L, edemas were observed in the heart and yolk sac, and a blood pool was also found. Read More

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The impact of tyrosine kinase inhibitors on allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

Leuk Res 2021 Jun 18;109:106647. Epub 2021 Jun 18.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Heping District, Tianjin, 300020, China. Electronic address:

In the tyrosine kinase inhibitor (TKI) era, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still the most potential approach for cure of adult patients with Philadelphia chromosome-positive acute lymphocytic leukemia (Ph ALL). TKI plus chemotherapy has strikingly increased response rates and depth of response, and facilitated allo-HSCT, which decreases relapse and improves survival eventually. Meanwhile, for those with older age or comorbidities at diagnosis, TKI in combination with reduced-intensity chemotherapy or chemotherapy-free strategy reduces treatment-related mortality, deferred intensive chemotherapy increases molecular responses and reduced-intensity conditioning (RIC) allo-HSCT improves survival finally. Read More

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Changes in characteristics of drug overdose death trends during the COVID-19 pandemic.

Int J Drug Policy 2021 Jul 20;98:103392. Epub 2021 Jul 20.

Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. Electronic address:

Background: Reports analyzing drug overdose (OD) mortality data during the COVID-19 pandemic are limited. Outcomes across states are heterogenous, necessitating assessments of associations between COVID-19 and OD deaths on a state-by-state level. This report aims to analyze trends in OD deaths in Massachusetts during COVID-19. Read More

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Time to positivity as a prognostic factor in bloodstream infections with Enterococcus spp.

Diagn Microbiol Infect Dis 2021 Apr 20;101(3):115396. Epub 2021 Apr 20.

Institute of Medical Microbiology, Jena University Hospital, Germany; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Germany.

Time to positivity (TTP) is the delay of time from incubation to blood culture positivity. Short TTP can predict mortality and source of infection. The aim of this study was to investigate the value of TTP of patients with bloodstream infections with enterococci (E-BSI). Read More

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Surface contamination with SARS-CoV-2: A systematic review.

Sci Total Environ 2021 Jul 24;798:149231. Epub 2021 Jul 24.

Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal; Epidemiology Research Unit (EPIunit), Institute of Public Health, University of Porto, Porto, Portugal.

Little is known about contaminated surfaces as a route of transmission for SARS-CoV- 2 and a systematic review is missing and urgently needed to provide guidelines for future research studies. As such, the aim of the present study was to review the current scientific knowledge and to summarize the existing studies in which SARS-CoV-2 has been detected in inanimate surfaces. This systematic review includes studies since the emergence of SARS-CoV-2, available in PubMed/MEDLINE and Scopus. Read More

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Percutaneous Coronary Intervention in Patients With a History of Gastrointestinal Bleeding (From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium).

Am J Cardiol 2021 Jul 26;155:9-15. Epub 2021 Jul 26.

Division of Cardiovascular Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan. Electronic address:

Potent antithrombotic agents are routinely prescribed after percutaneous coronary intervention (PCI) to reduce ischemic complications. However, in patients who are at an increased bleeding risk, this may pose significant risks. We sought to evaluate the association between a history of gastrointestinal bleeding (GIB) and outcomes after PCI. Read More

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Degradation and deactivation of plasmid-encoded antibiotic resistance genes during exposure to ozone and chlorine.

Water Res 2021 Jul 6;202:117408. Epub 2021 Jul 6.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea. Electronic address:

Degradation and deactivation kinetics of an antibiotic resistance gene (ARG) by ozone (O) and free available chlorine (FAC) were investigated in phosphate-buffered solutions at pH 7 for O (in the presence of tert‑butanol), and pH 6.8 or 8.1 for FAC. Read More

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Variation of the mangrove sediment microbiomes and their phenanthrene biodegradation rates during the dry and wet seasons.

Environ Pollut 2021 Jul 26;289:117849. Epub 2021 Jul 26.

Department of Biology, Faculty of Science, Mahidol University, 272 Rama VI Road, Rachadhavi, Bangkok, 10400, Thailand. Electronic address:

Mangrove sediment is a major sink for phenanthrene in natural environments. Consequently, this study investigated the effects of seasonal variation on the biodegradation rates of low (150 mg kg), moderate (600 mg kg), and high (1200 mg kg) phenanthrene-contaminated mangrove sediments using a microcosm study and identified potential key phenanthrene-degrading bacteria using high throughput sequencing of 16 S rRNA gene and quantitative-PCR of the PAH-ring hydroxylating dioxygenase (PAH-RHD) genes. The biodegradation rates of phenanthrene in all treatments were higher in the wet-season sediments (11. Read More

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Factors associated with paid employment 12 months after stroke in A Very Early Rehabilitation Trial (AVERT).

Ann Phys Rehabil Med 2021 Jul 26:101565. Epub 2021 Jul 26.

Stroke, Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia. Electronic address:

Background: Returning to work is an important outcome for stroke survivors.

Objectives: This sub-study of a randomised controlled trial aimed to provide characteristics of working-age stroke participants and identify factors associated with return to work at 12 months.

Methods: We used paid employment data collected as part of A Very Early Rehabilitation Trial (AVERT, n=2104), an international randomised controlled trial studying the effects of very early mobilisation after stroke at 56 acute stroke units across Australia, New Zealand, the United Kingdom, Malaysia and Singapore. Read More

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Toe-First Technique for End to Side Microvascular Anastomosis - A Technical Note.

World Neurosurg 2021 Jul 26. Epub 2021 Jul 26.

Professor, Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address:

Introduction: The use of the classic two-ends anchoring technique is common in end-to side (ES) microvascular anastomosis. The literature on the Toe-first (TF) technique is limited. In the current study we present the successful outcomes with the TF technique in ES anastomoses in rat femoral vessels model. Read More

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Determinants of surgical remission in prolactinomas: a systematic review and meta-analysis.

World Neurosurg 2021 Jul 26. Epub 2021 Jul 26.

Division of Endocrinology, Diabetes and Metabolism, NYU Langone Medical Center/ Bellevue Hospital Center, 550 1st Avenue, New York, NY 10016. Electronic address:

Objective: Prolactin secreting tumors respond well to medical management with a small fraction of patients requiring surgery. We conducted a systematic review and meta-analysis to study the determinants of surgical remission in these tumors.

Methods: We searched PubMed to identify eligible studies reporting postoperative remission in patients treated with transsphenoidal surgery for prolactinoma. Read More

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Effect of Biomodulina-T® and VA-MENGOC-BC® on lymphocyte subpopulations in older adults.

Exp Gerontol 2021 Jul 26:111497. Epub 2021 Jul 26.

Institute of Hematology and Immunology, Immunochemistry-Immunology Department, 19th St, between 8th and 10th St, Vedado, 10400 Plaza de la Revolución, Havana, Cuba.

Introduction: The elderly population suffers from the natural process called immunosenescence, which may be related to the high mortality rates it has against the SARS-CoV2 virus, which is why therapies that improve the immune status are required. The combined treatment of the VA-MENGOC-BC® (V-BC) vaccine and the Biomodulina T® (BT) drug could achieve this purpose. This treatment could immunomodulate both the innate and adaptive branches of the immune system simultaneously. Read More

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