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Biofilm formation of Ancylobacter sp. TS-1 on different granular materials and its ability for chemolithoautotrophic As(III)-oxidation at high concentrations.

J Hazard Mater 2021 Jul 27;421:126733. Epub 2021 Jul 27.

Departamento de Ingeniería Hidráulica y Ambiental, Pontificia Universidad Católica de Chile, Santiago, Chile; CEDEUS, Centro de Desarrollo Urbano Sustentable, Chile. Electronic address:

The oxidation of arsenic (As) is a key step in its removal from water, and biological oxidation may provide a cost-effective and sustainable method. The biofilm-formation ability of Ancylobacter sp. TS-1, a novel chemolithoautotrophic As oxidizer, was studied for four materials: polypropylene, graphite, sand, and zeolite. Read More

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Insights of metallic nanoparticles and ions in accelerating the bacterial uptake of antibiotic resistance genes.

J Hazard Mater 2021 Jul 24;421:126728. Epub 2021 Jul 24.

Advanced Water Management Centre (AWMC), The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. Electronic address:

The increasing release of nanomaterials has attracted significant concerns for human and environmental health. Similarly, the dissemination of antimicrobial resistance (AMR) is a global health crisis affecting approximately 700,000 people a year. However, a knowledge gap persists between the spread of AMR and nanomaterials. Read More

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Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study.

J Hazard Mater 2021 Jul 26;421:126750. Epub 2021 Jul 26.

Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, P.O. Box 249,130 Dong-An Road, Shanghai 200032, China; Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China. Electronic address:

The biological mechanisms underlying the associations between atmospheric ozone exposure and adverse cardiometabolic outcomes are yet to be identified. Imbalanced autonomic nervous system (ANS) as well as activations of the sympatho-adrenomedullary (SAM) and hypothalamic-pituitary-adrenal (HPA) axes are among possible early biological responses triggered by ozone, and may eventually lead to cardiometabolic abnormalities. To determine whether acute ozone exposure causes ANS imbalance and increases the secretion of neuroendocrine stress hormones, we conducted a randomized, double-blind, crossover trial, under controlled 2-hour exposure to either ozone (200 ppb) or clean air with intermittent exercise among 22 healthy young adults. Read More

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Ferroptosis-related gene model to predict overall survival of papillary thyroid carcinoma.

Am J Otolaryngol 2021 Jul 26;42(6):103163. Epub 2021 Jul 26.

Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Electronic address:

Background: Ferroptosis is a form of programmed cell death that is closely associated with the development of various tumors. However, the correlation between ferroptosis and papillary thyroid carcinoma (PTC) is unclear. This study was performed to investigate the expression and prognostic value of ferroptosis-related genes (FRG) in PTC. Read More

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Cost-effectiveness of point-of-care creatinine testing to assess kidney function prior to contrast-enhanced computed tomography imaging.

Eur J Radiol 2021 Jul 27;142:109872. Epub 2021 Jul 27.

Centre for Health Economics, University of York, Heslington, UK.

Background: Patients undergoing contrast-enhanced computed tomography (CECT) imaging in a non-emergency outpatient setting often lack a recent estimated Glomerular Filtration Rate measurement. This may lead to inefficiencies in the CECT pathway. The use of point-of-care (POC) creatinine tests to evaluate kidney function in these patients may provide a safe and cost-effective alternative to current practice, as these can provide results within the same CECT appointment. Read More

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Socioeconomic patterns and COVID-19 outcomes before, during and after the lockdown in Italy (2020).

Health Place 2021 Jul 29;71:102642. Epub 2021 Jul 29.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy; Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.

The objective was to investigate the association between deprivation and COVID-19 outcomes in Italy during pre-lockdown, lockdown and post-lockdown periods using a retrospective cohort study with 38,534,169 citizens and 222,875 COVID-19 cases. Multilevel negative binomial regression models, adjusting for age, sex, population-density and region of residence were conducted to evaluate the association between area-level deprivation and COVID-19 incidence, case-hospitalisation rate and case-fatality. During lockdown and post-lockdown, but not during pre-lockdown, higher incidence of cases was observed in the most deprived municipalities compared with the least deprived ones. Read More

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Examining risky riding behavior in India using Motorcycle rider behavior questionnaire.

Accid Anal Prev 2021 Jul 30;160:106312. Epub 2021 Jul 30.

Transportation Planning & Environment Division, CSIR-Central Road Research Institute (CRRI) New Delhi, India.

Powered two-wheelers (PTW) constitute the most vulnerable type of road user, primarily due to their lack of protection compared to other motorized vehicles, which can lead to a severe accident in the event of crashes. A notable increase in the percentage of PTW accidents resulting in fatalities has raised a serious need for further research in understanding riding behavior. The Motorcycle rider behavior questionnaire (MRBQ) based studies have shown promising results by using MRBQ to relate riding behavior with crash risk. Read More

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Child restraint system use and its associated factors in Shenzhen.

Accid Anal Prev 2021 Jul 31;160:106321. Epub 2021 Jul 31.

National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Electronic address:

Child restraint system (CRS) is effective to protect child passenger safety in a motor vehicle crash. However, research on CRS is limited and the use rate of CRS is not high in China. We carried out a cross-sectional study to examine the use of CRS and its associated factors in Shenzhen. Read More

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Transfusion Guidelines in Adult Spine Surgery: A Systematic Review and Critical Summary of Currently Available Evidence.

Spine J 2021 Jul 30. Epub 2021 Jul 30.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, TX, USA 75235; University of Texas Southwestern Medical Center, Spine Center, Dallas, TX, USA 75235.

Background Context: Red blood cell transfusion can be associated with complications in medical and surgical patients. Acute anemia in ambulatory patients undergoing surgery can also impede wound healing and independent self-care. Current transfusion threshold guidelines are still based on evidence derived from critically-ill intensive care unit medical patients and may not apply to spine surgery candidates. Read More

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Risk factors for postoperative recurrence of anal fistula identified by an international, evidence-based Delphi consultation survey of surgical specialists.

Int J Surg 2021 Jul 30;92:106038. Epub 2021 Jul 30.

Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background: Despite the emerging knowledge about postoperative anal fistula recurrence (AFR) and the increasing number of clinical studies, there is no better understanding or consensus regarding the risk factors for AFR. The aim of this study was to generate international consensus guidance statements focusing on AFR.

Methods: A two-round modified Delphi process was conducted among international surgical specialists via an online survey delivered by email with a secure link created with Google Forms. Read More

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Macula thickness and microvasculature loss in glaucoma suspect eyes.

Ophthalmol Glaucoma 2021 Jul 30. Epub 2021 Jul 30.

Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To characterize the change of ganglion cell complex (GCC) thickness and macula vessel density in eyes diagnosed as being glaucoma suspect eyes with ocular hypertension (OHT) or glaucomatous optic neuropathy (GON).

Design: Prospective, longitudinal study.

Participants: 83 eyes (24 healthy eyes, 30 OHT eyes, and 29 GON eyes) of 65 subjects who had at least 3 visits were included from the Diagnostic Innovations in Glaucoma Study. Read More

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Advances in cell death - related signaling pathways in acute-on-chronic liver failure.

Clin Res Hepatol Gastroenterol 2021 Jul 30:101783. Epub 2021 Jul 30.

Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China. Electronic address:

Acute-on-chronic liver failure (ACLF) has been a hot spot in the field of liver disease research in recent years, with high morbidity, rapid course change and high mortality. Currently, there is the absence of specific treatment in clinical practice. Liver transplantation has the best therapeutic effect, but it is prone to have internal environment disorder and liver cell death after transplantation, which leads to the failure of transplantation. Read More

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Sinus Node Sparing Hybrid Thoracoscopic Ablation Outcomes in Patients with Inappropriate Sinus Tachycardia (SUSRUTA-IST Registry).

Heart Rhythm 2021 Jul 21. Epub 2021 Jul 21.

Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS.

Background: Medical treatment for inappropriate sinus tachycardia (IST) remains suboptimal. Radiofrequency sinus node (RF-SN) ablation has poor success and higher complication rates.

Objective: We aimed to compare clinical outcomes of novel SN sparing hybrid ablation technique versus RF-SN modification for IST management. Read More

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RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.

Pharmacol Res 2021 Jul 30:105793. Epub 2021 Jul 30.

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China; School of Basic Medical Sciences, Fudan Unvieristy, Shanghai 200032, China. Electronic address:

To date, the overall response rate to checkpoint blockade remains unsatisfactory, partially due to the limited understanding of the tumor immune microenvironment. The retinoic acid-related orphan receptor γt (RORγt) is the key transcription factor of T helper cell 17 (Th17) cells and plays an essential role in tumor immunity. In this study, we used JG-1, a potent and selective small-molecule RORγt agonist to evaluate the therapeutic potential and mechanism of action of targeting RORγt in tumor immunity. Read More

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Influence of behavioral state on the neuromodulatory effect of low-intensity transcranial ultrasound stimulation on hippocampal CA1 in mouse.

Neuroimage 2021 Jul 30:118441. Epub 2021 Jul 30.

School of Electrical Engineering, Yanshan University, Qinhuangdao, 066004, China; Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, Yanshan University, Qinhuangdao, 066004, China. Electronic address:

In process of brain stimulation, the influence of any external stimulus depends on the features of the stimulus and the initial state of the brain. Understanding the state-dependence of brain stimulation is very important. However, it remains unclear whether neural activity induced by ultrasound stimulation is modulated by the behavioral state. Read More

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In vivo assessment of anisotropy of apparent magnetic susceptibility in white matter from a single orientation acquisition.

Neuroimage 2021 Jul 30:118442. Epub 2021 Jul 30.

Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany.

Multiple studies have reported a significant dependence of the effective transverse relaxation rate constant (R) and the phase of gradient-echo based (GRE) signal on the orientation of white matter fibres in the human brain. It has also been hypothesized that magnetic susceptibility, as obtained by single-orientation quantitative susceptibility mapping (QSM), exhibits such a dependence. In this study, we investigated this hypothesized relationship in a cohort of healthy volunteers. Read More

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Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: Systematic review and meta-analysis.

Exp Gerontol 2021 Jul 30:111502. Epub 2021 Jul 30.

Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.

The excessive deposition of β-amyloid proteins (Aβ) is directly correlated with the establishment and development of Alzheimer's Disease (AD). Current treatments for AD only reduce symptoms instead of acting on Aβ, which is the primary etiological agent. Hence, the anti-amyloid effect of regular exercise has been widely investigated as an alternative therapy. Read More

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Teaching of the Repair of Defective Composite Restorations in Middle Eastern and North African Dental Schools.

J Dent 2021 Jul 30:103753. Epub 2021 Jul 30.

Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.

Objectives: To evaluate the status of teaching of repair of defective resin-based composite restorations in dental schools in the Middle Eastern and North African (MENA) countries.

Methods: A validated 14-item questionnaire was mailed to the directors of the operative/restorative dentistry department in 40 MENA dental schools. Data were collected on teaching, including whether the repair of resin-based composite restorations was part of the dental school curriculum; the rationale behind the teaching; how techniques were taught, indications for repair, operative techniques, materials used, patient acceptability and expected longevity of the repair procedure. Read More

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The temptin gene of the clade Lophotrochozoa is involved in formation of the prismatic layer during biomineralization in molluscs.

Int J Biol Macromol 2021 Jul 30. Epub 2021 Jul 30.

Key Laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Agriculture, Shanghai 201306, China. Electronic address:

The biomineralization mechanism of mollusc shell has been studied for a long time, but there is a lack of understanding about the relationship between the shell formation in vitro and the signaling system in vivo. In this study, we cloned a novel shell matrix protein gene (hc-temptin), which only be characterized as a water-borne protein pheromone of molluscs in previous studies, from the freshwater mussel Hyriopsis cumingii. By bioinformatics analysis we found that temptin was a gene unique to the clade Lophotrochozoa, and it exists in all mollusc taxa except Cephalopoda. Read More

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A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering.

Int J Biol Macromol 2021 Jul 30. Epub 2021 Jul 30.

State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address:

Nowadays, decellularized extracellular matrix (dECM) has received widespread attention due to its diversity in providing the unique structural and functional components to support cell growth, and finding material with good biocompatibility and anti-infection capability for skin tissue engineering is still a challenge. In this study, a novel dECM/Gel/CS scaffold with appropriate mechanical strength, good antibacterial activity and high biocompatibility was prepared using a one-pot method. The results showed that the immune components such as cells and DNA (about 98. Read More

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Non-carbapenem beta-lactam/beta-lactamase inhibitors versus carbapenems for urinary tract infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae: a systematic review.

Int J Antimicrob Agents 2021 Jul 30:106410. Epub 2021 Jul 30.

Centre of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing 100853, China. Electronic address:

Objective: The systematic review was conducted to compare the efficacy of non-carbapenem beta-lactam/beta-lactamase inhibitors (BLBLIs) versus carbapenems for the treatment of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) induced urinary tract infections (UTIs).

Methods: A comprehensive search of the Cochrane Library, PubMed and Embase was conducted from January 1979 to December 2020. Clinical success, microbiologic success, clinical and microbiologic success, and mortality were assessed as efficacy outcomes. Read More

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A Mendelian randomization study found causal linkage between telomere attrition and chronic kidney disease.

Kidney Int 2021 Jul 30. Epub 2021 Jul 30.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Kidney Research Institute, Seoul National University, Seoul, Korea. Electronic address:

Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is rarely investigated whether kidney function is causally linked to biological aging itself. In this Mendelian randomization study, genetic instruments for telomere attrition were applied to a CKDGen genome wide association study results for 41,395 cases of CKD among 480,698 individuals as summary-level Mendelian randomization. Read More

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Nanoscale Dynamics of Cellulose Digestion by the Cellobiohydrolase TrCel7A.

J Biol Chem 2021 Jul 30:101029. Epub 2021 Jul 30.

Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802. Electronic address:

Understanding the mechanism by which cellulases from bacteria, fungi, and protozoans catalyze the digestion of lignocellulose is important for developing cost effective strategies for bioethanol production. Cel7A from the fungus Trichoderma reesei is a model exoglucanase that degrades cellulose strands from their reducing ends by processively cleaving individual cellobiose units. Despite being one of the most studied cellulases, the binding and hydrolysis mechanisms of Cel7A are still debated. Read More

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The Evolving Landscape of the ABE Certification Process: What it Means for the Future of the Specialty.

J Endod 2021 Jul 30. Epub 2021 Jul 30.

Texas A&M University College of Dentistry, 3302 Gaston Ave, Dallas, TX 75246.

Introduction: ABE Board-certification is an evolving process to ensure the continuing existence of the specialty of endodontics. Recent exam changes have resulted in greater numbers of Diplomates. To fully understand the implications of such changes and evaluate current Diplomates' views of the examination process, a specific set of questions was developed focusing on beliefs and perceptions, age relationships, test components, and hypotheticals for potential changes. Read More

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Prognostic and clinicopathological significance of TMEFF2, SMOC-2, and SOX17 expression in endometrial carcinoma.

Exp Mol Pathol 2021 Jul 30:104670. Epub 2021 Jul 30.

Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Egypt.

Background there is a need for novel biomarkers and targeting therapies for predicting Endometrial carcinoma (EC) progression and recurrence. TMEFF2 is a gene that was found to play a role in EMT. SMOC-2 is expressed in embryogenesis and it was identified as a recent stem cell-related gene that has a role in cancer progression. Read More

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The effects of exercise training on the lungs and cardiovascular function of animals exposed to diesel exhaust particles and gases.

Environ Res 2021 Jul 30:111768. Epub 2021 Jul 30.

Department of Clinical Medicine (LIM 20), School of Medicine, University of Sao Paulo, Sao Paulo, Brazil; Department of Bioscience, Universidade Federal de São Paulo, São Paulo, 11015-020, Brazil.

Air pollution has been identified as one of the main environmental risks to health. Since exercise training seems to act as an anti-inflammatory modulator, our hypothesis is that exercise training prevents damage to respiratory and cardiovascular function caused by diesel exhaust particle (DEP) exposure. This study aimed to evaluate whether aerobic exercise training prior to DEP exposure prevents inflammatory processes in the pulmonary and cardiovascular systems. Read More

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Environmentally benign Prosopis juliflora extract for corrosion protection by sorption - Gravimetric, mechanistic and thermodynamic studies.

Environ Res 2021 Jul 30:111816. Epub 2021 Jul 30.

Department of Chemical Engineering, Annamalai University, Annamalai Nagar, PC -608002, India.

Environmentally benign plant extract compounds have gained significant attention in the corrosion prevention applications due to their biodegradability and eco-friendliness. The adsorptive corrosion control action of Prosopis juliflora plant extract was investigated using differential mass change experiments and the mechanism was validated using Tafel and Nyquist plots. The effect of green corrosion inhibitor concentration (0-800 ppm) on corrosion rate at different solution temperatures (305. Read More

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Optimal Noninvasive Medicare Access Promotion: Patients with Central Sleep Apnea A Technical Expert Panel Report from the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Chest 2021 Jul 28. Epub 2021 Jul 28.

Department of Medicine, Veterans Affairs Medical Center, Martinsburg, WV.

This document summarizes suggestions of the central sleep apnea (CSA) technical expert panel (TEP) working group. This paper shares our vision for bringing the right device to the right patient at the right time. For patients with CSA, current coverage criteria do not align with guideline treatment recommendations. Read More

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Optimal Noninvasive Medicare Access Promotion: Patients with Hypoventilation Syndromes A Technical Expert Panel Report from the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Chest 2021 Jul 29. Epub 2021 Jul 29.

University of California San Diego, San Diego, CA.

The existing coverage criteria for home noninvasive ventilation (NIV) do not recognize the diversity of hypoventilation syndromes and advances in technologies. This document summarizes the work of the Hypoventilation Syndromes Technical Expert Panel working group. The most pressing current coverage barriers identified were: 1) overreliance on arterial blood gases (particularly during sleep); 2) need to perform testing on prescribed oxygen; 3) requiring a sleep study to rule out obstructive sleep apnea as the cause of sustained hypoxemia; 4) need for spirometry; 5) need to demonstrate BPAP without a backup rate failure to qualify for BPAP S/T; and 6) qualifying hospitalized patients for home NIV therapy at the time of discharge. Read More

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Optimal Noninvasive Medicare Access Promotion: Patients with COPD Technical Expert Panel Report from the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society.

Chest 2021 Jul 28. Epub 2021 Jul 28.

National Jewish Health, Denver, CO.

This document summarizes the work of the Chronic Obstructive Pulmonary Disease (COPD) Technical Expert Panel working group. For patients with COPD, the most pressing current coverage barriers identified were onerous diagnostic requirements focused on oxygenation (rather than ventilation), and difficulty obtaining bilevel devices with backup rate capabilities. Because of these difficulties, many patients with COPD were instead sometimes prescribed home mechanical ventilators. Read More

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