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The Online Life Story Book: A randomized controlled trial on the effects of a digital reminiscence intervention for people with (very) mild dementia and their informal caregivers.

PLoS One 2021 15;16(9):e0256251. Epub 2021 Sep 15.

Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

This paper describes a randomized controlled trial on the Online Life Story Book (OLSB), a digital reminiscence intervention for people with (very) mild dementia living at home. The aim of the study was to investigate the effectiveness of the OLSB on (i) neuropsychiatric symptoms (NPS) in persons with dementia and (ii) the distress and quality of life (QOL) of primary informal caregivers. A randomized controlled trial with individual randomization to one of two conditions was conducted: 1) intervention "Online Life Story Book"; 2) wait list control condition. Read More

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September 2021

Potential of Medical Management to Mitigate Suction Events in Ventricular Assist Device Patients.

ASAIO J 2021 Sep 9. Epub 2021 Sep 9.

From the Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium Institute of Clinical Physiology, National Research Council, Pisa, Italy Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.

Ventricular suction is a common adverse event in ventricular assist device (VAD) patients and can be due to multiple underlying causes. The aim of this study is to analyze the potential of different therapeutic interventions to mitigate suction events induced by different pathophysiological conditions. To do so, a suction module was embedded in a cardiovascular hybrid (hydraulic-computational) simulator reproducing the entire cardiovascular system. Read More

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September 2021

Elite and viremic HIV-1 controllers in West Africa.

AIDS 2021 Sep 14. Epub 2021 Sep 14.

Inserm 1219, University of Bordeaux, IRD, Bordeaux, France PACCI/ANRS Research Center Département de Dermatologie et Maladies Infectieuses, Université Felix Houphouët Boigny, Abidjan, Côte d'Ivoire AP-HP, CHU Necker Enfants Malades, Université Paris Descartes, Paris, France CeDReS, CHU de Treichville, Abidjan, Côte d'Ivoire Faculté de Médecine, Université Paris Descartes, Paris AP-HP Paris Saclay, Hôpital Bicêtre, Clinical Immunology Department Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IDMIT/IMVA-HB), Le Kremlin Bicêtre, France.

Background: Data on HIV-1 controllers in Africa are scarce. We report the proportion of HIV-1 controllers in a group of adults prospectively monitored with frequent viral load measurements as part of a clinical trial in West Africa.

Methods: For the Temprano trial, antiretroviral therapy (ART)-naïve HIV-1 infected adults with no criteria for starting ART were randomized to start ART immediately or defer ART until the WHO starting criteria were met. Read More

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September 2021

Pharmacokinetically guided, once-daily intravenous busulfan in combination with fludarabine for elderly AML/MDS patients as a conditioning regimen for allogeneic stem cell transplantation.

Int J Hematol 2021 Sep 14. Epub 2021 Sep 14.

Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

The efficacy of pharmacokinetically (PK) guided, once-daily administration of busulfan (BU) was evaluated in elderly patients with acute myeloid leukemia/myelodysplastic syndrome (AML/MDS). Twenty-one patients (median age 61) received 30 mg/m fludarabine for 6 days and BU for 4 days, starting from 3.2 mg/m and subsequently adjusted to the target area under the curve (AUC) of 6000 µmol-min/L. Read More

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September 2021

Ventriculolumbar perfusion and inhalational anesthesia with sevoflurane in an accidental intrathecal injection of tranexamic acid: unreported treatment options.

Reg Anesth Pain Med 2021 Sep 14. Epub 2021 Sep 14.

Clinical Department of Anaesthesiology and Intensive Therapy, University Medical Center, Ljubljana, Slovenia

Background: Tranexamic acid (TXA) decreases hemorrhage-related mortality in trauma patients and is increasingly being used during obstetric and orthopedic surgeries. Inadvertent intrathecal injection of TXA is a rare, potentially lethal event leading to dose-dependent cardiotoxicity and neurotoxicity. TXA enhances neuronal excitation by antagonizing inhibitory γ-aminobutyric acid type A and glycine receptors. Read More

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September 2021

Antimicrobial Resistance Trends of Isolates from Outpatient and Inpatient Urinary Infections over a 20-Year Period.

Microb Drug Resist 2021 Sep 14. Epub 2021 Sep 14.

Department of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale di Monza ASST-Monza, Desio Hospital, Desio, Italy.

Antimicrobial resistance is a worldwide problem, and resistance in Enterobacteriaceae, particularly and , is a critical threat to human health. Inappropriate and unnecessary use of antibiotics in human health care is the most common cause for the development and spread of antimicrobial resistance. In this work, we retrospectively analyzed the antimicrobial data of strains isolated from midstream urinary samples over a 20-year period (2000-2019). Read More

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September 2021

Electronic cigarettes for smoking cessation.

Cochrane Database Syst Rev 2021 Sep 14;9:CD010216. Epub 2021 Sep 14.

Wolfson Institute of Preventive Medicine, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Background: Electronic cigarettes (ECs) are handheld electronic vaping devices which produce an aerosol formed by heating an e-liquid. Some people who smoke use ECs to stop or reduce smoking, but some organizations, advocacy groups and policymakers have discouraged this, citing lack of evidence of efficacy and safety. People who smoke, healthcare providers and regulators want to know if ECs can help people quit and if they are safe to use for this purpose. Read More

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September 2021

INVESTIGATION OF THE EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS ON ANEMIA IN PATIENTS WITH NORMAL OR MILDLY LOW GLOMERULAR FILTRATION RATE.

Turk J Med Sci 2021 Sep 14. Epub 2021 Sep 14.

Background: The relationship between the activation of the renin-angiotensin system and the increase in erythropoiesis has been shown in many studies. In addition, the use of angiotensin converting enzyme inhibitors or angiotensin-receptor blockers has been reported to reduce hemoglobin levels in various patient groups at risk for secondary erythrocytosis/polycythemia.

Aims: To investigate whether there is any change in hemoglobin levels after starting ACEI or ARB in patients who have not previously used them. Read More

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September 2021

Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss.

Bone Res 2021 Sep 13;9(1):42. Epub 2021 Sep 13.

Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.

High erythropoietin (Epo) levels are detrimental to bone health in adult organisms. Adult mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone resorption. In humans, high serum Epo levels are linked to fractures in elderly men. Read More

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September 2021

Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials.

Pharm Biol 2021 Dec;59(1):1276-1285

School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Context: Desloratadine, an H1 receptor antagonist, is suggested as an effective first-line drug for chronic urticarial (CU). However, the efficacy of desloratadine alone is limited, and the recurrence rate of CU is relatively high.

Objective: We sought to evaluate the efficacy and clinical feasibility of desloratadine in combination with compound glycyrrhizin in the treatment of CU. Read More

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December 2021

Preterm infant heart rate is lowered after Family Nurture Intervention in the NICU: Evidence in support of autonomic conditioning.

Early Hum Dev 2021 Aug 31;161:105455. Epub 2021 Aug 31.

Nurture Science Program, Department of Pediatrics, Columbia University Medical Center, New York, NY, United States of America; Developmental Neuroscience, Department of Psychiatry, Columbia University Medical Center, New York, NY, United States of America. Electronic address:

Background: Cardiac complications after premature birth are associated with negative long-term consequences to health. The Family Nurture Intervention (FNI) has been designed to support mother-infant parasympathetic calming sessions in the neonatal intensive care unit (NICU). FNI has shown neurodevelopmental and autonomic benefit across infant development. Read More

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More Live Births in Primary Subfertile Intracytoplasmic Sperm Injection-Treated Women with High Normal TSH Levels.

Gynecol Obstet Invest 2021 Aug 26;86(4):398-407. Epub 2021 Aug 26.

Department of Obstetrics, Gynaecology and Reproductive Medicine, Division of Reproductive Medicine, Amsterdam Reproduction & Development, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: The aim of this study was to analyze the fertility outcome in intracytoplasmic sperm injection (ICSI)-treated women across normal range thyroid-stimulating hormone (TSH) levels. Published results are inconclusive about optimal TSH levels and fertility.

Design: This is a retrospective cohort study in 752 ICSI-treated women with predominantly severe male factor subfertility, starting treatment between the first of January 2008 and the first of March 2012 with a follow-up until 2014. Read More

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CovH2SD: A COVID-19 detection approach based on Harris Hawks Optimization and stacked deep learning.

Expert Syst Appl 2021 Dec 5;186:115805. Epub 2021 Sep 5.

Computers Engineering and Systems Department, Faculty of Engineering, Mansoura University, Egypt.

Starting from Wuhan in China at the end of 2019, coronavirus disease (COVID-19) has propagated fast all over the world, affecting the lives of billions of people and increasing the mortality rate worldwide in few months. The golden treatment against the invasive spread of COVID-19 is done by identifying and isolating the infected patients, and as a result, fast diagnosis of COVID-19 is a critical issue. The common laboratory test for confirming the infection of COVID-19 is Reverse Transcription Polymerase Chain Reaction (RT-PCR). Read More

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December 2021

Timing of syncope in ictal asystole as a guide when considering pacemaker implantation.

J Cardiovasc Electrophysiol 2021 Sep 12. Epub 2021 Sep 12.

Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 3, 2103 SW Heemstede and Dokter Denekampweg 20, 8025, BV, Zwolle, The Netherlands.

Introduction: In patients with ictal asystole (IA) both cardioinhibition and vasodepression may contribute to syncopal loss of consciousness. We investigated the temporal relationship between onset of asystole and development of syncope in IA, in order to estimate the frequency with which pacemaker therapy, by preventing severe bradycardia, may diminish syncope risk.

Methods: In this retrospective cohort study we searched video-EEG databases for individuals with focal seizures and IA (asystole ≥3 seconds preceded by heart rate deceleration) and assessed the durations of asystole and syncope and their temporal relationship. Read More

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September 2021

Prophylactic and therapeutic efficacy of clinoptilolite against Cryptosporidium parvum in experimentally challenged neonatal lambs.

Vet Parasitol 2021 Sep 9;299:109574. Epub 2021 Sep 9.

Department of Internal Medicine, Veterinary Faculty, Aydın Adnan Menderes University, 09100, Aydın, Turkey. Electronic address:

This study was designed to test the prophylactic and therapeutic efficacy of clinoptilolite against Cryptosporidium (C.) parvum infection in lambs. Within the first day of life, three groups of 10 lambs were each inoculated with 1 × 10 oocysts of C. Read More

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September 2021

Short-lived sensitization of cardiovascular outcomes of postpartum endotoxemia in preeclamptic rats: Role of medullary solitary tract neuroinflammation.

Eur J Pharmacol 2021 Sep 8;910:174494. Epub 2021 Sep 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait. Electronic address:

Preeclampsia (PE) is a pregnancy-related disorder with serious maternal complications. Considering the increased importance of postpartum infection in maternal morbidity and mortality, we investigated whether preeclamptic maternal programming alters cardiovascular consequences of endotoxemia in rats and the role of cardiac and brainstem neuroinflammation in this interaction. Preeclampsia was induced by oral administration of L-NAME (50 mg/kg/day) for 7 days starting from day 14 of conception. Read More

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September 2021

Drug fever induced by carboplatin-based regimens: Higher incidence in a women's hospital.

Taiwan J Obstet Gynecol 2021 Sep;60(5):882-887

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. Electronic address:

Objective: Previous studies have reported low incidence of carboplatin-related drug fever in early cancer treatment cycles. This study describes and analyzes relatively higher incidence rate of carboplatin-related drug fever associated with gynecologic cancer chemotherapy in order to allay anxiety in patients and avoid unnecessary interventions.

Materials And Methods: All gynecologic cancer cases treated with carboplatin in a women's hospital in 2017 and 2018 were retrospectively reviewed and analyzed. Read More

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September 2021

Fertility preservation among young breast cancer patients: A single-center experience in China.

Taiwan J Obstet Gynecol 2021 Sep;60(5):827-830

Department of Breast Surgery, Sichuan Cancer Hospital, Chengdu, 610041, Sichuan, China. Electronic address:

Objective: This study aims to investigate the status of fertility preservation (FP) in young breast cancer patients.

Materials And Methods: A clinical database of six women with breast cancer who wished to undergo FP before starting chemotherapy were analyzed between January 2018 and December 2019 in our hospital. Among the six women, three were unmarried and three were married. Read More

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September 2021

Attack by a common parasitoid stabilizes population dynamics of multi-host communities.

Authors:
Abhyudai Singh

J Theor Biol 2021 Sep 7:110897. Epub 2021 Sep 7.

Department of Electrical and Computer Engineering, Department of Biomedical Engineering, Department of Mathematical Sciences, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19713. Electronic address:

We model the population dynamics of two host species attacked by a common parasitoid using a discrete-time formalism that captures their population densities from year to year. It is well known starting from the seminal work of Nicholson and Bailey that a constant parasitoid attack rate leads to an unstable host-parasitoid interaction. However, a Type III functional response, where the parasitoid attack rate accelerates with increasing host density stabilizes the population dynamics. Read More

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September 2021

Improved Survival over Time After Resection of Colorectal Liver Metastases and Clinical Impact of Multigene Alteration Testing in Patients with Metastatic Colorectal Cancer.

J Gastrointest Surg 2021 Sep 10. Epub 2021 Sep 10.

Departments of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1484, Houston, TX, USA.

Background: The past 20 years have seen advances in colorectal cancer management. We sought to determine whether survival in patients undergoing resection of colorectal liver metastases (CLM) has improved in association with three landmark advances: introduction of irinotecan- and/or oxaliplatin-containing regimens, molecular targeted therapy, and multigene alteration testing.

Methods: Patients undergoing CLM resection during 1998-2014 were identified and grouped by resection year. Read More

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September 2021

Predictors of attrition among adults in a rural HIV clinic in southern Mozambique: 18-year retrospective study.

Sci Rep 2021 Sep 9;11(1):17897. Epub 2021 Sep 9.

Department of Internal Medicine, University General Hospital of Alicante and Miguel Hernandez University, Elche, Spain.

HIV remains a major cause of morbidity and mortality for people living in many low-income countries. With an HIV prevalence of 12.4% among people aged over 15 years, Mozambique was ranked in 2019 as one of eight countries with the highest HIV rates in the world. Read More

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September 2021

Use of antipsychotic drugs and cholinesterase inhibitors and risk of falls and fractures: self-controlled case series.

BMJ 2021 09 9;374:n1925. Epub 2021 Sep 9.

School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Objective: To evaluate the association between the use of antipsychotic drugs and cholinesterase inhibitors and the risk of falls and fractures in elderly patients with major neurocognitive disorders.

Design: Self-controlled case series.

Setting: Taiwan's National Health Insurance Database. Read More

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September 2021

Innovative Partnerships to Address Food Insecurity during the COVID-19 Pandemic: The Brighter Bites Produce Voucher Program.

Int J Environ Res Public Health 2021 08 31;18(17). Epub 2021 Aug 31.

Department of Epidemiology, Human Genetics and Environmental Sciences, Michael & Susan Dell Center for Healthy Living, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Pressler Street, Houston, TX 77030, USA.

The purpose of this communication is to describe the Brighter Bites produce voucher program, and its implementation and utilization across Brighter Bites families in four cities in the U.S., during the COVID-19 pandemic. Read More

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Toward a Greener World-Cyclodextrin Derivatization by Mechanochemistry.

Molecules 2021 Aug 27;26(17). Epub 2021 Aug 27.

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.

Cyclodextrin (CD) derivatives are a challenge, mainly due to solubility problems. In many cases, the synthesis of CD derivatives requires high-boiling solvents, whereas the product isolation from the aqueous methods often requires energy-intensive processes. Complex formation faces similar challenges in that it involves interacting materials with conflicting properties. Read More

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Factors Associated with Seroconversion of Hepatitis C Virus in End Stage Renal Disease Patients.

J Coll Physicians Surg Pak 2021 Sep;31(9):1040-1045

Department of Nephrology, King Edward Medical University, Lahore, Pakistan.

Objective: To determine patient and dialysis services-related factors associated with seroconversion of hepatitis C virus (HCV) in hemodialysis (HD) patients.

Study Design: Cross-sectional study.

Place And Duration Of Study: Department of Nephrology, Mayo Hospital, King Edward Medical University (KEMU), Lahore, from January to December, 2018. Read More

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September 2021

Impact of kidney function on the occurrence of new-onset atrial fibrillation in patients with ST-elevation myocardial infarction.

Anatol J Cardiol 2021 Sep;25(9):638-645

University Clinical Center of Serbia, Emergency Hospital, Coronary Care Unit and Cardiology Clinic, Belgrade, Serbia.

Objective: In this study, we aimed to examine the prognostic impact of decreased kidney function at admission on the occurrence of new-onset atrial fibrillation (AF) in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI).

Methods: The study enrolled 3,115 consecutive patients with STEMI. Kidney function was assessed by estimation of the glomerular filtration rate (eGFR) at admission. Read More

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September 2021

Incidence of Chronic Immune-Mediated Inflammatory Diseases After Diagnosis with Kawasaki Disease: A Population-Based Cohort Study.

Rheumatology (Oxford) 2021 Sep 8. Epub 2021 Sep 8.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.

Objectives: Kawasaki disease (kDa) is an immune-mediated vasculitis of childhood with multi-organ inflammation. We determined the risk of subsequent immune-mediated inflammatory disease (IMID), including arthritis, type 1 diabetes, inflammatory bowel disease (IBD), autoimmune liver disease (ALD), primary sclerosing cholangitis (PSC) and multiple sclerosis (MS).

Methods: We conducted a matched population-based cohort study using health administrative data from Ontario, Canada. Read More

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September 2021

[Correlation between aspiration and long-term survival of inpatients with chronic obstructive pulmonary disease].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Sep;44(9):800-805

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.

To retrospectively analyze the high risk factors of death in patients with chronic obstructive pulmonary disease (COPD) and to explore the influence of aspiration on the long-term survival rate of COPD patients. A retrospective analysis of clinical data of inpatients, who were admitted to the First Affiliated Hospital of Guangzhou Medical University from April 2012 to December 2013 due to COPD exacerbations and had radionuclide aspiration test, was conducted. Meanwhile, we phoned the patients' family members, whose phone numbers were recorded in the electronic patient record system, to follow up the patients' survival status, and learn the causes of death from their death records if patients died during follow-up period. Read More

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September 2021

Secukinumab provides sustained improvement in nail psoriasis, signs and symptoms of psoriatic arthritis and low rate of radiographic progression in patients with concomitant nail involvement: 2-year results from the Phase III FUTURE 5 study.

Clin Exp Rheumatol 2021 Sep 3. Epub 2021 Sep 3.

Novartis Pharma AG, Basel, Switzerland.

Objectives: To evaluate the impact of secukinumab on nail psoriasis and other psoriatic disease manifestations in patients with psoriatic arthritis (PsA) with concomitant nail psoriasis from the FUTURE 5 study.

Methods: Eligible patients were randomly allocated to receive subcutaneous secukinumab (300 mg load [300 mg], 150 mg load [150 mg], and 150 mg [no load]) or placebo weekly and then every 4 weeks starting Week 4. Key assessments through Week 104 in this post hoc analysis included modified Nail Psoriasis Severity (mNAPSI), Psoriasis Area and Severity Index (PASI 90), resolution of dactylitis and enthesitis, Dermatology Life Quality Index (DLQI) and radiographic progression (assessed by vdH-mTSS). Read More

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September 2021

Influence of surface topography on PCL electrospun scaffolds for liver tissue engineering.

J Mater Chem B 2021 Sep 7. Epub 2021 Sep 7.

Institute of Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, UK.

Severe liver disease is one of the most common causes of death globally. Currently, whole organ transplantation is the only therapeutic method for end-stage liver disease treatment, however, the need for donor organs far outweighs demand. Recently liver tissue engineering is starting to show promise for alleviating part of this problem. Read More

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September 2021