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Retrospective evaluation of gastrointestinal foreign bodies and presurgical predictors for enterectomy versus enterotomy in dogs (2013-2016): 82 cases.

J Vet Emerg Crit Care (San Antonio) 2021 Sep 23. Epub 2021 Sep 23.

Department of Clinical Studies, Matthew J. Ryan Veterinary Teaching Hospital, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objective: To evaluate preoperative diagnostics in dogs with gastrointestinal foreign body (GIFB) obstruction and to identify clinical variables associated with the performance of simple enterotomy (EO) versus enterectomy (EC).

Design: Retrospective case control study from October 2013 to January 2016.

Setting: Veterinary Teaching Hospital. Read More

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September 2021

Fabrication and field emission properties of vertical, tapered GaN nanowires etched via phosphoric acid.

Nanotechnology 2021 Sep 23. Epub 2021 Sep 23.

Advanced Materials Sciences, Sandia National Laboratories, P.O Box 5800, Albuquerque, New Mexico, 87185-5820, UNITED STATES.

The controlled fabrication of vertical, tapered, and high-aspect ratio GaN nanowires via a two-step top-down process consisting of an inductively couple plasma reactive ion etch (ICP-RIE) followed by a hot, 85% H3PO4 crystallographic wet etch is explored. The vertical nanowires are oriented in the [0001] direction and are bound by sidewalls comprising of {336-2} semipolar planes which are at a 12° angle from the [0001] axis. High temperature H3PO4 etching between 60 and 95°C result in smooth semipolar faceting with no visible micro-facets, whereas a 50°C etch reveals a micro-faceted etch evolution. Read More

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September 2021

Otolith mass asymmetry in three sparid fish species collected from the Iraqi waters.

Mar Pollut Bull 2021 Sep 20;173(Pt A):112968. Epub 2021 Sep 20.

University of South Bohemia, Faculty of Agriculture, Department of Animal Science, České Budějovice, Czech Republic.

Saccular otolith mass asymmetry is examined in three sparid fish species, Acanthopagrus bifasciatus, A. arabicus, and Sparidentex hasta collected from Khor Abdullah at the North Persian Gulf. This characteristic was computed as the disparity between the weight of the right and left otoliths divided by mean otolith weight in the three sparid species investigated. Read More

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September 2021

Relationship between carbohydrate-to-fat intake ratio and the development of chronic kidney disease: A community-based prospective cohort study.

Clin Nutr 2021 Sep 9;40(10):5346-5354. Epub 2021 Sep 9.

Division of Nephrology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea; Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: It is well-known that high protein intake is associated with renal hyperfiltration and faster renal function decline, but the association of other macronutrients, carbohydrate and fat, with development of chronic kidney disease (CKD) is still inconclusive. Therefore, we aimed to examine the relationship between fat-to-carbohydrate intake ratio (F/C ratio) and incident CKD.

Methods: We included 9226 subjects from the Korean Genome and Epidemiology Study. Read More

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September 2021

Binary combinations of thymol, carvacrol and eugenol for Amblyomma sculptum control: Evaluation of in vitro synergism and effectiveness under semi-field conditions.

Ticks Tick Borne Dis 2021 Sep 3;12(6):101816. Epub 2021 Sep 3.

Post-graduate program in Animal Science, Federal University of Goiás (UFG). Avenida Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74.690-900 Brazil; Institute of Tropical Pathology and Public Health, Federal University of Goiás (UFG). Rua 235, s/n, Setor Universitário, Goiânia, Goiás, 74605-050 Brazil. Electronic address:

This study aimed to investigate the in vitro acaricidal effect of thymol, carvacrol and eugenol (binary combinations) and their synergistic effect on unfed larvae and nymphs of Amblyomma sculptum, estimate the cost to prepare a formulation with these compounds, and evaluate the formulations under semi-field conditions against A. sculptum larvae. To evaluate the acaricidal effect of the compounds alone or their binary combinations (1:1 ratio) the larval packet test was performed using six concentrations (0. Read More

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September 2021

Self-harm in children and adolescents by ethnic group: an observational cohort study from the Multicentre Study of Self-Harm in England.

Lancet Child Adolesc Health 2021 Sep 20. Epub 2021 Sep 20.

Centre for Mental Health and Safety, School of Health Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK; The National Institute for Health Research Greater Manchester Patient Safety Translational Research Centre, Manchester, UK.

Background: Studies report an increasing incidence of self-harm in children and adolescents, but the extent to which this is seen in different ethnic groups is unclear. We aimed to investigate rates of emergency department presentations for self-harm in children and adolescents by ethnicity, as well as to examine their demographic characteristics, clinical characteristics, and outcomes.

Methods: In this observational cohort study, we used data on hospital emergency department presentations for self-harm in children and adolescents aged 10-19 years between 2000 and 2016 from the Multicentre Study of Self-harm in England. Read More

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September 2021

Blink index as a response predictor of blepharospasm to botulinum neurotoxin-A treatment.

Brain Behav 2021 Sep 23:e2374. Epub 2021 Sep 23.

Department of Ophthalmology, CHA Bundang Medical Center, College of Medicine, CHA University, Seongnam, Republic of Korea.

Purpose: We investigated the blink profiles and blink index using ocular surface interferometer in the patients with blepharospasm (BSP) and identified points to consider predictive factor after BSP treatment.

Methods: In total, 117 eyelids of 59 elderly patients and 20 eyelids of 10 age-matched control group were studied. All BSP patients applied botulinum toxin-A (BoNT-A) injection for treatment of BSP. Read More

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September 2021

Non-invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea.

Cochrane Database Syst Rev 2021 Sep 23;9:CD013169. Epub 2021 Sep 23.

Cochrane Afilliate Rio de Janeiro, Cochrane, Petrópolis, Brazil.

Background: Obstructive sleep apnoea syndrome (OSAS) is associated with several chronic diseases, including erectile dysfunction (ED). The association of OSAS and ED is far more common than might be found by chance; the treatment of OSAS with non-invasive positive airway pressure therapy is associated with improvement of respiratory symptoms, and may contribute to the improvement of associated conditions, such as ED.

Objectives: To assess the effectiveness and acceptability of non-invasive positive airway pressure therapy for improving erectile dysfunction in OSAS. Read More

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September 2021

Advanced radiotherapy technique in hepatocellular carcinoma with portal vein thrombosis: Feasibility and clinical outcomes.

PLoS One 2021 23;16(9):e0257556. Epub 2021 Sep 23.

Faculty of Medicine, Division of Radiation Oncology, Department of Radiology, Chulalongkorn University, Bangkok, Thailand.

Background: In Thailand, individuals with hepatocellular carcinoma (HCC) who develop portal vein tumor thrombosis (PVTT) have a restricted treatment option because to the extent of the disease, poor underlying liver function, and non-coverage of immuno/targeted therapy. Radiotherapy (RT) plays an increasingly important function in these patients. To investigate the feasibility, efficacy, and adverse event rates, we performed a retrospective analysis of patients with HCC with PVTT who underwent 3-dimensional conformal radiation (3DCRT), intensity-modulated radiation (IMRT), volumetric-modulated radiotherapy (VMAT), and stereotactic body radiotherapy (SBRT) in a single-institution. Read More

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September 2021

Allograft Versus Autograft Osteochondral Transplant for Chondral Defects of the Talus: Systematic Review and Meta-analysis.

Am J Sports Med 2021 Sep 23:3635465211037349. Epub 2021 Sep 23.

Department of Orthopedic, Trauma, and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.

Background: It is unclear whether the results of osteochondral transplant using autografts or allografts for talar osteochondral defect are equivalent.

Purpose: A systematic review of the literature was conducted to compare allografts and autografts in terms of patient-reported outcome measures (PROMs), MRI findings, and complications.

Study Design: Systematic review; Level of evidence, 4. Read More

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September 2021

Hyperbaric oxygen treatment for University of Texas grade 3 diabetic foot ulcers: a retrospective cohort study.

J Wound Care 2021 Sep;30(9):722-728

Amsterdam University Medical Centers, Department of Anesthesiology, Amsterdam, the Netherlands.

Aim: Hard-to-heal diabetic foot ulcers (DFUs) may increase the risk of amputation. This study reports the positive influence of hyperbaric oxygen therapy (HBOT) on hard-to-heal DFUs involving underlying bone.

Method: A single-centre, retrospective cohort study reporting the results of HBOT and wound care on hard-to-heal University of Texas grade 3 DFUs (i. Read More

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September 2021

Impact of Mobile Technologies on Cervical Cancer Screening Practices in Lagos, Nigeria (mHealth-Cervix): A Randomized Controlled Trial.

JCO Glob Oncol 2021 Aug;7:1418-1425

Department of Obstetrics and Gynaecology, Stanford University School of Medicine, Stanford, CA.

Purpose: We assessed the impact of mHealth on Pap test screening uptake and also determined the factors that affect screening uptake among women in Lagos, Nigeria.

Materials And Methods: A randomized controlled trial was carried out among women in two tertiary health institutions in Lagos, Nigeria, between July 2020 and March 2021. Participants were randomly assigned to either a text message (mHealth) intervention or usual care arm. Read More

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Efficacy of Intrawound Treatments to Prevent Surgical Site Infection after Spine Surgery: A Systematic Review and Network Meta-analysis.

Pain Physician 2021 Sep;24(6):E709-E720

Department of Orthopedic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Intrawound treatments have been reported to have favorable efficacy for preventing surgical site infection (SSI); however, the best strategy remains unknown.

Objective: The aim of this systematic review and network meta-analysis was to evaluate the efficacy of intrawound treatments to prevent SSI after spine surgery.

Study Design: A systematic review and network meta-analysis. Read More

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September 2021

Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial.

J Cachexia Sarcopenia Muscle 2021 Sep 23. Epub 2021 Sep 23.

Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: The potential effects of aerobic and resistance training in patients with severe chronic kidney disease (CKD) are not fully elucidated. This study investigated the effects of a home-based exercise programme on physical functioning and health-related quality of life (HRQOL) in patients with Stage 4 CKD, equivalent to estimated glomerular filtration rate of 15-30 mL/min/1.73 m . Read More

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September 2021

Variability in estimated glomerular filtration rate and patients' outcomes in a real-world heart failure population.

ESC Heart Fail 2021 Sep 23. Epub 2021 Sep 23.

Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Aims: The prognostic significance of renal function variability has not been fully elucidated in heart failure (HF). This multicentre, prospective cohort study aimed to evaluate the usefulness of visit-to-visit variability in estimated glomerular filtration rate (eGFR) for predicting patients' outcomes in a real-world HF population.

Methods: A total of 564 patients who had survived HF hospitalization were randomly assigned with a 2:1 ratio to derivation and validation cohorts, and they were then followed after discharge. Read More

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September 2021

Renoprotection by long-term low-dose tolvaptan in patients with heart failure and hyponatremia.

ESC Heart Fail 2021 Sep 23. Epub 2021 Sep 23.

Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.

Aims: In previous randomized controlled trials, the use of tolvaptan (TLV) at a fixed dose of 30 mg/day for 1 year did not provide renal benefits in patients with heart failure (HF). This retrospective, cohort study examined the renoprotective effects of long-term, flexible-dose, and lower-dose TLV use.

Methods And Results: Tolvaptan users were defined as patients receiving TLV for at least 180 consecutive days or those who continued it until death, any cardiac events, or renal replacement therapy even if it was taken for <180 days. Read More

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September 2021

Impact of preoperative comorbidities on postoperative complication rate and outcome in surgically resected non-small cell lung cancer patients.

Gen Thorac Cardiovasc Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Thoracic Surgery, Zurich University Hospital, Raemistrasse 100, 8091, Zurich, Switzerland.

Objective: This study aimed to analyze whether comorbidities impact postoperative complication rate or survival after anatomical lung resection for non-small cell lung cancer (NSCLC).

Methods: A retrospective analysis of 1219 patients who underwent NSCLC resection between 2000 and 2015 was performed. Analyzed comorbidities included chronic obstructive lung disease (COPD), hypertension, coronary artery disease (CAD), peripheral artery disease, myocardial infarction history, diabetes mellitus, renal insufficiency and other malignancies. Read More

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September 2021

Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.

JAMA Netw Open 2021 Sep 1;4(9):e2124750. Epub 2021 Sep 1.

Lung Cancer Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Importance: Although the incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have been thought to have increased during the past decades, updated epidemiologic and survival data are lacking.

Objectives: To conduct an epidemiologic and survival analysis of the largest cohort of patients with GEP-NETs using the latest data and to establish a novel nomogram to predict the survival probability of individual patients with GEP-NETs.

Design, Setting, And Participants: In this cohort study, 43 751 patients with GEP-NETs diagnosed from January 1, 1975, to December 31, 2015, were identified from the Surveillance, Epidemiology, and End Results Program. Read More

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September 2021

Thyroid Lobectomy for T1 Papillary Thyroid Carcinoma in Pediatric Patients.

JAMA Otolaryngol Head Neck Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia.

Importance: The current recommendation for pediatric patients with papillary thyroid cancer (PTC) is a total thyroidectomy. This recommendation applies to all stages of PTC, including papillary thyroid microcarcinoma (≤1 cm, T1a) tumors.

Objective: To evaluate the characteristics of American Joint Committee on Cancer T1 PTC tumors in a large pediatric population and to identify a subgroup of patients who may benefit from a thyroid lobectomy instead of a total thyroidectomy. Read More

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September 2021

Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial.

JAMA Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Isocitrate dehydrogenase 1 (IDH1) variations occur in up to approximately 20% of patients with intrahepatic cholangiocarcinoma. In the ClarIDHy trial, progression-free survival as determined by central review was significantly improved with ivosidenib vs placebo.

Objective: To report the final overall survival (OS) results from the ClarIDHy trial, which aimed to demonstrate the efficacy of ivosidenib (AG-120)-a first-in-class, oral, small-molecule inhibitor of mutant IDH1-vs placebo for patients with unresectable or metastatic cholangiocarcinoma with IDH1 mutation. Read More

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September 2021

Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.

JAMA Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Human Oncology, University of Wisconsin, Madison.

Importance: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.

Objectives: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate differences in survival, particularly after treatment with androgen-signaling inhibitors (ASIs). Read More

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September 2021

Wnt/β-catenin pathway proteins in end-stage renal disease.

Biomark Med 2021 Sep 23. Epub 2021 Sep 23.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

To delineate the association of end-stage renal disease (ESRD) and Wnt-proteins including the agonist R-spondin-1, the transducer β-catenin and the antagonists DKK1 and sclerostin. Serum Wnt-pathway proteins levels were measured by ELISA in 60 ESRD patients and 30 normal controls. DKK1 and sclerostin were significantly higher in ESRD than in controls, and β-catenin and the catenin + R-sponin-1/DKK1 + sclerostin ratio, reflecting the ratio of agonist and transducer on antagonists (AT/ANTA), were significantly lower in ESRD. Read More

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September 2021

Dual-Functional MgO Nanocrystals Satisfying Both Polysulfides and Li Regulation toward Advanced Lithium-Sulfur Full Batteries.

Small 2021 Sep 22:e2103744. Epub 2021 Sep 22.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, and State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Lithium-sulfur battery (LSB) is regarded as a preferential option for next-generation energy-storage system, but the lithium polysulfides (LiPSs) shuttling effect and the uncontrollable growth of dendritic Li in the anode impede its commercial viability. To address both of the issues simultaneously, a well-designed hybrid of MgO ultrafine nanocrystals dispersed on graphene-supported carbon nanosheets (MCG) is developed via a facile self-template strategy as dual-functional host for both sulfur and lithium. Relying on the coordination of strong LiPS-capturing capability, the shuttling effect is inhibited. Read More

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September 2021

Malignant Transformation and Treatment Recommendations of Chronic Hyperplastic Candidiasis- A Six-year Retrospective Cohort Study.

Mycoses 2021 Sep 22. Epub 2021 Sep 22.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, PR China.

Background: Oral chronic hyperplastic candidiasis (CHC) is the most uncommon type of oral candidiasis with diverse manifestations. Up to date the diagnosis, long term management and prognosis of this oral potentially malignant disorder remain obscure.

Objectives: The aim of this study was to provide the recommendations guiding the diagnostic procedure, clinical management and prognosis assessment of CHC. Read More

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September 2021

Use of dipyridamole is associated with lower risk of lymphoid neoplasms: a propensity score-matched cohort study.

Br J Haematol 2021 Sep 23. Epub 2021 Sep 23.

Department of Clinical Sciences Malmö, Center for Primary Health Care Research, Lund University, Lund, Sweden.

The anti-cancer potential of dipyridamole has been suggested from experiments, but evidence from population-based studies is still lacking. We aimed to explore if dipyridamole use was related to a lower risk of lymphoid neoplasms. We identified individuals with prescription of aspirin after diagnosis of ischaemic cerebrovascular disease since 2006 by linking several Swedish registers. Read More

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September 2021

Methionine restriction exposes a targetable redox vulnerability of triple-negative breast cancer cells by inducing thioredoxin reductase.

Breast Cancer Res Treat 2021 Sep 22. Epub 2021 Sep 22.

Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.

Purpose: Tumor cells are dependent on the glutathione and thioredoxin antioxidant pathways to survive oxidative stress. Since the essential amino acid methionine is converted to glutathione, we hypothesized that methionine restriction (MR) would deplete glutathione and render tumors dependent on the thioredoxin pathway and its rate-limiting enzyme thioredoxin reductase (TXNRD).

Methods: Triple (ER/PR/HER2)-negative breast cancer (TNBC) cells were treated with control or MR media and the effects on reactive oxygen species (ROS) and antioxidant signaling were examined. Read More

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September 2021

High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study.

Ann Intensive Care 2021 Sep 22;11(1):139. Epub 2021 Sep 22.

CHU Bordeaux, Department of Nephrology-Transplantation-Dialysis-Apheresis, Hôpital Pellegrin, F-33000, Bordeaux, France.

Background: The optimal mean arterial pressure (MAP) in cases of septic shock is still a matter of debate in patients with prior hypertension. An MAP between 75 and 85 mmHg can improve glomerular filtration rate (GFR) but its effect on tubular function is unknown. We assessed the effects of high MAP level on glomerular and tubular renal function in two intensive care units of a teaching hospital. Read More

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September 2021

The impact of estradiol on pregnancy outcomes in letrozole-stimulated frozen embryo transfer cycles.

F S Rep 2021 Sep 27;2(3):320-326. Epub 2021 May 27.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.

Objective: To assess the impact of low estradiol (E2) levels in letrozole-stimulated frozen embryo transfer (FET) cycles on pregnancy and neonatal outcomes.

Design: Retrospective cohort.

Setting: University-affiliated fertility center. Read More

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September 2021