2,245 results match your criteria rate postsurgical

IL-12 inhibits postoperative residual tumor growth in murine models of sarcoma and renal carcinoma.

Anticancer Drugs 2021 Jun 17. Epub 2021 Jun 17.

School of Basic Medical Sciences, Qingdao University Kanglitai Pharmaceutical Co., Ltd., Qingdao, Shandong Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, China.

Background: Surgical tumor removing is the most common procedure after a confirmed cancer diagnosis with no detected metastasis. Surgery can reduce tumor burden and address pathologic changes caused by local compression of tissues by the tumor. This lowers the chances of tumor cell spreading and creates more favorable conditions for further treatment. Read More

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Transit Time Measurement in Indicator Dilution Curves: Overcoming the Missing Ground Truth and Quantifying the Error.

Front Physiol 2021 28;12:588120. Epub 2021 May 28.

Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany.

The vascular function of a vessel can be qualitatively and intraoperatively checked by recording the blood dynamics inside the vessel via fluorescence angiography (FA). Although FA is the state of the art in proving the existence of blood flow during interventions such as bypass surgery, it still lacks a quantitative blood flow measurement that could decrease the recurrence rate and postsurgical mortality. Previous approaches show that the measured flow has a significant deviation compared to the gold standard reference (ultrasonic flow meter). Read More

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Impact of Opioid Prescribing Guidelines on Postoperative Opioid Prescriptions Following Elective Spine Surgery: Results From an Institutional Quality Improvement Initiative.

Neurosurgery 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: With a dramatic rise in prescription opioid use, it is imperative to review postsurgical prescribing patterns given their contributions to the opioid epidemic.

Objective: To evaluate the impact of departmental postoperative prescribing guidelines on opioid prescriptions following elective spine surgery.

Methods: Patients undergoing elective cervical or lumbar spine surgery between 2017 and 2018 were identified. Read More

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Impact of intermediate to high-doses of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation.

Int J Clin Pract 2021 Jun 9:e14479. Epub 2021 Jun 9.

Medical Director, Doctor Peset University Hospital, Valencia, Spain.

Introduction: In addition to respiratory support needs, patients´ characteristics to guide indication or timing of corticosteroid treatment in COVID-19 patients are not completely established. This study aimed to evaluate the impact of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation (PI-SSI).

Methods: Between March 9 and May 5, 2020 (final follow-up July 2, 2020), a retrospective cohort study was conducted in hospitalized patients with COVID-19 PI-SSI (≥2 inflammatory biomarkers (IB): temperature ≥38ºC, lymphocyte ≤800cell/microL, C-reactive protein ≥100mg/L, lactate dehydrogenase ≥300units/L, ferritin ≥1000mcg/L, D-dimer ≥500ng/mL). Read More

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Editorial Commentary: Tranexamic Acid Is Beneficial in the Very Early Postoperative Period in Anterior Cruciate Ligament Reconstruction Patients.

Arthroscopy 2021 Jun;37(6):1890-1891

National Yang-Ming University.

Tranexamic acid (TXA) has been administrated in many orthopaedic surgical procedures to decrease perioperative and postsurgical bleeding. Relatively scant literature exists regarding the effect of TXA in patients after anterior cruciate ligament reconstruction. Currently, most evidence shows that within about 1 month after anterior cruciate ligament reconstruction, TXA can effectively reduce postoperative joint swelling and pain, as well as the aspiration rate. Read More

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Can Preoperative Mapping with Functional MRI Reduce Morbidity in Brain Tumor Resection? A Systematic Review and Meta-Analysis of 68 Observational Studies.

Radiology 2021 Jun 1:204723. Epub 2021 Jun 1.

From the Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins Hospital, 600 N Wolfe St, Phipps B100F, Baltimore, MD 21287 (L.P.L., F.G.S., H.I.S.); Department of Neurosurgery, Johns Hopkins University, Baltimore, Md (D.M.); Department of Radiology, Hospital Geral de Fortaleza, Fortaleza, Brazil (I.B.O.); and Medical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Brazil (C.A.K.).

Background Preoperative functional MRI (fMRI) is one of several techniques developed to localize critical brain structures and brain tumors. However, the usefulness of fMRI for preoperative surgical planning and its potential effect on neurologic outcomes remain unclear. Purpose To assess the overall postoperative morbidity among patients with brain tumors by using preoperative fMRI versus surgery without this tool or with use of standard (nonfunctional) neuronavigation. Read More

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Role of -Acetylcysteine in the Treatment of Acute Nonacetaminophen, Nonalcoholic and Nonviral Hepatitis: A Meta-analysis.

J Can Assoc Gastroenterol 2021 Jun 15;4(3):125-130. Epub 2020 Jul 15.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Introduction: -acetylcysteine (NAC) has been extensively investigated for the use in acetaminophen and alcoholic hepatitis and is indicated in acetaminophen overdose. Studies assessing the effect of NAC on other forms of acute hepatitis in adult patients are limited and therefore here we aimed at evaluating the effect of NAC on survival in nonacetaminophen, nonalcoholic and nonviral hepatitis in adults.

Methods: A comprehensive literature search up to September 2019 was completed for randomized controlled trials (RCTs) comparing NAC to placebo in the management of acute nonacetaminophen, nonalcoholic and nonviral hepatitis. Read More

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An investigation of the effectiveness of oral cyclosporine on perioperative myocardial injury (PMI) in patients who undergo the surgical procedure of coronary artery bypass graft (CABG): A Randomized Controlled Clinical Trial.

J Family Med Prim Care 2021 Feb 27;10(2):675-680. Epub 2021 Feb 27.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Routine clinical strategies for the prevention of myocardial infarction (MI) during the surgical procedure of CABG include cross-clamp fibrillation and cardioplegia have failed to decrease the risk of perioperative myocardial injury (PMI). Cyclosporine-A (CsA) might be able to prevent mitochondrial dysfunction and PMI.

Methods: In the present clinical trial, patients were divided into two groups (Case receive 2. Read More

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February 2021

Total Knee Arthroplasty Postsurgical Chronic Pain, Neuropathic Pain, and the Prevalence of Neuropathic Symptoms: A Prospective Observational Study in Turkey.

J Pain Res 2021 19;14:1315-1321. Epub 2021 May 19.

Sakarya University Faculty of Medicine, Department of Orthopedics and Traumatology, Sakarya, Turkey.

Purpose: Chronic post-surgical pain (CPSP) is a detrimental condition that persists at least two months after surgical procedures and seriously affects patients' quality of life. Although its incidence varies according to operation types and definitions, its prevalence is between 3% and 85%. The purpose of this study is to evaluate the prevalence of CPSP and neuropathic pain in patients undergoing TKA for osteoarthritis. Read More

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Glypican-3 and hepatocyte paraffin-1 combined with alpha-fetoprotein as a novel risk scoring model for predicting early recurrence of hepatocellular carcinoma after curative resection.

Eur J Gastroenterol Hepatol 2021 May 21. Epub 2021 May 21.

Organ Transplantation Center, The First Affiliated Hospital, Kunming Medical University, Kunming Department of Transplantation, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: At present, the predictive model of postsurgical recurrence for hepatocellular carcinoma (HCC) is not well-established. The aim of this study was to develop a novel model for prediction of postsurgical recurrence and survival for HCC.

Patients And Methods: Data from 112 patients who underwent curative liver resection from June 2014 to June 2017 in the First Affiliated Hospital of Kunming Medical University were collected retrospectively. Read More

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Fracture risk in hypoparathyroidism: a systematic review and meta-analysis.

Osteoporos Int 2021 May 22. Epub 2021 May 22.

National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

In this meta-analysis, we analyzed 7 observational studies for assessing the fracture risk in patients with hypoparathyroidism (hypoPT). We found that the risk of vertebral fractures is increased by almost 2-fold, especially those with nonsurgical hypoPT.

Purpose: Patients with hypoPT have higher bone mineral density than age- and sex-matched controls. Read More

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Gastric Peroral Endoscopic Myotomy: A Specific Learning Curve.

J Clin Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

Rutgers Robert Wood Johnson Medical School, New Brunswick Ichan School of Medicine, Mount Sinai, New York, NY Borland Groover, Jacksonville, FL Hospital Juarez, Mexico City, Mexico.

Introduction: Gastric peroral endoscopic pyloromyotomy (G-POEM) is a novel option for patients with gastroparesis. It involves submucosal tunneling across the pylorus, followed by pyloromyotomy, and subsequent closure of the endoscopic tunnel. The aim of this study was to determine the learning curve for G-POEM. Read More

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Immediate single-tooth replacement with acellular dermal matrix allogeneic bone on sloped platform-switching implants: A case series.

Int J Oral Implantol (Berl) 2021 May;14(2):213-222

Achieving predictable success with implants in the aesthetic zone is essential for clinicians. Promoting marginal bone and stability of the gingival environment is key to obtaining a predictable aesthetic outcome. The present study aimed to describe a technique that combines a flapless approach to immediate extraction and placement of sloped implants, using an acellular dermal matrix to contain the coronal aspect of a deproteinised bovine bone mineral graft. Read More

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Right anterior mini thoracotomy approach for isolated aortic valve replacement: Early outcomes at a Canadian center.

J Card Surg 2021 Jul 18;36(7):2365-2372. Epub 2021 May 18.

Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, Calgary, Alberta, Canada.

Objective: The goal of this manuscript was to report the clinical outcomes of the initial series of 100 consecutive Right Anterior Mini Thoracotomy (RAMT) aortic valve replacement (AVR) implantations at a Canadian Center.

Methods: This retrospective study reported the clinical outcomes of the first 100 patients who underwent the RAMT approach for isolated surgical AVR in Calgary, Canada, between 2016 and 2020. Primary outcomes were death within 30 days of surgery and disabling stroke. Read More

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Spinal block and delirium in oncologic patients after laparoscopic surgery in the Trendelenburg position: A randomized controlled trial.

PLoS One 2021 17;16(5):e0249808. Epub 2021 May 17.

Department of Anaesthesiology, A.C.Camargo Cancer Center, São Paulo, Brazil.

Delirium is the most common postsurgical neurological complication and has a variable incidence rate. Laparoscopic surgery, when associated with the Trendelenburg position, can cause innumerable physiological changes and increase the risk of neurocognitive changes. The association of general anesthesia with a spinal block allows the use of lower doses of anesthetic agents for anesthesia maintenance and facilitates better control over postoperative pain. Read More

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Reliability of Postsurgical Soft Tissue Reaction Grading Scales for Bone-anchored Hearing Implants.

Otol Neurotol 2021 May 14. Epub 2021 May 14.

Department of Experimental Surgery Department of Pediatric Surgery, Faculty of Medicine, McGill University McGill Otolaryngology Sciences Laboratory, McGill University Health Centre - Research Institute Shriner's Hospital for Children's Canada Research Institute, Montreal, Quebec, Canada Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Utrecht, Utrecht, the Netherlands Division of Clinical Epidemiology and Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Faculty of Medicine, McGill University Department of Otolaryngology - Head and Neck Surgery, The Montreal Children's Hospital, Montreal, Quebec, Canada.

Objective: This study aims to assess and compare the reliability of the Holgers, the IPS, and the Tullamore scales for skin tolerability assessment of postoperative bone-anchored hearing implant images.

Study Design: A survey study and retrospective review of percutaneous osseointegrated auditory implant images for scoring using three skin classification scales.

Setting: McGill University Health Center, Montreal, Quebec, Canada. Read More

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Autologous Fat Injection for Augmentation Rhinoplasty: A Systematic Review.

Aesthet Surg J Open Forum 2021 Jun 2;3(2):ojab010. Epub 2021 Mar 2.

Emory University, Atlanta, GA, USA.

Background: Autologous fat has become more frequently used for nasal volume augmentation and nasal correction. Nasal lipofilling refers to the use of injectable autologous fat grafts for nonsurgical aesthetic corrections.

Objectives: This systematic review aims to assess the satisfaction, complication, and retention rates of fat injection in nasal shape corrections. Read More

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[F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the "Negative" Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Endocrine Surgery, Endokrines Zentrum Stuttgart, Diakonie-Klinikum Stuttgart, 70176 Stuttgart, Germany.

Background: The diagnostic performance of [F]fluoro-ethylcholine-PET-CT&4D-CT (FEC-PET&4D-CT) to identify parathyroid adenomas (PA) was analyzed when ultrasound (US) or MIBI-Scan (MS) failed to localize. Postsurgical one year follow-up data are presented.

Methods: Patients in whom US and MS delivered either incongruent or entirely negative findings were subjected to FEC-PET&4D-CT and cases from July 2017 to June 2020 were analyzed, retrospectively. Read More

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Minimally Invasive Laparoscopic Technique for Lymph Node Dissection in Penile Cancer: The Pelvic and Inguinal Single-Site Approach: PISA Technique.

Urology 2021 Apr 27. Epub 2021 Apr 27.

Servicio de Urología. Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Lymph node dissection(LND) remains the gold standard in the staging and treatment of locally advanced penile cancer(PC).

Objective: To describe our initial experience with a new minimally invasive inguinal and pelvic single-access laparoscopic approach,for performing LND in PC, first described in Urology by our group in 20153: the Pelvic and Inguinal Single Access(PISA) technique (Fig. 1). Read More

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Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model.

Oncoimmunology 2021 Apr 13;10(1):1912473. Epub 2021 Apr 13.

Department of Urology, Lausanne University Hospital and University of Lausanne, Lausanne, Swizterland.

High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of head and neck squamous-cell carcinoma (HNSCC) and thus therapeutic E7-vaccines may be used to control HPVHNSCC tumors. Herein we investigated the effects of an optimized nanoparticle-conjugated E7 long-peptide vaccine adjuvanted with CpG (NP-E7LP) in an orthotopic immunocompetent mouse model of HPVHNSCC which is based on injection of HPV16 E6/E7-expressing mEERL95-cells into the submental space. In absence of surgery, vaccination performed before or after tumor-cell injection decreased tumor growth or prolonged mice survival only marginally, despite the high numbers of vaccine-induced circulating E7-specific IFN-γ-secreting CD8 T-cells. Read More

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Efficacy and Safety of Ultrasound Cycloplasty for Refractory Glaucoma: A 3-Year Study.

J Glaucoma 2021 May;30(5):428-435

Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France.

Precis: Ultrasound cycloplasty (UCP) treatment using high-intensity focused ultrasound is an effective and safe therapy to reduce intraocular pressure (IOP) in patients with refractory glaucoma over a 3-year period.

Purpose: The purpose of this study was to evaluate the 3-year efficacy and safety of UCP in patients with refractory glaucoma.

Patients And Methods: In all, 104 patients with refractory glaucoma recruited from 2 university hospitals underwent UCP. Read More

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Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?

J Am Heart Assoc 2021 May 26;10(9):e019778. Epub 2021 Apr 26.

Department of Acute Critical Care and Disaster Medicine Tokyo Medical and Dental University Tokyo Japan.

Background Abnormal cardiac repolarization is observed in patients with epilepsy and can be associated with sudden death. We investigated whether structural brain abnormalities are correlated with abnormal cardiac repolarizations in patients with seizure or epilepsy. Methods and Results We retrospectively analyzed and compared 12-lead ECG parameters following seizures between patients with and without structural brain abnormalities. Read More

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Postoperative duration of opioid use and acute healthcare services use in cancer patients hospitalized for thoracic surgery.

J Surg Oncol 2021 Apr 24. Epub 2021 Apr 24.

Clinical and Health Informatics Research Group, Department of Medicine, McGill University, Montreal, Quebec, Canada.

Background: Postoperative pain control is an important cancer care component. However, opioid consumption has resulted in a surge of adverse events, with thoracic surgery patients having the highest rate of persistent use. The effect of opioid duration post-discharge and the risk of increased acute healthcare use in this population remains unclear. Read More

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Clinical and Economic Outcomes Associated With Use of Liposomal Bupivacaine Versus Standard of Care for Management of Postsurgical Pain in Pediatric Patients Undergoing Spine Surgery.

J Health Econ Outcomes Res 2021 Apr 14;8(1):29-35. Epub 2021 Apr 14.

Pacira BioSciences, Inc., Parsippany, NJ.

Approximately 60% of hospitalized children undergoing surgery experience at least 1 day of moderate-to-severe pain after surgery. Pain following spine surgery may affect opioid exposure, length of stay (LOS), and costs in hospitalized pediatric patients. This is a retrospective cohort analysis of pediatric patients undergoing inpatient primary spine surgery. Read More

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Acute Pain Predictors of Remote Postoperative Pain Resolution After Hand Surgery.

Pain Ther 2021 Apr 18. Epub 2021 Apr 18.

Division of Hand and Plastic Surgery, Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.

Introduction: Chronic postsurgical pain (CPSP) is a global issue with high prevalence. This study compared acute pain descriptors among patients undergoing carpal tunnel release (CTR) or trigger finger release (TFR). We hypothesized worst pain intensity on postoperative day (POD) 10 would be best to predict the time to pain resolution. Read More

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ESR1 as a recurrence-related gene in intrahepatic cholangiocarcinoma: a weighted gene coexpression network analysis.

Cancer Cell Int 2021 Apr 17;21(1):225. Epub 2021 Apr 17.

Department of Hepatic Surgery (II) of the Eastern Hepatobiliary Surgery Hospital, Navy Medical University, (Second Military Medical University), #225 Changhai Road, Shanghai, 200438, China.

Background: Intrahepatic cholangiocarcinoma (iCCA) is the second most common malignant hepatic tumor and has a high postoperative recurrence rate and a poor prognosis. The key roles of most tumor recurrence-associated molecules in iCCA remain unclear. This study aimed to explore hub genes related to the postsurgical recurrence of iCCA. Read More

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Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice.

Sci Rep 2021 Apr 16;11(1):8376. Epub 2021 Apr 16.

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Postoperative delirium is a common neuropsychiatric syndrome resulting a high postsurgical mortality rate and decline in postdischarge function. Extensive research has been performed on both human and animal delirium-like models due to their clinical significance, focusing on systematic inflammation and consequent neuroinflammation playing a key role in the pathogenesis of postoperative cognitive dysfunctions. Since animal models are widely utilized for pathophysiological study of neuropsychiatric disorders, this study aimed at examining the validity of the scopolamine-induced delirium-like mice model with respect to the neuroinflammatory hypothesis of delirium. Read More

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Frequency and Temporal Distribution of Postoperative Respiratory Depressive Events.

Anesth Analg 2021 05;132(5):1206-1214

From the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Background: The frequency and temporal distribution of postoperative respiratory depression (RD) events are not completely understood. This study determined the temporal distribution and frequency of RD episodes in postsurgical patients continuously monitored by bedside capnography and pulse oximetry.

Methods: This was a post hoc study of a subset of postsurgical patients enrolled in The PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) trial from 2 sites in the United States. Read More

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Association between postsurgical pain and heart rate variability: protocol for a scoping review.

BMJ Open 2021 04 13;11(4):e044949. Epub 2021 Apr 13.

Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada

Introduction: Surgical interventions can elicit neuroendocrine responses and sympathovagal imbalance, ultimately affecting cardiac autonomic function. Cardiac complications account for 30% of postoperative complications and are the leading cause of morbidity and mortality following non-cardiac surgery. One cardiovascular parameter, heart rate variability (HRV), has been found to be predictive of postoperative morbidity and mortality. Read More

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The surgical management of the cavity and bone defects in enchondroma cases: A prospective randomized trial.

Surg Oncol 2021 Jun 5;37:101565. Epub 2021 Apr 5.

Science Research Department, Alexander Muss High School in Israel (AMHSI) Affiliated with Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon, Israel. Electronic address:

Background: We compared the curettage/bone grafting and the curettage/bone graft substitutes surgical techniques in their relation to functional outcomes, oncologic outcome (recurrence, malignant transformation), the rate of postsurgical complications, durations of surgery and of postsurgical immobilization for hand-localized cases of solitary and multiple enchondromas.

Methods: The current prospective randomized trial analyzed 200 adult patients (2012-2017) with enchondroma who underwent surgical intervention. The cases were randomly divided into Group 1 (n = 100; F 56, M 44) for surgeries with curettage and autogenous bone grafting, and Group 2 (n = 100; F 55, M 45) for surgeries with curettage and bone graft substitutes. Read More

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