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Pharmacokinetic profile, tissue residue depletion and anthelmintic efficacy of supramolecular fenbendazole.

Int J Pharm 2021 Jul 28:120957. Epub 2021 Jul 28.

Federal State Budget Scientific Institution "Federal Scientific Centre VIEV", B. Cheremushkinskaya street 28, 117218 Moscow, Russia.

A supramolecular complex of fenbendazole (SFBZ) with polyvinylpyrrolidone (PVP) was created by mechanochemical processing to increase its anthelmintic efficacy and to reduce the dose of applied drugs. The aim of our research was to study the pharmacokinetic profile and tissue residue depletion of fenbendazole (FBZ) and its metabolites: sulfoxide and sulfone in sheep after SFBZ treatment by high-performance liquid chromatography with tandem mass spectrometric detection and to evaluate its efficacy against gastrointestinal strongylatosis of sheep in field trials. The results revealed that FBZ and its metabolites were detected in blood serum in 2 hours after SFBZ administration and in 4-6 hours after the administration of the basic - FBZ. Read More

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Biological elimination of a high concentration of hydrogen sulfide from landfill biogas.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Université de Sherbrooke Water Research Group, Department of Civil and Building Engineering, Université de Sherbrooke, 2500 boul. de l'Université, Sherbrooke, Québec, J1K 2R1, Canada.

Hydrogen sulfide (HS) is one of the main contaminants found in biogas, which is one of the end products of the anaerobic biodegradation of proteins and other sulfur-containing compounds in solid waste. The presence of HS is one of the factors limiting the valorization of biogas. To valorize biogas, HS must be removed. Read More

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Optimal Control Strategies and Sensitivity Analysis of an HIV/AIDS-Resistant Model with Behavior Change.

Acta Biotheor 2021 Jul 30. Epub 2021 Jul 30.

School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Durban, South Africa.

Despite several research on HIV/AIDS, it is still incumbent to investigate more effective control measures to mitigate its infection level. Therefore, we introduce an HIV/AIDS-resistant model with behavior change and study its basic properties. In order to determine the most sensitive parameters that are responsible for disease transmission with respect to the basic reproduction number and those responsible for disease prevalence with respect to the endemic equilibrium, the sensitivity analysis was established and it was confirmed that the influx rate of people into the infected population and total abstinence from all risk practices and endemic areas are some of the most sensitive parameters for disease spread and disease eradication, respectively. Read More

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Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation: A Prospective, Multicenter Experience.

JACC Clin Electrophysiol 2021 Jul 19. Epub 2021 Jul 19.

Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA; Interventional Electrophysiology, Scripps Clinic, La Jolla, California, USA; Department of Cardiology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Objectives: The aim of this study was to evaluate the efficacy of radiofrequency (RF) energy applications targeting the atrial side of a significant residual leak in patients with acute and chronic evidence of incomplete percutaneous left atrial appendage (LAA) occlusion.

Background: RF applications have been proved to prevent recanalization of intracranial aneurysms after coil embolization, thereby favoring complete sealing. From a mechanistic standpoint, in vitro and in vivo experiments have demonstrated that RF promotes collagen deposition and tissue retraction. Read More

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Hyperchloremia and Postoperative Acute Kidney Injury in Adult Cardiac Patients: A Propensity-Matched Cohort Study.

J Cardiothorac Vasc Anesth 2021 Jul 8. Epub 2021 Jul 8.

Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Objectives: Hyperchloremia is a potential risk factor for acute kidney injury (AKI) in critically ill patients. However, the relationship between hyperchloremia and postoperative AKI in adult patients undergoing cardiovascular surgery with cardiopulmonary bypass (CPB) remains unclear. The authors aimed to determine whether postoperative hyperchloremia was associated with postoperative AKI in these populations. Read More

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Predicting biomass and hydrocarbon productivities and colony size in continuous cultures of Botryococcus braunii showa.

Bioresour Technol 2021 Jul 24;340:125653. Epub 2021 Jul 24.

Wageningen University, Bioprocess Engineering, AlgaePARC, PO Box 16, 6700 AA, Wageningen, the Netherlands.

Mathematical models were developed to predict biomass and hydrocarbon productivities and colony size (ouputs) of Botryococcus braunii showa cultures based on light intensity, temperature and dilution rate (inputs). These models predicted the following maximum values: biomass productivity, 1.3 g L d; hydrocarbon productivity, 1. Read More

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Hierarchical core-shell [email protected]@metallic oxide architecture: An efficient flame retardant and toxic smoke suppression for polystyrene.

J Colloid Interface Sci 2021 Jul 21;605:241-252. Epub 2021 Jul 21.

State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, China. Electronic address:

[email protected]@CuO and [email protected]@FeO are prepared in this study. Then SiO and its hybrids are incorporated into PS through solution blending method. The thermal stability, mechanical performance, combustion performance and smoke density of PS and its nanocomposite are investigated. Read More

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Molecules and fossils tell distinct yet complementary stories of mammal diversification.

Curr Biol 2021 Jul 23. Epub 2021 Jul 23.

Department of Ecology & Evolutionary Biology, Yale University, New Haven, CT 06511, USA; Center for Biodiversity and Global Change, Yale University, New Haven, CT 06511, USA. Electronic address:

Reconstructing the tempo at which biodiversity arose is a fundamental goal of evolutionary biologists, yet the relative merits of evolutionary-rate estimates are debated based on whether they are derived from the fossil record or time-calibrated phylogenies (timetrees) of living species. Extinct lineages unsampled in timetrees are known to "pull" speciation rates downward, but the temporal scale at which this bias matters is unclear. To investigate this problem, we compare mammalian diversification-rate signatures in a credible set of molecular timetrees (n = 5,911 species, ∼70% from DNA) to those in fossil genus durations (n = 5,320). Read More

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Dose-dense brentuximab vedotin plus ifosfamide, carboplatin, and etoposide for second-line treatment of relapsed or refractory classical Hodgkin lymphoma: a single centre, phase 1/2 study.

Lancet Haematol 2021 Aug;8(8):e562-e571

Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address:

Background: Relapsed or refractory classical Hodgkin lymphoma could be treated with multiagent salvage chemotherapy followed by autologous haematopoietic stem-cell transplantation. The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma.

Methods: We conducted a single-arm, open-label, phase 1/2 study of dose-dense BV-ICE at the Seattle Cancer Care Alliance, University of Washington (Seattle, WA, USA). Read More

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Mode-locked all-PM Nd-doped fiber laser near 910  nm.

Opt Lett 2021 Aug;46(15):3564-3567

We present a compact passively mode-locked fiber laser emitting near 910 nm with an all-polarization-maintaining fiber laser architecture. The ring-cavity laser configuration includes a core-pumped neodymium-doped fiber as a gain medium and a semiconductor saturable absorber mirror as a passive mode-locking element. A bandpass filter is used to suppress parasitic emission near 1. Read More

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Concentrating nutrients and recovering water and energy from source separated urine using osmotic microbial fuel cell.

Chemosphere 2021 Jul 13;285:131548. Epub 2021 Jul 13.

Institute of Physics, Academia Sinica, Taipei, 11529, Taiwan.

This work presents the use of osmotic microbial fuel cell (OsMFC), for the first time, to concentrate nutrients and recover water and energy from source separated urine. Four sets of concentration of fresh urine as feed and NaCl as draw were examined: 10% fresh urine vs 0.25 M NaCl; 10% fresh urine vs 2 M NaCl; fresh urine vs 0. Read More

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Slow pyrolysis of agro-food wastes and physicochemical characterization of biofuel products.

Chemosphere 2021 Jul 5;285:131431. Epub 2021 Jul 5.

Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Effective management and utilization of food waste and agricultural crop residues are highly crucial to mitigate the challenges of greenhouse gas generation upon natural decomposition and waste accumulation. Conversion of biogenic wastes to biofuels and bioproducts can address the energy crisis and promote environmental remediation. This study was focused on exploring the characteristics of food waste and agricultural crop residues (e. Read More

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The superior adsorption capacity of 2,4-Dinitrophenol under ultrasound-assisted magnetic adsorption system: Modeling and process optimization by central composite design.

J Hazard Mater 2021 Jun 8;418:126348. Epub 2021 Jun 8.

Department of Environmental Health Engineering, School of Public Health, Hamadan University of Medical Science, Hamadan, Iran.

2,4-Dinitrophenol (DNP) was listed as a priority pollutant; accordingly, DNP-contaminated effluent must be treated before discharging to the receiving resources. In the present study, the hybrid ultrasound-assisted GO-FeO system was employed to decontaminate DNP solution. Ultrasound irradiation makes the mass transfer of adsorbate improved and FeO enables GO separation from liquid phase under external magnetic field. Read More

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Strategic evaluation of limiting factors affecting algal growth - An approach to waste mitigation and carbon dioxide sequestration.

Sci Total Environ 2021 Jul 14;796:149049. Epub 2021 Jul 14.

School of Renewable Energy, Maejo University, Chiang Mai 50290, Thailand; College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address:

This work outlines major critical physico-chemical parameters that play a key role in increasing the fixation of CO from coal-fired flue gas CO into green microalgae biomass. Nitrogen concentration, gas flow rate, initial medium pH, and incident light intensity were determined to be the most important process variables with significant impact on CO fixation. Therefore, NaNO (500-3000 mg L), pH (6. Read More

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Sorption of endocrine disrupting compounds onto polyamide microplastics under different environmental conditions: Behaviour and mechanism.

Sci Total Environ 2021 Jul 10;796:148983. Epub 2021 Jul 10.

Instituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, RS, Brazil. Electronic address:

Microplastics of polyamide are commonly found in aquatic environments and might act as vectors of different contaminants such as endocrine disrupting compounds (EDC). Therefore, sorption of 17α-ethynylestradiol (EE2), 17β-estradiol (E2), and estriol (E3) on polyamide microplastics was studied under different simulated environments. The results suggest that the sorption process was affected by the presence of dissolved organic matter (DOM) and salinity, where both positive and negative effects were observed. Read More

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Effects of the mechanical response of low-permeability sandstone reservoirs on CO geological storage based on laboratory experiments and numerical simulations.

Sci Total Environ 2021 Jul 15;796:149066. Epub 2021 Jul 15.

Key Laboratory of Groundwater Resources and Environment, Ministry of Education, Jilin University, Changchun 130021, China.

Carbon dioxide (CO) geological storage (CGS) is an effective way for reducing greenhouse emissions. The injection of CO into the deep formation changes the pore pressure and effective stresses in the reservoir, thus leading to changes in stress-dependent porosity and permeability. These changes give feedback to the injection rate, migration, storage amount of CO in the target reservoir. Read More

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Evaluation of the efficacy of perineal urethrostomy for patients with anterior urethral stricture: insights from surgical and patient-reported outcomes.

World J Urol 2021 Jul 30. Epub 2021 Jul 30.

Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Purpose: To examine the efficacy of perineal urethrostomy (PU) in patients with anterior urethral stricture.

Methods: Patients who underwent PU for anterior urethral stricture between 2013 and 2020 were retrospectively reviewed (n = 56). Surgical success was defined as no need for additional intervention. Read More

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Augmentation of freshwater productivity in a single-slope solar still using ball marbles.

Environ Sci Pollut Res Int 2021 Jul 29. Epub 2021 Jul 29.

Solar Energy Laboratory, Department of Mechanical Engineering, National Institute of Technology Puducherry, of Puducherry, Karaikal, UT, 609609, India.

In the current research, the energy and economic performance in single-slope solar still using ball marbles (BMSS) has been investigated and compared the results with conventional solar still (CSS) under the similar weather conditions of Karaikal (10.92° N, 79.83° E), India, during October 2020. Read More

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Immune-Related lncRNA Signature for Predicting the Immune Landscape of Head and Neck Squamous Cell Carcinoma.

Front Mol Biosci 2021 13;8:689224. Epub 2021 Jul 13.

Department of Otorhinolaryngology, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.

Long non-coding RNA (lncRNA) plays a significant role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). This article aims to develop an immune-related lncRNA (irlncRNA) model, regardless of expression levels, for risk assessment and prognosis prediction in HNSCC patients. We obtained clinical data and corresponding full transcriptome expression of HNSCC patients from TCGA, downloaded GTF files to distinguish lncRNAs from Ensembl, discerned irlncRNAs based on co-expression analysis, distinguished differentially expressed irlncRNAs (DEirlncRNAs), and paired these DEirlncRNAs. Read More

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Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers.

Front Pharmacol 2021 13;12:696165. Epub 2021 Jul 13.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China.

Tebipenem pivoxil (TBPM-PI), an oral carbapenem antibiotic, has shown special advantages in pediatric infections and was in urgent need in China. Although pharmacokinetics, urinary excretion, and metabolite information of its active form tebipenem (TBPM) has been reported, ethnic differences may exist among the Chinese and Japanese population. By now, no systematic pharmacokinetics, urinary excretion, metabolites, or safety information has been revealed to the Chinese population. Read More

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Auxiliary Aids to Alleviate Pain and Anxiety during Local Anesthesia Administration: A Comparative Study.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):104-108

Department of Pedodontic and Preventive Dentistry, National Dental College and Hospital, Dera Bassi, Punjab, India.

Introduction: In dentistry, pain and anxiety have been the most challenging aspect in the management of a pediatric patient. When every effort to perform local anesthesia (LA) is not successful, the result would be more stressful for both the dentist and the patient. The so-called clichéd paradigm that "pain and dentistry are inseparable" can be resolved by updating the knowledge and skills of the practitioner by using the more advanced techniques in controlling and managing the pain. Read More

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Gas-liquid mass transfer characteristics of aviation fuel scrubbing in an aircraft fuel tank.

Sci Rep 2021 Jul 29;11(1):15426. Epub 2021 Jul 29.

College of Mechanical and Electrical Engineering, Xi'an Polytechnic University, Xi'an, China.

Dissolved oxygen evolving from aviation fuel leads to an increase in the oxygen concentration in an inert aircraft fuel tank ullage that may increase the flammability of the tank. Aviation fuel scrubbing with nitrogen-enriched air (NEA) can largely reduce the amount of dissolved oxygen and counteract the adverse effect of oxygen evolution. The gas-liquid mass transfer characteristics of aviation fuel scrubbing are investigated using the computational fluid dynamics method, which is verified experimentally. Read More

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Exercise and Heat Stress: Inflammation and the Iron Regulatory Response.

Int J Sport Nutr Exerc Metab 2021 Jul 29:1-6. Epub 2021 Jul 29.

Western Australian Institute of Sport.

This study determined the impact of heat stress on postexercise inflammation and hepcidin levels. Twelve moderately trained males completed three, 60-min treadmill running sessions under different conditions: (a) COOL, 18 °C with speed maintained at 80% maximum heart rate; (b) HOTHR, 35 °C with speed maintained at 80% maximum heart rate; and (c) HOTPACE, 35 °C completed at the average running speed from the COOL trial. Venous blood samples were collected pre-, post-, and 3-hr postexercise and analyzed for serum ferritin, interleukin-6 (IL-6), and hepcidin concentrations. Read More

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Thromboelastography predicts dual antiplatelet therapy-related hemorrhage in patients with acute ischemic stroke.

J Neurointerv Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Neurology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China

Background: Stratification of the risk of hemorrhage in patients with acute ischemic stroke following dual antiplatelet therapy (DAPT) is challenging. It remains unclear whether thromboelastography (TEG) can be used to predict DAPT-related hemorrhagic events.

Objective: The present study aims to discover predictors for hemorrhage events after DAPT based on parameters such as TEG. Read More

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Modelling the impact of delaying vaccination against SARS-CoV-2 assuming unlimited vaccine supply.

Theor Biol Med Model 2021 Jul 29;18(1):14. Epub 2021 Jul 29.

School of Medicine, University of Sao Paulo and LIM01-HCFMUSP, Sao Paulo, Brazil.

Background: At the moment we have more than 177 million cases and 3.8 million deaths (as of June 2021) around the world and vaccination represents the only hope to control the pandemic. Imperfections in planning vaccine acquisition and difficulties in implementing distribution among the population, however, have hampered the control of the virus so far. Read More

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Enhanced anaerobic digestion of swine manure via a coupled microbial electrolysis cell.

Bioresour Technol 2021 Jul 22;340:125619. Epub 2021 Jul 22.

Yunnan Normal University, Kunming 650500, PR China; Yunnan Research Center of Biogas Technology and Engineering, Kunming 650500, PR China; Jilin Dongsheng Institute of Biomass Energy Engineering, Tonghua 134118, PR China. Electronic address:

Microbial electrolysis cell coupled anaerobic digestion (MEC-AD) is a new technology in energy recovery and waste treatment, which could be used to recycle swine manure. Here, different applied voltage effects were studied using MEC-AD with swine manure as a substrate. The maximum cumulative biogas and methane yields, both occurring with 0. Read More

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Iron nanoparticles supported on N-doped carbon foam with honeycomb microstructure: An efficient potassium peroxymonosulfate activator for the degradation of fluoranthene in water and soil.

Chemosphere 2021 Jul 24;286(Pt 1):131603. Epub 2021 Jul 24.

College of Chemistry and Material Science, Shandong Agricultural University, Taian, 271018, Shandong, PR China. Electronic address:

A promising technology was developed for the remediation of fluoranthene (FLT) contaminated water and soil. Specifically, iron nanoparticles supported on N-doped carbon foam ([email protected]) was synthesized by in-situ impregnation and a unique calcination process using pine cone as the precursor. The obtained [email protected] was used as an activator of potassium peroxymonosulfate (PMS) to degrade FLT in water and soil. Read More

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Survival of Hepatitis A Virus on Two-month Stored Freeze-dried Berries.

J Food Prot 2021 Jul 29. Epub 2021 Jul 29.

US Food and Drug Administration 6502 S Archer Rd UNITED STATES Bedford Park IL 60501 1-630-822-5484.

Imported berries have contributed to U.S. hepatitis A virus (HAV) infections. Read More

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Nanoflakes-like nickel cobaltite as active electrode material for 4-nitrophenol reduction and supercapacitor applications.

J Hazard Mater 2021 Jun 27;419:126453. Epub 2021 Jun 27.

Photocatalysis International Research Center (PIRC), Tokyo University of Science, Yamazaki, Noda 278-8510, Chiba, Japan. Electronic address:

Catalytic reduction of nitroaromatic compounds present in wastewater by nanostructured materials is a promising process for wastewater treatment. A multifunctional electrode based on ternary spinal nickel cobalt oxide is used in the catalytic reduction of a nitroaromatic compound and supercapacitor application. In this study, we designed nanoflakes- like nickel cobaltite (NiCoO) using a simple, chemical, cost-effective hydrothermal method. Read More

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Evaluating psychotherapist competence: Testing the generalizability of clinical competence assessments of graduate trainees.

J Couns Psychol 2021 Jul 29. Epub 2021 Jul 29.

Department of Counseling Psychology.

Health service psychology (HSP) graduate programs are shifting from knowledge- to competency-based assessments of trainees' psychotherapy skills. This study used Generalizability Theory to test the dependability of psychotherapy competence assessments based on video observation of trainees. A 10-item rating form was developed from a collection of forms used by graduate programs ( = 102) in counseling and clinical psychology, and a review of the common factors research literature. Read More

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