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Demographics and long-term outcomes of children with end-stage kidney disease: a 20-year territory-wide study.

Nephrology (Carlton) 2021 Nov 26. Epub 2021 Nov 26.

Paediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong.

Aim: To evaluate the demographics and long-term patient outcomes of children with end-stage kidney disease in Hong Kong.

Methods: We conducted a cohort study at the Paediatric Nephrology Centre, the designated site providing kidney replacement therapy (KRT) for children in Hong Kong. The clinical characteristics and outcomes of all children who initiated chronic KRT before 19 years, between 2001-2020, were analyzed. Read More

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November 2021

Incidence and risk factors of gonococcal urethritis reinfection among Thai male patients in a multicenter, retrospective cohort study.

Sci Rep 2021 Nov 26;11(1):22992. Epub 2021 Nov 26.

Division of Dermatology, Department of Medicine, Phramongkutklao Hospital, Bangkok, 10400, Thailand.

Gonococcal urethritis (GU) is the second most common sexually transmitted infection (STI). Epidemiologic studies of the situation of GU reinfection and its related risk factors among patients with a history of GU in Thailand remain somewhat limited. A hospital-based retrospective cohort study was conducted between January 1, 2010 and December 31, 2020 to determine the incidence and risk factors of GU reinfection among male patients visiting in Royal Thai Army (RTA) Hospitals. Read More

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November 2021

Drug Resistance Profile and Clinical Features for Hepatitis C Patients Experiencing DAA Failure in Taiwan.

Viruses 2021 Nov 17;13(11). Epub 2021 Nov 17.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 10002, Taiwan.

About 4% of the population in Taiwan are seropositive for anti-HCV Ab and 70% with HCV RNA. To address this high chronic hepatitis C disease load, Taiwan National Health Insurance started reimbursing genotype-specific DAAs in 2017 and pangenotype DAAs in mid-2018. With a 97% SVR12 rate, there were still 2-3% of patients that failed to clear HCV. Read More

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November 2021

Effects of Mean Artery Pressure and Blood pH on Survival Rate of Patients with Acute Kidney Injury Combined with Acute Hypoxic Respiratory Failure: A Retrospective Study.

Medicina (Kaunas) 2021 Nov 14;57(11). Epub 2021 Nov 14.

Department of Life Sciences, and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.

In the intensive care unit (ICU), renal failure and respiratory failure are two of the most common organ failures in patients with systemic inflammatory response syndrome (SIRS). These clinical symptoms usually result from sepsis, trauma, hypermetabolism or shock. If this syndrome is caused by septic shock, the Surviving Sepsis Campaign Bundle suggests that vasopressin be given to maintain mean arterial pressure (MAP) > 65 mmHg if the patient is hypotensive after fluid resuscitation. Read More

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November 2021

Polyethylene Oxide as a Multifunctional Binder for High-Performance Ternary Layered Cathodes.

Polymers (Basel) 2021 Nov 19;13(22). Epub 2021 Nov 19.

School of New Energy, North China Electric Power University, Beijing 102206, China.

Nickel cobalt manganese ternary cathode materials are some of the most promising cathode materials in lithium-ion batteries, due to their high specific capacity, low cost, etc. However, they do have a few disadvantages, such as an unstable cycle performance and a poor rate performance. In this work, polyethylene oxide (PEO) with high ionic conductance and flexibility was utilized as a multifunctional binder to improve the electrochemical performance of LiNiCoMnO cathode materials. Read More

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November 2021

Experimental Investigation on Dynamic Tensile Behaviors of Engineered Cementitious Composites Reinforced with Steel Grid and Fibers.

Materials (Basel) 2021 Nov 20;14(22). Epub 2021 Nov 20.

Key Laboratory of Urban Security and Disaster Engineering, Beijing University of Technology, Ministry of Education, Beijing 100124, China.

Engineered cementitious composites (ECC) used as runway pavement material may suffer different strain rate loads such as aircraft taxiing, earthquakes, crash impacts, or blasts. In this paper, the dynamic tensile behaviors of the steel grid-polyvinyl alcohol (PVA) fiber and KEVLAR fiber-reinforced ECC were investigated by dynamic tensile tests at medium strain rates. The mixture was designed with different volume fractions of fibers and layer numbers of steel grids to explore the reinforcement effectiveness on the dynamic performance of the ECC. Read More

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November 2021

Direct Oral Anticoagulants versus Warfarin in Octogenarians with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis.

J Clin Med 2021 Nov 12;10(22). Epub 2021 Nov 12.

Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain.

Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF). This meta-analysis aims to assess the effect of DOACS vs. VKA in patients ≥ 80 and AF. Read More

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November 2021

Comparative Efficacy of Levetiracetam for Epilepsy in School-Aged Children with Intellectual Disability and Normal Intelligence.

Brain Sci 2021 Oct 31;11(11). Epub 2021 Oct 31.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Choosing optimal anti-seizure medication (ASM) is very important in pediatric patients with epilepsy who attend school, especially children with an intellectual disability (ID). Levetiracetam (LEV) has proven to be an effective, safe, generally well-tolerated, broad-spectrum ASM in children. In the context of increasing use of LEV in school-aged children with epilepsy and ID, we evaluate relevant clinical data, including efficacy, safety, and tolerability in children with epilepsy and an intellectual disability (ID) or normal intelligence (NI). Read More

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October 2021

Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India.

Int Ophthalmol 2021 Nov 25. Epub 2021 Nov 25.

Grandhi Mallikarjun Rao Varalakshmi Campus, L V Prasad Eye Institute, Vishakhapatnam, Andhra Pradesh, India.

Objective: To describe the clinical profile and microbiology trends in patients undergoing therapeutic keratoplasty at a multi-tier ophthalmology hospital network in India.

Methods: This cross-sectional hospital-based study included 3147 eyes undergoing therapeutic keratoplasty between Jan 2016 and Dec 2020 (5 years period) as cases. The demographic data, clinical profile and microbiological analysis were collected using an electronic medical record system. Read More

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November 2021

Comparison of False-Positive Versus True-Positive Findings on Contrast-Enhanced Digital Mammography.

AJR Am J Roentgenol 2021 Nov 24. Epub 2021 Nov 24.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Contrast-enhanced digital mammography (CEDM) has been shown to outperform standard mammography while performing comparably to contrast-enhanced MRI. To compare imaging characteristics of false-positive and true-positive findings on CEDM. This retrospective study included women who underwent baseline screening CEDM between January 2013 and December 2018 assessed as BI-RADS category 0, 3, 4, or 5 and who underwent biopsy with histopathologic diagnosis or had two-year imaging follow-up. Read More

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November 2021

Gestational Age and Neonatal Electrocardiograms.

Pediatrics 2021 Nov 24. Epub 2021 Nov 24.

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Interpretation of the neonatal electrocardiogram (ECG) is challenging due to the profound changes of the cardiovascular system in this period. We aimed to investigate the impact of gestational age (GA) on the neonatal ECG and create GA-specific reference values.

Methods: The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation of neonates. Read More

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November 2021

Increasing Oxygen Uptake in Cross-Country Skiers by Speed Variation in Work Intervals.

Int J Sports Physiol Perform 2021 Nov 22:1-7. Epub 2021 Nov 22.

Purpose: Accumulated time at a high percentage of peak oxygen consumption (VO2peak) is important for improving performance in endurance athletes. The present study compared the acute physiological and perceived effects of performing high-intensity intervals with roller ski double poling containing work intervals with (1) fast start followed by decreasing speed (DEC), (2) systematic variation in exercise intensity (VAR), and (3) constant speed (CON).

Methods: Ten well-trained cross-country skiers (double-poling VO2peak 69. Read More

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November 2021

Cryobiopsy as a reliable technique for the preoperative identification of micropapillary/solid components in early-stage lung adenocarcinoma.

Lung Cancer 2021 Nov 13;162:147-153. Epub 2021 Nov 13.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

Objectives: Micropapillary (MIP) and solid (SOL) subtypes of early-stage lung adenocarcinomas are associated with lymph node metastasis and local recurrence after limited resection. Preoperative identification of these components may influence the decisions of treatment strategy, additional lymph node evaluation, indication for limited resection, and extent of lymph node dissection. However, conventional biopsy specimens are insufficient for identifying these subtypes, especially MIP components. Read More

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November 2021

Cardiac Dose Control and Optimization Strategy for Left Breast Cancer Radiotherapy With Non-Uniform VMAT Technology.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211053752

Huadong Hospital, 535038Fudan University, Shanghai, China.

A novel in-house technology "Non-Uniform VMAT (NU-VMAT)" was developed for automated cardiac dose reduction and treatment planning optimization in the left breast radiotherapy. The NU-VMAT model based on I (gantry MLC Movement coefficient index) was established to optimize the volumetric modulated arc therapy (VMAT) MLC movement and modulation intensity in certain gantry angles. The ESAPI embedded in Eclipse® was employed to connect TPS and the optimization program via I/O relevant DICOM RT files. Read More

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November 2021

La K FeO: An Anion Intercalative Pseudocapacitive Electrode for Supercapacitor Application.

ACS Omega 2021 Nov 1;6(45):30488-30498. Epub 2021 Nov 1.

Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh 221005, India.

The green energy alternative to a fossil fuel-based economy can be provided only by coupling renewable energy solution solutions such as solar or wind energy plants with large-scale electrochemical energy storage devices. Enabling high-energy storage coupled with high-power delivery can be envisaged though high-capacitive pseudocapacitor electrodes. A pseudocapacitor electrode with multiple oxidation state accessibility can enable more than 1 charge/transfer per molecule to facilitate superior energy storage. Read More

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November 2021

Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma.

Am J Ophthalmol 2021 Nov 18. Epub 2021 Nov 18.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA. Electronic address:

Purpose: To evaluate the association of macular superficial vessel density (SVD) and projection-resolved deep vessel density (DVD) with past visual field (VF) progression in primary open angle glaucoma patients.

Design: Retrospective cohort MATERIALS AND METHODS: In this longitudinal study, 208 eyes of 147 glaucoma patients from the Diagnostics Innovations in Glaucoma Study were included. Eligible participants were required to have at least five 24-2 VF tests over a minimum follow-up period of 3 years prior to macular optical coherence tomography angiography (OCTA) imaging. Read More

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November 2021

Predictive factors of postoperative outcome in the elderly after resective epilepsy surgery.

Rev Neurol (Paris) 2021 Nov 17. Epub 2021 Nov 17.

Department of Clinical Neurosciences, Bordeaux University Hospital, Bordeaux, France.

Objective: To evaluate the efficiency of resective epilepsy surgery (RES) in patients over 50 years and determine prognostic factors.

Results: Over the 147 patients over 50 years (54.9±3. Read More

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November 2021

Long-term outcomes following thrombolysis of arteriovenous grafts.

J Vasc Access 2021 Nov 19:11297298211027470. Epub 2021 Nov 19.

Division of Vascular Surgery, Department of Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Background: Thrombolysis for arteriovenous grafts (AVG) yields high technical success rates, however, long-term outcomes are unclear. We conducted a multicenter retrospective cohort study to analyze 5-year patency rates following AVG thrombolysis.

Methods: All patients who underwent AVG thrombolysis between 2005 and 2015 at three academic hospitals were included. Read More

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November 2021

[The clinical value of further accurate staging of pT2 gastric cancer based on the depth of invasion].

Zhonghua Zhong Liu Za Zhi 2021 Nov;43(11):1197-1202

Department of External Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

To investigate the clinical value of pT2 gastric cancer staging pT2a and pT2b according to the depth of muscularis propria invasion in evaluating the prognosis of gastric cancer. According to the 8th edition of TNM staging system for gastric cancer proposed by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC), patients with gastric cancer who underwent radical surgery in the Fourth Hospital of Hebei Medical University from January 1, 2008 to January 1, 2015 were selected and divided into pT2a and pT2b stage group according to the depth of tumor invasion. The 5-year overall survival (OS) and disease-free survival (DFS) were compared between the two groups. Read More

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November 2021

High pre-diagnosis inflammation-related risk score associated with decreased ovarian cancer survival.

Cancer Epidemiol Biomarkers Prev 2021 Nov 17. Epub 2021 Nov 17.

Department of Preventive Medicine, University of Southern California.

Background There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined effects. Methods This analysis used pooled data on 8,147 women with invasive epithelial ovarian cancer from the Ovarian Cancer Association Consortium. Read More

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November 2021

Surveillance of liver function in uveitis with or without chronic HBV infection.

Ophthalmic Res 2021 Nov 15. Epub 2021 Nov 15.

Introduction: Immunosuppressive therapy for uveitis may cause liver damage.

Methods: To investigate incidence of liver damage during uveitis treatment, we compared serological Hepatitis B core antibody (HBcAb) status with risk of liver dysfunction in all participants (n=992), in anterior uveitis (AU) (n=489) and combined of intermediate, posterior or panuveitis patients (IPPU) (n=503). The primary endpoint was incidence of elevated serum ALT level above two-fold upper limits of normal (ULN) within 6 months. Read More

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November 2021

Deep Learning-Based Computer-Aided Detection System for Automated Treatment Response Assessment of Brain Metastases on 3D MRI.

Front Oncol 2021 27;11:739639. Epub 2021 Oct 27.

Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Although accurate treatment response assessment for brain metastases (BMs) is crucial, it is highly labor intensive. This retrospective study aimed to develop a computer-aided detection (CAD) system for automated BM detection and treatment response evaluation using deep learning.

Methods: We included 214 consecutive MRI examinations of 147 patients with BM obtained between January 2015 and August 2016. Read More

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October 2021

Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial.

Lancet 2021 Nov 9;398(10315):1984-1996. Epub 2021 Nov 9.

Pfizer, New York, NY, USA.

Background: Tofacitinib is an oral Janus kinase inhibitor. This trial assessed the efficacy and safety of tofacitinib versus placebo in patients with polyarticular course juvenile idiopathic arthritis (JIA).

Methods: This double-blind, withdrawal phase 3 trial enrolled patients with polyarticular course JIA (extended oligoarthritis, rheumatoid factor-positive or rheumatoid factor-negative polyarthritis, or systemic JIA without active systemic features) aged 2 years to younger than 18 years, and was done at 64 centres of the Paediatric Rheumatology International Trials Organisation and Pediatric Rheumatology Collaborative Study Group networks in 14 countries. Read More

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November 2021

The burden of injuries according to maturity status and timing: a two-decade study with 110 growth curves in an elite football academy.

Eur J Sport Sci 2021 Nov 12:1-21. Epub 2021 Nov 12.

Medical Services, Athletic Club, Barrio Garaioltza 147, 48196 Lezama, Spain.

Injuries have a negative impact on the development of football players. Maturation is a potential risk factor for football injuries but available data on this topic provide limited evidence due to methodological shortcomings. The aim of this study was to describe the injury burden of male academy football players according to growth curve-derived maturity status and timing. Read More

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November 2021

The Preventive Value of Acupoint Sensitization for Patients with Stable Angina Pectoris: A Randomized, Double-Blind, Positive-Controlled, Multicentre Trial.

Evid Based Complement Alternat Med 2021 2;2021:7228033. Epub 2021 Nov 2.

Chinese Evidence-based Medicine Centre, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: Acupoint sensitization is considered an important factor in the efficacy of acupoint therapy. This study aimed to evaluate the efficacy of acupressure in the prevention of stable angina pectoris using acupoints with different pressure-pain sensitivities.

Methods: A total of 202 patients were enrolled and randomly assigned to a high-sensitivity group (HSG) ( = 109) in which patients received acupressure at the five acupoints with the highest sensitivity to pain and a low-sensitivity group (LSG) ( = 93) in which patients received acupressure at the five acupoints with the lowest sensitivity to pain. Read More

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November 2021

Residual risk for clinically significant copy number variants in low-risk pregnancies, following exclusion of NIPS-detectable findings.

Am J Obstet Gynecol 2021 Nov 8. Epub 2021 Nov 8.

Genetics Institute, Carmel Medical Center, affiliated to the Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Background: Chromosomal microarray analysis (CMA) detects clinically significant copy number variants (CNVs) in about 1% of low-risk pregnancies. As the constantly growing wide use of non-invasive prenatal screening (NIPS) facilitates the detection of chromosomal aberrations, defining the rate of abnormal CMA findings following normal NIPS is of importance for informed decisions regarding prenatal testing and screening options.

Objective: To calculate the residual risk for clinically significant CNVs following theoretically normal NIPS. Read More

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November 2021

Influence of doctors' perception on the diagnostic status of chronic kidney disease: results from 976 409 individuals with electronic health records in China.

Clin Kidney J 2021 Nov 8;14(11):2428-2436. Epub 2021 May 8.

National Institute of Health Data Science at Peking University, Beijing, PR China.

Background: The diagnostic status of chronic kidney disease (CKD) and its underlying reasons provide evidence that can improve CKD management. However, the situation in developing countries remains under-investigated.

Methods: Adults with electronic health records (EHRs; 2008-19) in Yinzhou, China were included. Read More

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November 2021

Uterine serous carcinoma: role of surgery, risk factors and oncologic outcomes. Experience of a tertiary center.

Eur J Surg Oncol 2021 Oct 26. Epub 2021 Oct 26.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Objective: To evaluate factors impacting survival outcomes in patients with uterine serous carcinoma (USC).

Methods: Data of consecutive patients diagnosed with USC undergoing surgery between 2000 and 2020 at Fondazione IRCCS Istituto Nazionale Tumori of Milan (Italy) were reviewed. Progression-free (PFS) and overall survival (OS) outcomes were evaluated using Kaplan-Meier and Cox proportional hazard models. Read More

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October 2021

Association of Mental Stress-Induced Myocardial Ischemia With Cardiovascular Events in Patients With Coronary Heart Disease.

JAMA 2021 11;326(18):1818-1828

Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

Importance: Mental stress-induced myocardial ischemia is a recognized phenomenon in patients with coronary heart disease (CHD), but its clinical significance in the contemporary clinical era has not been investigated.

Objective: To compare the association of mental stress-induced or conventional stress-induced ischemia with adverse cardiovascular events in patients with CHD.

Design, Setting, And Participants: Pooled analysis of 2 prospective cohort studies of patients with stable CHD from a university-based hospital network in Atlanta, Georgia: the Mental Stress Ischemia Prognosis Study (MIPS) and the Myocardial Infarction and Mental Stress Study 2 (MIMS2). Read More

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November 2021

Differences in the torsional anharmonicity between reactant and transition state: the case of 3-butenal + H abstraction reactions.

Phys Chem Chem Phys 2021 Nov 17;23(44):25414-25423. Epub 2021 Nov 17.

Departamento de Físico-Química, Instituto de Química - Universidade Federal da Bahia, Rua Barão de Jeremoabo, 147, Salvador, Bahia, 40170-115, Brazil.

Thermal rate coefficients for the hydrogen-abstraction reactions of 3-butenal by a hydrogen atom were obtained applying multipath canonical variational theory with small-curvature tunneling (MP-CVT/SCT). Torsional anharmonicity due to the hindered rotors was taken into account by calculating the rovibrational partition function using the extended two-dimensional torsional (E2DT) method. For comparison, rovibrational partition functions were also estimated using the multistructural method with torsional anharmonicity based on a coupled torsional potential (MS-T(C)). Read More

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November 2021