39,146 results match your criteria rat skin

Effects of tamoxifen therapy on sciatic nerve crush injury: An experimental study in rats.

Acta Orthop Traumatol Turc 2021 Mar;55(2):87-93

Department of Pathology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.

Objective: This study aimed to determine the effects of tamoxifen on sciatic nerve crush injury in a rat model using histopathological, histomorphometric, and immunohistochemical approaches.

Methods: In this study, 24 male Sprague-Dawley rats aged of 5 to 7 weeks and weighing between 300 g and 400 g were used. The rats were randomly divided into 3 groups: control (group C), sciatic nerve injury (group SNI), and sciatic nerve injury with tamoxifen (group SNT). Read More

View Article and Full-Text PDF

Blue laser-induced selective vasorelaxation by the activation of NOSs.

Microvasc Res 2021 Apr 9:104165. Epub 2021 Apr 9.

Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, South Korea. Electronic address:

Phototherapy has been tried for treating cardiovascular diseases. In particular, ultraviolet and blue visible lights were suggested to be useful due to their nitric oxide (NO)-production ability in the skin. However, the effects of blue light on the arterial contractility is controversial. Read More

View Article and Full-Text PDF

Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats.

Channels (Austin) 2021 Dec;15(1):398-407

Department of Anesthesiology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.

Our previous studies have implicated Ca3.2 isoform of T-type Ca2+ channels (T-channels) in the development of postsurgical pain. We have also previously established that different T-channel antagonists can alleviate in vivo postsurgical pain. Read More

View Article and Full-Text PDF
December 2021

Bushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis.

Bioengineered 2021 Dec;12(1):1212-1225

Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Systemic sclerosis (SSc) refers to a group of autoimmune rheumatic diseases. Bushen Yijing decoction (BSYJ) is used for treating SSc. However, its underlying mechanism remains unknown. Read More

View Article and Full-Text PDF
December 2021

Phenolic, Antioxidant, Antimicrobial, and Wound Healing Properties of L. Root Extract in Diabetic Rats.

Iran J Pharm Res 2020 ;19(4):264-274

Department of Biology, Faculty of Science, Gazi University, 06500, Ankara, Turkey.

As stated in many ethnobotany studies, genus is traditionally used in the treatment of wound healing. In this study, we aimed to investigate to time-course effects of the methanolic extract of (MEPE) on diabetic wounds. The subject of the experiments was 36 Wistar rats, divided into three main groups: non-diabetic control (NDM), diabetic control (STZ-DM), and -treated (MEPE). Read More

View Article and Full-Text PDF
January 2020

Innervation of Meissner's corpuscles and Merkel -cells by transplantation of embryonic dorsal root ganglion cells after peripheral nerve section in rats.

J Tissue Eng Regen Med 2021 Apr 10. Epub 2021 Apr 10.

Department of Hand SurgeryNagoya University Graduate School of Medicine65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Objectives: Transplantation of embryonic motor neurons has been shown to improve motor neuron survival and innervation of neuromuscular junctions in peripheral nerves. However, there have been no reports regarding transplantation of sensory neurons and innervation of sensory receptors. Therefore, we hypothesized that transplantation of embryonic sensory neurons may improve sensory neuron in the skin and innervate Merkel cells and Meissner's corpuscles. Read More

View Article and Full-Text PDF

Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect.

J Nanobiotechnology 2021 Apr 9;19(1):100. Epub 2021 Apr 9.

Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Background: Carvedilol, the anti-hypertensive drug, has poor bioavailability when administered orally. Ethosomes-mediated transdermal delivery is considered a potential route of administration to increase the bioavailability of carvedilol. The central composite design could be used as a tool to optimize ethosomal formulation. Read More

View Article and Full-Text PDF

The Intra.Ox Near-Infrared Spectrometer Measures Variations in Flap Oxygenation That Correlate to Flap Necrosis in a Preclinical Rodent Model.

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine.

Background: Mastectomy flap necrosis affects 7 to 40 percent of patients undergoing immediate breast reconstruction, with many cases resulting in infection and/or explantation. The Intra.Ox near-infrared spectrometer is one of several novel devices that assesses tissue perfusion by measuring the interactions of light with oxygenated and deoxygenated hemoglobin. Read More

View Article and Full-Text PDF

Efficacy of Combined Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study.

Front Surg 2021 23;8:639661. Epub 2021 Mar 23.

Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Preventing surgical flaps necrosis remains challenging. Laser Doppler imaging and ultrasound can monitor blood flow in flap regions, but they do not directly measure the cellular response to ischemia. The study aimed to investigate the efficacy of synergistic electroporation-mediated gene transfer of interleukin 10 (IL-10) with either hepatocyte growth factor (HGF) or vascular endothelial growth factor (VEGF) on the survival of a modified McFarlane flap, and to evaluate the effect of the treatment on cell metabolism, using label-free fluorescence lifetime imaging. Read More

View Article and Full-Text PDF

The Comparison of Clinical and Histopathological Effects of Topical Psyllium () Powder and Silver Sulfadiazine on Second-Degree Burn Wound Healing in Rats.

World J Plast Surg 2021 Jan;10(1):96-103

Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Burn wounds are a worldwide health problem, leading to physical and psychological disabilities in all age's groups. With regard to absorbent properties of mucilage which can decrease wound moisture, we aimed to compare the effect of silver sulfadiazine (SSD) 1% and powdered on second-degree burn wound healing in rats.

Methods: This experimental study was conducted on 30 male Wistar rats with second-degree burn in three groups. Read More

View Article and Full-Text PDF
January 2021

Effect of White Tea () Extract on Skin Wound Healing Process in Rats.

World J Plast Surg 2021 Jan;10(1):85-95

Medical Plants Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: White tea () has anti-inflammatory and antioxidant properties and a protective effect against wrinkles, sunburn and UV damages on the skin. Thus, we aimed to evaluate the effect of white tea extract on the healing process of skin wounds in rats.

Methods: This study was done in the Research Center of Shahrekord University of Medical Sciences, Shahrekord, Iran in 2019. Read More

View Article and Full-Text PDF
January 2021

Toxicological evaluation of a glycan preparation from an enzymatic hydrolysis of Saccharomyces cerevisiae.

Regul Toxicol Pharmacol 2021 Apr 5:104924. Epub 2021 Apr 5.

Alltech France SARL, Rue Charles Amand, 14500 Vire, France.

The aim of this paper was to provide a comprehensive toxicological and safety evaluation of a yeast cell wall preparation (YCWP) for use as an animal feed ingredient. The following toxicological assessments were carried out: the mutagenic activity was tested using the Ames' Test in five Salmonella typhimurium strains; clastogenic activity was investigated using the mammalian micronucleus test in Swiss ICO OF1 (IOPS Caw) mice; genotoxic activity was assessed using the in vitro mammalian chromosomal aberration test in human lymphocytes; acute oral toxicity was tested by administration of a single dose of 2,000 mg/kg BW. Eye and skin irritation were assessed in rabbits according to OECD guidelines; skin sensitivity was established in guinea pigs by means of the Buehler test, while acute dermal and inhalation studies in rats were further completed, also according to OECD guidelines. Read More

View Article and Full-Text PDF

Clinical guideline for vascularized composite tissue cryopreservation.

J Tissue Eng Regen Med 2021 Mar 26. Epub 2021 Mar 26.

Department of Hand and Foot Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

At the Summit on Organ Banking through Converging Technologies held recently in Boston, tissue and organ cryopreservation technology was a topic of considerable interest. Although cryopreservation has been widely used in clinical practice, it currently remains limited to bloodless tissues with simple structures and functions that are small or thin, for example, ultra-thin skin, ovarian tissue slices, and other similar tissues. For whole organs, except for successful cryopreservation of rat ovaries (2002) and hind limbs (August 2002), successful cryopreservation of vascularized animal tissues or organs and their replantation have not yet been reported. Read More

View Article and Full-Text PDF

Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.

Mol Pain 2021 Jan-Dec;17:1744806921997206

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In the current study, we examined the therapeutic efficacy of the β2-AR agonist clenbuterol in a rat model of persistent postsurgical hypersensitivity induced by disruption of descending noradrenergic signaling in rats with plantar incision. We used growth curve modeling of ipsilateral mechanical paw withdrawal thresholds following incision to examine effects of treatment on postoperative trajectories. Read More

View Article and Full-Text PDF

Selective Denervation of the Facial Dermato-Muscular Complex in the Rat: Experimental Model and Anatomical Basis.

Front Neuroanat 2021 22;15:650761. Epub 2021 Mar 22.

Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.

The facial dermato-muscular system consists of highly specialized muscles tightly adhering to the overlaying skin and thus form a complex morphological conglomerate. This is the anatomical and functional basis for versatile facial expressions, which are essential for human social interaction. The neural innervation of the facial skin and muscles occurs via branches of the trigeminal and facial nerves. Read More

View Article and Full-Text PDF

Alleviating neuropathy of diabetic foot ulcer by co-delivery of venlafaxine and matrix metalloproteinase drug-loaded cellulose nanofiber sheets: production, in vitro characterization and clinical trial.

Pharmacol Rep 2021 Apr 7. Epub 2021 Apr 7.

Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The objective of the present study was co-delivery of venlafaxin (VEN) and doxycycline (DOX), a matrix metalloproteinase inhibitor drug, for alleviating inflammation and neuropathy in diabetic foot ulcer (DFU).

Methods: Bacterial cellulose nanofiber sheets (BCNS) were loaded with DOX and VEN and categorized by their loading efficiency, release profiles and ex vivo permeation throughrat skin. The optimized nanofibers were used in patients with DFU to compare with the standard wound care regimen during a 12-week trial. Read More

View Article and Full-Text PDF

Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects.

Stem Cell Res Ther 2021 Apr 6;12(1):226. Epub 2021 Apr 6.

Department of Plastic Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Background: Wound healing is impaired in patients with diabetes due to the multifactorial etiology of the disease, which limits the therapeutic efficacy of various approaches. This study hypothesizes that the combination of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) might achieve optimally efficient diabetic wound healing.

Methods: ADSCs were isolated from the adipose tissues of Sprague-Dawley (SD) rats. Read More

View Article and Full-Text PDF

Age-related changes in NG2-expressing telocytes of rat stomach.

PLoS One 2021 6;16(4):e0249729. Epub 2021 Apr 6.

Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Japan.

NG2 immunoreactive cells (NG2 cells) are found in the brain and peripheral tissues including the skin, intestinal tracts, and bladder. In a previous study, we observed the presence of NG2 cells in the stomach using bioluminescence imaging techniques in NG2-firefly luciferase (fLuc) transgenic (Tg) rats. Here, we aimed to identify and characterize NG2 cells in the adult rat stomach. Read More

View Article and Full-Text PDF

Extracellular Vesicles From a Three-Dimensional Culture of Perivascular Cells Accelerate Skin Wound Healing in a Rat.

Aesthetic Plast Surg 2021 Apr 5. Epub 2021 Apr 5.

Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, School of Medicine, Eulji University, 68, Hangeulbiseok-ro, Nowon-gu, Seoul, Republic of Korea.

Background: Soluble proteins and extracellular vesicles (EVs) are crucial wound repair mediators in cell-based therapy. Previous studies reported that EVs of perivascular cells stimulated migration and proliferation of cell types involved in the dermatological wound healing process. However, these studies only show effects of EVs from perivascular cells (PVCs) for in vitro models. Read More

View Article and Full-Text PDF

Ursolic acid-loaded lipid-core nanocapsules reduce damage caused by estrogen deficiency in wound healing.

Colloids Surf B Biointerfaces 2021 Mar 24;203:111720. Epub 2021 Mar 24.

Department of Pharmaceutical Sciences, State University of Ponta Grossa, Paraná, Brazil.

The skin aging process in women is accelerated due to decreases in serum estrogen levels triggered by the menopause process. Hence, poly(L-lactic acid) lipid-core nanocapsules containing ursolic acid (NPLA-UA) were developed using the interfacial deposition of the preformed polymer methodology as a strategy to reduce damages to the healing process caused by hormonal deficiency in ovariectomized rats. The colloidal suspensions of nanocapsules presented adequate size and morphology (254 and 375 nm), negative zeta potential (-31 and -37 mV), high encapsulation efficiency (99. Read More

View Article and Full-Text PDF

miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation.

Int Immunopharmacol 2021 Apr 2;96:107587. Epub 2021 Apr 2.

Department of Dermatology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, PR China. Electronic address:

Psoriasis is a chronic and relapsing disorder with considerable negative effects on patients' quality of life. The finer details associated with the molecular mechanism of psoriasis and its pathogenesis remain somewhat elusive. Extensive studies have highlighted the crucial role of microRNAs (miRNAs) in the development of psoriasis. Read More

View Article and Full-Text PDF

Hypertension due to loss of water.

Armin Just

Acta Physiol (Oxf) 2021 Apr 5:e13658. Epub 2021 Apr 5.

Physiologisches Institut Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Germany.

In the current issue of Acta Physiologica, two papers are published investigating the development of arterial hypertension under conditions of pathological loss of free water in two disease models. Kovaric et al studied rats with chronic renal failure, shedding excessive free water via their remnant kidney due to a hypostenuric concentrating defect. Wild et al. Read More

View Article and Full-Text PDF