272,755 results match your criteria rat liver

In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.

Bioorg Chem 2021 Aug 24;116:105300. Epub 2021 Aug 24.

Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, 11884, Egypt. Electronic address:

Based on the biological importance of the thiazole nucleus, we decided to prepare and evaluate the biological activity of some new isatin derivatives containing thiazole moiety. The 5-(piperidin-1-ylsulfonyl)indoline-2,3-dione (1) was prepared and used as a starting material in the synthesis of many isatin derivatives for anticonvulsant evaluation. All the newly synthesized thiazlidino/thiosemicarbazide-indolin-2-one derivatives screened in vivo for their anticonvulsant activity against pentylenetetrazole-induced convulsions in mice. Read More

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Isolation and Characterization Methods of Human Invariant NKT Cells.

Rui Liu Hua Wang

Methods Mol Biol 2021 ;2388:79-85

Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Natural killer T cells (NKT) are abundant in the hepatic sinuses and account for about 20-50% of rat liver lymphocytes. Type I or invariant NKT cells (iNKT) exert a powerful pro-inflammatory effect when activated, while type II NKT cells are more heterogeneous and mainly play an immunomodulatory role. Here we mainly introduced the isolation and characterization methods of human invariant NKT cells. Read More

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January 2021

Histopathological examination of the impact of sodium hypochlorite on the hepatobiliary system. An experimental study.

Ann Ital Chir 2021 ;92:412-418

Background: The liver is the most common organ for settlement of hydatic cyst disease. All acknowledged protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The sodium hypochlorite is an effective protoscolicidal agent for treatment of hydatid liver cysts in vitro. Read More

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September 2021

Toxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats.

Environ Sci Pollut Res Int 2021 Sep 15. Epub 2021 Sep 15.

Faculty of Medicine, Department of Medical Biochemistry, Tekirdag Namik Kemal University, Tekirdağ, Turkey.

In the present study, toxic effects, both alone and combined, of bisphenol A (BPA), lead (Pb) and endosulfan (ES) in the low doses were investigated in rat liver and kidney functions. In the study, bisphenol A (BPA), lead (Pb) and endosulfan (ES) were chosen because although they are the chemicals people are most frequently exposed to, no combined toxic effect studies were conducted with these chemicals. Sixty-four male Wistar albino rats were used in the study, and they were randomly divided into eight groups (n = 8 per group); control, BPA (5 mg/kg), Pb (100 ppm), ES (0. Read More

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September 2021

Therapeutic efficacy of a extract in a rat model of hepatocellular carcinoma: Histopathological aspects.

J Tradit Complement Med 2021 Sep 13;11(5):400-408. Epub 2021 Feb 13.

Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

Hepatocellular carcinoma (HCC) is most common in adults and has a high mortality rate because of a lack of effective treatment options. We investigated the effect of a medicinal plant as a potential source of drugs against HCC. The rhizomes of Pierre (DM), Hua-Khao-Yen in Thai, are commonly used as ingredients for alternative treatment of cancer in Thailand. Read More

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September 2021

Effect of ethanolic extract of Benth on subacute experimental models of inflammation and some underlying mechanisms.

Res Pharm Sci 2021 Oct 19;16(5):516-527. Epub 2021 Aug 19.

Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.

Background And Purpose: This study was designed to evaluate the anti-inflammatory activities of S. pilifera (HESP) in two sub-acute models of inflammation and clarified some possible mechanisms.

Experimental Approach: Colorimetric methods were used to determine total phenol and flavonoid contents. Read More

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October 2021

Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids.

Nanotechnol Sci Appl 2021 7;14:139-159. Epub 2021 Sep 7.

Debina Diagnostics Inc., Newtown Square, PA, USA.

Background: We recently reported on preferential deposition of bare fluorescent diamond particles FDP-NV-700/800nm (FDP-NV) in the liver following intravenous administration to rats. The pharmacokinetics of FDP-NV in that species indicated short residency in the circulation by rapid clearance by the liver. Retention of FDP-NV in the liver was not associated with any pathology. Read More

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September 2021

Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways.

Sci Rep 2021 Sep 14;11(1):18263. Epub 2021 Sep 14.

School of Pharmacy, Bengbu Medical College, Donghai Road, Bengbu, 233030, Anhui, China.

Shikonin is the main component of the traditional Chinese medicine comfrey, which can inhibit the activity of PKM2 by regulating glycolysis and ATP production. Rheumatoid arthritis synovial cells (RA-FLSs) have been reported to increase glycolytic activity and have other similar hallmarks of metabolic activity. In this study, we investigated the effects of shikonin on glycolysis, mitochondrial function, and cell death in RA-FLSs. Read More

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September 2021


J Pharmacol Exp Ther 2021 Sep 14. Epub 2021 Sep 14.

University of Toledo, United States.

Ketone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity. β-hydroxybutyrate (βHB) is the most abundant ketone body. The secondary alcohol, 1,3-butanediol (1,3-BD), is commonly administered to raise βHB bioavailability and in the absence of nutrient deprivation. Read More

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September 2021

Effect of Lycium barbarum polysaccharide supplementation in non-alcoholic fatty liver disease patients: study protocol for a randomized controlled trial.

Trials 2021 Aug 26;22(1):566. Epub 2021 Aug 26.

School of Public Health and Management, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China.

Background: Non-alcohol fatty liver disease (NAFLD) is the most common chronic liver disease in the world, with a high incidence and no effective treatment. At present, the targeted therapy of intestinal microbes for NAFLD is highly valued. Lycium barbarum polysaccharide (LBP), as the main active ingredient of Lycium barbarum, is considered to be a new type of prebiotic substance, which can improve NAFLD by regulating the gut microbiota. Read More

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Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats.

Planta Med 2021 Sep 14. Epub 2021 Sep 14.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong SAR, P. R. China.

Although Polygoni Multiflori Radix (PMR) has been widely used as a tonic and an anti-aging remedy for centuries, the extensively reported hepatotoxicity and potential kidney toxicity hindered its safe use in clinical practice. To better understand its toxicokinetics, the current study was proposed, aiming to evaluate the biodistributions of the major PMR components including 2,3,5,4'-tetrahydroxystilbene-2---D-glucopyranoside (TSG), emodin, emodin-8---D-glucopyranoside (EMG) and physcion as well as their corresponding glucuronides following bolus and multiple oral administrations of PMR to rats. Male Sprague-Dawley rats received a bolus dose or 21 days of oral administrations of PMR concentrated granules at 4. Read More

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September 2021

Novel [F]-Labeled Meta-Bromobenzylguanidine Derivatives: Potential Positron Emission Tomography Imaging Probes for the Norepinephrine Transporter.

Mol Pharm 2021 Sep 14. Epub 2021 Sep 14.

Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

To develop novel norepinephrine transporter (NET)-targeting positron emission tomography (PET) probes with optimal pharmacokinetic properties, a series of -bromobenzylguanidine derivatives was synthesized. 4-Fluorodiethoxyethane-3-bromobenzylguanidine (compound ) showed relatively good affinity for the NET (IC = 1.00 ± 0. Read More

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September 2021

miR-221, miR-190b, miR-363-3p, miR-200c are involved in rat liver ischemia-reperfusion injury through oxidative stress, apoptosis and endoplasmic reticulum stress.

Int J Clin Pract 2021 Sep 14:e14848. Epub 2021 Sep 14.

University of Health Sciences Turkey, Sultan Abdulhamid Han Training and Research Hospital, Department of Anesthesia and Reanimation.

Aim: In this study, it was aimed to investigate the relationship between expression levels of micrornas, endoplasmic reticulum (ER) stress, apoptosis and oxidative stress markers in hepatic ischemia reperfusion (IR) injury.

Methods: Sixteen rats were randomized into two groups: sham and IR group. In IR group, portal vein and hepatic artery were totally clamped with an atraumatic microvascular clamp and 60 minutes later unclamped and finally IR model was accomplished (60 min ischemia and 60 min reperfusion). Read More

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September 2021

Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism.

Pharm Biol 2021 Dec;59(1):1256-1259

Department of Medicinal Medicine, The Second Hospital of Shandong University, Jinan, China.

Context: Pachymic acid and bavachin are commonly used drugs in the therapy of lung cancer.

Objective: The co-administration of pachymic acid and bavachin was investigated to evaluate their potential drug-drug interaction.

Materials And Methods: The pharmacokinetics of bavachin (10 mg/kg) was studied in male Sprague-Dawley (SD) rats in the presence of pachymic acid (5 mg/kg) ( = 6). Read More

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December 2021

Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect.

Pharm Biol 2021 Dec;59(1):1286-1293

Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, PR China.

Context: Rosmarinic acid (RA) dose-dependently ameliorates acetaminophen (APAP) induced hepatotoxicity in rats. However, whether RA hepatoprotective effect is by regulating RACK1 and its downstream signals is still unclear.

Objective: This study explores the RA protective effect on APAP-induced ALI and its mechanism. Read More

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December 2021

Toxic mechanisms and pharmacological properties of euptox A, a toxic monomer from A. adenophora.

Fitoterapia 2021 Sep 10:105032. Epub 2021 Sep 10.

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China. Electronic address:

A. adenophora (Spreng.) R. Read More

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September 2021

Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds.

J Pharm Pharm Sci 2021 ;24:475-483

College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Purpose: Organic anion transporting polypeptide (OATP) 1B3 transports many clinically important drugs, including statins, from blood into the liver. It exclusively expresses in human liver under normal physiological conditions. There is no rodent ortholog of human OATP1B3. Read More

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January 2021

Evaluation of the Liver and Blood Micronucleus, and Comet Assay Endpoints in a 14-Day Repeated Dose Study with Methyl Carbamate and 1, 3-Propane Sultone.

Mutagenesis 2021 Sep 13. Epub 2021 Sep 13.

Shanghai InnoStar Bio-Tech Co. Ltd/National Shanghai Center for New Drug Safety Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, China.

The repeated-dose liver micronucleus (RDLMN) assay is a novel method for detecting genotoxic chemicals. Two carcinogens methyl carbamate (MC) and 1, 3-propane sultone (PS) were evaluated for the liver micronucleus in a 14-day repeated-dose study with Sprague Dawley rats. Additionally, micronucleated reticulocytes (MN-RET) in peripheral blood and DNA damage (alkaline comet assay) in the liver were also assessed in the same animals. Read More

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September 2021

Short-term fenofibrate treatment improves ultrastructure of hepatocytes of old rats.

Folia Histochem Cytobiol 2021 Sep 13. Epub 2021 Sep 13.

Department of Histology, Medical University of Gdansk, Gdansk.

Introduction: Fenofibrate (FN) is a hypolipemic drug used for the treatment of mixed dyslipidemia. Since in our previous study FN administration to young and old rats adversely affected the serum activity of liver marker enzymes, we decided to examine the effects of FN on liver ultrastructure of young and old animals.

Material And Methods: Young and old rats were fed standard rodent chow supplemented with 0. Read More

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September 2021

Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase.

Pharmacology 2021 Sep 7:1-10. Epub 2021 Sep 7.

Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang, China.

Introduction: Canagliflozin (CANA) is a sodium-glucose cotransporter 2 inhibitor that was recently approved for treating diabetes. However, its effects on liver function are not well understood. The function of asparagine synthetase (ASNS) has been studied in several cancers but not in liver injury. Read More

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September 2021

In Vivo Treatment Efficacy of Essential Oil Isolated from Seeds of Momordica charantia in Streptozotocin Induced Diabetes Mellitus.

Recent Pat Biotechnol 2021 Sep 9. Epub 2021 Sep 9.

Department of Zoology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu. India.

Background: All parts of Momordica charantia L have potential hypoglycemic property in reversing the metabolic disorder of diabetes mellitus. But there exists a need for preparing an effective and safer formulation of active phytochemical. We have also reviewed certain patents on such preparatory methods for Momordica charantia L and analysis. Read More

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September 2021

Dietary Protein From Different Sources Exerted a Great Impact on Lipid Metabolism and Mitochondrial Oxidative Phosphorylation in Rat Liver.

Front Nutr 2021 26;8:719144. Epub 2021 Aug 26.

Key Laboratory of Meat Processing and Quality Control MOE, Nanjing Agricultural University, Nanjing, China.

Associations between meat diets and human health have been widely considered. In this study, we focused on long-term effects of different sources of meat protein on liver metabolic enzymes. For 90 days, rats were fed with semisynthetic diets that differed only with protein source. Read More

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Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol.

Adv Pharm Bull 2021 May 5;11(3):530-536. Epub 2020 Aug 5.

Biopharmaceutics and Pharmacokinetics Division, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

MDMA (methylenedioxymethamphetamine) is a synthetic compound, which is a structurally derivative of amphetamine. Also, it acts like an amphetamine, structurally, and functionally. MDMA uses mechanism-based inhibition, to inhibit isoenzyme CYP2D6. Read More

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Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages.

Oxid Med Cell Longev 2021 2;2021:9719906. Epub 2021 Sep 2.

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Department of Biology, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, 30000 Fez, Morocco.

Bee products are a promising source of phenolic compounds with strong antioxidant activity. The present study was designed to explore the protective effect of honey, propolis, and their combination on gentamicin-induced oxidative stress and hepatorenal dysfunction. This study was conducted on male Wistar rats by intraperitoneal injections of gentamicin (120 mg/kg BW/day, i. Read More

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September 2021

Paeoniflorin Protects against ANIT-Induced Cholestatic Liver Injury in Rats via the Activation of SIRT1-FXR Signaling Pathway.

Evid Based Complement Alternat Med 2021 2;2021:8479868. Epub 2021 Sep 2.

Department of Pharmacy, Hebei North University, Zhangjiakou 075000, China.

Paeoniflorin (PF), a water-soluble monoterpene glycoside, is initially isolated from the dried roots of Pall., which has effects on ameliorating cholestasis in our previous study. However, comprehensive approaches for understanding the protective effects and mechanisms underlying cholestatic liver injury from the regulating of bile acid metabolism have not been sufficiently elucidated. Read More

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September 2021

Predicting Target Genes of San-Huang-Chai-Zhu Formula in Treating ANIT-Induced Acute Intrahepatic Cholestasis Rat Model via Bioinformatics Analysis Combined with Experimental Validation.

Evid Based Complement Alternat Med 2021 1;2021:5320445. Epub 2021 Sep 1.

The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China.

Background: San-Huang-Chai-Zhu formula (SHCZF) has been used to improve cholestasis for many years. This study aims to predict the possible gene targets of SHCZF in treating acute intrahepatic cholestasis (AIC) in rats.

Materials And Methods: Eighteen SD rats were randomly assigned to the normal group, ANIT group, and ANIT + SHCZF group. Read More

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September 2021

[A protective effect of acetaminophen on ibuprofen-induced small intestinal damage in rats via the suppression of MMP-13].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(9):840-850

Pharmaceutical Research Laboratories, Research & Development Headquarters, Lion Corporation.

Background & Aims: Capsule endoscopy has revealed that nonsteroidal anti-inflammatory drugs may cause damage not only to the stomach but also to the small intestine, which has become one of the most serious issues in gastroenterology. However, few studies have reported the effect of ibuprofen (IBP), which is widely prescribed worldwide, on the small intestine, and it remains unclear whether IBP can cause small intestinal damage. We have previously shown that acetaminophen (APAP), which is used as an antipyretic/analgesic drug, inhibits IBP-induced gastric damage by suppressing matrix metalloprotease-13 (MMP-13) gene expression. Read More

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September 2021

A Maternal Low-protein Diet during Gestation Induces Hepatic Autophagy-related Gene Expression in a Sex-specific Manner in Sprague-Dawley Rats.

Br J Nutr 2021 Sep 13:1-29. Epub 2021 Sep 13.

Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801.

This study investigates the mechanism by which maternal protein restriction induces hepatic autophagy-related gene expression in the offspring of rats. Pregnant Sprague-Dawley rats were fed either a control diet (C, 18% energy from protein) or a low-protein diet (LP, 8.5% energy from protein) during gestation, followed by the control diet during lactation and post-weaning. Read More

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September 2021

Lactobacillus johnsonii BS15 combined with abdominal massage on intestinal permeability in rats with nonalcoholic fatty liver and cell biofilm repair.

Bioengineered 2021 Dec;12(1):6354-6363

Department of Massage, The First Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin, China.

This study aimed to analyze the effect of lactobacillus johnsonii BS15 (isolation of homemade yogurt from Ahu Hongyuan Grassland) combined with abdominal massage on intestinal permeability in rats with nonalcoholic fatty liver disease (NAFLD) and cell biofilm repair. Forty-five rats were divided randomly into five groups, four of which were fed with high-fat diet to establish NAFLD models. According to the treatment methods, they were grouped into group A (lactic acid bacteria feeding), group B (abdominal massage), group A + B (a combination of the two methods), model group (distilled water feeding), and normal group (distilled water feeding). Read More

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December 2021

Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites.

Hepatol Commun 2021 Sep 10;5(9):1507-1517. Epub 2021 Jun 10.

Digestive Diseases Section, Yale University, New Haven, CT, USA.

The intestinal microbiome and bacterial translocation (BT), the passage of microorganisms from the gut lumen to mesenteric lymph nodes and other extra-intestinal sites, are main mechanisms implicated in liver injury and further decompensation in patients with cirrhosis. We hypothesized that obeticholic acid (OCA), a semisynthetic bile acid, would change the microbiome composition and reduce bacterial translocation in experimental cirrhosis. Rats with cirrhosis induced by carbon tetrachloride inhalation (a nonseptic model) with ascites present for at least 7 days were randomized to receive a 14-day course of OCA at a dose of 5 mg/kg/day (n = 34) or placebo (n = 34). Read More

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September 2021