10,337 results match your criteria rare problem

When to ask for an MRI of the scrotum.

Andrology 2021 May 8. Epub 2021 May 8.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome Viale Regina Elena, 324, 00161, Roma, Italy.

Background: Multiparametric MRI of the scrotum has been established as a useful second-line diagnostic tool for the investigation of scrotal diseases. Recently, recommendations on clinical indications for scrotal MRI were issued by the Scrotal and Penile Imaging Working Group of the European Society of Urogenital Radiology.

Objective: To update current research on when to ask for an MRI of the scrotum. Read More

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A case report of necrotizing soft tissue infection of the chest wall: Effective management with serial debridement.

Int J Surg Case Rep 2021 Apr 27;82:105908. Epub 2021 Apr 27.

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, Hokkaido, Japan.

Introduction: Necrotizing soft tissue infection (NSTI) of the chest wall is a rare, rapidly spreading, highly lethal surgical disease. Radical debridement interferes with the important anatomical function of the chest wall. We report a case of chest wall NSTI that was successfully managed with early diagnosis and serial debridement. Read More

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[Features of surgical treatment of urinary incontinence in women with urethral destruction].

Urologiia 2021 May(2):86-89

Novosibirsk Research Institute of Traumatology and Orthopedics n.a. Ya.L. Tsivyan, Novosibirsk, Russia.

Urethral destruction in women is a rare pathology which is result of traumatic damage of the urethra during pelvic fractures, sexual trauma, iatrogenic effects (operative vaginal delivery, prolonged catheterization of the bladder, complicated surgical interventions on the urethra, etc.). The main symptom of urethral destruction is involuntary urinary incontinence. Read More

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Research on the Tufts Be Well at Work Program for Employees With Depression: 2005-2020.

Psychiatr Serv 2021 May 7:appips202000762. Epub 2021 May 7.

Program on Health, Work and Productivity, Institute for Clinical Research and Health Policy Studies (Lerner, Adler, Rogers), and Departments of Psychiatry and Medicine (Lerner, Adler), Tufts Medical Center, Boston; Department of Psychiatry, University of Massachusetts Medical School, Worcester (Shayani).

Objective: Although depression is a prevalent and costly health problem exacting a large toll on work productivity, interventions targeting occupational functioning are rare. This article describes the development of the Tufts Be Well at Work intervention, a brief telephonic program designed to improve occupational functioning among employees with depression and reduce depression symptom severity. Results from 15 years of research are summarized evaluating the occupational, clinical, and economic impact of Be Well at Work. Read More

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Carotid endarterectomy with stent graft removal and end to end bypass in the treatment of in-stent occlusion after endovascular therapy of carotid gunshot injury.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Cardiac Surgery, Peking University Third Hospital, Beijing, China.

Carotid jugular fistula and pseudoaneurysm are easy to form after gunshot injury of carotid artery. Endovascular therapy, such as stent graft implantation, can successfully block the fistula and pseudoaneurysm cavity. However, the possibility of in-stent restenosis or occlusion will lead to treatment failure. Read More

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Acute pancreatitis secondary to cocaine use: a case-based systematic literature review.

Clin J Gastroenterol 2021 May 4. Epub 2021 May 4.

University of Missouri School of Medicine, Columbia, MO, USA.

Cocaine use continues to be an important global public health problem. As the use of cocaine remains pervasive so have a myriad of adverse events associated with this drug. These deleterious effects are well-studied, but gastrointestinal complications remain esoteric and the existing clinical evidence is scarce. Read More

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Spinal cord infarction. A case report and narrative review.

Acta Biomed 2021 Apr 30;92(S1):e2021080. Epub 2021 Apr 30.

Emergency Department, University Hospital of Parma, Italy.

Spinal cord infarction is a rare but severe disorder, consistently less frequent than ischemic brain injury. It constitutes only 1-2% of all neurological vascular emergencies. Here we describe a case of spinal cord infarction in a 68-year-old Caucasian man without any neurological problem in his clinical history. Read More

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Atypical Reye syndrome: three cases of a problem that pediatricians should consider and remember.

Acta Biomed 2021 Apr 30;92(S1):e2021110. Epub 2021 Apr 30.

Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS - Università Cattolica Sacro Cuore, Rome, Italy .

Introduction: Reye syndrome is a rare acquired metabolic disorder appearing almost always during childhood. Its aetiopathogenesis, although controversial, is partially understood. The classical disease is typically anticipated by a viral infection with 3-5 days of well-being before the onset of symptoms, while the biochemical explanation of the clinical picture is a mitochondrial metabolism disorder, which leads to a metabolic failure of different tissues, especially the liver. Read More

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[Pediatric foreign body. A two case report.]

Arch Esp Urol 2021 May;74(4):449-454

Servicio de Urología Pediátrica. Hospital de Niños "Víctor J. Vilela". Rosario. Prov. Santa Fe. Argentina.

Introduction: Urethral insertion of foreign bodies is an infrequent emergency, being it exceptionally rare in prepubertal children. Both clinical presentation and the introduced elements are varied. Although sexualabuse and mental disorders must always be considered, these events are mainly related to the children's own  body self-discovery without any sexual connotation. Read More

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Phase I trial compensation: How much do healthy volunteers actually earn from clinical trial enrollment?

Clin Trials 2021 May 2:17407745211011069. Epub 2021 May 2.

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background/aims: Financial compensation for research participation is a major focus of ethical concern regarding human subject recruitment. Phase I trials are sometimes considered to be a lucrative source of income for healthy volunteers, encouraging some people to become "professional guinea pigs." Yet, little is known about how much these clinical trials actually pay and how much healthy volunteers earn from them. Read More

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Multi-task Learning via Adaptation to Similar Tasks for Mortality Prediction of Diverse Rare Diseases.

AMIA Annu Symp Proc 2020 25;2020:763-772. Epub 2021 Jan 25.

Department of Computer Science, Peking University, Beijing, China.

The mortality prediction of diverse rare diseases using electronic health record (EHR) data is a crucial task for intelligent healthcare. However, data insufficiency and the clinical diversity of rare diseases make it hard for deep learning models to be trained. Mortality prediction for these patients with different diseases can be viewed as a multi-task learning problem with insufficient data but a large number of tasks. Read More

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January 2021

Acute Stent Thrombosis: Severe In-Stent Malapposition and Insufficient Platelet Inhibition as Partners in Crime!

J Invasive Cardiol 2021 May;33(5):E400

Clinical and Interventional Cardiology, Sassari University Hospital, Sassari Italy, Via Enrico De Nicola 14, 07100 Sassari, Italy.

Acute stent thrombosis is a rare event. When it occurs, procedure- and patient-related factors need to be assessed. First, our case showed that wiring was only successful with a chronic total occlusion-derived technique, indirectly demonstrating a stent-related problem. Read More

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Extrahepatic alveolar echinococcus on multi-slice computed tomography and magnetic resonance imaging.

Sci Rep 2021 Apr 30;11(1):9409. Epub 2021 Apr 30.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Medical Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.

Alveolar echinococcus (AE) is a severe health problem in endemic areas. In recent years, the incidence of this disease in China has been increasing. The study was designed to illustrate the multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) features of extrahepatic AE. Read More

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Identification of Novel Candidate Genes and Variants for Hearing Loss and Temporal Bone Anomalies.

Genes (Basel) 2021 Apr 13;12(4). Epub 2021 Apr 13.

Philippine National Ear Institute, University of the Philippines (UP) Manila-National Institutes of Health (NIH), Manila 1000, Philippines.

Hearing loss remains an important global health problem that is potentially addressed through early identification of a genetic etiology, which helps to predict outcomes of hearing rehabilitation such as cochlear implantation and also to mitigate the long-term effects of comorbidities. The identification of variants for hearing loss and detailed descriptions of clinical phenotypes in patients from various populations are needed to improve the utility of clinical genetic screening for hearing loss. Clinical and exome data from 15 children with hearing loss were reviewed. Read More

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Identification of Genetic Variants in 65 Obesity Related Genes in a Cohort of Portuguese Obese Individuals.

Genes (Basel) 2021 Apr 19;12(4). Epub 2021 Apr 19.

H&TRC Health and Technology Research Center, Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, 1990-096 Lisbon, Portugal.

Obesity is a major public health problem, which has a strong genetic component that interplays with environmental factors. Several genes are known to be implicated in the regulation of body weight. The identification of alleles that can be associated with obesity is a key element to control this pandemic. Read More

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Next Generation Sequencing for the Prediction of the Antibiotic Resistance in : A Literature Review.

Antibiotics (Basel) 2021 Apr 14;10(4). Epub 2021 Apr 14.

Department of Medical and Surgical Sciences, IRCCS St. Orsola Polyclinic, University of Bologna, 40138 Bologna, Italy.

: Only a few antimicrobials are effective against , and antibiotic resistance is an increasing problem for eradication therapies. In 2017, the World Health Organization categorized clarithromycin resistant as a "high-priority" bacterium. Standard antimicrobial susceptibility testing can be used to prescribe appropriate therapies but is currently recommended only after the second therapeutic failure. Read More

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Determining Risk Factors Associated with Depression and Anxiety in Young Lung Cancer Patients: A Novel Optimization Algorithm.

Medicina (Kaunas) 2021 Apr 1;57(4). Epub 2021 Apr 1.

Biostatistical Consulting Lab, Department of Speech Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan.

: Identifying risk factors associated with psychiatrist-confirmed anxiety and depression among young lung cancer patients is very difficult because the incidence and prevalence rates are obviously lower than in middle-aged or elderly patients. Due to the nature of these rare events, logistic regression may not successfully identify risk factors. Therefore, this study aimed to propose a novel algorithm for solving this problem. Read More

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Simultaneous development of COVID-19 pneumonia and pulmonary metastasis in a known case of chondrosarcoma: a case report.

J Med Case Rep 2021 Apr 28;15(1):218. Epub 2021 Apr 28.

Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Shohada-e Tajrish Hospital, Shahrdari St, 1989934148, Tehran, Iran.

Background: The outbreak of coronavirus disease 2019 (COVID-19) started in December 2020, and is a global problem now. There are several sets of established data regarding computed tomography (CT) findings in COVID-19 pneumonia with many differential diagnoses. During the early days of the pandemic, there was little data regarding lung CT features of COVID-19 in a cancer patient. Read More

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Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities.

Cancer 2021 Apr 28. Epub 2021 Apr 28.

Department of Epidemiology, Regional Health Council, Biomedical Research Institute of Murcia-Arrixaca, Murcia University, Murcia, Spain.

Background: Among sarcomas, which are rare cancers, many types are exceedingly rare; however, a definition of ultra-rare cancers has not been established. The problem of ultra-rare sarcomas is particularly relevant because they represent unique diseases, and their rarity poses major challenges for diagnosis, understanding disease biology, generating clinical evidence to support new drug development, and achieving formal authorization for novel therapies.

Methods: The Connective Tissue Oncology Society promoted a consensus effort in November 2019 to establish how to define ultra-rare sarcomas through expert consensus and epidemiologic data and to work out a comprehensive list of these diseases. Read More

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Identifying challenges in neurofibromatosis: a modified Delphi procedure.

Eur J Hum Genet 2021 Apr 26. Epub 2021 Apr 26.

Department of General Paediatrics, Sophia's Children's Hospital, Rotterdam, The Netherlands.

Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are rare conditions with pronounced variability of clinical expression. We aimed to reach consensus on the most important manifestations meriting the development of drug trials. The five-staged modified Delphi procedure consisted of two questionnaires and a consensus meeting for 40 NF experts, a survey for 63 patient representatives, and a final workshop. Read More

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Why are women still dying from obstetric hemorrhage? A narrative review of perspectives from high and low resource settings.

Int J Obstet Anesth 2021 Mar 25:102982. Epub 2021 Mar 25.

Department of Women's and Children's Health, University of Liverpool (for Liverpool Health Partners), Liverpool, UK.

The possibility of hemorrhage will always co-exist with pregnancy, whether anticipated or not. It remains the unwelcome guest in the corner of every delivery room, stealing the lives of young women every day across the globe. In 2014, the World Health Organization reported that hemorrhage was the leading contributor to maternal mortality worldwide, with nearly 75% of maternal deaths due to postpartum hemorrhage. Read More

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Prevalence and risk factors of severe postpartum hemorrhage: a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Apr 26;21(1):332. Epub 2021 Apr 26.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Background: Although maternal deaths are rare in developed regions, the morbidity associated with severe postpartum hemorrhage (SPPH) remains a major problem. To determine the prevalence and risk factors of SPPH, we analyzed data of women who gave birth in Guangzhou Medical Centre for Critical Pregnant Women, which received a large quantity of critically ill obstetric patients who were transferred from other hospitals in Southern China.

Methods: In this study, we conducted a retrospective case-control study to determine the prevalence and risk factors for SPPH among a cohort of women who gave birth after 28 weeks of gestation between January 2015 and August 2019. Read More

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wound infection in a burn patient.

Radiol Case Rep 2021 Jun 9;16(6):1348-1351. Epub 2021 Apr 9.

Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittssburgh, Pennsylvania, USA.

Burns are one of the most common and devastating forms of trauma. Burns are a significant problem with high associated morbidity and mortality worldwide. Burn wound infection is a serious complication, which plays an important role in increasing the overall fatality rate in burn patients. Read More

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Evaluation of In-Hospital Management of Inhaler Therapy for Chronic Obstructive Pulmonary Disease.

Can J Hosp Pharm 2021 1;74(2):110-116. Epub 2021 Apr 1.

, BSc, BScPharm, PharmD, ACPR, FCSHP, is a Pharmacotherapeutic and Research Specialist (Internal Medicine) with Vancouver General Hospital and an Assistant Professor (Partner) with the Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia.

Background: In the past decade, the number of inhaled devices approved for management of chronic obstructive pulmonary disease (COPD) has tripled. Management of at-home inhaled COPD therapy can present a problem when patients are admitted to hospital, because only a limited number of these therapies are currently included in hospital formularies and there is a lack of established interchanges.

Objectives: To characterize and evaluate the appropriateness of management of patients' before-admission inhaled therapy upon hospital admission. Read More

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Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants.

David Curtis

Alcohol Alcohol 2021 Apr 24. Epub 2021 Apr 24.

UCL Genetics Institute, UCL, Darwin Building, Gower Street, London WC1E 6BT, UK.

Aims: The study aimed to identify specific genes and functional genetic variants affecting susceptibility to two alcohol-related phenotypes: heavy drinking and problem drinking.

Methods: Phenotypic and exome sequence data were downloaded from the UK Biobank. Reported drinks in the last 24 hours were used to define heavy drinking, while responses to a mental health questionnaire defined problem drinking. Read More

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DenseCapsNet: Detection of COVID-19 from X-ray images using a capsule neural network.

Comput Biol Med 2021 Apr 15;133:104399. Epub 2021 Apr 15.

College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110001, China. Electronic address:

At present, the global pandemic as it relates to novel coronavirus pneumonia is still a very difficult situation. Due to the recent outbreak of novel coronavirus pneumonia, novel chest X-ray (CXR) images that can be used for deep learning analysis are very rare. To solve this problem, we propose a deep learning framework that integrates a convolutional neural network and a capsule network. Read More

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A case report of foreign body appendicitis caused by tongue piercing ingestion.

Int J Surg Case Rep 2021 Apr 26;81:105808. Epub 2021 Mar 26.

Departments of Surgery and Health Policy, Mount Sinai Hospital, 1468 Madison Ave, New York, NY 10029, USA. Electronic address:

Introduction: Foreign body ingestion is an uncommon clinical problem in healthy adults. Furthermore, it is even less common for an ingested foreign body to cause any obstructive symptoms within the gastrointestinal tract.

Presentation Of Case: Here, we describe an unusual case of acute appendicitis induced by a tongue piercing that was ingested by a 32-year-old woman with a recent history of endotracheal intubation. Read More

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Enantioselective Preparation of Planar-Chiral Transition Metal Complexes by Asymmetric Olefin-Metathesis Reactions in Metal Coordination Spheres.

Chem Rec 2021 Apr 22. Epub 2021 Apr 22.

Department of Natural Science Graduate School of Science and Technology and Tokushima International Science Institute, Tokushima University, 2-1 Minamijosanjima-cho, Tokushima, 770-8506, Japan.

Planar-chiral transition metal complexes are useful chiral auxiliaries in organic and organometallic chemistry, and they have been utilized as chiral ligands, chiral catalysts, or chiral building blocks, etc. Despite the importance of such planar-chiral species in asymmetric synthesis, their preparation in optically active forms is still a challenging problem. Indeed, reported examples of catalytic enantioselective synthesis of planar-chiral complexes have been rare, and this has been a developing area in this field. Read More

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Otorhinolaryngological myiasis: the problem and its presentations in the weak and forgotten.

Ghana Med J 2020 Sep;54(3):173-178

Apollo Indraprastha Hospital, New Delhi, India.

Introduction: Myiasis is common in tropical regions, but now increasing incidence is seen in the west due to international travel. Otorhinolaryngological myiasis is uncommon and is seen in diabetics, alcoholics or patients unable in self-care.

Objectives: To study presentations of otorhinolaryngological myiasis, identify associated risk factors and species of flies causing myiasis. Read More

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September 2020