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Toward a transitional care from childhood and adolescence to adulthood in surgical neurooncology? A lesson from the Necker-Enfants Malades and the Sainte-Anne Hospitals collaboration.

J Neurosurg Pediatr 2021 Jul 30:1-7. Epub 2021 Jul 30.

1Service de Neurochirurgie, GHU Paris-Hôpital Sainte-Anne, Paris.

Objective: Transitional care in surgical neurooncology is poorly studied. However, this period is pivotal, since it allows the patient to be empowered in his or her disease management. Here, the authors describe the experience of the Necker-Enfants Malades and the Sainte-Anne Hospital collaboration. Read More

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LaSnO/g-CN nanocomposites: Rapid and green sonochemical fabrication and photo-degradation performance for removal of dye contaminations.

Ultrason Sonochem 2021 Jul 24;77:105678. Epub 2021 Jul 24.

Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P. O. Box.87317-51167, Iran. Electronic address:

The deficiency of drinking water sources has become a serious crisis for the future of the world that the photocatalytic process is one of the most favorable methods for removal of artificial dyes and poisonous organic impurities. In the present study, rapid ultrasonic treatment was performed to obtain LaSnO/Graphitic carbon nitrides (LSO/CN) nanocomposites with advanced photo-catalytic performance. Broccoli extract was utilized as a natural surfactant with active surface groups to control nucleation and growth of formed crystals with the creation of spatial barriers around the cations, and finally prevent nano-product agglomeration. Read More

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Primary synovial sarcoma of thyroid gland: A case report and review of literature.

Int J Surg Case Rep 2021 Jul 26;85:106245. Epub 2021 Jul 26.

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Read More

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"Barcode" cell sensor microfluidic system: Rapid and sample-to-answer antimicrobial susceptibility testing applicable in resource-limited conditions.

Biosens Bioelectron 2021 Jul 21;192:113516. Epub 2021 Jul 21.

Department of Chemistry, Hong Kong Baptist University. Waterloo Road, Kowloon, Hong Kong, China; HKBU Institute of Research and Continuing Education, Shenzhen, China; State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Waterloo Road, Kowloon, Hong Kong, China. Electronic address:

Many rapid antimicrobial susceptibility testing (AST) methods have been proposed to contain clinical antimicrobial resistance (AMR) and preserve the effectiveness of remaining antimicrobials. However, far fewer methods have been proposed to test AMR in resource-limited conditions, such as for frequent safety screenings of water/food/public facilities, urgent surveys of massive samples during a pandemic, or AMR tests in low-income countries. Rapid AST methods realized thus far have a variety of drawbacks when used for such surveys, e. Read More

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Bad neighbors? Niche overlap and asymmetric competition between native and Lessepsian limpets in the Eastern Mediterranean rocky intertidal.

Mar Pollut Bull 2021 Jul 27;171:112703. Epub 2021 Jul 27.

Department of Palaeontology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria; Department of Animal Conservation and Public Engagement, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.

The Eastern Mediterranean Sea hosts more non-indigenous species than any other marine region, yet their impacts on the native biota remain poorly understood. Focusing on mollusks from the Israeli rocky intertidal, we explored the hypothesis that this abiotically harsh habitat supports a limited trait diversity, and thus may promote niche overlap and competition between native and non-indigenous species. Indeed, native and non-indigenous assemblage components often had a highly similar trait composition, caused by functionally similar native (Patella caerulea) and non-indigenous (Cellana rota) limpets. Read More

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Recent developments and strategies of Ebola virus vaccines.

Curr Opin Pharmacol 2021 Jul 27;60:46-53. Epub 2021 Jul 27.

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Gangwon-do, Republic of Korea. Electronic address:

The Filovirus family member, Ebola virus (EBOV), is a highly infectious pathogen responsible for viral hemorrhagic fever. EBOV has a fatality rate in the range 50%-90% in primates. The lethal viral hemorrhagic attack in 2014 by EBOV has forced the human race to look for rapid countermeasures. Read More

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Dynamics of urban landscape nexus spatial dependence of ecosystem services in rapid agglomerate cities of Ethiopia.

Sci Total Environ 2021 Jul 23;798:149192. Epub 2021 Jul 23.

Addis Ababa University, Center for Environmental Science, Ethiopia.

Understanding the dependence of ecosystem services (ESs) on the dynamics of human-semi nature-coupled ecosystems is crucial for urban ecosystem resilience. In the present study, the responses of ESs to land use land cover transitions were explored and compared, selecting Addis Ababa, Adama, Hawassa, and Bahir Dar cities in Ethiopia. The geospatial data and benefit transfer approach was used to estimate the nexus over a three-decade period (1990-2020). Read More

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Early detection of marine invasive species following the deployment of an artificial reef: Integrating tools to assist the decision-making process.

J Environ Manage 2021 Jul 27;297:113333. Epub 2021 Jul 27.

Grupo de Ecología en Ambientes Costeros (GEAC), Argentina; Instituto de Biología de Organismos Marinos (IBIOMAR-CONICET), Blvd. Brown 2915, Puerto Madryn, Chubut, Argentina.

Early detection and rapid response plans are a set of principles to reduce the establishment, spread and impact of invasive species and it is a critical step in management in marine ecosystems. Two potentially invasive ascidians attached to the hull of a recently sunk fishing vessel were early detected in Patagonia. With the aim of assisting in the management decision-making process during the early steps of a rapid response, we conducted several analyses through different approaches. Read More

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Fast determination of 16 circulating neurotransmitters and their metabolites in plasma samples of spontaneously hypertensive rats intervened with five different Uncaria.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 14;1179:122856. Epub 2021 Jul 14.

Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Shanghai 201203, China; University of Chinese Academy of Sciences, No.19A Yuanquan Road, Beijing 100049, China. Electronic address:

This study aimed to establish a sensitive, reproducible, and rapid liquid chromatography method with tandem mass spectrometry detection to perform simultaneous quantitative analysis of 16 neurotransmitters and their metabolites in rat plasma, including levodopa, dopamine, norepinephrine, epinephrine, L-tryptophan, kynurenic acid, serotonin, melatonin, choline, acetylcholine, histamine, phenylethylamine, as well as excitatory (L-glutamic acid and L-aspartic acid) and inhibitory (γ-aminobutyric acid and L-glycine) neurotransmitters. These analytes were measured by ultra-high performance chromatography coupled with triple quadrupole mass spectrometry using a hydrophilic interaction chromatographic column (ethylene-bridged hybrid amide column). The internal standards of stable isotope labeling were used to improve the reliability of the results. Read More

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Simultaneous determination of dantrolene and paracetamol in human plasma by liquid chromatography tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 6;1179:122816. Epub 2021 Jul 6.

Modern University for Technology and Information, Cairo, Egypt. Electronic address:

A simple, sensitive, rapid and specific method based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the simultaneous quantification of dantrolene (DAN) and paracetamol (PAR) in real human plasma was developed and validated. The preparation of sample was achieved by liquid-liquid extraction with tertiary butyl methyl ether. The analysis was performed on a reversed-phase Ccolumn (1. Read More

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S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: biofunctionality and preclinical evaluation.

Acta Biomater 2021 Jul 27. Epub 2021 Jul 27.

Center for Biomedical Research, Medical University Vienna, Austria; Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria; Austrian Cluster for Tissue Regeneration. Electronic address:

Currently available synthetic small diameter vascular grafts reveal low patency rates due to thrombosis and intimal hyperplasia. Biofunctionalized grafts releasing nitric oxide (NO) in situ may overcome these limitations. In this study, a drug-eluting vascular graft was designed by blending polycaprolactone (PCL) with S-nitroso-human-serum-albumin (S-NO-HSA), a nitric oxide donor with prolonged half-life. Read More

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Hypoxia modifies calcium handling in the Pacific hagfish, Eptatretus stoutii.

Comp Biochem Physiol A Mol Integr Physiol 2021 Jul 27:111042. Epub 2021 Jul 27.

Bamfield Marine Sciences Centre, Bamfield, British Columbia, Canada; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.

Hagfishes may encounter low dissolved oxygen in their natural habitats, a consequence of association with hypoxic sediments and their feeding behaviour. In teleost fish, hypoxia exposure decreases ion uptake, speculated to be a mechanism for energy conservation. Although hagfishes osmoconform, they do regulate extracellular fluid concentrations of divalent cations such as calcium. Read More

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The role of antibody-based troponin detection in cardiovascular disease: A critical assessment.

J Immunol Methods 2021 Jul 27:113108. Epub 2021 Jul 27.

School of Biotechnology, Dublin City University, Dublin 9 D09 V2O9, Ireland; Qatar Foundation and Hamad Bin Khalifa University, Research Complex, Education City, Doha, Qatar. Electronic address:

Cardiovascular disease has remained the world's biggest killer for 30 years. To aid in the diagnosis and prognosis of patients suffering cardiovascular-related disease accurate detection methods are essential. For over 20 years, the cardiac-specific troponins, I (cTnI) and T (cTnT), have acted as sensitive and specific biomarkers to assist in the diagnosis of various types of heart diseases. Read More

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Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma.

J Hepatol 2021 Jul 27. Epub 2021 Jul 27.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) microenvironment is hypovascularized, with a prominent development of lymphatic vessels. This leads to a rapid cancer spread into regional lymph nodes and the liver parenchyma, precluding curative treatments. Here, we investigated which factors released in the iCCA stroma drive the inhibition of angiogenesis, promoting lymphangiogenesis. Read More

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Cytokine Stimulation via MRGPRX2 Occurs with Lower Potency than by FcεRI-aggregation but with Similar Dependence on the ERK1/2 Module in Human Skin Mast Cells.

J Invest Dermatol 2021 Jul 27. Epub 2021 Jul 27.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Skin mast cells (MCs) contribute to chronic dermatoses that partially rely on MC-derived cytokines. The discovery of MRGPRX2 explains MC-dependent symptoms independently of FcεRI-activation. Here, we investigated whether MRGPRX2 can elicit cytokines, determined its relative potency versus FcεRI and addressed the underlying mechanisms. Read More

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Mechanisms of punctuated vision in fly flight.

Curr Biol 2021 Jul 27. Epub 2021 Jul 27.

Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address:

To guide locomotion, animals control gaze via movements of their eyes, head, and/or body, but how the nervous system controls gaze during complex motor tasks remains elusive. In many animals, shifts in gaze consist of periods of smooth movement punctuated by rapid eye saccades. Notably, eye movements are constrained by anatomical limits, which requires resetting eye position. Read More

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Hebbian Learning on Small Data Enables Experimental Discovery of High Polyimides.

J Phys Chem A 2021 Jul 30. Epub 2021 Jul 30.

IBM Research, Almaden Research Center, 650 Harry Road, San Jose, California 95120, United States.

We report a study combining computational design and experimental evaluation of polyimides with high glass transition temperatures: between 220 °C and 500 °C. The computational approach is based on the recently introduced competitive learning algorithm, supervised self-organizing maps (SUSI), which we recast as an ensemble method, e-SUSI. We use e-SUSI to solve both unsupervised and supervised/semisupervised learning tasks capturing structure-property relationships of high- polyimides historically studied at Almaden Research Center. Read More

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Rapid and Direct Photocatalytic C(sp3)-H Acylation and Arylation in Flow.

Angew Chem Int Ed Engl 2021 Jul 30. Epub 2021 Jul 30.

University of Amsterdam, Van't Hoff Institute for Molecular Science, PO Box 94157, Science Park 904, 1090 GD, Amsterdam, NETHERLANDS.

Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp 3 )-C(sp 2 ) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced from 12-48 hours to only 5-15 minutes. Read More

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Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults.

Sleep 2021 Jul 30. Epub 2021 Jul 30.

School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

The rs1344706 polymorphism in ZNF804A is robustly associated with schizophrenia and schizophrenia is, in turn, associated with abnormal non-rapid eye movement (NREM) sleep neurophysiology. To examine whether rs1344706 is associated with intermediate neurophysiological traits in the absence of disease, we assessed the relationship between genotype, sleep neurophysiology, and sleep-dependent memory consolidation in healthy participants. We recruited healthy adult males with no history of psychiatric disorder from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Read More

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SARS-CoV-2 normalized viral loads and subgenomic RNA detection as tools for improving clinical decision-making and work reincorporation.

J Infect Dis 2021 Jul 30. Epub 2021 Jul 30.

Department of Microbiology, Hospital Clínic of Barcelona. Institut of Global Health (ISGlobal), Barcelona, Spain.

Background: SARS-CoV-2 RT-PCR provides a highly variable cycle-threshold (Ct) value that cannot distinguish viral infectivity. Subgenomic RNA (sgRNA) has been used to monitor active replication. Given the importance of long RT-PCR positivity and the need for work reincorporation and discontinuing isolation, we studied the functionality of normalized viral loads (NVL) for patient monitoring and sgRNA for viral infectivity detection. Read More

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When I'm 64: Age-related variability in over 40,000 online cognitive test takers.

J Gerontol B Psychol Sci Soc Sci 2021 Jul 30. Epub 2021 Jul 30.

Department of Psychology, University of Toronto, Toronto, Canada.

Objectives: Age-related differences in cognition are typically assessed by comparing groups of older to younger participants, but little is known about the continuous trajectory of cognitive changes across age, or when a shift to older adulthood occurs. We examined the pattern of mean age differences and variability on episodic memory and executive function measures over the adult lifespan, in a more fine-grained way than past group or lifespan comparisons.

Methods: We used a sample of over 40,000 people aged 18-90 who completed psychometrically validated online tests measuring episodic memory and executive functions (the Cogniciti Brain Health Assessment). Read More

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Higher comorbidity burden predicts worsening neurocognitive trajectories in people with HIV.

Clin Infect Dis 2021 Jul 30. Epub 2021 Jul 30.

Department of Psychiatry, University of California, San Diego, UCSD HNRC, San Diego, CA, United States.

Background: Age-related comorbidities accumulate faster in people with HIV (PWH) than in those without (PWoH). We evaluated whether a validated multimorbidity scale, the Charlson Index, predicted neurocognitive trajectories in PWH.

Methods: Scaled scores a comprehensive neuropsychological battery were averaged across all visits. Read More

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Structural characteristics and proximity comparison of China's urban innovation cooperation network.

PLoS One 2021 30;16(7):e0255443. Epub 2021 Jul 30.

School of Geography, Liaoning Normal University, Dalian, Liaoning, China.

How to promote and improve the level of urban innovation cooperation is a major issue in China's current high-quality economic development. Thus, enhancing innovation ability is essential to achieving high-quality economic growth under the "new normal". Based on the data of Chinese invention patents from 1985 to 2017, this paper analyzes the characteristics of China's urban innovation cooperation network and the different roles of proximity by using social network analysis and exploratory spatial data analysis methods. Read More

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COVID-19 vaccine access and attitudes among people experiencing homelessness from pilot mobile phone survey in Los Angeles, CA.

PLoS One 2021 30;16(7):e0255246. Epub 2021 Jul 30.

Department of Family Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

People experiencing homelessness (PEH) are at high risk for COVID-19 complications and fatality, and have been prioritized for vaccination in many areas. Yet little is known about vaccine acceptance in this population. The objective of this study was to determine the level of vaccine hesitancy among PEH in Los Angeles, CA and to understand the covariates of hesitancy in relation to COVID-19 risk, threat perception, self-protection and information sources. Read More

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Rapid whole-brain electric field mapping in transcranial magnetic stimulation using deep learning.

PLoS One 2021 30;16(7):e0254588. Epub 2021 Jul 30.

Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States of America.

Transcranial magnetic stimulation (TMS) is a non-invasive neurostimulation technique that is increasingly used in the treatment of neuropsychiatric disorders and neuroscience research. Due to the complex structure of the brain and the electrical conductivity variation across subjects, identification of subject-specific brain regions for TMS is important to improve the treatment efficacy and understand the mechanism of treatment response. Numerical computations have been used to estimate the stimulated electric field (E-field) by TMS in brain tissue. Read More

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Non-Planck thermal emission from two-level media.

Opt Lett 2021 Aug;46(15):3584-3587

Thermal emission is a universal phenomenon of stochastic electromagnetic emission from absorbing bodies at elevated temperatures. A defining feature of this emission is the monotonic and rapid growth of its intensity with the object's temperature for most known materials. This growth originates from the Bose-Einstein statistics of the thermal photonic field. Read More

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High-speed hyperspectral four-wave-mixing microscopy with frequency combs.

Opt Lett 2021 Aug;46(15):3556-3559

A four-wave-mixing, frequency-comb-based, hyperspectral imaging technique that is spectrally precise and potentially rapid, and can in principle be applied to any material, is demonstrated in a near-diffraction-limited microscopy application. Read More

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Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer.

Aging (Albany NY) 2021 Jul 30;13(undefined). Epub 2021 Jul 30.

Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan.

Breast cancer is a complex disease, and several processes are involved in its development. Therefore, potential therapeutic targets need to be discovered for these patients. Proteasome 26S subunit, ATPase gene (PSMC) family members are well reported to be involved in protein degradation. Read More

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Application of free and immobilized novel bifunctional biocatalyst in biotransformation of recalcitrant lignocellulosic biomass.

Chemosphere 2021 Jul 2;285:131412. Epub 2021 Jul 2.

Department of Systems and synthetic Biology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran; Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address:

Herein, an innovative, green, and practical biocatalyst was developed using conjugation of a novel bifunctional mannanase/xylanase biocatalyst (PersiManXyn1) to the modified cellulose nanocrystals (CNCs). Firstly, PersiManXyn1 was multi-stage in-silico screened from rumen macrobiota, and then cloned, expressed, and purified. Next, CNCs were synthesized from sugar beet pulp using enzymatic and acid hydrolysis processes, and then FeO NPs were anchored on their surface to produce magnetic CNCs (MCNCs). Read More

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Simultaneous and sequential combination of electrocoagulation and ozonation by Al and Fe electrodes for DirectBlue71 treatment in a new reactor: Synergistic effect and kinetics study.

Chemosphere 2021 Jul 5;285:131424. Epub 2021 Jul 5.

Department of Environmental Engineering, Civil & Environmental Engineering Faculty, Tarbiat Modares University, P.O. Box 14115-397, Tehran, Iran. Electronic address:

In this study, the simultaneous combination of electrocoagulation and ozonation (EC-O) was optimized in a new reactor for Direct Blue 71 treatment and compared to electrocoagulation (EC), ozonation (O), and their sequential combination (EC→O) by considering the performance criteria (dye and naphthalene ring removal efficiency), economic assessment (energy and anode consumption), chemical degradability, mineralization rate, and kinetic study. Applying a middle wall in the reactor improved coagulation under ozone-induced rapid mixing on the first side and flocculation under flow-induced slow mixing on the other side which reduced the floc breakage at high ozone dosages. Dye, COD, and TOC removal rate was in the following order: EC(Al)-O>EC(Fe)-O>EC(Al)→O>EC(Fe)→O>EC(Al)>EC(Fe)>O. Read More

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