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Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.

J Natl Compr Canc Netw 2021 Apr 20:1-7. Epub 2021 Apr 20.

3Division of Medical Oncology, and.

Background: Bone metastases and skeletal-related events (SREs) are a frequent cause of morbidity in patients with metastatic non-small cell lung cancer (mNSCLC). Data are limited on bone metastases and SREs in patients with mNSCLC treated using immune checkpoint inhibitors (ICIs), and on the efficacy of bone-modifying agents (BMAs) in this setting. Here we report the incidence, impact on survival, risk factors for bone metastases and SREs, and impact of BMAs in patients with mNSCLC treated with ICIs in a multi-institutional cohort. Read More

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Defining the risk profile of women with stage 1 hypertension: A time to event analysis.

Am J Obstet Gynecol MFM 2021 Apr 17:100376. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Chronic hypertension complicates up to 5% of pregnancies and is increasing in prevalence. Women with hypertension have increased risks of serious maternal morbidity and mortality in pregnancy including the development of preeclampsia. In 2017, new guidelines reclassified blood pressure into four categories: normal (<120/<80 mmHg), elevated (120-129/<80 mmHg), stage 1 hypertension (130-139/80-89 mmHg), and stage 2 hypertension (>140/>90 mmHg). Read More

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ChIP-R: Assembling reproducible sets of ChIP-seq and ATAC-seq peaks from multiple replicates.

Genomics 2021 Apr 17. Epub 2021 Apr 17.

School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, QLD 4072, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, QLD 4072, Australia. Electronic address:

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the primary protocol for detecting genome-wide DNA-protein interactions, and therefore a key tool for understanding transcriptional regulation. A number of factors, including low specificity of antibody and cellular heterogeneity of sample, may cause "peak" callers to output noise and experimental artefacts. Statistically combining multiple experimental replicates from the same condition could significantly enhance our ability to distinguish actual transcription factor binding events, even when peak caller accuracy and consistency of detection are compromised. Read More

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Inhalation Profiles Through a Dry Powder Inhaler: Relation Between Inhalation Technique and Spirometric Measures.

J Aerosol Med Pulm Drug Deliv 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland.

The understanding of the real flow profiles through a dry powder inhaler (DPI), generated by asthma patients, is a prerequisite for satisfactory drug delivery to the lungs. The aims of the study were to assess the relationship between spirometric measures and inhalation profiles through a low-resistance DPI, and to compare parameters of those profiles between optimal and suboptimal inhalation technique type. Both healthy adult volunteers and patients with asthma were included in the study. Read More

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Clinicopathologic Characteristics and Survival of Patients with Rare Malignant Ovarian Yolk Sac Tumors: A Population-based Analysis.

Curr Med Sci 2021 Apr 20;41(2):342-347. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Yolk sac tumors (YSTs) are rare malignant germ cell tumors that usually affect young females. To date, there have been few studies on YSTs. We evaluated the relationship between clinicopathologic characteristics of patients with ovarian YSTs and disease outcome based on Surveillance, Epidemiology, and End Results data. Read More

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Monocyte-to-High-Density Lipoprotein Cholesterol Ratio Is Independently Associated With All-Cause Mortality in Deceased Donor Kidney Transplant Recipients.

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the Department of Urology, Faculty of Medicine, Uludag University, Bursa, Turkey.

Objectives: The primary objective of this study was to evaluate the impact of monocyte-to-high-density lipoprotein cholesterol ratio on all-cause mortality in deceased donor kidney transplant recipients.

Materials And Methods: This was a retrospective observational study in which all deceased donor kidney transplant recipients were included. Relevant data for analyses included clinical and demographic features, laboratory values, number of HLA matches, occurrence of delayed graft function, cold ischemia time, and survival status. Read More

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COVID-19 and Comorbidities: Audit of 2,000 COVID-19 Deaths in India.

J Epidemiol Glob Health 2021 Mar 9. Epub 2021 Mar 9.

Global Institute of Public Health, Thiruvananthapuram, Kerala, India.

Background: On September 5, 2020, India reported the second highest COVID-19 cases globally. Given India's unique disease burden including both infectious and chronic diseases, there is a need to study the survival patterns of COVID-19. We aimed to describe the factors associated with COVID-19 deaths in the State of Tamil Nadu that has the highest COVID-19 case burden among the Indian states, and to compare deaths among COVID patients with and without comorbidities. Read More

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Evaluation of the efficacy of laser-assisted flapless corticotomy in accelerating canine retraction: a split-mouth randomized controlled clinical trial.

Oral Maxillofac Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Orthodontics, University of Damascus Dental School, Damascus, Syria.

Objective: To evaluate the efficacy of laser-assisted flapless corticotomy in the acceleration of canine retraction compared with the conventional technique and to evaluate patients' pain and discomfort levels after corticotomy.

Materials And Methods: A single-center randomized controlled trial was conducted on 18 class II division 1 patients (7 males, 11 females; age range: 16 to 24 years) who required the first-upper-premolar extraction followed by canine retraction. A split-mouth design was used in which the Er:YAG laser-assisted flapless corticotomy was randomly allocated to one side, whereas the other side served as the control side. Read More

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Photoacoustic needle improves needle tip visibility during deep peripheral nerve block.

Sci Rep 2021 Apr 19;11(1):8432. Epub 2021 Apr 19.

Department of Anesthesiology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo, 181-8611, Japan.

We developed a novel technology using the photoacoustic effect that improve needle tip visibility. We evaluated whether this technology improves needle tip visibility when performing a deep peripheral nerve block in a cadaver model. A photoacoustic needle was developed using a conventional echogenic needle with an intraluminal optical fiber. Read More

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The Influence of Dissonance Induction and Assessment Reactivity in Improving Adherence to COVID-19 Precautionary Measures: A Cluster Randomised Controlled Trial.

Int Dent J 2021 Mar 20. Epub 2021 Mar 20.

Assistant Professor, Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, AP, India.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, adherence to suggested precautionary measures has been emphasized as important in preventing and curtailing its spread. However, strict adherence to precautionary measures can be demanding.

Methods: This cluster randomised controlled trial done among 1517 undergraduate dental students tested the effectiveness of 'dissonance induction' (DI) and 'assessment reactivity' (AR) in improving adherence to World Health Organization (WHO) measures as compared to a control group. Read More

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Effect of dual-task training on balance in patients with multiple sclerosis: A systematic review and meta-analysis.

Clin Rehabil 2021 Apr 20:2692155211010372. Epub 2021 Apr 20.

Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy.

Objective: To evaluate the effects of dual-task training on static and dynamic balance in patients with multiple sclerosis.

Data Sources: PubMed/MEDLINE, EMBASE, Scopus, and PEDro databases were searched from inception to March 1, 2021.

Methods: This study was conducted in agreement with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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Examining the test-retest reliability and construct validity of the Six-Spot Step Test in older adults with self-reported balance problems.

Clin Rehabil 2021 Apr 20:2692155211010278. Epub 2021 Apr 20.

Faculty of Health Science, VIA University College, Research Centre for Health and Welfare Technology - Programme for Rehabilitation, Aarhus, Denmark.

Objective: To evaluate the test-retest reliability and construct validity of the Six-Spot Step Test in older adults.

Design: Cross-sectional study.

Setting: Outpatient clinics. Read More

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[Effect analysis of early application of sequential laser treatment on hypertrophic scar of burn children].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-6. Epub 2021 Mar 24.

Department of Burn Surgery, the First Hospital of Jilin University, Changchun 130061, China.

To explore the effects of early application of sequential treatment of intensive pulsed light and carbon dioxide laser on burn children. The retrospective cohort before-after study in the same patient was conducted. From January 2016 to December 2018, 145 burn children with hypertrophic scar in the early stage and met the inclusion criteria were admitted to the First Hospital of Jilin University. Read More

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[Clinical characteristics of heart failure with recovered ejection fraction].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Apr 24;49(4):333-339. Epub 2021 Apr 24.

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

To summarize the clinical characteristics of heart failure patients with recovered ejection fraction (HFrecEF) and identify variables capable of predicting left ventricular ejection fraction (LVEF) recovery. This case control study included patients with heart failure, who admitted to Department of Cardiology of Beijing Hospital from January 1, 2009 to December 31, 2017. The patients were divided into 3 groups based on the baseline LVEF and changes of LVEF: heart failure with reduced ejection fraction (HFrEF, baseline LVEF≤40%, follow-up LVEF≤40% or follow-up LVEF>40% but LVEF increase<10% from baseline), HFrecEF(baseline LVEF≤40%, follow-up LVEF>40% and increase≥10% from baseline), and heart failure with preserved ejection fraction (HFpEF, baseline LVEF>40%). Read More

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[A prospective randomized controlled study on the effect of balance training on lower limb movement and balance dysfunction in severe burn patients].

Zhonghua Shao Shang Za Zhi 2021 Mar 30;37:1-7. Epub 2021 Mar 30.

Institute of Burns, Tongren Hospital of Wuhan University&Wuhan Third Hospital, Wuhan 430060, China.

To observe the rehabilitation effect of balance training on motor and balance function of lower extremities of deep burn patients. A prospective randomized controlled study was conducted. From January 2016 to January 2020, sixty-four patients with lower limb motor and balance dysfunction after deep burn were admitted to Tongren Hospital of Wuhan University&Wuhan Third Hospital, the burn area was 30% to 70% Total Body Surface Area, and the burn depth of more than one hip, knee and ankle joint of both lower limbs and their periphery were deep second or third degree. Read More

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Comparison of Bronchial Sleeve Lobectomy with Pulmonary Arterioplasty versus Pneumonectomy.

Ann Thorac Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University. Electronic address:

Background: To evaluate the efficacy of bronchial sleeve lobectomy with pulmonary arterioplasty by comparing to pneumonectomy in centrally located non-small cell lung cancer (NSCLC) with bronchovascular invasion.

Methods: The entire cohort consisted of 212 patients receiving pneumonectomy and 156 patients undergoing bronchial sleeve lobectomy with pulmonary arterioplasty. Propensity score matching was adopted to create a fully balanced cohort, after which, baseline characteristics, perioperative performance and oncological results were compared between two groups. Read More

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Real-world experience of olaparib as maintenance therapy in BRCA-mutated recurrent ovarian cancer.

Arch Gynecol Obstet 2021 Apr 19. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: The primary objective of our study was to investigate the effectiveness and safety of olaparib maintenance therapy in patients with BRCA-mutated recurrent ovarian cancer in daily practice. The secondary objective of this study was to identify prognostic factors associated with prolonged progression-free survival (PFS) in such patients.

Methods: We conducted a retrospective analysis of 40 patients who received olaparib maintenance treatment. Read More

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Differentiation of clinical patterns and survival outcomes of hepatocellular carcinoma on hepatitis B and nonalcoholic fatty liver disease.

J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan, ROC Department of Pathology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan, ROC Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan, ROC University of Taipei, Taipei, Taiwan, ROC.

Background: The main etiologies of hepatocellular carcinoma (HCC) were often hepatitis B virus (HBV) or C and alcohol, rarely autoimmune and biliary diseases. Nonalcoholic fatty liver disease (NAFLD) has been an emerging role that could lead to chronic liver disease, nonalcoholic steatohepatitis, cirrhosis, and eventually HCC in recent years. The aim of our study is to investigate and compare the clinical features of HCC in NAFLD and HBV patients, including age, gender, cirrhosis, liver function tests, largest tumor size and cancer stage at the time of diagnosis. Read More

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Evaluation of the relationship between central serous chorioretinopathy and liver cirrhosis: A nationwide, population-based study.

J Chin Med Assoc 2021 Apr 13. Epub 2021 Apr 13.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC Department of Ophthalmology, Song-Shan Branch of Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan, ROC Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.

Background: Central serous chorioretinopathy (CSCR) and liver cirrhosis share numerous risk factors and may have possible connections. We aimed to investigate whether patients with liver cirrhosis and the severity of cirrhosis have an increased incidence of CSCR.

Methods: This population-based retrospective cohort study was conducted by collecting data from the Taiwan National Health Insurance Research Database from January 1, 2000 to December 31, 2015. Read More

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Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis.

Indian J Dermatol Venereol Leprol 2021 Mar 9:1-7. Epub 2021 Mar 9.

Department of Cardiology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.

Background: Carotid intima-media thickness test is a surrogate marker of subclinical atherosclerosis. Epicardial fat thickness is an early marker of coronary artery disease. Several studies have noted that psoriasis patients have an increased risk of coronary artery disease. Read More

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Concurrent Diagnosis of Anxiety Increases Postoperative Length of Stay Among Patients Receiving Esophagectomy for Esophageal Cancer.

Psychooncology 2021 Apr 18. Epub 2021 Apr 18.

Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Objective: Psychiatric comorbidities disproportionately affect patients with cancer. While identified risk factors for prolonged length of stay (LOS) after esophagectomy are primarily medical comorbidities, the impact of psychiatric comorbidities on perioperative outcomes is unclear. We hypothesized that psychiatric comorbidities would prolong LOS in patients with esophageal cancer. Read More

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FOXP4-AS1 is a favourable prognostic-related enhancer RNA in ovarian cancer.

Biosci Rep 2021 Apr 19. Epub 2021 Apr 19.

Affiliated Xing Tai People Hospital of Hebei Medial University, Xing tai, China.

Ovarian cancer (OV) is a main cause of death worldwide in female reproductive system malignancies. Enhancer RNAs (eRNAs) are derived from the transcription of enhancers and has attracted increasing attention in cancers recently. However, the biological functions and clinical significance of eRNAs in OV have not been well described presently. Read More

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Prognostic value of neutrophils for patients with nasopharyngeal carcinoma.

Laryngoscope Investig Otolaryngol 2021 Apr 11;6(2):219-225. Epub 2021 Mar 11.

Department of Radiation Oncology Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fujian Medical University Fuzhou Fujian Province China.

Objective: To investigate the relationship between absolute neutrophils count (ANC) in different periods of treatment and the outcomes of patients and assess effect of longitudinal neutrophils variation during radiotherapy (RT) on prognosis in patients with nasopharyngeal carcinoma (NPC).

Methods: A total of 1753 patients with newly diagnosed NPC were retrospectively analyzed. Complete blood counts of patients were obtained before treatment, before, during, and end of RT. Read More

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Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics.

Biomed Res Int 2021 1;2021:6657767. Epub 2021 Apr 1.

Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.

Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral cancer and has a poor prognosis. We aimed to identify new biomarkers or potential therapeutic targets for OSCC.

Materials And Methods: Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differentially expressed genes (DEGs) were screened via high-throughput RNA sequencing (RNA-seq). Read More

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The Association Between Pleural Empyema and Peripheral Arterial Disease in Younger Patients: A Retrospective National Population-Based Cohort Study.

Front Med (Lausanne) 2021 19;8:621330. Epub 2021 Mar 19.

Graduate Institute of Biomedical Sciences Science, College of Medicine, China Medical University, Taichung, Taiwan.

To investigate the relationship between pleural empyema (PE) and peripheral arterial disease (PAD). We conducted a retrospective cohort study using data from the National Health Institute Research Database. Univariable and multivariable Cox's proportional hazard regressions were performed to investigate the association between PE and the risk of PAD. Read More

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Effect of Applying Leakage Correction on rCBV Measurement Derived From DSC-MRI in Enhancing and Nonenhancing Glioma.

Front Oncol 2021 23;11:648528. Epub 2021 Mar 23.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands.

Purpose: Relative cerebral blood volume (rCBV) is the most widely used parameter derived from DSC perfusion MR imaging for predicting brain tumor aggressiveness. However, accurate rCBV estimation is challenging in enhancing glioma, because of contrast agent extravasation through a disrupted blood-brain barrier (BBB), and even for nonenhancing glioma with an intact BBB, due to an elevated steady-state contrast agent concentration in the vasculature after first passage. In this study a thorough investigation of the effects of two different leakage correction algorithms on rCBV estimation for enhancing and nonenhancing tumors was conducted. Read More

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Computational Image Analysis Identifies Histopathological Image Features Associated With Somatic Mutations and Patient Survival in Gastric Adenocarcinoma.

Front Oncol 2021 31;11:623382. Epub 2021 Mar 31.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States.

Computational analysis of histopathological images can identify sub-visual objective image features that may not be visually distinguishable by human eyes, and hence provides better modeling of disease phenotypes. This study aims to investigate whether specific image features are associated with somatic mutations and patient survival in gastric adenocarcinoma (sample size = 310). An automated image analysis pipeline was developed to extract quantitative morphological features from H&E stained whole-slide images. Read More

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A Nomogram Combining a Four-Gene Biomarker and Clinical Factors for Predicting Survival of Melanoma.

Front Oncol 2021 1;11:593587. Epub 2021 Apr 1.

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: Currently there is no effective prognostic indicator for melanoma, the deadliest skin cancer. Thus, we aimed to develop and validate a nomogram predictive model for predicting survival of melanoma.

Methods: Four hundred forty-nine melanoma cases with RNA sequencing (RNA-seq) data from TCGA were randomly divided into the training set I (n = 224) and validation set I (n = 225), 210 melanoma cases with RNA-seq data from Lund cohort of Lund University (available in GSE65904) were used as an external test set. Read More

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Medical Student Engagement in a Virtual Learning Environment Positively Correlates with Course Performance and Satisfaction in Psychiatry.

Med Sci Educ 2021 Apr 12:1-8. Epub 2021 Apr 12.

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN USA.

Introduction: There has been a move to a "flipped classroom" (FC) in medical education. The FC promotes active learning and utilizes independent preparation prior to in-class sessions. Few studies have evaluated the effectiveness of the FC approach in medical education, specifically via virtual learning. Read More

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