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Anal Squamous Cell Carcinoma in Ulcerative Colitis: Can Pouches Withstand Traditional Treatment Protocols?

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio General Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio Department of Gastroenterology, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Anal squamous cell carcinoma has rarely reported in ulcerative colitis.

Objective: Understand the prognosis of anal squamous cell carcinoma in the setting of ulcerative colitis.

Design: Retrospective review. Read More

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Bulbar Urethral Stents for Bulbar Urethral Strictures: Long-Term Follow-Up after Stent Removal.

Urol Int 2021 May 5:1-6. Epub 2021 May 5.

Department of Urology, Kocaeli University School of Medicine, Kocaeli, Turkey.

Background/aim: The aim of this study was to assess long-term clinical efficacy of temporary bulbar urethral stent (BUS) used for treatment of recurrent bulbar urethral stricture (US).

Materials And Methods: A total of 168 patients with recurrent bulbar US who underwent BUS placement after internal urethrotomy between 2009 and 2019 were enrolled. An indwelling time of 12 months was planned for the stents. Read More

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Does Auditory Environment Predict Speech Perception Outcomes in Elderly Cochlear Implant Patients?

Audiol Neurootol 2021 May 5:1-9. Epub 2021 May 5.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine, Ear Institute, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.

Introduction: Cochlear implantation (CI) is a reliable and safe means by which sensorineural hearing loss can be ameliorated in the elderly population. However, a high degree of variation exists in postimplantation hearing outcomes for which some modifiable factors of the daily natural auditory environment may be contributory. In this study, we analyze the relationship between cochlear implant patient age, natural auditory environment, and postimplantation speech perception among older adults. Read More

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Determination of anthocyanin and moisture content of purple sweet potatoes during drying process by their optical properties in the 400-1050 nm range.

Food Chem 2021 Apr 20;359:129811. Epub 2021 Apr 20.

College of Food Science and Technology, Nanjing Agricultural University, No. 1 Weigang Road, Nanjing 210095, China. Electronic address:

This research investigated the potential of using optical properties to assess quality attributes of purple sweet potatoes (PSPs) during drying process. The absorption (μ) and scattering (μ) properties of PSPs during drying were determined at 400-1050 nm using a single integrating sphere system. The absorption spectra were marked by pronounced anthocyanin peaks around 545 nm, and very small water peaks around 980 nm. Read More

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Collateral ligament sprains of the metacarpophalangeal joint of the long fingers: Results of a surgical series of 15 patients.

Orthop Traumatol Surg Res 2021 May 2. Epub 2021 May 2.

Institut Montpelliérain de la Main et du Membre Supérieur, Clinique Saint-Roch, 560 Avenue du Colonel Pavelet, 34070 Montpellier, France.

Introduction Collateral ligament sprains of the metacarpophalangeal joint (MP) of the long fingers are rare and mostly treated conservatively. Clinical examination to diagnose the severity of these injuries is mandatory. The purpose of our study is to report the results of 15 patients treated surgically. Read More

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Bioactive naphthoquinones and triterpenoids from the fruiting bodies of Taiwanofungus salmoneus.

Bioorg Chem 2021 Apr 23;112:104939. Epub 2021 Apr 23.

School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. Electronic address:

Drug resistance of cancer cells stands for the major problem of the treatment failure for chemotherapy or target therapy. Overexpression of efflux pumps leading to multidrug resistance (MDR) is still an important issue needed to be solved. In the present study, Taiwanofungus salmoneus was selected as the topic and eleven undescribed constituents including four naphthoquinones salmonones A-D (1-4) and seven triterpenoids salmoneatins A-G (5-11), along with one chromanone (12) and two benzenoids (13 and 14) reported from the natural sources for the first time, as well as twenty-one known compounds were characterized. Read More

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Aspiration Thrombectomy with the Indigo System for Acute Lower Limb Ischemia: preliminary experience and analysis of parameters affecting the outcome.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Surgical and Medical Sciences and Translational Medicine, "Sapienza" - University of Rome, Italy. Radiology and Interventional Radiology Unit, Sant'Andrea University Hospital.

Purpose: The purpose of our study is to assess the short-term technical success and the safety of the Indigo System in a series of patients undergoing vacuum-assisted catheter direct thrombus aspiration (IS-CDTA) for acute lower limb ischemia (ALLI) and to evaluate which parameters may affect the outcome.

Materials And Methods: All procedures using the IS-CDTA for ALLI, performed in a single-centre Interventional Radiology Unit from February 2016 to March 2020, were retrospectively analysed. Technical success was defined as the achievement of nearly-complete or complete revascularization (TIPI grade 2/3) and considered as a good outcome. Read More

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Individuals aged 1-64 years with documented congenital heart defects at healthcare encounters, five U.S. surveillance sites, 2011-2013.

Am Heart J 2021 May 2. Epub 2021 May 2.

Department of Epidemiology, Colorado School of Public Health, University of Colorado | Anschutz Medical Campus, Aurora, Colorado.

Background: Many individuals born with CHD survive to adulthood. However, population estimates of CHD beyond early childhood are limited in the U.S. Read More

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3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution.

Adv Healthc Mater 2021 May 5:e2100117. Epub 2021 May 5.

Department of Materials, Imperial College London, London, SW7 2AZ, United Kingdom.

Inorganic-organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate)-star-SiO hybrid inks are printed with pore channels in the range of 100-200 µm. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre-osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Read More

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Paying for performance to improve the delivery of health interventions in low- and middle-income countries.

Cochrane Database Syst Rev 2021 May 5;5:CD007899. Epub 2021 May 5.

Institute for Global Health and Development, Queen Margaret University, Edinburgh, UK.

Background: There is growing interest in paying for performance (P4P) as a means to align the incentives of healthcare providers with public health goals. Rigorous evidence on the effectiveness of these strategies in improving health care and health in low- and middle-income countries (LMICs) is lacking; this is an update of the 2012 review on this topic.

Objectives: To assess the effects of paying for performance on the provision of health care and health outcomes in low- and middle-income countries. Read More

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Machine learning for reparameterization of four-site water models: TIP4P-BG and TIP4P-BGT.

Phys Chem Chem Phys 2021 May 14;23(17):10164-10173. Epub 2021 Apr 14.

International Research Center for Computational Mechanics, State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Faculty of Vehicle Engineering and Mechanics, Dalian University of Technology, Dalian 116024, P. R. China.

Parameterizing an effective water model is a challenging issue because of the difficulty in maintaining a comprehensive balance among the diverse physical properties of water with a limited number of parameters. The advancement in machine learning provides a promising path to search for a reliable set of parameters. Based on the TIP4P water model, hence, about 6000 molecular dynamics (MD) simulations for pure water at 1 atm and in the range of 273-373 K are conducted here as the training data. Read More

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Increasing Hemoglobin Concentration With An Artificial Oxygen Carrier Improves Severe Anemia-Induced Degraded Cognitive Function.

J Trauma Acute Care Surg 2021 May 5. Epub 2021 May 5.

Professor Emeritus, University of California, San Francisco; Professor, Department of Pathology, University of Michigan Medical School; Director of Research, U.S. Army Institute of Surgical Research, JBSA-Ft Sam Houston, San Antonio, TX, and Professor of Medicine, Uniformed Services University, Bethesda MD; Wellstar Pulmonary and Critical Care Medicine, Marietta, GA; Professor, Department of Anesthesiology and Perioperative Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA; Assistant Professor, Laboratory Medicine Program and Department of Medical Oncology & Hematology, University Health Network, University of Toronto, Ontario, Canada;

Abstract: Prior to death patients commonly experience impaired consciousness for a significant period of time, frequently preventing family and others from final interactions with the patient. Some of these episodes of cognitive impairment may be treatable, with treatment not offered owing to the perception of ultimate futility, or expense, or both. One of the causes of terminal loss of consciousness or decreased lucidity can be inadequate cerebral oxygen delivery. Read More

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Differential impacts of hemolysis on coagulation parameters of blood samples: A STROBE-compliant article.

Medicine (Baltimore) 2021 May;100(18):e25798

Department of Emergency Medicine, E-Da Hospital.

Abstract: This study aimed at investigating the impact of hemolysis on different coagulation parameters.A total of 216 venous blood samples without visible hemolysis were collected from adult patients at a tertiary referral center over six months. The plasma obtained was quantified for six coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, antithrombin III, and protein C. Read More

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The efficacy and safety of moxibustion for chronic fatigue syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25742

Guizhou University of Traditional Chinese Medicine, Guizhou.

Background: The pathogenesis of chronic fatigue syndrome (CFS) is not clear. The main purpose of treatment is to improve autoimmune function and relieve fatigue symptoms. Moxibustion is often used to treat diseases caused by low autoimmunity, especially in relieving fatigue symptoms. Read More

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Comparisons between Locomat and Walkbot robotic gait training regarding balance and lower extremity function among non-ambulatory chronic acquired brain injury survivors.

Medicine (Baltimore) 2021 May;100(18):e25125

TBI rehabilitation center, National Traffic Injury Rehabilitation Hospital, Gyeonggi-do.

Abstract: Lower limb rehabilitation exoskeleton robots connect with the human body in a wearable way and control the movement of joints in the gait rehabilitation process. Among treadmill-based lower limb rehabilitation exoskeleton robots, Lokomat (Hocoma AG, Volketswil, Switzerland) has 4 actuated joints for bilateral hips and knees whereas Walkbot (P&S Mechanics, Seoul, Korea) has 6 bilateral actuated joints for bilateral hips, knees, and ankles. Lokomat and Walkbot robotic gait training systems have not been directly compared previously. Read More

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Protein Quantification Using the "Rapid Western Blot" Approach.

Methods Mol Biol 2021 ;2228:29-39

Medizinisches Proteom-Center (MPC), Medical Faculty, Ruhr-University Bochum, Bochum, Germany.

For the quantification of certain proteins of interest within a complex sample, Western blot analysis is the most widely used method. It enables detection of a target protein based on the use of specific antibodies. However, the whole procedure is often very time-consuming. Read More

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January 2021

Patient-caregiver agreement and test-retest reliability of the EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients with haematological malignancies.

Eur J Health Econ 2021 May 5. Epub 2021 May 5.

Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, Singapore.

Background: In 2019, the EuroQol Group developed a 'beta' 5-level version of EQ-5D-Y (Y-5L) by increasing the number of descriptive levels to five for each health dimension, as compared to the standard 3-level EQ-5D-Y (Y-3L).

Objective: To assess patient-caregiver agreement and test-retest reliability of the Y-5L and Y-3L in paediatric patients with haematological malignancies.

Methods: Paediatric inpatients aged 8-17 years were interviewed with the Y-5L and Y-3L questionnaires twice, while their caregivers were interviewed at the same time using the proxy versions of the questionnaires. Read More

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SynBac: Enhanced Baculovirus Genomes by Iterative Recombineering.

Methods Mol Biol 2021 ;2305:141-152

Bristol Synthetic Biology Centre BrisSynBio, Biomedical Sciences, School of Biochemistry, University of Bristol, Bristol, UK.

Baculovirus expression vector systems (BEVS) are widely used to produce heterologous proteins for a wide range of applications. Developed more than 30 years ago, BEVS have been constantly modified to improve product quality and ease-of-use. Plasmid reagents were tailored and engineered to facilitate introduction of heterologous genes into baculoviral genomes. Read More

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January 2021

Effects of Growth Hormone treatment on sleep-related parameters in adults with Prader-Willi syndrome.

J Clin Endocrinol Metab 2021 May 5. Epub 2021 May 5.

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Background: Prader-Willi Syndrome (PWS) is a rare, genetic, multi-symptom, neurodevelopmental disease, due to lack of the expression of the paternal genes in the q11-q13 region of chromosome 15. The main characteristics of PWS are muscular hypotonia, hyperphagia, obesity, behavioral problems, cognitive disabilities and endocrine deficiencies, including growth hormone (GH) deficiency. Sleep apnea and abnormal sleep patterns are common in PWS. Read More

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Ionisation of PF: absolute partial electron ionisation cross sections and the formation and reactivity of dication states.

Phys Chem Chem Phys 2021 May 5. Epub 2021 May 5.

Department of Chemistry, University College London, London WC1H 0AJ, UK.

Absolute partial electron ionisation cross sections, and precursor-specific partial electron ionisation cross sections, for the formation of cations from phosphorus trifluoride (PF3) are reported over the electron energy range 50-200 eV. The absolute values are determined by the measurement of cross sections relative to the formation of PF3+ using 2D ion-ion coincidence time-of-flight mass spectrometry and subsequent scaling using binary encounter-Bethe calculations of the total ionisation cross section. This new dataset significantly augments the partial ionisation cross sections for electron ionization of PF3 found in literature, addressing previous discrepancies in the branching ratios of product ions, and provides the first values for the precursor-specific cross sections. Read More

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Encephalitis Associated With Immune Checkpoint Inhibitor Treatment in Patients With Melanoma.

J Immunother 2021 Jun;44(5):204-207

Medical Oncology Department, Hospital Clinic.

Since the approval of immune checkpoint anti-programmed cell death protein 1 antibodies (pembrolizumab and nivolumab) and anti-cytotoxic T-lymphocyte-associated protein 4 (ipilimumab) in combination or monotherapy, significant advances have been made in the treatment of metastatic melanoma. The nonspecific immune stimulation resulting from these drugs can case a wide range of side effects in many organs including the nervous system, named immune-related adverse events. Few immune-related encephalitis associated with these antibodies have been described in the literature. Read More

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The time-resolved hard X-ray diffraction endstation KMC-3 XPP at BESSY II.

J Synchrotron Radiat 2021 May 19;28(Pt 3):948-960. Epub 2021 Mar 19.

Helmholtz-Zentrum Berlin für Materialien und Energie, Wilhelm-Conrad-Röntgen Campus, BESSY II, Albert-Einstein-Strasse 15, 12489 Berlin, Germany.

The time-resolved hard X-ray diffraction endstation KMC-3 XPP for optical pump/X-ray probe experiments at the electron storage ring BESSY II is dedicated to investigating the structural response of thin film samples and heterostructures after their excitation with ultrashort laser pulses and/or electric field pulses. It enables experiments with access to symmetric and asymmetric Bragg reflections via a four-circle diffractometer and it is possible to keep the sample in high vacuum and vary the sample temperature between ∼15 K and 350 K. The femtosecond laser system permanently installed at the beamline allows for optical excitation of the sample at 1028 nm. Read More

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The new X-ray absorption fine-structure beamline with sub-second time resolution at the Taiwan Photon Source.

J Synchrotron Radiat 2021 May 12;28(Pt 3):930-938. Epub 2021 Mar 12.

National Synchrotron Radiation Research Center, Hsin-Ann Road, Hsinchu Science Park, Hsinchu 30076, Taiwan.

The new TPS 44A beamline at the Taiwan Photon Source, located at the National Synchrotron Radiation Research Center, is presented. This beamline is equipped with a new quick-scanning monochromator (Q-Mono), which can provide both conventional step-by-step scans (s-scans) and on-the-fly scans (q-scans) for X-ray absorption fine-structure (XAFS) spectroscopy experiments, including X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine-structure (EXAFS) spectral measurements. Ti and Te K-edge XAFS spectra were used to demonstrate the capability of collecting spectra at the limits of the working energy range. Read More

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Staircase array of inclined refractive multi-lenses for large field of view pixel super-resolution scanning transmission hard X-ray microscopy.

J Synchrotron Radiat 2021 May 12;28(Pt 3):732-740. Epub 2021 Mar 12.

Institute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Baden-Württemberg, Germany.

Owing to the development of X-ray focusing optics during the past decades, synchrotron-based X-ray microscopy techniques allow the study of specimens with unprecedented spatial resolution, down to 10 nm, using soft and medium X-ray photon energies, though at the expense of the field of view (FOV). One of the approaches to increase the FOV to square millimetres is raster-scanning of the specimen using a single nanoprobe; however, this results in a long data acquisition time. This work employs an array of inclined biconcave parabolic refractive multi-lenses (RMLs), fabricated by deep X-ray lithography and electroplating to generate a large number of long X-ray foci. Read More

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Determinants of usage and non-adherence to noninvasive ventilation in children and adults with Duchenne muscular dystrophy.

J Clin Sleep Med 2021 May 4. Epub 2021 May 4.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, CA.

Study Objectives: Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to chronic respiratory insufficiency and failure. Use of home noninvasive ventilation (NIV) has been linked to improved outcomes including reduced mortality. Despite the importance of NIV, factors promoting optimal NIV usage and determinants of non-adherence have not been rigorously examined. Read More

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Cytotoxicity and Target Modulation in Pediatric Solid Tumors by the Proteasome Inhibitor Carfilzomib.

Curr Cancer Drug Targets 2021 May 3. Epub 2021 May 3.

Division of Pediatric Hematology, Oncology and Transplant Alberta Children's Hospital 2888 Shaganappi Tr. NW Calgary AB T3B 6A8, Canada.

Background: Most children with recurrent metastatic solid tumors have high mortality rates. Recent studies have shown that proteasome inhibition leads to effective tumor killing in cells that have acquired treatment resistance and metastatic properties.

Objective: The purpose of this study was to test the potential of Carfilzomib (CFZ), a proteasome inhibitor, in refractory pediatric solid tumors, which is currently unknown. Read More

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Empirically-informed guidelines for first-time adult ADHD diagnosis.

J Clin Exp Neuropsychol 2021 May 5:1-12. Epub 2021 May 5.

Department of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.

: Adult Attention Deficit/Hyperactivity Disorder (ADHD) is prone to misdiagnosis because its symptoms are subjective, share features with a broad range of mental, behavioral and physical disorders, and express themselves heterogeneously. Furthermore, Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria for adult ADHD diagnosis remain underdeveloped, prompting a need for systematic and empirically-informed guidelines.: This article presents a brief history of research on adult ADHD and reviews common sources of false positive and false negative diagnoses. Read More

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Synthesis, X-ray Single-Crystal Structural Characterization, and Thermal Analysis of Bis(O-alkylxanthato)Cd(II) and Bis(O-alkylxanthato)Zn(II) Complexes Used as Precursors for Cadmium and Zinc Sulfide Thin Films.

Inorg Chem 2021 May 5. Epub 2021 May 5.

Department of Materials, University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

This work investigates tuning of the molecular structure of a series of O-alkylxanthato zinc and cadmium precursor complexes to enhance production of ZnS and CdS materials. The structures of several bis(O-alkylxanthato) cadmium(II) complexes (-) and bis(O-alkyl xanthato)zinc(II) complexes ( and ) are reported based on single crystal X-ray diffraction data. CdS and ZnS films were produced by the spin-coating of these metal complexes followed by their thermal decomposition to the corresponding metal sulfides. Read More

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Bag-in-the-lens intraocular lens in paediatric cataract surgery: intraoperative and postoperative outcomes.

Acta Ophthalmol 2021 May 5. Epub 2021 May 5.

Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway.

Purpose: To report intra- and postoperative surgical outcome using the bag-in-the-lens (BIL) technique in paediatric cataract surgery.

Methods: In a retrospective case series, we studied the outcomes of children aged <12 years operated for cataract with the bag-in-the-lens intraocular lens (IOL), with a minimum of 6 months of follow-up.

Results: Since 2013, 50 eyes in 30 patients <12 years (20 bilateral and 10 unilateral) have been operated at our department with the BIL technique, with a median follow-up time of 33. Read More

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Does the LENT score risk-stratify patients with malignant pleural mesothelioma? An observational study.

Thorac Cancer 2021 May 5. Epub 2021 May 5.

Department of Thoracic Oncology, Pleural Diseases, and Interventional Pulmonology, Hôpital Nord, Marseille, France.

Background: Malignant pleural mesothelioma (MPM) is a rare, highly aggressive and deadly disease with a poor patient life expectancy. A few years ago, the main challenge was the histological diagnosis of this disease; at present, the search for the best therapeutic strategy is now a priority. However, an optimal therapeutic strategy is not yet clear, despite growing efforts in the treatment armamentarium and research, and at the era of tailored and individualized treatment, tools to predict patient survival are needed for therapeutic decision-making. Read More

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