1,522,272 results match your criteria range 019-212


Pan-cancer application of a lung-adenocarcinoma-derived gene-expression-based prognostic predictor.

Brief Bioinform 2021 May 10. Epub 2021 May 10.

Lund University, Sweden.

Gene-expression profiling can be used to classify human tumors into molecular subtypes or risk groups, representing potential future clinical tools for treatment prediction and prognostication. However, it is less well-known how prognostic gene signatures derived in one malignancy perform in a pan-cancer context. In this study, a gene-rule-based single sample predictor (SSP) called classifier for lung adenocarcinoma molecular subtypes (CLAMS) associated with proliferation was tested in almost 15 000 samples from 32 cancer types to classify samples into better or worse prognosis. Read More

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Knowledge bases and software support for variant interpretation in precision oncology.

Brief Bioinform 2021 May 10. Epub 2021 May 10.

Health Data Science Unit, Heidelberg University Hospital, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.

Precision oncology is a rapidly evolving interdisciplinary medical specialty. Comprehensive cancer panels are becoming increasingly available at pathology departments worldwide, creating the urgent need for scalable cancer variant annotation and molecularly informed treatment recommendations. A wealth of mainly academia-driven knowledge bases calls for software tools supporting the multi-step diagnostic process. Read More

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Risk of Infection after Deep Brain Stimulation Surgery with Externalization and Local-Field Potential Recordings: Twelve-Year Experience from a Single Institution.

Stereotact Funct Neurosurg 2021 May 10:1-9. Epub 2021 May 10.

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Deep brain stimulation (DBS) has been an established surgical procedure in the field of functional neurosurgery for many years. The experimental electrophysiological method of local field potential (LFP) recordings in postsurgically externalized patients has made substantial contributions to the better understanding of pathophysiologies underlying movement disorders. As interest in LFP recordings for the development of improved stimulation strategies increases, this study's aim was to provide evidence concerning safety of this research method, in a major DBS center. Read More

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Early Experience with Comaneci, a Newly FDA-Approved Controllable Assist Device for Wide-Necked Intracranial Aneurysm Coiling.

Cerebrovasc Dis 2021 May 10:1-8. Epub 2021 May 10.

Department of Neurosurgery, NYU Langone Health, New York, New York, USA.

Background: Comaneci (Rapid Medical) is a compliant, adjustable mesh that provides temporary scaffolding during coiling of wide-necked intracranial aneurysms (WNAs) that preserves antegrade flow. We report our early multi-institutional experience with the Comaneci device in the USA.

Method: We reviewed all patients with WNAs that were treated using the Comaneci device for coil remodeling of ruptured and unruptured aneurysms at 4 institutions between July 2019 and May 2020. Read More

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Patient Experiences of Postinfectious Olfactory Dysfunction.

ORL J Otorhinolaryngol Relat Spec 2021 May 10:1-5. Epub 2021 May 10.

Fifth Sense, Phoenix Business Centre, Unit 8, Barrow-in-Furness, United Kingdom.

Introduction: To highlight the importance of the need for new treatment modalities, this study aimed to characterise the experience of patients with postinfectious olfactory dysfunction (PIOD) in terms of the treatment they received.

Methods: An online survey was hosted by the Norwich Clinical Trials Unit on the secure REDCap server. Members of the charity Fifth Sense (the UK charity that represents and supports people affected by smell and taste disorders) were invited to participate. Read More

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Absence of long-range magnetic order in lithium-containing honeycombs in the Li-Cr-Sb(Te)-O phases.

J Phys Condens Matter 2021 May 10. Epub 2021 May 10.

Department of Physics, The University of Texas at El Paso, 500 W University Ave, El Paso, El Paso, Texas, 79968, UNITED STATES.

Li$_3$((LiCr)(Te/Sb))O$_{6}$ compounds where Cr atoms along with Li and Te or Sb are part of a honeycomb and are studied using magnetic susceptibility, specific heat, X-ray photoelectron spectroscopy and neutron diffraction. The oxides stoichiometries as determined from the neutron diffraction studies are Li$_{4.47}$Cr$_{0. Read More

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Low-energy in-gap states of vortices in superconductor-semiconductor heterostructures.

J Phys Condens Matter 2021 May 10. Epub 2021 May 10.

Institute for Quantum Information, RWTH Aachen University, Otto-Blumenthal Straße, Aachen, Nordrhein-Westfalen, 52074, GERMANY.

The recent interest in the low-energy states in vortices of semiconductor-superconductor heterostructures are mainly fuelled by the prospects of using Majorana zero modes for quantum computation. The knowledge of low-lying states in the vortex core is essential as they pose a limitation on the topological computation with these states. Recently, the low-energy spectra of clean heterostructures, for superconducting-pairing profiles that vary slowly on the scale of the Fermi wavelength of the semiconductor, have been analytically calculated. Read More

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Semiconductor nanowire arrays for optical sensing: a numerical insight on the impact of array periodicity and density.

Nanotechnology 2021 May 10. Epub 2021 May 10.

Photonics, Tyndall National Institute, Lee Maltings Complex Dyke Parade, Cork, T12 R5CP, IRELAND.

Recent advances in the nanofabrication and modelling of metasurfaces have shown the potential of these systems in providing unprecedented control over light-matter interactions at the nanoscale, enabling immediate and tangible improvement of features and specifications of photonic devices that are becoming always more crucial in enhancing everyday life quality. In this work, we theoretically demonstrate that metasurfaces made of periodic and non-periodic deterministic assemblies of vertically aligned semiconductor nanowires can be engineered to display a tailored effective optical response and provide a suitable route to realize advanced systems with controlled photonic properties particularly interesting for sensing applications. The metasurfaces investigated in this paper correspond to nanowire arrays that can be experimentally realized exploiting nanolithography and bottom-up nanowire growth methods: the combination of these techniques allow to finely control the position and the physical properties of each individual nanowire in complex arrays. Read More

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Miniaturized scintillator dosimeter for small field radiation therapy.

Phys Med Biol 2021 May 10. Epub 2021 May 10.

Optics, Institut FEMTO - ST, Route de Gray, 25030 Besançon cedex, Besancon, FRANCE.

The concept of a miniaturized inorganic scintillator detector is demonstrated in the analysis of the small static photon fields used in external radiation therapy. Such a detector is constituted by a 0.25-millimeter diameter and 0. Read More

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Experiences of responsiveness to exercise in people with chronic whiplash: A qualitative study.

Musculoskelet Sci Pract 2021 Apr 21;54:102380. Epub 2021 Apr 21.

Faculty of Medicine & Health, The University of Sydney, NSW, Australia; John Walsh Centre for Rehabilitation Research, Royal North Shore Hospital, NSW, Australia. Electronic address:

Exercise is recommended in clinical guidelines for the treatment of chronic whiplash associated disorders (WAD). However, randomised controlled trials have shown similar effects for comprehensive exercise programs and advice. To date, there is no clear understanding of why some individuals with WAD appear to respond to exercise whilst others do not. Read More

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Per and polyfluoroalkyl substances (PFAS) at high concentrations in neonatal Australian pinnipeds.

Sci Total Environ 2021 Apr 30;786:147446. Epub 2021 Apr 30.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia. Electronic address:

Per and polyfluorinated substances (PFAS) exposure was investigated in Australian pinnipeds. Concentrations of 16 PFAS were measured in the livers of Australian sea lion (Neophoca cinerea), Australian fur seal (Arctocephalus pusillus doriferus) and a long-nosed Fur Seal (Arctocephalus forsteri) pup sampled between 2017 and 2020 from colonies in South Australia and Victoria. Findings reported in this study are the first documented PFAS concentrations in Australian pinnipeds. Read More

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Thermal tolerance, safety margins and vulnerability of coastal species: Projected impact of climate change induced cold water variability in a temperate African region.

Mar Environ Res 2021 Apr 29;169:105346. Epub 2021 Apr 29.

South African Institute for Aquatic Biodiversity, Makhanda, 6140, South Africa; Department of Ichthyology and Fisheries Science, Rhodes University, Makhanda, 6140, South Africa.

Anthropogenic induced climate change is predicted to increase the thermal variability in coastal waters, which can have strong physiological effects on individuals and populations of marine ectotherms. The magnitude and direction of these thermal effects varies depending on species, life stage, biogeography, habitat and season. This study aimed to compare the thermal tolerance of a range of juvenile fish and adult macro-invertebrates from intertidal and estuarine habitats in a warm-temperate, thermally variable region on the south-east coast of South Africa. Read More

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Effective atomic numbers of boron compounds obtained using Rayleigh to compton scattering intensity ratio.

Appl Radiat Isot 2021 May 2;174:109753. Epub 2021 May 2.

Department of Physics, Faculty of Sciences, Atatürk University, 25240, Erzurum, Turkey.

In this study, we measured the effective atomic numbers of some boron compounds (HBNa, HBO, NaBOH, BC, BN, NaCaBOH, BO, CaBOH, ZnBOH, TiB, FeB, NiB, ZrB, and LaBO) by using 59.54 keV energy gamma rays emitted from an Am-241 radioactive source. Rayleigh and Compton scattering peaks were detected using a high purity germanium detector with a resolution of 182 eV at 5. Read More

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Towards point-of-care diagnosis of Alzheimer's disease: Multi-analyte based portable chemiresistive platform for simultaneous detection of β-amyloid (1-40) and (1-42) in plasma.

Biosens Bioelectron 2021 May 4;186:113294. Epub 2021 May 4.

Department of Electrical Engineering, Indian Institute of Technology Hyderabad, 502285, India. Electronic address:

Label-free simultaneous detection of Alzheimer's disease (AD) specific biomarkers Aβ40 and Aβ42 peptides on a single platform using polypyrrole nanoparticle-based chemiresistive biosensors is reported here. The proposed interdigitated-microelectrode based inexpensive multisensor-platform can concurrently detect Aβ40 and Aβ42 in spiked-plasma in the range of 10 - 10 g/mL (with LoDs being 5.71 and 9. Read More

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Application of lectin immobilized on polyHIPE monoliths for bioprocess monitoring of glycosylated proteins.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 25;1174:122731. Epub 2021 Apr 25.

Faculty for Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia; COBIK, Tovarniška 26, 5270 Ajdovščina, Slovenia. Electronic address:

In-process monitoring of glycosylated protein concentration becomes very important with the introduction of perfusion bioprocesses. Affinity chromatography based on lectins allows selective monitoring when carbohydrates are accessible on the protein surface. In this work, we immobilized lectin on polyHIPE type of monoliths and implemented it for bioprocess monitoring. Read More

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Transgenerational effects of selenomethionine on behaviour, social cognition, and the expression of genes in the serotonergic pathway in zebrafish.

Environ Pollut 2021 May 3;286:117289. Epub 2021 May 3.

Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan, S7N 5E2, Canada; Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan, S7N 5B3, Canada.

Elevated levels of contaminants from human activities have become a major threat to animals, particularly within aquatic ecosystems. Selenium (Se) is a naturally occurring element with a narrow range of safe intake, but excessive Se has toxicological effects, as it can bioaccumulate and cause cognitive and behavioural impairments. In this study, we investigated whether exposure to Se would also have transgenerational effects, causing changes in the descendants of exposed individuals. Read More

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General Surgery Residency Application Evaluation in a USMLE Step 1 Pass/Fail World: A Retrospective Comparison.

J Surg Res 2021 May 7;265:317-322. Epub 2021 May 7.

Department of General Surgery, Geisinger Medical Center, 100 N Academy Ave, Danville, 17822, Pennsylvania.

Introduction The United States Medical Licensure Exam (USMLE) Step 1 has been used as both a licensing exam and a way for residency programs to evaluate applicants. It has had significant impact upon the match process over time. With the 2020 decision to make the exam pass/fail due to its unclear validity as an evaluation for future physician performance, programs will go through the match without the Step 1 score. Read More

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Non-parameningeal head and neck rhabdomyosarcoma in children, adolescents, and young adults: Experience of the European paediatric Soft tissue sarcoma Study Group (EpSSG) - RMS2005 study.

Eur J Cancer 2021 May 7;151:84-93. Epub 2021 May 7.

SIREDO Oncology Center, Institute Curie, PSL University, Paris, France.

Background/objectives: The primary aim of this study was to analyse and evaluate the impact of different local treatments on the pattern of relapse in children with primary head and neck non-parameningeal (HNnPM) rhabdomyosarcoma (RMS), treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 study. The secondary aim was to assess whether current risk stratification is valid for this specific site.

Design/methods: This study includes all patients with localised HNnPM RMS enrolled in the RMS2005 study between 2005 and 2016. Read More

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Effect of tunable π bridge on two-photon absorption property and intramolecular charge transfer process of polycyclic aromatic hydrocarbons.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 20;259:119830. Epub 2021 Apr 20.

Department of Physics, Harbin Institute of Technology, Harbin 150001, China.

The influences of the conjugation effect on the charge transfer and nonlinear optical (NLO) properties of polycyclic aromatic hydrocarbons (PAHs) are comprehensively investigated at the microscopic molecular level. We found that the conjugation effect of π bridge is negatively correlated with molecular planarity, excitation energy, two-photon absorption (TPA) cross-section, and the second hyperpolarizability. For the first time, the charge transfer matrix (CTM) is applied to the molecular two-photon transition process. Read More

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Novel luteolin sensor of tannic acid-stabilized copper nanoclusters with blue-emitting fluorescence.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 30;259:119887. Epub 2021 Apr 30.

College of Arts, Taiyuan University of Technology, Jinzhong, 030600, Shanxi, China. Electronic address:

In this work, the fluorescent copper nanoclusters (Cu NCs) were firstly adopted to detect luteolin with excellent performance. The blue-emitting Cu NCs was successfully prepared through a facile one-pot approach by protection of tannic acid (TA) and chemical reduction of ascorbic acid (AA). The water-soluble nanoclusters possessed uniform size and displayed good stability. Read More

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Innovative use of σ and π electron acceptors in the development of three high throughput 96-microwell spectrophotometric assays for crizotinib.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 30;259:119884. Epub 2021 Apr 30.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Crizotinib (CZT) is a potent and selective tyrosine kinase inhibitor used for treatment of non-small cell lung cancer (NSCLC). The development of high-throughput assays for its quality control (QC) is very essential to assure its therapeutic benefits. CZT molecule has multiple electron-donating atoms that can contribute to the formation of colored charge-transfer (CT) complex with iodine as σ-electron acceptor and with 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (CHBQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-electron acceptors. Read More

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How much leeway is there to relax COVID-19 control measures?

Epidemics 2021 Mar 18;35:100453. Epub 2021 Mar 18.

Department of Mathematics, Simon Fraser University, Burnaby, BC, Canada; Department of Mathematics, Imperial College London, London, UK. Electronic address:

Following successful non-pharmaceutical interventions (NPI) aiming to control COVID-19, many jurisdictions reopened their economies and borders. As little immunity had developed in most populations, re-establishing higher contact carried substantial risks, and therefore many locations began to see resurgence in COVID-19 cases. We present a Bayesian method to estimate the leeway to reopen, or alternatively the strength of change required to re-establish COVID-19 control, in a range of jurisdictions experiencing different COVID-19 epidemics. Read More

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Emerging role of galectin family in inflammatory autoimmune diseases.

Autoimmun Rev 2021 May 7:102847. Epub 2021 May 7.

Department of Rheumatology and Immunology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. Electronic address:

Galectin family is a group of glycan-binding proteins. Members in this family are expressed in different tissues, immune or non-immune cells. These molecules are important regulators in innate and adaptive immune response, performing significantly in a broad range of cellular and pathophysiological functions, such as cell proliferation, adhesion, migration, and invasion. Read More

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Histopathological features of systemic sclerosis-associated myopathy: A scoping review.

Autoimmun Rev 2021 May 7:102851. Epub 2021 May 7.

Division of Rheumatology, Centre hospitalier de l'Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: Scleromyositis (SM) is an emerging subset of myositis associated with features of systemic sclerosis (SSc) but it is currently not recognized as a distinct histopathological subset by the European NeuroMuscular Center (ENMC). Our aim was to review studies reporting muscle biopsies from SSc patients with myositis and to identify unique histopathological features of SM.

Methods: A scoping review was conducted and included all studies reporting histopathological findings in SSc patients with myositis searching the following databases: PubMed, MEDLINE, EMBASE, CINAHL and EBM-Reviews. Read More

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Artificial Intelligence for Adult Spinal Deformity: Current State and Future Directions.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.

As we experience a technological revolution unlike any other time in history, neurosurgery as a discipline is poised to undergo a dramatic transformation. As enormous amounts of data become digitized and more readily available, medical professionals approach a critical juncture with respect to how advanced computational techniques may be incorporated into clinical practices. Within neurosurgery, spinal disorders in particular, represent a complex and heterogeneous disease entity that can vary dramatically in its clinical presentation and how it may impact patients' lives. Read More

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Growth of the branch pulmonary arteries after employing 'Shunt-only' strategy for neonates with pulmonary atresia or stenosis.

Semin Thorac Cardiovasc Surg 2021 May 7. Epub 2021 May 7.

Division of Pediatric Cardiac Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

We sought to determine the impact of juxtaductal stenosis (JDS) on branch pulmonary artery (PA) growth after systemic-to-pulmonary shunt (SPS) placement without pulmonary arterioplasty (i.e. the 'shunt-only' strategy). Read More

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Pre-sewn Multi-branched Aortic Graft and 3D-Printing Guidance for Crawford Extent II or III Thoracoabdominal Aortic Aneurysm Repair.

Semin Thorac Cardiovasc Surg 2021 May 7. Epub 2021 May 7.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Reconstruction of the visceral and segmental arteries is a challenging part of open surgical repair of extensive thoracoabdominal aortic aneurysm (TAAA). For more efficient reconstruction of these branching vessels, a technique of using pre-hand-sewn multi-branched aortic graft (octopod technique) has been adopted with the aid of 3D-printing-guidance in latest cases. The octopod graft has been employed for the extent II or III TAAA repair, in which the commercially available two 4-branched aortic grafts were interconnected before surgery. Read More

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eGFR Variability in Patients with Heart Failure and Chronic Kidney Disease.

J Card Fail 2021 May 7. Epub 2021 May 7.

Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address:

Background: Greater variability in estimated glomerular filtration rate (eGFR) is associated with higher mortality in patients with chronic kidney disease (CKD). Heart failure (HF) is common in CKD and may increase variability through changes in hemodynamic and volume regulation. We sought to determine if patients with versus without HF have higher kidney function variability in CKD, and to define the association with mortality. Read More

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Dual-axis Volta phase plate cryo-electron tomography of Ebola virus-like particles reveals actin-VP40 interactions.

J Struct Biol 2021 May 7:107742. Epub 2021 May 7.

Schaller Research Groups, Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany; Research Group "Membrane Biology of Viral Infection", Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany. Electronic address:

Cryo-electron tomography (cryo-ET) is a pivotal imaging technique for studying the structure of pleomorphic enveloped viruses and their interactions with the host at native conditions. Owing to the limited tilting range of samples with a slab geometry, electron tomograms suffer from so-called missing wedge information in Fourier space. In dual-axis cryo-ET, two tomograms reconstructed from orthogonally oriented tilt series are combined into a tomogram with improved resolution as the missing wedge information is reduced to a pyramid. Read More

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oColonic delivery of metronidazole-loaded capsules for local treatment of bacterial infections: a clinical pharmacoscintigraphy study.

Eur J Pharm Biopharm 2021 May 7. Epub 2021 May 7.

Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Drug delivery to the colon offers great promise for local treatment of colonic diseases as it allows bypassing systemic absorption in the small intestine, thereby increasing luminal drug concentrations in the colon. The primary objective of this in vivo pharmaco-scintigraphy study was to assess the colon drug targeting accuracy of a metronidazole benzoate colonic drug delivery system intended for local treatment of Clostridioides difficile infections. Additionally, it was assessed if the concept of mucoadhesion would increase colonic residence time and promote higher drug bioavailability. Read More

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