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A longitudinal investigation of landing biomechanics following anterior cruciate ligament reconstruction.

Phys Ther Sport 2021 Mar 31;50:36-41. Epub 2021 Mar 31.

School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia; OrthoSport Victoria Research Unit, Melbourne, Australia.

Objective: Abnormal movement patterns have been shown during landing in patients who have undergone anterior cruciate ligament (ACL) reconstruction surgery. The purpose of this study was to investigate landing biomechanics over time in this patient group to determine whether asymmetry between limbs reduced with time and after a return to physical activity.

Design: Prospective longitudinal study. Read More

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Early enteral nutrition and factors related to in-hospital mortality in people on extracorporeal membrane oxygenation.

Nutrition 2021 Feb 28;89:111222. Epub 2021 Feb 28.

Department of Thoracic and Cardiovascular Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea. Electronic address:

Objectives: There are concerns about adverse events related to early enteral nutrition (EN) in people receiving extracorporeal membrane oxygenation (ECMO). This was a retrospective study evaluating. This nutritional support of people receiving ECMO, factors that may confer benefits in outcomes. Read More

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February 2021

Use of academic electronic medical records in nurse education: A scoping review.

Nurse Educ Today 2021 Apr 9;101:104889. Epub 2021 Apr 9.

School of Nursing and Midwifery, La Trobe University, Bundoora, Victoria 3086, Australia.

Background: Use of academic electronic medical records is internationally recognised as a means for preparing health professional students for the digital healthcare environment. Reported practice benefits include skills for electronic documentation, health informatics, point-of-care clinical decision support systems, as well as preparation for information technology-enabled clinical settings, while challenges include lack of access to simulation software, faculty-related barriers, limited finances and educational software costs. However, little is known about best practices related to its use within pre-licensure or entry-to-practice nursing curricula and impact on clinical practice outcomes. Read More

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Nursing applicants' reasoning skills and factors related to them: A cross-sectional study.

Nurse Educ Today 2021 Apr 9;101:104890. Epub 2021 Apr 9.

Department of Nursing Science, Hospital District of Satakunta, 20014 University of Turku, Finland. Electronic address:

Background: The assessment of reasoning skills is recommended in undergraduate nursing student selection. Reasoning skills are crucial for sound decision-making, improving patient safety and are necessary from the very beginning of studies. Nursing applicants' reasoning skills based on the reasoning process have not been previously measured. Read More

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Hyperspectral image-based analysis of thermal damage for ex-vivo bovine liver utilizing radiofrequency ablation.

Surg Oncol 2021 Apr 7;38:101564. Epub 2021 Apr 7.

Biomedical Engineering Department, Military Technical College, Cairo, Egypt.

Background & Objective: Thermal ablation is the predominant methodology to treat liver tumors for segregating patients who are not permitted to have surgical intervention. However, noticing or predicting the size of the thermal strategies is a challenging endeavor. We aim to analyze the effects of ablation district volume following radiofrequency ablation (RFA) of ex-vivo liver exploiting a custom Hyperspectral Imaging (HSI) system. Read More

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Screening of tick-borne pathogens in argasid ticks in Zambia: Expansion of the geographic distribution of Rickettsia lusitaniae and Rickettsia hoogstraalii and detection of putative novel Anaplasma species.

Ticks Tick Borne Dis 2021 Apr 5;12(4):101720. Epub 2021 Apr 5.

Laboratory of Parasitology, Graduate School of Infectious Diseases, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. Electronic address:

Ticks (Ixodidae and Argasidae) are important arthropod vectors of various pathogens that cause human and animal infectious diseases. Many previously published studies on tick-borne pathogens focused on those transmitted by ixodid ticks. Although there are increasing reports of viral pathogens associated with argasid ticks, information on bacterial pathogens they transmit is scarce. Read More

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First record of Ixodes simplex found on a human host, with a review of cases of human infestation by bat tick species occurring in Europe.

Ticks Tick Borne Dis 2021 Apr 6;12(4):101722. Epub 2021 Apr 6.

University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Faculty of Veterinary Medicine, Department of Parasitology and Parasitic Diseases, Romania; Department of Parasitology and Zoology, University of Veterinary Medicine, Budapest, Hungary. Electronic address:

Ixodes simplex is a bat tick species, a common parasite of the Schreibers' bent-winged bat, Miniopterus schreibersii. Its distribution is linked to the range of its host, free stages occurring exclusively inside the underground bat shelters. Here we present the first case of human infestation with I. Read More

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Oxygen vacancy induced peroxymonosulfate activation by Mg-doped FeO composites for advanced oxidation of organic pollutants.

Chemosphere 2021 Apr 3;279:130482. Epub 2021 Apr 3.

Environmental Process Modelling Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, 637141, Singapore; School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. Electronic address:

Oxygen vacancy engineering has emerged as an effective approach to improve the performance of catalysts for peroxymonosulfate (PMS) activation. Herein, we report a facile precipitation method followed by calcination to synthesize cost-effective and environmentally friendly magnesium-doped hematite (Mg/FeO) composites. Multiple characterization results reveal that the incorporation of Mg can significantly increase the oxygen vacancies and specific surface area of 5%Mg/FeO, leading to a significantly enhanced performance in degrading Rhodamine B (RhB) through PMS activation. Read More

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Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic.

Public Health 2021 Mar 6;194:60-66. Epub 2021 Mar 6.

Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objective: To clarify which variables are associated with the health-related quality of life (HRQoL) among homeless individuals during the COVID-19 pandemic.

Study Design: Cross-sectional research.

Methods: Data were taken from the Hamburg survey of homeless individuals (n = 151). Read More

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Modeling the effects of temperature on the migration and transformation of nitrate during riverbank filtration using HYDRUS-2D.

Sci Total Environ 2021 Mar 30;783:146656. Epub 2021 Mar 30.

School of Water Conservancy and Environment, University of Jinan, Shandong 250022, PR China.

Riverbank filtration is a natural aquifer-based process. The nitrogen dynamics in a riverbank filtration system are affected by many factors, including temperature, water quality, and travel time, which cannot be quantified easily. In this study, a field experiment was conducted to investigate nitrogen transport during riverbank filtration. Read More

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Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings.

Sci Total Environ 2021 Apr 5;783:146894. Epub 2021 Apr 5.

Environmental Health and Radiation Safety, Temple University, Philadelphia, PA, USA.

Despite the modern ventilation and waste anesthetic gas (WAG) scavenging systems, occupational exposure to common volatile anesthesia, isoflurane, can occur in the hospital and veterinary settings, but limited information exists on potential exposure and health risk of isoflurane. We assessed exposure dose rates and risks among clinicians and veterinary professionals from occupational exposure to isoflurane. Through a critical review of open literature (1965 to 2020), we summarized potential adverse effects and exposure scenarios of isoflurane among the professional groups, including anesthetists, nurses, operating room personnel, researchers, and/or veterinarians. Read More

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Threshold dose rates for the cytogenetic effects in crested hairgrass populations from the Semipalatinsk nuclear test site, Kazakhstan.

J Hazard Mater 2021 Apr 6;416:125817. Epub 2021 Apr 6.

Russian Institute of Radiology and Agroecology, Kievskoe shosse, 109 km, 49020 Obninsk, Russia.

An assessment of cytogenetic effects in crested hairgrass (Koeleria gracilis Pers.) populations was carried out within the Semipalatinsk nuclear test site (Kazakhstan) where combat radioactive substances were tested in 1953-1957. Current levels of radioactive contamination within this site are varied by orders of magnitude, while soil characteristics and heavy metal pollution are similar. Read More

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Characterization of interactions between whey protein isolate and hyaluronic acid in aqueous solution: Effects of pH and mixing ratio.

Colloids Surf B Biointerfaces 2021 Apr 10;203:111758. Epub 2021 Apr 10.

Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun, Jilin, 130062, China. Electronic address:

Interactions between whey protein isolate (WPI) and hyaluronic acid (HA) were characterized as functions of pH (6.0-1.0) and protein to polysaccharide ratio (R, 1:4-10:1). Read More

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Comparing respiratory polygraphy with pulse transit time analysis versus overnight polysomnography in the diagnosis of obstructive sleep apnoea in children.

Sleep Med 2021 Mar 1;81:457-462. Epub 2021 Mar 1.

FHKAM(Otolaryngology), Department of Otolaryngology, Tuen Mun Hospital, Hong Kong.

Objective: Obstructive sleep apnea syndrome in children is associated with significant morbidity. Polysomnography is the main diagnostic tool but is time consuming and requires skilled manpower to supervise the patient overnight and hence long referral to diagnosis time. However, there are limitations and underestimation of the apnoea hyponea index (AHI) with alternative home sleep apnoea testing (HSAT), such as type 3 respiratory polygraphy (RP). Read More

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Excitation functions of proton induced reactions on titanium and copper.

Appl Radiat Isot 2021 Apr 14;173:109713. Epub 2021 Apr 14.

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.

Excitation functions of the Tnati(p,x)S43,47c, V48 and Cnatu(p,x)Cu, Z62,65n reactions were measured in the energy range of 8.8-18.4 MeV by using the stacked-foil activation technique and off-line gamma spectroscopy. Read More

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Physical activity status and quality of life in patients with epilepsy - Survey from level four epilepsy monitoring units.

Epilepsy Res 2021 Apr 9;173:106639. Epub 2021 Apr 9.

Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, USA. Electronic address:

Purpose: People with epilepsy (PWE) tend to have sedentary lifestyles which may predispose them to a lower perceived quality of life (QOL). Moreover, the relationship between physical activity (PA) and QOL in populations of PWE with high disease burden has been under-studied. The goal of this study was to evaluate PA level and its impact on health-related QOL in PWE who were admitted to Level-4 epilepsy monitoring units (EMU). Read More

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Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases.

Biomed Pharmacother 2021 Apr 14;139:111551. Epub 2021 Apr 14.

Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi Province, China. Electronic address:

The central nervous system (CNS) is a vital part of the human nervous system, and the incidence of CNS disease is increasing year by year, which has become a major public health problem and a prominent social problem. At present, the drugs most commonly used in the clinic are receptor regulators, and neurotransmitter inhibitors, but they are accompanied by serious side effects. Therefore, the identification of new drugs and treatment strategies for CNS disease has been a research hotspot in the medical field. Read More

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On-line speciation analysis of arsenic compounds in commercial edible seaweed by HPLC-UV-thermo-oxidation-HG-AFS.

Food Chem 2021 Apr 5;357:129725. Epub 2021 Apr 5.

Instituto de Investigación e Ingeniería Ambiental-IIIA, UNSAM, CONICET, 3iA, Campus Miguelete, 25 de mayo y Francia, 1650-San Martín, Provincia de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Godoy Cruz 2290, C1425FQB Buenos Aires, Argentina. Electronic address:

Arsenic speciation analysis in dried seaweeds was carried out using an on-line HPLC-UV-thermo-oxidation-HG-AFS system. Species separated and quantified were: arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and different arsenosugars. Extraction efficiency ranged between 38 and 83%. Read More

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Recovery of sulfur from sulfur-rich filter cakes in a rotary kiln: Process optimization.

Waste Manag 2021 Apr 14;126:567-577. Epub 2021 Apr 14.

Department of Civil and Industrial Engineering, Largo Lazzarino 1, 56122 Pisa, Italy. Electronic address:

In this work, sulfur recovery from sulfur-rich wastes deriving from sulfur filtration was investigated through laboratory experiments and full-scale tests in an industrial combustion rotary kiln, where elemental sulfur is converted to SO in a sulfuric acid production plant. Phase equilibria experiments carried out in the temperature range 1100-1400 °C and industrial scale tests demonstrated that temperature is the most important operating parameter in determining the recovery efficiency and the plant operability. The full-scale tests performed on the rotary kiln showed that, at operating temperatures around 1200 °C, a continuous sulfur recovery from the filter cakes was obtained with an average efficiency of 87% and a consequent reduction of about 70% of the solid waste material to be disposed as inert in landfills or used in cement/glass industries. Read More

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Aged microplastics decrease the bioavailability of coexisting heavy metals to microalga Chlorella vulgaris.

Ecotoxicol Environ Saf 2021 Apr 14;217:112199. Epub 2021 Apr 14.

College of Ecology and Environment, Hainan University, Haikou 570228, Hainan Province, PR China; Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province, Hainan University, Haikou 570228, Hainan Province, PR China. Electronic address:

Environmental aging of ubiquitous microplastics (MP) occurs through the action of biotic and abiotic factors, and aged MP exhibit different physicochemical properties and environmental behavior from virgin MP. This study aimed to investigate the aged micro-sized polystyrene (mPS) and polyvinyl chloride (mPVC), and the heavy metals copper (Cu) and cadmium (Cd), and examine the effects of their combined toxicities on microalga Chlorella vulgaris. Results showed that the presence of MP inhibited cell growth as compared with the control, the inhibition rate (I) decreased as concentrations of MP rose and aged MP exhibited stronger inhibition of cells than did virgin MP. Read More

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Estimated Glomerular Filtration Rate (eGFR) based on cystatin C was associated with increased risk of hip and proximal humerus fractures in women and decreased risk of hip fracture in men, whereas eGFR based on creatinine was not associated with fracture risk in both sexes: The Tromsø Study.

Bone 2021 Apr 14:115960. Epub 2021 Apr 14.

Women's Health and Perinatalogy Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Department of Gynecology and Obstetrics, University Hospital of North Norway, Tromsø, Norway; Norwegian Research Centre for Women's Health, Oslo University Hospital, Oslo, Norway. Electronic address:

Purpose: Patients with end-stage kidney disease have an increased fracture risk. Whether mild to moderate reductions in kidney function is associated with increased fracture risk is uncertain. Results from previous studies may be confounded by muscle mass because of the use of creatinine-based estimates of the glomerular filtration rate (eGFRcre). Read More

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Biomechanical analysis of a novel clavicular hook plate for the treatment of acromioclavicular joint dislocation: A finite element analysis.

Comput Biol Med 2021 Apr 14;133:104379. Epub 2021 Apr 14.

The Second Department of Orthopedics, Xi'an Centeral Hospital, No. 161, West Fifth Road, Xincheng District, Xi'an, 710003, Shaanxi, China. Electronic address:

Background: Clavicular hook plates are frequently used in clinical orthopedics to treat acromioclavicular joint dislocation. However, patients often exhibit acromial osteolysis and peri-implant fracture after hook plate fixation. To solve the above problems, we developed a novel double-hook clavicular plate and used finite element analysis (FEA) to investigate its biomechanical properties. Read More

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Transjugular intrahepatic portosystemic shunt creation for the prevention of gastric variceal rebleeding in patients with hepatocellular carcinoma: a multicenter retrospective study.

J Vasc Interv Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Purpose: To evaluate the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) creation for the prevention of gastric variceal rebleeding in patients with Hepatocellular carcinoma (HCC).

Materials And Methods: This multicenter retrospective study included 126 cirrhotic patients (mean age, 54.1 ± 10. Read More

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Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126 Naples, Italy. Electronic address:

The long-range communication between the two exosites of human α-thrombin (thrombin) tightly modulates the protein-effector interactions. Duplex/quadruplex aptamers represent an emerging class of very effective binders of thrombin. Among them, NU172 and HD22 aptamers are at the forefront of exosite I and II recognition, respectively. Read More

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A comprehensive review on the impact of β-glucan metabolism by Bacteroides and Bifidobacterium species as members of the gut microbiota.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

School of Microbiology & APC Microbiome Ireland, University College Cork, Ireland University College Cork, Cork, Ireland. Electronic address:

β-glucans are polysaccharides which can be obtained from different sources, and which have been described as potential prebiotics. The beneficial effects associated with β-glucan intake are that they reduce energy intake, lower cholesterol levels and support the immune system. Nevertheless, the mechanism (s) of action underpinning these health effects related to β-glucans are still unclear, and the precise impact of β-glucans on the gut microbiota has been subject to debate and revision. Read More

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Low Rates of Urologic Side Effects Following COVID Vaccination: An Analysis of the FDA Vaccine Adverse Event Reporting System.

Urology 2021 Apr 14. Epub 2021 Apr 14.

Division of Urology, Cedars-Sinai Medical Center, Los Angeles CA. Electronic address:

Objective: To quantify and describe urologic adverse events and symptoms after vaccination with the Pfizer-BioNTech and Moderna COVID-19 vaccines.

Methods And Materials: We queried the FDA Vaccine Adverse Event Reporting System (VAERS) for all reported symptoms following the Pfizer-BioNTech and Moderna vaccines as of February 12th, 2021. All urologic symptoms were isolated and the reported adverse events associated with each symptom were reviewed. Read More

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Modified Superior Capsule Reconstruction Using the Long Head of the Biceps Tendon as Reinforcement to Rotator Cuff Repair Lowers Retear Rate in Large to Massive Reparable Rotator Cuff Tears.

Arthroscopy 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedics, National Cheng Kung University Hospital, Tainan, Taiwan, R.O.C.

Purpose: To retrospectively assess the clinical outcomes of the patients with large to massive reparable rotator cuff tears (RCTs) treated by arthroscopic rotator cuff repair (ARCR) combined with modified superior capsule reconstruction (mSCR) using the long head of biceps tendon (LHBT) as reinforcement with a minimum of 2 years of follow-up.

Methods: We retrospectively evaluated 40 patients with large to massive reparable RCTs who underwent ARCR and mSCR (Group I) between February 2017 and June 2018 (18 patients) or underwent ARCR and tenotomy of LHBT performed at the insertion site (Group II) between January 2015 and January 2017 (22 patients). The pain visual analog score (VAS) was assessed preoperatively and 1, 3, 6, 12, 24 months postoperatively. Read More

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A morphovolumetric analysis of aneurysm sac evolution after elective endovascular abdominal aortic repair.

J Vasc Surg 2021 Apr 14. Epub 2021 Apr 14.

Objectives: Abdominal aortic aneurysm (AAA) sac shrinkage after endovascular repair (EVAR) has been regarded as positive marker of EVAR success durability. The purpose of this study was to describe the morphovolumetric changes of the AAA sac during follow-up after elective EVAR, and to analyze sac shrinkage related variables.

Methods: This is a single center, retrospective, observational cohort study from a tertiary referral university hospital. Read More

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α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter A pharmacological characterization of interactions between pyrrolidinopropiophenones and high and low affinity monoamine transporters.

Neuropharmacology 2021 Apr 14:108570. Epub 2021 Apr 14.

Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Währingerstraße 13A, 1090, Vienna, Austria; AddRess Centre for Addiction Research and Science, Medical University of Vienna, Währingerstraße 13A, 1090, Vienna, Austria. Electronic address:

While classical cathionones, such as methcathinone, have been shown to be monoamine releasing agents at human monoamine transporters, the subgroup of α-pyrrolidinophenones has thus far solely been characterized as monoamine transporter reuptake inhibitors. Herein, we report data from previously undescribed α-pyrrolidinopropiophenone (α-PPP) derivatives and compare them with the pharmacologically well-researched α-PVP (α-pyrrolidinovalerophenone). Radiotracer-based in vitro uptake inhibition assays in HEK293 cells show that the investigated α-PPP derivatives inhibit the human high-affinity transporters of dopamine (hDAT) and norepinephrine (hNET) in the low micromolar range, with α-PVP being ten times more potent. Read More

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Determination of the size of lipid rafts studied through single-molecule FRET simulations.

Biophys J 2021 Apr 14. Epub 2021 Apr 14.

Biological Physics Laboratory, Physics Institute, Universidad Autónoma de San Luis Potosí, Álvaro Obregón 64, San Luis Potosí, S.L.P. 78290, Mexico. Electronic address:

Fluorescence Resonance Energy Transfer (FRET) is a high resolution technique that allows the characterization of spatial and temporal properties of biological structures and mechanisms. In the present work, we developed an in silico single-molecule FRET methodology to study the dynamics of fluorophores inside lipid rafts. We monitored the fluorescence of a single acceptor molecule in the presence of several donor molecules. Read More

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