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Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children.

N Engl J Med 2021 09;385(12):1104-1115

From the Malawi-Liverpool-Wellcome Program (P.D.P., P.P., J.E.M., T.M., F.M., C.M., H.M., D.B., M.M., M.H., M.G., M.A.G.), the Blantyre Malaria Project (N.N., O.M.N.), the Department of Paediatrics, Queen Elizabeth Central Hospital (Q.D.), the District Health Office, Blantyre District Council (G.K.), and Kamuzu University of Health Sciences (M.A.G.) - all in Blantyre, Malawi; the Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore (Y.L., J.K.T., F.A., K.S., E.R., M.B., K.K., M.B.L., K.M.N.); and Oxford Vaccine Group, the Department of Paediatrics, Oxford University, Oxford (J.E.M.), Liverpool School of Tropical Medicine (C.M., M.H., M.G.), and the Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool (M.A.G.), and the Division of Infection and Immunity, University College London, London (R.S.H.) - all in the United Kingdom.

Background: Typhoid fever caused by multidrug-resistant H58 Typhi is an increasing public health threat in sub-Saharan Africa.

Methods: We conducted a phase 3, double-blind trial in Blantyre, Malawi, to assess the efficacy of Vi polysaccharide typhoid conjugate vaccine (Vi-TCV). We randomly assigned children who were between 9 months and 12 years of age, in a 1:1 ratio, to receive a single dose of Vi-TCV or meningococcal capsular group A conjugate (MenA) vaccine. Read More

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September 2021

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months.

N Engl J Med 2021 Sep 15. Epub 2021 Sep 15.

From the State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., S.B., W.V.K., D.C., Q.Y., P.L., P.R.D., W.C.G., K.U.J.) - both in New York; Associação Obras Sociais Irmã Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and iTrials-Hospital Militar Central (G.P.M.) and Fundacion INFANT, Buenos Aires (F.P.P.) - all in Brazil; Centro Paulista de Investigação Clinica, São Paulo (C.Z.); Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., X.X.) and Worldwide Safety, Safety Surveillance, and Risk Management (D.B.T., S.M.), Pfizer, Collegeville, PA; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children's Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (Ö.T., U.Ş.) and Medizentrum Essen Borbeck, Essen (A.S.) - both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape Town, South Africa (H.N.); Hacettepe University, Ankara, Turkey (S.Ü.); and Worldwide Safety, Safety Surveillance, and Risk Management, Pfizer, Groton, CT (D.B.T., S.M.).

Background: BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine encoding a prefusion-stabilized, membrane-anchored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length spike protein. BNT162b2 is highly efficacious against coronavirus disease 2019 (Covid-19) and is currently approved, conditionally approved, or authorized for emergency use worldwide. At the time of initial authorization, data beyond 2 months after vaccination were unavailable. Read More

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September 2021

Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.

PLoS One 2021 15;16(9):e0255322. Epub 2021 Sep 15.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.

Background: Colorectal cancer (CRC) is among the most common cancers in economically developed countries and developing world. While dietary factors are associated with risk of CRC in the West and urban China, little is known about risk or protective factors in rural China.

Methods: The Linxian General Population Nutrition Intervention Trial (NIT) cohort was established over 30 years ago to test whether daily multivitamin/mineral supplements could reduce the incidence and mortality of esophageal/gastric cardia cancer. Read More

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September 2021

Spousal emotional support and relationship quality buffers pupillary response to horror movies.

PLoS One 2021 15;16(9):e0256823. Epub 2021 Sep 15.

Department of Psychology, Brigham Young University, Provo, Utah, United States of America.

Being satisfied in marriage provides protective stress buffering benefits to various health complications but the causal mechanisms and speed at which this is accomplished is less well understood. Much of the research on health and marriage has conceptualized marital quality in a unidimensional way, with high levels of either positivity or negativity. This conceptualization may not fully capture the nuanced benefits of marital relationships. Read More

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September 2021

Comparable glucose control with fast-acting insulin aspart versus insulin aspart using a second-generation hybrid closed-loop system during exercise.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

University of Melbourne, Department of Melbourne (St Vincent's Hospital), 4th Floor Clinical Sciences Building, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia, 3065;

Background We aimed to compare glucose control with FiAsp versus insulin aspart following moderate-intensity exercise (MIE) and high-intensity exercise (HIE) using a second-generation closed-loop (CL) system in people with type 1 diabetes. Materials and methods This randomised crossover study compared FiAsp versus insulin aspart over four sessions during MIE and HIE with CL insulin delivery by the MiniMed TM Medtronic Advanced hybrid CL system. Participants were randomly assigned FiAsp and insulin aspart each for six weeks and within each period performed, in random order, 40min MIE (~50% VO2max) and HIE (6x2min ~80% VO2max; 5min recovery). Read More

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September 2021

Gut Microbiota Serves a Predictable Outcome of Short-Term Low-Carbohydrate Diet (LCD) Intervention for Patients with Obesity.

Microbiol Spectr 2021 Sep 15:e0022321. Epub 2021 Sep 15.

Department of Endocrinology and Metabolism, Zhujiang Hospital, Southern Medical Universitygrid.284723.8, Guangzhou, China.

To date, much progress has been made in dietary therapy for obese patients. A low-carbohydrate diet (LCD) has reached a revival in its clinical use during the past decade with undefined mechanisms and debatable efficacy. The gut microbiota has been suggested to promote energy harvesting. Read More

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September 2021

Narrow vessels cavitate first during a simulated drought in Eucalyptus camaldulensis.

Physiol Plant 2021 Sep 15. Epub 2021 Sep 15.

CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.

Establishing drying-limits for mortality of different tree species and understanding the anatomical and physiological traits involved is crucial to predict forests' responses to climate change. The xylem of Eucalyptus camaldulensis presents a complex of solitary vessels surrounded by different imperforate tracheary elements and parenchyma that influence, in a poorly known way, its hydraulic functioning. We aimed at describing the dynamics of embolism propagation in this type of xylem, seeking any vessel-size pattern, and unravelling the threshold of xylem embolism leading to non-recovery after drought in E. Read More

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September 2021

High-flow nasal oxygen cannula vs. noninvasive mechanical ventilation to prevent reintubation in sepsis: a randomized controlled trial.

Ann Intensive Care 2021 Sep 14;11(1):135. Epub 2021 Sep 14.

Office of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: High-flow nasal oxygen cannula (HFNC) and noninvasive mechanical ventilation (NIV) can prevent reintubation in critically ill patients. However, their efficacy in post-extubated sepsis patients remains unclear. The objective of this study was to compare the efficacy of HFNC vs. Read More

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September 2021

Computerised cognitive remediation to enhance mobility in older adults: a single-blind, single-centre, randomised trial.

Lancet Healthy Longev 2021 Sep 2;2(9):e571-e579. Epub 2021 Sep 2.

(Prof J Verghese MBBS, J R Mahoney PhD, E Ayers MPH, C Wang PhD, Prof R Holtzer PhD), (Prof J Verghese), (A Ambrose MD), (C Wang), (Prof R Holtzer).

Background: Decline in executive functions and related cognitive processes is associated with mobility decline, and these functions might be amenable to cognitive remediation. This study aimed to examine whether a computerised cognitive remediation programme would improve walking in adults aged 70 years and older.

Methods: This single-blind, randomised trial at one academic centre in the USA evaluated the efficacy of an 8-week computerised programme (also known as brain games) of progressive intensity and complexity to improve walking in older adults at high-risk for mobility disability. Read More

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September 2021

Inter-rater reliability of the neonatal adverse event severity scale using real-world Neonatal clinical trial data.

J Perinatol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Objective: The Neonatal Adverse Event Severity Scale (NAESS) was developed to improve scoring of neonatal adverse events (AEs) and accelerate neonatal drug development. This is the first validation study of the novel tool.

Study Design: Retrospective validation study assessing the inter-rater reliability (IRR) of the NAESS. Read More

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September 2021

Lurbinectedin versus pegylated liposomal doxorubicin or topotecan in patients with platinum-resistant ovarian cancer: A multicenter, randomized, controlled, open-label phase 3 study (CORAIL).

Gynecol Oncol 2021 Sep 11. Epub 2021 Sep 11.

Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, and Fondazione Policlinico Gemelli IRCCS, Rome, Italy.

Objective: The randomized phase 3 CORAIL trial evaluated whether lurbinectedin improved progression-free survival (PFS) compared to pegylated liposomal doxorubicin (PLD) or topotecan in patients with platinum-resistant ovarian cancer.

Methods: Patients were randomly assigned (1:1) to lurbinectedin 3.2 mg/m 1-h i. Read More

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September 2021

Effects of menopausal hormone therapy on ambulatory blood pressure and arterial stiffness in postmenopausal Korean women with grade 1 hypertension: a randomized, placebo-controlled trial.

Clin Hypertens 2021 Sep 15;27(1):18. Epub 2021 Sep 15.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Estrogen therapy in early menopausal women decreases the risk of coronary heart disease and parenteral, but not oral, estrogen is reported to reduce blood pressure (BP). Progestogens are typically added to estrogens to prevent unopposed endometrial stimulation. The effects of progestogen on BP have been less well studied to date. Read More

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September 2021

Effect of Lycium barbarum polysaccharide supplementation in non-alcoholic fatty liver disease patients: study protocol for a randomized controlled trial.

Trials 2021 Aug 26;22(1):566. Epub 2021 Aug 26.

School of Public Health and Management, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China.

Background: Non-alcohol fatty liver disease (NAFLD) is the most common chronic liver disease in the world, with a high incidence and no effective treatment. At present, the targeted therapy of intestinal microbes for NAFLD is highly valued. Lycium barbarum polysaccharide (LBP), as the main active ingredient of Lycium barbarum, is considered to be a new type of prebiotic substance, which can improve NAFLD by regulating the gut microbiota. Read More

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Effects of canagliflozin on NT-proBNP stratified by left ventricular diastolic function in patients with type 2 diabetes and chronic heart failure: a sub analysis of the CANDLE trial.

Cardiovasc Diabetol 2021 Sep 14;20(1):186. Epub 2021 Sep 14.

Department of Cardiovascular Medicine, Saga University, Saga, Japan.

Background: Identification of the effective subtypes of treatment for heart failure (HF) is an essential topic for optimizing treatment of the disorder. We hypothesized that the beneficial effect of SGLT2 inhibitors (SGLT2i) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) might depend on baseline diastolic function. To elucidate the effects of SGLT2i in type 2 diabetes mellitus (T2DM) and chronic HF we investigated, as a post-hoc sub-study of the CANDLE trial, the effects of canagliflozin on NT-proBNP levels from baseline to 24 weeks, with the data stratified by left ventricular (LV) diastolic function at baseline. Read More

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September 2021

Development and validation of a risk prediction nomogram for in-stent restenosis in patients undergoing percutaneous coronary intervention.

BMC Cardiovasc Disord 2021 Sep 14;21(1):435. Epub 2021 Sep 14.

Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, People's Republic of China.

Background: This study aimed to develop and validate a nomogram to predict probability of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI).

Methods: Patients undergoing PCI with drug-eluting stents between July 2009 and August 2011 were retrieved from a cohort study in a high-volume PCI center, and further randomly assigned to training and validation sets. The least absolute shrinkage and selection operator (LASSO) regression model was used to screen out significant features for construction of nomogram. Read More

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September 2021

Patient Choice in Depression Psychotherapy: Outcomes of Patient-Preferred Therapy Versus Randomly Allocated Therapy.

Am J Psychother 2021 Aug;74(3):103-111

Department of Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam (Kuzminskaite, Huibers); Department of Psychiatry, Amsterdam University Medical Center, Amsterdam (Kuzminskaite); Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands (Lemmens, van Bronswijk, Peeters); Department of Psychology, University of Pennsylvania, Philadelphia (Huibers).

Objective: Patient choice is recognized as a factor that influences clinical outcomes and treatment evaluation in mental health care. However, research on how having a choice affects patients with depression has been rare. This Dutch study examined whether patients randomly selected to choose between two types of depression psychotherapy benefited more from treatment than patients randomly assigned to an intervention. Read More

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A Randomized Controlled Trial Evaluating the Effectiveness of Supported Employment Integrated in Primary Care.

Psychiatr Serv 2021 Sep 15:appips202000926. Epub 2021 Sep 15.

Research Service, Department of Veterans Affairs (VA) Medical Center, Tuscaloosa, Alabama (Davis, Mumba, Toscano, Pilkinton, Blansett, McCall, MacVicar); Department of Psychiatry and Behavioral Neurobiology, University of Alabama School of Medicine, Birmingham (Davis); Capstone College of Nursing, University of Alabama, Tuscaloosa (Mumba); Department of Psychiatry and Behavioral Medicine, University of Alabama College of Community Health Sciences, Tuscaloosa (Pilkinton); Department of Biostatistics, University of Alabama at Birmingham, Birmingham (Bartolucci).

Objectives: Mental health issues can cause serious problems in occupational functioning, including higher rates of unemployment. Individual placement and support (IPS) is an evidence-based supported employment intervention that is typically integrated within a mental health setting; however, many primary care patients view referral to a mental health clinic as stigmatizing. Thus, this study examined whether delivery of IPS in a primary care setting provides an effective treatment option and avoids unnecessary delays in obtaining competitive employment. Read More

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September 2021

[Studies on efficacy of a bioabsorbable steroid-eluting sinus stent in the frontal sinus opening of chronic rhinosinusitis with nasal polyps].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):824-829

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, Shanghai 200433, China.

To assess the efficacy of a bioabsorbable steroid-eluting sinus stent in improving surgical outcomes when placed in the frontal sinus ostium (FSO) following full endoscopic sinus surgery (ESS) in patients with whole group chronic rhinosinusitis with nasal polyps (CRSwNP). Patients with whole group CRSwNP who had similar lesions on bilateral sinus between September 2019 and March 2020 in Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Changhai Hospital were chosen. Patients with CRSwNP who underwent extended ESS were randomly assigned to receive a steroid-eluting sinus stent in one FSO whereas the contralateral side received surgery alone. Read More

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Noisy waters can influence young-of-year lobsters' substrate choice and their antipredatory responses.

Environ Pollut 2021 Sep 7;291:118108. Epub 2021 Sep 7.

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, Biologische Anstalt Helgoland, Shelf Sea System Ecology, Helgoland, 27498, Germany.

Offshore human activities lead to increasing amounts of underwater noise in coastal and shelf environments, which may affect commercially-important benthic invertebrate groups like the re-stocked Helgoland European lobster (Homarus gammarus) in the German Bight (North Sea). It is crucial to understand the impact tonal low-frequency noises, like maritime transport and offshore energy operations, may have on substrate choice and lobsters' behavior to assess potential benefits or bottlenecks of new hard-substrate artificial offshore environments that become available. In this study, we investigated the full factorial effect of a tonal low-frequency noise and predator presence on young-of-year (YOY) European lobsters' in a diurnal and nocturnal experiment. Read More

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September 2021

Outer Retinal Folds Following Pars Plana Vitrectomy vs Pneumatic Retinopexy for Retinal Detachment Repair: Post Hoc Analysis from PIVOT.

Ophthalmol Retina 2021 Sep 11. Epub 2021 Sep 11.

Department of Ophthalmology and Vision Sciences, University of Toronto, CANADA; Department of Ophthalmology, St. Michael's Hospital, Unity Health Toronto, CANADA; Kensington Vision and Research Centre, University of Toronto, CANADA; Keenan Research Centre for Biomedical Science/ Li Ka Shing Knowledge Institute, Toronto, Canada. Electronic address:

Purpose: To assess the incidence of post-operative outer retinal folds (ORFs) in pars plana vitrectomy (PPV) vs pneumatic retinopexy (PnR) following rhegmatogenous retinal detachment (RRD) repair and to determine the association of ORFs with functional outcomes at 1 year.

Design: Randomized controlled trial PARTICIPANTS: Patients with primary macula-off RRD meeting PIVOT trial criteria randomly assigned to PPV vs PnR.

Methods: Post-hoc analysis of the PIVOT trial. Read More

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September 2021

Micro-Computed Tomography Guided Artificial Intelligence for Pulp Cavity and Tooth Segmentation on Cone-beam Computed Tomography.

J Endod 2021 Sep 11. Epub 2021 Sep 11.

Department of Endodontics, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Electronic address:

Introduction: This study proposes a novel data pipeline based on micro-CT data for training the U-Net network to realize the automatic and accurate segmentation of pulp cavity and tooth on cone-beam computed tomography (CBCT) images.

Methods: We collected CBCT data and micro-CT data of thirty teeth. CBCT data were processed and transformed into a small field of view and high-resolution CBCT images of each tooth. Read More

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September 2021

Beneficial effects of inorganic nitrate in non-alcoholic fatty liver disease.

Arch Biochem Biophys 2021 Sep 11;711:109032. Epub 2021 Sep 11.

Medical School, University of Western Australia, Perth, WA, Australia; Dobney Hypertension Centre, Medical School, University of Western Australia, Perth, WA, Australia. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic representation of the metabolic disorders. Inorganic nitrate/nitrite can be converted to nitric oxide, regulate glucose metabolism, lower lipid levels, and reduce inflammation, thus raising the hypothesis that inorganic nitrate/nitrite could be beneficial for improving NAFLD. This study assessed the therapeutic effects of chronic dietary nitrate on NAFLD in a mouse model. Read More

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September 2021

Promoting Teen-to-Teen Contraceptive Communication with the SpeakOut Intervention, a Cluster Randomized Trial.

Contraception 2021 Sep 11. Epub 2021 Sep 11.

Center for Healthcare Policy and Research, University of California, Davis 2103 Stockton Blvd., Sacramento, CA 95817. Electronic address:

Background: To improve teen contraceptive use, the SpeakOut intervention combines structured counseling, online resources, and text reminders to encourage teens to share their experiences using intrauterine contraception (IUC) or an implant with peers.

Methods: To evaluate the effectiveness of remote delivery of the SpeakOut intervention in increasing teen contraceptive use, we conducted a cluster randomized trial involving female adolescents who were recruited online. Primary participants (n=520) were randomly assigned to receive SpeakOut or an attention control; each primary participant recruited a cluster of up to five female peers as secondary participants (n=581). Read More

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September 2021

Hepatectomy Followed by mFOLFOX6 Versus Hepatectomy Alone for Liver-Only Metastatic Colorectal Cancer (JCOG0603): A Phase II or III Randomized Controlled Trial.

J Clin Oncol 2021 Sep 14:JCO2101032. Epub 2021 Sep 14.

National Cancer Center Hospital, Tokyo, Japan.

Purpose: Adjuvant chemotherapy after hepatectomy is controversial in liver-only metastatic colorectal cancer (CRC). We conducted a randomized controlled trial to examine if adjuvant modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) is superior to hepatectomy alone for liver-only metastasis from CRC.

Patients And Methods: In this phase II or III trial (JCOG0603), patients age 20-75 years with confirmed CRC and an unlimited number of liver metastatic lesions were randomly assigned to hepatectomy alone or 12 courses of adjuvant mFOLFOX6 after hepatectomy. Read More

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September 2021

Consolidation and Maintenance in Newly Diagnosed Multiple Myeloma.

J Clin Oncol 2021 Sep 14:JCO2101045. Epub 2021 Sep 14.

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Purpose: To address the role of consolidation treatment for newly diagnosed, transplant eligible patients with multiple myeloma in a controlled clinical trial.

Patients And Methods: The EMN02/HOVON95 trial compared consolidation treatment with two cycles of bortezomib, lenalidomide, and dexamethasone (VRD) or no consolidation after induction and intensification therapy, followed by continuous lenalidomide maintenance. Primary study end point was progression-free survival (PFS). Read More

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September 2021

A Suite of Mobile Conversational Agents for Daily Stress Management (Popbots): Mixed Methods Exploratory Study.

JMIR Form Res 2021 Sep 14;5(9):e25294. Epub 2021 Sep 14.

Stanford School of Medicine, Stanford University, Stanford, CA, United States.

Background: Approximately 60%-80% of the primary care visits have a psychological stress component, but only 3% of patients receive stress management advice during these visits. Given recent advances in natural language processing, there is renewed interest in mental health chatbots. Conversational agents that can understand a user's problems and deliver advice that mitigates the effects of daily stress could be an effective public health tool. Read More

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September 2021

Catch the tweet to fight the flu: Using Twitter to promote flu shots on a college campus.

J Am Coll Health 2021 Sep 14:1-15. Epub 2021 Sep 14.

Department of Mathematics, The Ohio State University, Columbus, Ohio, USA.

Objective: Over the 2018-2019 flu season we conducted a randomized controlled trial examining the efficacy of a Twitter campaign on vaccination rates. Concurrently we investigated potential interactions between digital social network structure and vaccination status. : Undergratuates at a large midwestern public university were randomly assigned to an intervention ( = 353) or control ( = 349) group. Read More

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September 2021

Data Mountain: Self-Monitoring, Goal Setting, and Positive Attributions to Enhance the Oral Reading Fluency of Elementary Students With or At-Risk for Reading Disabilities.

J Learn Disabil 2021 Sep 14:222194211043482. Epub 2021 Sep 14.

The University of Texas at Austin, USA.

Data Mountain is a self-determination program that has shown early promise in enhancing the oral reading fluency (ORF) of students with or at-risk for reading disabilities (RD). This program supports self-determined learning behaviors through explicit teaching of self-monitoring, goal setting, and positive attributions. The present study tested the effects of Data Mountain on the ORF of 81 students with or at-risk for RD in second through fifth grades, randomly assigned to one of three conditions: Data Mountain delivered in small groups, Data Mountain delivered individually, or a comparison condition. Read More

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September 2021

Effectiveness of Four Different Interventions against Schistosoma haematobium in a Seasonal Transmission Setting of Côte d'Ivoire: A Cluster Randomized Trial.

Clin Infect Dis 2021 Sep 14. Epub 2021 Sep 14.

Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire.

Background: Annual mass drug administration (MDA) using praziquantel is the cornerstone of schistosomiasis morbidity control, but is not sufficient to interrupt transmission. We implemented a cluster-randomized trial to compare the effectiveness of four different intervention packages to interrupt transmission of Schistosoma haematobium in a seasonal transmission setting of Côte d'Ivoire.

Methods: Sixty-four localities with a S. Read More

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September 2021

Impact of blended learning on manual defibrillator's use: A simulation-based randomized trial.

Nurs Crit Care 2021 Sep 13. Epub 2021 Sep 13.

Department of Paediatric Emergency Medicine, Geneva Children's Hospital, Geneva University Hospitals, Geneva, Switzerland.

Background: Blended learning, defined as the combination of traditional face-to-face instructor-led learning and e-learning course, has never been validated as a teaching method for the effective use of manual defibrillators in cardiopulmonary resuscitation.

Aim: To evaluate whether paediatric emergency and critical care providers exposed to a blended learning session performed better and recalled more defibrillator skills than those exposed to face-to-face learning only.

Study Design: A two-period prospective, stratified, single-centre, simulation-based, randomized, controlled trial. Read More

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September 2021