824,317 results match your criteria randomized trial


Is it more effective or efficient to coach teachers in pairs or individually? A comparison of teacher and student outcomes and coaching costs.

J Sch Psychol 2022 Jun 17;92:346-359. Epub 2022 May 17.

University of Virginia, School of Education and Human Development, PO Box 400270, Charlottesville, VA 22904, USA.

A growing body of research documents the positive impacts of teacher coaching, but research contrasting the effectiveness of different coaching approaches is limited. This study contrasted paired coaching - delivered to two teachers simultaneously - with traditional coaching for individual in-service teachers. We examined the effects of these two approaches on observations of teachers' classroom management practices and student behavioral outcomes, relative to non-coached conditions, over the course of a single school year and at a 1-year follow-up. Read More

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Early language intervention improves behavioral adjustment in school: Evidence from a cluster randomized trial.

J Sch Psychol 2022 Jun 7;92:334-345. Epub 2022 May 7.

University of Oxford, UK; University of Oslo, Norway.

Oral language skills are critical for psychosocial development and children with language difficulties are more likely than peers to experience behavioral problems. This study investigated the effects of an oral language intervention on behavioral adjustment. We collected teacher ratings of behavioral adjustment for 1173 children taking part in a cluster randomized trial of the Nuffield Early Language Intervention (NELI) program in 193 primary schools. Read More

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Exploring profiles of coaches' fidelity to Double Check's Motivational Interviewing-embedded coaching: Outcomes associated with fidelity.

J Sch Psychol 2022 Jun 30;92:285-298. Epub 2022 Apr 30.

University of Virginia, School of Education and Human Development, United States of America.

Motivational interviewing (MI) is applied in a variety of clinical and coaching models to promote behavior change, with increasing interest in its potential to optimize school-based implementation fidelity. Yet there has been less consideration of fidelity indicators for MI-embedded coaching and their associations with outcomes. We leveraged exisiting data from 151 teachers across 18 schools, who were part of a larger 39 middle school randomized controlled trial of a teacher coaching model, to explore profiles of fidelity and the associations between fidelity and outcomes. Read More

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A randomized trial examining the effects of paraprofessional behavior support coaching for elementary students with disruptive behavior disorders: Paraprofessional and student outcomes.

J Sch Psychol 2022 Jun 25;92:227-245. Epub 2022 Apr 25.

Rutgers University, The State University of New Jersey, USA.

There is limited research on job-embedded professional development designed to promote paraprofessionals' use of research-based strategies to support students with disruptive behaviors. This study serves as the first clustered randomized controlled trial to investigate the efficacy of the Behavior Support Coaching for Paraprofessional Model (BSC-P), which is a job-embedded training intervention for elementary schools. BSC-P is a data-driven coaching model designed to enhance paraprofessionals' implementation of behavior interventions for elementary school students with or at risk for disruptive behavior disorders. Read More

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Solid as a rock, flexible as water? Effectiveness of a school-based intervention addressing students' intrapersonal and interpersonal domains.

J Sch Psychol 2022 Jun 24;92:1-18. Epub 2022 Feb 24.

Utrecht University, Child and Adolescent Studies, Heidelberglaan 1, 3584 CS Utrecht, the Netherlands.

Students following a preparatory vocational education track seem most in need of an intervention stimulating their competencies and preventing the development of problems in the intrapersonal and interpersonal domain. The aim of the present study was to examine, first, whether Rock & Water, a social emotional learning intervention that uses active forms of learning, is effective in improving students' competencies and preventing problems in the intra- and interpersonal domain, and second, whether intervention effects were influenced by the extent to which multiple systems are involved in the intervention. We conducted a randomized controlled trial with a sample of 7th grade students (N = 1299, M = 12. Read More

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The Effects of a Physical Education Intervention Program on the Bone Properties of Second- and Third-Grade Pupils: A Cluster Randomized Controlled Trial.

J Phys Act Health 2022 May 26:1-11. Epub 2022 May 26.

School of Education, The Academic College at Wingate, Netanya,Israel.

Background: Many young children do not participate in sufficient physical activity for promoting optimal bone growth. The objective of this study was to investigate the effect of young children who participated in a school-based intervention program on bone properties. The program included structured physical activity, with a focus on the application of mechanical loads on the upper and lower limbs. Read More

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Efficacy of pembrolizumab in patients with advanced cancer of unknown primary (CUP): a phase 2 non-randomized clinical trial.

J Immunother Cancer 2022 May;10(5)

Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Cancer of unknown primary (CUP) is an aggressive rare malignancy with limited treatment options. Data regarding clinical activity of immune checkpoint inhibitors in CUP is lacking. Therefore, we evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with CUP. Read More

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Heterogeneity of treatment effect in a randomized trial of a communication intervention.

J Pain Symptom Manage 2022 May 23. Epub 2022 May 23.

Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA; Cambia Palliative Care Center of Excellence, University of Washington, Seattle, WA, USA.

Context: Interventions to promote serious illness conversations have shown promise in promoting high-quality care. However, in randomized trials, some participants may benefit more from the intervention than others.

Objectives: To examine heterogeneity of treatment effect and identify subgroups of patients with serious illness who might benefit most from interventions to enhance communication about goals of care. Read More

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Cortical excitatory and inhibitory correlates of the fronto-limbic circuit in major depression and differential effects of left frontal brain stimulation in a randomized sham-controlled trial.

J Affect Disord 2022 May 23. Epub 2022 May 23.

Epworth Centre for Innovation in Mental Health, Epworth HealthCare and Department of Psychiatry, Monash University, Camberwell, Victoria, Australia. Electronic address:

Background: Major depressive disorder (MDD), particularly treatment-resistant ones, is associated with abnormal fronto-limbic glucose metabolism. 10-Hz repetitive transcranial magnetic stimulation (rTMS) over left prefrontal cortex (PFC) is believed to normalize the abnormal metabolism to treat depression. However, the exact molecular mechanisms underlying the mood circuit of depressed brains and whether brain stimulation techniques regulate the underlying molecules remain elusive. Read More

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Efficacy of dexmedetomidine versus magnesium sulfate as an adjuvant to intraperitoneal bupivacaine in pediatric laparoscopic surgery: a randomized clinical trial.

Braz J Anesthesiol 2022 May 23. Epub 2022 May 23.

Assiut University, Faculty of Medicine, Assiut Urology and Nephrology Hospital, Assiut, Egypt.

Background: We evaluated the efficacy of dexmedetomidine versus magnesium sulfate as an adjuvant to Intraperitoneal (IP) bupivacaine in pediatric laparoscopic inguinal herniorrhaphy.

Methods: Ninety-seven male children, ASA I-II, 1-6 years old, undergoing laparoscopic inguinal herniorrhaphy, were randomized to receive before peritoneal insufflation, IP 2 mg.kg bupivacaine 0. Read More

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Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial.

Lancet Respir Med 2022 May 23. Epub 2022 May 23.

Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel, Basel, Switzerland; Clinic of Respiratory Medicine and Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Background: PCR-based testing has transformed the management of suspected respiratory viral infections. We aimed to determine whether multiplex bacterial PCR of bronchoalveolar lavage fluid aids antibiotic stewardship in patients with pneumonia.

Methods: This investigator-initiated, multicentre, randomised controlled trial was conducted at two tertiary care centres in Switzerland (University Hospital of Basel and Kantonsspital St Gallen). Read More

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Video-assisted informed consent in a clinical trial of resuscitation of extremely preterm infants: Lessons learned.

Am J Perinatol 2022 May 26. Epub 2022 May 26.

Department of Pediatrics, Oregon Health & Science University, Portland, United States.

Objective: Obtaining informed consent for clinical trials is challenging in acute clinical settings. For the VentFirst randomized clinical trial (assisting ventilation during delayed cord clamping for infants <29 weeks' gestation), we created an informational video that sites could choose to use to supplement the standard in-person verbal and written consent. Using a post-consent survey, we sought to describe the impact of the video on subject recruitment, satisfaction with the consent process, and knowledge about the study. Read More

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Heterologous ChAdOx1/BNT162b2 vaccination induces stronger immune response than homologous ChAdOx1 vaccination: The pragmatic, multi-center, three-arm, partially randomized HEVACC trial.

EBioMedicine 2022 May 23;80:104073. Epub 2022 May 23.

Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck, Peter-Mayr-Str. 4b, 6020 Innsbruck, Austria. Electronic address:

Background: Several COVID-19 vaccines have been approved. The mRNA vaccine from Pfizer/BioNTech (Comirnaty, BNT162b2; BNT) and the vector vaccine from AstraZeneca (Vaxzevria, ChAdOx1; AZ) have been widely used. mRNA vaccines induce high antibody and T cell responses, also to SARS-CoV-2 variants, but are costlier and less stable than the slightly less effective vector vaccines. Read More

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Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial.

Maturitas 2022 Apr 29;162:58-65. Epub 2022 Apr 29.

Division of Geriatrics, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison Geriatric Research Education and Clinical Center (GRECC), United States.

Objective: The relationships between cardiometabolic indices and cognition were examined in recently menopausal women.

Methods: Cross-sectional analysis of baseline data from the KEEPS (Kronos Early Estrogen Prevention Study)-Cognitive ancillary study (n = 621). Cognitive performance was assessed by the Modified Mini Mental Status (3MS) score (primary outcome). Read More

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Examining the cognitive benefits of probiotic supplementation in physically active older adults: A randomized clinical trial.

Appl Physiol Nutr Metab 2022 May 26. Epub 2022 May 26.

Kent State University College of Arts and Sciences, 142731, Psychological Sciences; Brain Health Research Institute, Kent, Ohio, United States;

The prevalence of dementia is projected to increase with the growing older adult population and prevention strategies are urgently needed. Two promising interventions include physical activity (PA) and probiotic supplementation, with initial findings suggesting their combined use may confer greater cognitive benefits than either intervention alone. However, no study has yet examined the effects of probiotic supplementation on cognitive function in healthy, physically active older adults. Read More

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Efficiency of ursodeoxycholic acid for the treatment of nonalcoholic steatohepatitis: a systematic review and meta-analysis.

Expert Rev Gastroenterol Hepatol 2022 May 26. Epub 2022 May 26.

Department of Nutrition, School of Public Health, Guangdong Medical University, Zhanjiang 524023, China.

Background: Previous studies have demonstrated that ursodeoxycholic acid (UDCA) possesses anti-inflammatory, antioxidant and anti-fibrotic properties, and it may reduce the degree of liver damage caused by nonalcoholic steatohepatitis (NASH). However, the effectiveness of UDCA in improving liver function and histology in cases of NASH remains unclear. Therefore, we performed a meta-analysis to assess the efficacy of UDCA in the treatment of NASH. Read More

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Economic Evaluation of an Intervention to Prevent Adolescent Dating Violence (Me & You).

J Interpers Violence 2022 May 26:8862605221104534. Epub 2022 May 26.

UTHealth, Center for Health Promotion & Prevention Research, Houston, TX, USA.

is a multilevel, technology-enhanced adolescent dating violence (DV) prevention program that aimed to reduce DV among ethnic-minority, early adolescent, urban youth. A group-randomized control trial of Me & You, conducted with 10 middle schools from a large urban school district in Southeast Texas in 2014-2015, found it to be effective in reducing DV perpetration and decreasing some forms of DV victimization. Economic evaluations of DV interventions are extremely limited, despite calls for more economic analyses to be incorporated in research. Read More

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Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial.

Trends Psychiatry Psychother 2022 May 26;44. Epub 2022 May 26.

Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa, PB, Brazil. Brazilian Cannabis Study Society (SBEC), Brazil.

Introduction: Autism Spectrum Disorder is characterized by persistent deficits in social communication, social interaction, and restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of autistic children without causing serious adverse effects, thus providing a therapeutic alternative.

Method: This was a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in autistic children. Read More

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Real-Time Telehealth Versus Face-to-Face Management for Patients With PTSD in Primary Care: A Systematic Review and Meta-Analysis.

J Clin Psychiatry 2022 May 23;83(4). Epub 2022 May 23.

Institute for Evidence-Based Healthcare, Bond University, Robina, Queensland, Australia.

We conducted a systematic review and meta-analysis of randomized controlled trials comparing real-time telehealth (video, phone) with face-to-face therapy delivery to individuals with posttraumatic stress disorder (PTSD), by primary or allied health care practitioners.

We searched MEDLINE, Embase, CINAHL, and Cochrane Central (inception to November 18, 2020); conducted a citation analysis on included studies (January 7, 2021) in Web of Science; and searched ClinicalTrials.gov and WHO ICTRP (March 25, 2021). Read More

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[Educational Tools to Improve the Therapeutic Relationship of Psychiatrists and Psychiatric Residents with Patients Suffering from Psychosis: A Systematic Review].

Sante Ment Que 2021 ;46(2):417-438

Département de psychiatrie, Université McGill ; Centre Hospitalier de St-Mary, Département de psychiatrie ; Centre Hospitalier Universitaire de Sherbrooke, Département de psychiatrie.

Objectives This systematic review identifies the literature on educational tools specifically targeting 2 of the keys competencies that a psychiatrist must acquire according to the Royal College of Physicians and Surgeons of Canada: the therapeutic relationship and empathy, in the context of psychosis. Method This review was carried out in the Medline databases via Ovid, PsycInfo (EBSCO) and Scopus using combinations of terms associated with therapeutic tools, empathy, residents in psychiatry, psychiatrists and psychosis. Two independent reviewers reviewed 1169 titles and abstracts, and retained 5 articles. Read More

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January 2021

Simulation-based Education Improves Military Trainees' Skill Performance and Self- Confidence in Tourniquet Placement: A Randomized Controlled Trial.

J Trauma Acute Care Surg 2022 May 23. Epub 2022 May 23.

University of Miami Miller School of Medicine.

Background: Tactical Combat Casualty Care (TCCC) is the standard of care for stabilization and treatment of military trauma patients. The DoD has mandated that all Service members receive role-based TCCC training and certification. Simulation education can increase procedural skills by providing opportunities for deliberate practice in safe, controlled environments. Read More

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Chemical peeling with 35% glycolic acid for the treatment of disseminated facial verruca plana: a randomized, split-face, evaluator-blinded trial.

Dermatol Ther 2022 May 26:e15594. Epub 2022 May 26.

Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.

Disseminated facial verruca plana is a chronic disorder that causes significant psychological distress. However, safe and effective treatment is lacking. This study aimed to explore the efficacy and safety of 35% glycolic acid for the treatment of disseminated facial verruca plana. Read More

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The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women.

J Perinat Med 2022 May 27. Epub 2022 May 27.

Maternal-fetal medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Preterm birth (PTB) is the common cause of neonatal mortality nationwide. The present study aimed to evaluate the efficacy of different doses of aspirin in preventing PTB in high-risk pregnant women. As secondary outcomes, other perinatal complications were compared. Read More

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Safety and immunogenicity of heterologous boost immunization with an adenovirus type-5-vectored and protein-subunit-based COVID-19 vaccine (Convidecia/ZF2001): A randomized, observer-blinded, placebo-controlled trial.

PLoS Med 2022 May 26;19(5):e1003953. Epub 2022 May 26.

NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Province Center for Disease Control and Prevention, Nanjing, PR China.

Background: Heterologous boost vaccination has been proposed as an option to elicit stronger and broader, or longer-lasting immunity. We assessed the safety and immunogenicity of heterologous immunization with a recombinant adenovirus type-5-vectored Coronavirus Disease 2019 (COVID-19) vaccine (Convidecia, hereafter referred to as CV) and a protein-subunit-based COVID-19 vaccine (ZF2001, hereafter referred to as ZF).

Methods And Findings: We conducted a randomized, observer-blinded, placebo-controlled trial, in which healthy adults aged 18 years or older, who have received 1 dose of Convidecia, with no history of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, were recruited in Jiangsu, China. Read More

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Resistance training reduced luteinising hormone levels in postmenopausal women in a substudy of a randomised controlled clinical trial: A clue to how resistance training reduced vasomotor symptoms.

PLoS One 2022 26;17(5):e0267613. Epub 2022 May 26.

Obstetrics and Gynaecology, Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Background: Vasomotor symptoms (VMS) are common around menopause. Menopausal hormone therapy is the most effective treatment for VMS. Physical exercise has been proposed as an alternative treatment since physically active women have previously been found to experience fewer VMS than inactive women. Read More

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The ESCAPE trial for older people with chronic low back pain: Protocol of a randomized controlled trial.

PLoS One 2022 26;17(5):e0266613. Epub 2022 May 26.

Postgradute Program in Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.

Background: Low-back pain is one of the most common health conditions worldwide. It is defined as pain below the costal margin and above the inferior gluteal folds. Current guidelines recommend management of chronic health (e. Read More

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Effects of different exercise training programs on the functional performance in fibrosing interstitial lung diseases: A randomized trial.

PLoS One 2022 26;17(5):e0268589. Epub 2022 May 26.

Department of Chest diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Objectives: We aimed to compare the effects of different aerobic exercise training (ET) programs on respiratory performance, exercise capacity, and quality of life in fibrosing interstitial lung diseases (f-ILD).

Methods: A case-control study where 31 patients with f-ILD diagnosis based on chest high-resolution computed tomography were recruited from Main Alexandria University hospital-Egypt. Ten patients were randomly assigned for only lower limbs (LL) endurance training program, and 10 patients for upper limbs, lower limbs, and breathing exercises (ULB) program for consecutive 18 sessions (3 sessions/week for 6 consecutive weeks). Read More

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Long-term impact of invasive meningococcal disease in children: SEINE study protocol.

PLoS One 2022 26;17(5):e0268536. Epub 2022 May 26.

Centre Hospitalier Intercommunal, Clinical Research Center, Créteil, France.

Introduction: Invasive meningococcal disease (IMD) is still an important cause of mortality in children and survivors can have significant long-term disabling sequelae. There are few prospective studies looking at the long term neuropsychological and developmental consequences of IMD in surviving children, and the rate of sequelae may be underestimated. The SEINE study aims to have a more reliable estimate of the real rate of sequelae by assessing the long-term physical, neuropsychological, learning disorders and sensory sequelae of IMD in children and adolescents and by assessing the post-traumatic stress in parents. Read More

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Effect of early mobilization combined with early nutrition on acquired weakness in critically ill patients (EMAS): A dual-center, randomized controlled trial.

PLoS One 2022 26;17(5):e0268599. Epub 2022 May 26.

Department of Intensive Care Unit, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Aim: The study aimed to investigate the effect of early mobilization combined with early nutrition (EMN) on intensive care unit-acquired weakness (ICU-AW) in intensive care unit (ICU) settings compared with early mobilization (EM) or routine care.

Methods: A prospective, dual-center, randomized controlled trial was conducted. The control group underwent standard care without a pre-established routine for mobilization and nutrition. Read More

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How effective is a blended web-based rehabilitation for improving pain, physical activity, and knee function of patients with knee osteoarthritis? Study protocol for a randomized control trial.

PLoS One 2022 26;17(5):e0268652. Epub 2022 May 26.

Physiotherapy Department of University of West Attica, Egaleo, Attica, Greece.

Due to the chronic nature of knee osteoarthritis (KOA) self-management is considered an essential part of therapy to improve physical function, activity, pain and quality of life (QoL). Web-based rehabilitation may be a potential innovative mode of patient' training to guide management compared to usual care, especially with the current restrictions pandemic imposed. Moreover, in order to alter KOA patients' behavior towards physical activity (PA), it may be more attractive and motivating to combine within their rehabilitation program, outdoor real life local activity that could feasible to be sustained in the future. Read More

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