19,163 results match your criteria rainbow trout

Clinical Value of Weight-Bearing CT and Radiographs for Detecting Patellofemoral Cartilage Visualized by MRI in the MOST Study.

Osteoarthritis Cartilage 2021 Jul 28. Epub 2021 Jul 28.

Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA, USA. Electronic address:

Objective: The patellofemoral joint is frequently affected by osteoarthritis (PFOA) and is incompletely imaged on radiographs (XR). Weight-Bearing CT (WBCT) could offer advantages for visualization. This study determined the sensitivity, specificity, and accuracy of axial WBCT and lateral XR for detection of PFOA features in comparison with cartilage damage on MRI. Read More

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The influence of visual supports and motivation on motor performance of the MABC-2 for Chinese school-aged children with autism spectrum disorder.

Sci Rep 2021 Jul 30;11(1):15557. Epub 2021 Jul 30.

Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, Beijing, China.

The influences of including visual supports and strategies to increase motivation for children with autism spectrum disorder (ASD) in motor assessments were examined. 97 children with ASD and 117 age-matched typically developing (TD) children performed the Movement Assessment Battery for Children, Second Edition (MABC-2) under traditional, visual support, motivation, and visual support plus motivation protocols. Results showed that children with ASD elicited lower MABC-2 scores than TD children. Read More

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Sub-Chronic Exposure to Environmental Concentrations of Chlorpyrifos Affect Swimming Activity of Rainbow Trout Larvae.

Environ Toxicol Chem 2021 Jul 30. Epub 2021 Jul 30.

University of Bordeaux, UMR5805 CNRS University of Bordeaux EPHE, Allée Geoffoy Saint-Hilaire, 33600, Pessac, France.

Chlorpyrifos (CPF), one organophosphorus pesticide, can be found in aquatic ecosystems at concentrations of up to several hundred ng/L because of water runoff from treated crops. While some previous studies have shown that low concentrations of CPF may have adverse effects on aquatic species, comparatively little is known about its effect on fish embryos and larvae. To investigate the developmental effects of CPF, rainbow trout (Oncorhynchus mykiss) eyed-stage embryos were exposed in semi-static conditions to 0. Read More

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Integrating multiple hybridization chain reactions on gold nanoparticle and alkaline phosphatase-mediated in situ growth of gold nanobipyramids: An ultrasensitive and high color resolution colorimetric method to detect the mecA gene of Staphylococcus aureus.

J Hazard Mater 2021 Jun 3;418:126223. Epub 2021 Jun 3.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China. Electronic address:

Colorimetry has been considered as a potential instrument-free platform for point-of-care genomic detection. However, it is limited by the poor sensitivity and low color resolution. Herein, we report a high-resolution colorimetric biosensor based on multiple hybridization chain reactions (HCRs) on gold nanoparticle (AuNP) and alkaline phosphatase (ALP)-mediated in situ growth of gold nanobipyramids (AuNBPs) for ultrasensitive detection of the Staphylococcus aureus (S. Read More

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Isolation and characterization of Lactococcus garvieae from rainbow trout, Onchorhyncus mykiss, from California, USA.

Transbound Emerg Dis 2021 Jul 30. Epub 2021 Jul 30.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.

Lactococcus garvieae is an emergent bacterial pathogen of salmonid fish in North America that causes acute infections particularly at water temperatures above 15°C. During 2020, L. garvieae was detected in rainbow trout, Onchorhyncus mykiss, cultured in Southern California and the Eastern Sierras. Read More

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Expression and characterization of rainbow trout Oncorhynchus mykiss recombinant myoglobin.

Fish Physiol Biochem 2021 Jul 30. Epub 2021 Jul 30.

Graduate School of Agriculture, Tohoku University, Aramaki, Aoba, Sendai, 980-8572, Japan.

Recombinant expression system was established for rainbow trout myoglobin (Mb) considering its unique primary structure of having one unusual deletion and two cysteine residues in contrast to the other fish Mbs. The obtained recombinant Mb without His-tag showed non-cooperative thermal denaturation profile. The presence of free cysteine residue(s) in rainbow trout Mb was demonstrated by reacting with a sulfhydryl agent, 4, 4´-dithiodipyridine, which ultimately resulted in the oxidation of Mb with characteristic changes in visible absorption spectra. Read More

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Opportunities for Regulatory Changes to Promote Pediatric Device Innovation in the United States: Joint Recommendations From Pediatric Innovator Roundtables.

IEEE J Transl Eng Health Med 2021 25;9:4800105. Epub 2021 Jun 25.

Cactus MedicalIrvineCA92612USA.

Objective: The purpose of this report is to provide insight from pediatric stakeholders with a shared desire to facilitate a revision of the current United States regulatory pathways for the development of pediatric healthcare devices.

Methods: On August 5, 2020, a group of innovators, engineers, professors and clinicians met to discuss challenges and opportunities for the development of new medical devices for pediatric health and the importance of creating a regulatory environment that encourages and accelerates the research and development of such devices. On January 6, 2021, this group joined regulatory experts at a follow-up meeting. Read More

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"The Child Is the Father of the Man": A Tribute to Ken Swaiman.

Mark Scher

Pediatr Neurol 2021 Jun 12. Epub 2021 Jun 12.

Emeritus Scholar, Tenured Full-Professor of Pediatrics and Neurology, Case Western Reserve University, School of Medicine, Department of Pediatrics, Division of Pediatric Neurology, Fetal/Neonatal Neurology Program, Rainbow Babies and Children's Hospital/McDonald Hospital for Women, University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address:

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Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients.

J Clin Immunol 2021 Jul 29. Epub 2021 Jul 29.

Pediatric Immunology, Hematology and Rheumatology Unit, Hôpital Necker-Enfants Malades, APHP, Paris, France.

Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2. Read More

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Normoxic limitation of maximal oxygen consumption rate, aerobic scope and cardiac performance in exhaustively exercised rainbow trout (Oncorhynchus mykiss).

J Exp Biol 2021 Aug 29;224(15). Epub 2021 Jul 29.

Department of Biological and Environmental Sciences, University of Gothenburg, PO Box 463, 405 30 Gothenburg, Sweden.

In fish, maximum O2 consumption rate (ṀO2,max) and aerobic scope can be expanded following exhaustive exercise in hyperoxia; however, the mechanisms explaining this are yet to be identified. Here, in exhaustively exercised rainbow trout (Oncorhynchus mykiss), we assessed the influence of hyperoxia on ṀO2,max, aerobic scope, cardiac function and blood parameters to address this knowledge gap. Relative to normoxia, ṀO2,max was 33% higher under hyperoxia, and this drove a similar increase in aerobic scope. Read More

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Superior Mesenteric Artery Injury during Radical Nephrectomy in an Infant: Delayed Diagnosis and Successful Management.

J Indian Assoc Pediatr Surg 2021 May-Jun;26(3):188-191. Epub 2021 May 17.

Consultant Pediatric Surgeon, Ankura Hospital, Hyderabad, Telangana, India.

Superior mesenteric artery (SMA) injury during a left radical nephrectomy is an uncommon complication in children with a potentially devastating outcome. Successful management depends on early diagnosis and re-establishing SMA perfusion. We report the successful management of an iatrogenic SMA injury during radical nephrectomy in a 10-month-old boy with left upper polar Wilms' tumor. Read More

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Subcutaneous fat necrosis in an infant with hypoxic ischaemic encephalopathy stage 3: an uncommon association.

BMJ Case Rep 2021 Jul 28;14(7). Epub 2021 Jul 28.

Skin and Venereal Diseases, Madhukar Rainbow Children's Hospital, Delhi, India.

Subcutaneous fat necrosis (SCFN) is inflammation and necrosis of adipose tissue associated with hypoxia and hypothermia. It leads to various metabolic abnormalities, of which the most dreaded is hypercalcaemia. We report a case of a 7-week-old boy with history of birth asphyxia (hypoxic ischaemic encephalopathy stage 3) who presented to us with features suggestive of hypercalcaemia with bilateral nephrocalcinosis. Read More

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Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.

Biomed Pharmacother 2020 Oct 18;130:110618. Epub 2020 Aug 18.

Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address:

Huoxin Pill (HXP), a Traditional Chinese Medicine, is used widely to treat patients with coronary heart disease and angina pectoris in China. However, the underlying protective mechanism of HXP on cardiac apoptosis and fibrosis has never been evaluated. Therefore, the aim of this study was to investigate the role of HXP in a myocardial infarction (MI) mouse model. Read More

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October 2020

Long-Term Complications in Youth-Onset Type 2 Diabetes.

N Engl J Med 2021 Jul;385(5):416-426

From the University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora (P.B., P.Z.); George Washington University, Rockville, MD (K.L.D., B.T.); Yale University, New Haven, CT (S.C.); Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland (R.G.-K.); the Massachusetts General Hospital Diabetes Center, Harvard Medical School, Boston (D.M.N.); the University of Oklahoma Health Sciences Center, Oklahoma City (J.T.); and Washington University School of Medicine, St. Louis (N.H.W.).

Background: The prevalence of type 2 diabetes in youth is increasing, but little is known regarding the occurrence of related complications as these youths transition to adulthood.

Methods: We previously conducted a multicenter clinical trial (from 2004 to 2011) to evaluate the effects of one of three treatments (metformin, metformin plus rosiglitazone, or metformin plus an intensive lifestyle intervention) on the time to loss of glycemic control in participants who had onset of type 2 diabetes in youth. After completion of the trial, participants were transitioned to metformin with or without insulin and were enrolled in an observational follow-up study (performed from 2011 to 2020), which was conducted in two phases; the results of this follow-up study are reported here. Read More

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Combined polystyrene microplastics and chlorpyrifos decrease levels of nutritional parameters in muscle of rainbow trout (Oncorhynchus mykiss).

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing, 100085, China.

Microplastic (MP) is a major contaminant in the aquatic environment. In addition to the physical threats posed by microplastic ingestion, their potential as a vector for the transport of hydrophobic pollutants is required to be adequately addressed. This study examined the effects of polystyrene microplastics individually or combined with chlorpyrifos insecticide on nutritional parameters in muscle of rainbow trout (Onchorhynchus mykiss). Read More

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Perventricular Transcatheter Pulmonary Valve Implantation in a Symptomatic 3-Year-Old Child With Repaired Tetralogy of Fallot.

JACC Case Rep 2021 May 14;3(5):712-714. Epub 2021 Apr 14.

Department of Pediatric Cardiology, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.

In select patients, transcatheter pulmonary valve replacement through a percutaneous approach can be challenging because of complicated anatomy or small patient size. In these patients, especially those weighing <20 kg, hybrid perventricular valve delivery may provide a preferred alternative approach. (). Read More

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Association between genes regulating neural pathways for quantitative traits of speech and language disorders.

NPJ Genom Med 2021 Jul 27;6(1):64. Epub 2021 Jul 27.

Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

Speech sound disorders (SSD) manifest as difficulties in phonological memory and awareness, oral motor function, language, vocabulary, reading, and spelling. Families enriched for SSD are rare, and typically display a cluster of deficits. We conducted a genome-wide association study (GWAS) in 435 children from 148 families in the Cleveland Family Speech and Reading study (CFSRS), examining 16 variables representing 6 domains. Read More

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Pendred Syndrome with C Cell Hyperplasia.

Endocr Pathol 2021 Jul 27. Epub 2021 Jul 27.

Departments of Pathology, University Hospitals Cleveland Medical Center, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, 44106, USA.

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Excipient-Induced Pulmonary Vascular Disease: An Underrecognized and Deadly Complication of Opioid Addiction.

Lung 2021 Jul 27. Epub 2021 Jul 27.

Division of Pulmonary, Critical Care, & Sleep Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Mail Stop #3007, Kansas City, KS, 66160-7381, USA.

Despite widespread public health concern regarding opioid misuse and overuse, there is a paucity of literature on the acute and chronic pulmonary vascular and cardiac implications of excipient lung disease. This case series describes the clinical presentation of five adult patients who experienced profound pulmonary hypertension and right heart failure in the setting of confirmed or suspected crushed opioid injection at a single academic center between 2012 and 2019. The clinical characteristics and right heart catheterization data presented in these cases demonstrate the acute intravascular effects of the intravenous injection of crushed opioids and potential for hemodynamic collapse. Read More

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COVID-19 in the Clinic: Human Testing of an Aerosol Containment Mask for Endoscopic Clinic Procedures.

Otolaryngol Head Neck Surg 2021 Jul 27:1945998211029184. Epub 2021 Jul 27.

Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Objective: To create an aerosol containment mask (ACM) for common otolaryngologic endoscopic procedures that also provides nanoparticle-level protection to patients.

Study Design: Prospective feasibility study .

Setting: In-person testing with a novel ACM. Read More

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A fast HRMA tool to authenticate eight salmonid species in commercial food products.

Food Chem Toxicol 2021 Jul 23:112440. Epub 2021 Jul 23.

LAQV-REQUIMTE, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portugal. Electronic address:

Atlantic and Pacific salmon are frequently consumed species with very different economic values: farmed Atlantic salmon is cheaper than wild-caught Pacific salmons. Species replacements occur with the high valued Pacific species (Oncorhynchus keta, O. gorbuscha, O. Read More

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Skeletal Maturity Using Knee X-rays: Understanding the Resilience of 7 Radiographic Parameters to Rotational Position.

J Pediatr Orthop 2021 Jul 26. Epub 2021 Jul 26.

Department of Orthopaedic Surgery, Rainbow Babies and Children's Hospital at Case Western Reserve University School of Medicine Center for Clinical Research, University Hospitals Cleveland Medical Center, Cleveland, OH.

Background: Recently, a skeletal maturity system using knee radiographs, named the modified Roche-Wainer-Thissen (RWT) system, has been developed using 7 discrete radiographic parameters. While the system has been shown to significantly outperform the Greulich and Pyle atlas, the effect of rotational variation of the knee radiograph on skeletal maturity determinations has not been studied.

Methods: Normal knee computed tomography scans of 12 male children ages 10 to 16 years and 8 female children ages 8 to 14 years were obtained retrospectively, converted into 3-dimensional reconstructions, and then used to simulate knee radiographs in 5 different rotational positions. Read More

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Estimating Skeletal Maturity Using Knee Radiographs During Preadolescence: The Epiphyseal: Metaphyseal Ratio.

J Pediatr Orthop 2021 Jul 26. Epub 2021 Jul 26.

Department of Orthopaedics, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center Division of Pediatric Orthopaedics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine Case Western Reserve University School of Medicine, Cleveland, OH.

Background: Though skeletal maturity is most relevant during adolescence, it has utility in treatment of younger patients in some circumstances. Accurate estimation of skeletal maturity using knee radiographs would be useful when treating limb length discrepancy and other general medical conditions in preadolescent patients. Currently, a quick, accurate, and reproducible method of estimating skeletal maturity in preadolescents is lacking. Read More

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Incidence, Risk Factors, and Outcomes of Neonatal Acute Kidney Injury: Protocol of a Multicentric Prospective Cohort Study [The Indian Iconic Neonatal Kidney Educational Registry].

Front Pediatr 2021 9;9:690559. Epub 2021 Jul 9.

Akron's Children Hospital, Akron, OH, United States.

Acute kidney injury (AKI) is a significant problem in neonates, but the evidence is sparse. Neonatal AKI is an independent risk factor for increased mortality and prolonged hospital stay. There are stark differences in the epidemiology of AKI in neonates amongst the developing and the developed world. Read More

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Bilateral Fracture Neck Femur in Child with Bilateral Delayed Union and Bilateral AVN: A Rare Occurrence and Literature Review.

Indian J Orthop 2021 Jul 18;55(Suppl 2):501-507. Epub 2021 Mar 18.

B J Medical College, Civil hospital, Ahmedabad, Gujarat India.

A bilateral neck of femur fracture in children is a rare occurrence with only twelve cases reported till the date. We report a case of a 3-year-old schoolgirl with bilateral Delbet type 2 fracture neck femur after a fall from height. She was managed elsewhere by bilateral closed reduction and screw fixation within 24 h. Read More

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Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected With Through Co-Expression and Machine Learning.

Front Immunol 2021 8;12:677730. Epub 2021 Jul 8.

Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, Busan, South Korea.

is a major pathogen that causes a high mortality rate in trout farms. However, systemic responses to the pathogen and its interactions with multiple organs during the course of infection have not been well described. In this study, dual-organ transcriptomic responses in the liver and head kidney and hemato-serological indexes were profiled under infection and recovery to investigate systemic immuno-physiological characteristics. Read More

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50 Years Ago in TheJournalofPediatrics: Assessing Congestive Heart Failure in Pediatrics.

J Pediatr 2021 Aug;235:169

Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH.

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Sirolimus in infants with congenital hyperinsulinism (CHI) - a single-centre experience.

Eur J Pediatr 2021 Jul 24. Epub 2021 Jul 24.

Department of Pediatrics Endocrinology Rainbow Children's Hospital, 500034, Hyderabad, India.

Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in neonates and infants. Medical treatment includes the use of high concentrations of glucose and combinations of diazoxide, octreotide and glucagon. We report our experience of using sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in the treatment of CHI in seven newborns who are poorly responding to standard medical therapy. Read More

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Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.

Science 2021 Jul 22. Epub 2021 Jul 22.

Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.

Understanding the causes and consequences of the emergence of SARS-CoV-2 variants of concern is crucial to pandemic control yet difficult to achieve, as they arise in the context of variable human behavior and immunity. We investigate the spatial invasion dynamics of lineage B.1. Read More

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