3,074 results match your criteria radius tumour

Collective Cell Migration in a Fibrous Environment: A Hybrid Multiscale Modelling Approach.

Front Appl Math Stat 2021 Jun 25;7. Epub 2021 Jun 25.

Department of Mathematics, University of Dundee, Dundee, UK.

The specific structure of the extracellular matrix (ECM), and in particular the density and orientation of collagen fibres, plays an important role in the evolution of solid cancers. While many experimental studies discussed the role of ECM in individual and collective cell migration, there are still unanswered questions about the impact of nonlocal cell sensing of other cells on the overall shape of tumour aggregation and its migration type. There are also unanswered questions about the migration and spread of tumour that arises at the boundary between different tissues with different collagen fibre orientations. Read More

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Open and Laparoscopic Partial Nephrectomy: Comparison and Validation of Preoperative Scoring Systems, Including PADUA, RENAL, ABC Nephrometric Scores and Perinephric Fat Evaluation with Mayo Adhesive Probability Score.

Res Rep Urol 2021 19;13:509-517. Epub 2021 Jul 19.

Department of Urology, University Hospital of Liège, Liège, Belgium.

Purpose: To evaluate potential associations between 4 nephrometric scoring systems, namely the PADUA (preoperative aspects and dimensions used for anatomical classification), RENAL (radius endophytic/exophytic nearness anterior posterior location), ABC (arterial-based complexity), and MAP (Mayo adhesive probability) scores and their individual components, with surgical and oncological outcomes of patients undergoing a partial nephrectomy.

Materials And Methods: A consecutive, monocentric cohort of partial nephrectomy patients was retrospectively analyzed. PADUA, RENAL, ABC and MAP nephrometry scores were determined from preoperative axial images. Read More

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Pathological fracture in paediatric bone tumours and tumour-like lesions: A predictor of benign lesions?

Br J Radiol 2021 Jul 28:20201341. Epub 2021 Jul 28.

Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.

Objective: To determine the incidence and causes of pathological fractures in paediatric bone tumours and tumour-like lesions, and to determine if they are predictive of benign lesions.

Methods And Materials: Retrospective review of children with suspected bone tumours referred to a specialist musculoskeletal oncology service between September 2019 and August 2020. Data recorded included patient age and gender, lesion location, the presence of a pathological fracture on the initial plain radiograph, and the final diagnosis made either by image-guided biopsy/curettage or based on typical imaging features. Read More

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Effects of control temperature, ablation time, and background tissue in radiofrequency ablation of osteoid osteoma: a computer modeling study.

Int J Numer Method Biomed Eng 2021 Jul 27:e3512. Epub 2021 Jul 27.

University of Groningen, University Medical Center Groningen, Department of Radiotherapy, Groningen, The Netherlands.

Purpose: To study the effects of the control temperature, ablation time, and the background tissue surrounding the tumor on the size of the ablation zone on radiofrequency ablation (RFA) of osteoid osteoma (OO).

Materials And Methods: Finite element models of non-cooled temperature-controlled RFA of typical OOs were developed to determine the resulting ablation radius at control temperatures of 70, 80, and 90°C. Three different geometries were used, mimicking common cases of OO. Read More

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Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling.

Acta Neuropathol 2021 Jul 24. Epub 2021 Jul 24.

Department of Paediatric Haematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Medulloblastoma (MB) is a childhood malignant brain tumour comprising four main subgroups characterized by different genetic alterations and rate of mortality. Among MB subgroups, patients with enhanced levels of the c-MYC oncogene (MB) have the poorest prognosis. Here we identify a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating MB. Read More

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CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study.

J Immunother Cancer 2021 Jul;9(7)

Department of Medical Oncology, Virginia Cancer Specialists, Fairfax, Virginia, USA.

Background: Probody therapeutics are antibody prodrugs that are activated in the tumor microenvironment by tumor-associated proteases, thereby restricting the activity to the tumor microenvironment and minimizing 'off-tumor' toxicity. We report dose-escalation and single-agent expansion phase data from the first-in-human study of CX-072 (pacmilimab), a Probody checkpoint inhibitor directed against programmed death-ligand 1 (PD-L1).

Methods: In the dose-escalation phase of this multicenter, open-label study (NCT03013491), adults with advanced solid tumors (naive to programmed-death-1/PD-L1 or cytotoxic T-lymphocyte-associated antigen 4 inhibitors) were enrolled into one of seven dose-escalation cohorts, with pacmilimab administered intravenously every 14 days. Read More

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CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose-finding study.

J Immunother Cancer 2021 Jul;9(7)

Department of Medical Oncology, The Christie Hospital NHS Foundation Trust and University of Manchester, Manchester, UK.

Background: Probody® therapeutics are antibody prodrugs designed to be activated by tumor-associated proteases. This conditional activation restricts antibody binding to the tumor microenvironment, thereby minimizing 'off-tumor' toxicity. Here, we report the phase 1 data from the first-in-human study of CX-072 (pacmilimab), a Probody immune checkpoint inhibitor directed against programmed death-ligand 1 (PD-L1), in combination with the anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody ipilimumab. Read More

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Development and Validation of a Simulation Model-Based Clinical Decision Tool: Identifying Patients Where 21-Gene Recurrence Score Testing May Change Decisions.

J Clin Oncol 2021 Jul 12:JCO2100651. Epub 2021 Jul 12.

Department of Oncology, Georgetown University Medical Center, Washington, DC.

Purpose: There is a need for industry-independent decision tools that integrate clinicopathologic features, comorbidities, and genomic information for women with node-negative, invasive, hormone receptor-positive, human epidermal growth factor receptor-2-negative (early-stage) breast cancer.

Methods: We adapted an extant Cancer Intervention and Surveillance Modeling Network simulation model to estimate the 10-year risk of distant recurrence, breast cancer-specific mortality, other-cause mortality, and life-years gained with chemoendocrine versus endocrine therapy. We simulated outcomes for 1,512 unique patient subgroups based on all possible combinations of age, tumor size, grade, and comorbidity level; simulations were performed with and without 21-gene recurrence scores (RSs). Read More

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Technical note: Validation of 3D ultrasound for image registration during oncological liver surgery.

Med Phys 2021 Jul 5. Epub 2021 Jul 5.

Department of Surgical Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Purpose: Registration of pre- and intraoperative images is a crucial step of surgical liver navigation, where rigid registration of vessel centerlines is currently commonly used. When using 3D ultrasound (US), accuracy during navigation might be influenced by the size of the intraoperative US volume, yet the relationship between registration accuracy and US volume size is understudied. In this study, we specify an optimal 3D US volume size for registration using varying volumes of liver vasculature. Read More

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An Investigation using Specific Absorption Rate Analysis to Diagnose Early-Stage Breast Tumor using UWB Antenna.

Curr Med Imaging 2021 Jun 29. Epub 2021 Jun 29.

Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai, India.

Aims: This study aimed to focus on the detection of early-stage breast tumor and its location.

Background: Breast Cancer is the disease with the highest rate of progression and mortality among women. Due to breast cancer/tumors, the risk of mortality for women has risen exponentially. Read More

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Modeling of Tumor Spheroid Formation and Growth.

Micromachines (Basel) 2021 Jun 25;12(7). Epub 2021 Jun 25.

Department of Mechanical Engineering, University of Victoria, Victoria, BC V8W 2Y2, Canada.

Mathematical modeling has significant potential for understanding of biological models of cancer and to accelerate the progress in cross-disciplinary approaches of cancer treatment. In mathematical biology, solid tumor spheroids are often studied as preliminary models of avascular tumors. The size of spheroids and their cell number are easy to track, making them a simple model to investigate tumor behavior, quantitatively. Read More

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Evaluation of Dosimetric Parameters for Tumor Therapy with Lu and Y Radionuclides in Gate Monte Carlo Code.

J Biomed Phys Eng 2021 Jun 1;11(3):263-270. Epub 2021 Jun 1.

MSc, Department of Medical Physics, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Background: Y and Lu are two well-known radionuclides used in radionuclide therapy to treat neuroendocrine tumors.

Objective: This current study aims to evaluate, compare and optimize tumor therapy with Y and Lu for different volumes of the tumor using the criterion of self-absorbed dose, cross-absorbed dose, absorbed dose profile, absorbed dose uniformity, and dose-volume histogram (DVH) curve using Gate Monte Carlo simulation code.

Material And Methods: In our analytical study, Gate Monte Carlo simulation code has been used to model tumors and simulate particle transport. Read More

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[Result analysis of percutaneous core needle biopsy for bone tumors in upper limbs with pathological fracture].

Zhongguo Gu Shang 2021 Jun;34(6):527-30

Department of Orthopaedic Oncology Surgery, Jishuitan Hospital, Beijing 100035, China.

Objective: To analyze the results of percutaneous core needle biopsy for bone tumors in upper limbs with pathologic fracture and to find the possible factors that could impact the results.

Methods: The including criteria for this study was the patients who had received percutaneous core needle biopsy and definitive surgery, whose tumor was located at upper limb with pathologic fracture. From January 2015 to December 2019, seventy-seven patients were enrolled. Read More

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I Intracavitary Irradiation Combined with I Seeds Implantation for Treatment of Locally Advanced Pancreatic Head Cancer: A Retrospective Analysis of 67 Cases.

Int J Gen Med 2021 18;14:2645-2653. Epub 2021 Jun 18.

Department of Hepatobiliary Pancreatic Surgery, Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital of Bengbu Medical College, Anhui, 233000, People's Republic of China.

Background: Pancreatic cancer is an aggressive malignant tumor of the digestive system and the fourth leading cause of tumor-related death. Intracavitary I seed irradiation has been recently developed as a therapy for locally advanced pancreatic head carcinoma. However, there are still many limitations, and more investigations are needed in order to optimize this new treatment method. Read More

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Forearm reconstruction by induced-membrane technique after sarcoma resection in children: technique and functional outcome in three cases.

Hand Surg Rehabil 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatric Orthopedics, Armand-Trousseau Hospital, Sorbonne University, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Department of Pediatric Orthopedics, Purpan Hospital, 330 Avenue de Grande Bretagne, 31300 Toulouse, France. Electronic address:

Forearm sarcoma is rare in children. Here, we report three cases. One child presented undifferentiated soft-tissue sarcoma involving the ulna, another had Ewing's sarcoma of the ulna, and the third had Ewing's sarcoma of the proximal radius. Read More

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Regulation of oligonucleotide adsorption by a thermo and pH dual-responsive copolymer layer.

Phys Chem Chem Phys 2021 Jul;23(26):14296-14307

National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing, 210093, China. and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

Oligonucleotides hold great promise as therapeutic agents to specifically and selectively inhibit gene expression. In order to achieve better targeting efficiency and treatment efficacy, nanocarriers that are dual-responsive to both temperature and pH are more attractive and suitable due to the fact that certain malignancies can cause a slight increase of local temperature and a minor decrease in extracellular pH around the tumor site at the same time. Here, we systematically study oligonucleotide adsorption on the poly(ethyleneimine)-b-poly(N-isopropylacrylamide) (PEI-b-PNIPAm) copolymer layer grafted on a planar surface and nanoparticles with various radii, where the single effect of temperature or pH alone on oligonucleotide adsorption has been extensively investigated, but the combined effect of temperature and pH is less discussed. Read More

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Do patients with atypical parathyroid adenoma need a close follow-up?

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Endocrine Unit, University Hospital of Pisa, Pisa, Italy.

Context: Atypical parathyroid adenomas (APAs) are neoplasms with uncertain malignant potential but lack unequivocal histological signs of malignancy.

Objective: To retrospectively evaluate the clinical and biochemical profiles of patients with APA, the outcome after parathyroidectomy (PTX), and the presence of CDC73 germline and somatic mutations.

Design: Monocentric study on consecutive patients undergoing PTX for primary hyperparathyroidism (PHPT) between June 2000 and December 2020. Read More

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Impact of Anti-HER2 Treatments Combined With Atezolizumab on the Tumor Immune Microenvironment in Early or Metastatic Breast Cancer: Results From a Phase Ib Study.

Clin Breast Cancer 2021 May 15. Epub 2021 May 15.

Department of Medicine, University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA.

Background: Despite advances, there continues to be unmet need in breast cancer. Combining anti-programmed death-ligand 1 (PD-L1) cancer immunotherapy atezolizumab with other targeted therapies may enhance T-cell-dependent cytolytic antitumor activity.

Methods: This open-label, phase Ib study evaluated the safety of atezolizumab-based combinations with antibody-dependent cellular cytotoxicity or antibody-drug conjugate (ADC) agents. Read More

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Giant Cell Tumor of the Distal Radius: Wide Resection, Ulna Translocation With Wrist Arthrodesis.

Cureus 2021 May 15;13(5):e15034. Epub 2021 May 15.

Orthopaedics, All India Institute of Medical Sciences (AIIMS) Raipur, Raipur, IND.

Giant cell tumor (GCT) of the bone is a locally aggressive neoplasm and usually managed with extended curettage and adjuvant therapy, which is associated with reduced risk of recurrence. The juxta-articular distal radius giant cell tumor is challenging due to the destruction of subchondral bone and articular cartilage, making it difficult to salvage the wrist joint anatomy and function. Various methods described include wide resection and reconstruction of allograft or centralization of the ulna with wrist arthrodesis. Read More

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Limb Salvage Surgery in Fungating Giant Cell Tumors: A Report of Three Cases.

J Orthop Case Rep 2021 Feb;11(2):19-23

Department of Orthopedics, All India Institute of Medical Sciences, New Delhi, India.

Introduction: The WHO defines giant cell tumor as a benign locally aggressive neoplasm with metastasizing capacity and aggressive behavior. Very rarely, these tumors are seen fungating, mostly when neglected. But when they do, the treatment option commonly conferred is amputation of the limb which is disabling and traumatizing. Read More

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February 2021

Added Value of Systemic Inflammation Markers in Predicting Clinical Stage T1 Renal Cell Carcinoma Pathologically Upstaged to T3a.

Front Oncol 2021 31;11:679536. Epub 2021 May 31.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: We aimed to determine preoperative risk factors associated with pathologic T3a (pT3a) upstaging of clinical T1 (cT1) renal cell carcinomas (RCCs) and develop a novel model capable of accurately identifying those patients at high risk of harboring occult pT3a characteristics.

Methods: A retrospective analysis of 1324 cT1 RCC patients who underwent partial nephrectomy (PN) or radical nephrectomy (RN) was performed. The study cohort was divided into training and testing datasets in a 70:30 ratio for further analysis. Read More

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Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens.

Sci Rep 2021 Jun 16;11(1):12654. Epub 2021 Jun 16.

Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. However, unfocused ultrasound with MBs (UUS-MBs) and an interchangeable acoustic lens can tune and enhance the pressure field for MB destruction to overcome the disadvantages of FUS-MB DDSs. We designed a lens suitable for an ultrasound-phased array probe and studied the optimal treatment conditions for MB destruction in vitro through an optical imaging setup. Read More

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Computer-aided clinical image analysis for non-invasive assessment of tumor thickness in cutaneous melanoma.

BMC Res Notes 2021 Jun 14;14(1):232. Epub 2021 Jun 14.

Department of Surgery, Helios University Hospital, Wuppertal, Germany.

Objective: Computerized clinical image analysis is shown to improve diagnostic accuracy for cutaneous melanoma but its effectiveness in preoperative assessment of melanoma thickness has not been studied. The aim of this study, is to explore how melanoma thickness correlates with computer-assisted objectively obtained color and geometric variables. All patients diagnosed with cutaneous melanoma with available clinical images prior to tumor excision were included in the study. Read More

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Impact of superparamagnetic iron oxide nanoparticles on in vitro and in vivo radiosensitisation of cancer cells.

Radiat Oncol 2021 Jun 12;16(1):104. Epub 2021 Jun 12.

Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, UK.

Purpose: The recent implementation of MR-Linacs has highlighted theranostic opportunities of contrast agents in both imaging and radiotherapy. There is a lack of data exploring the potential of superparamagnetic iron oxide nanoparticles (SPIONs) as radiosensitisers. Through preclinical 225 kVp exposures, this study aimed to characterise the uptake and radiobiological effects of SPIONs in tumour cell models in vitro and to provide proof-of-principle application in a xenograft tumour model. Read More

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Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer.

Ann Oncol 2021 Jun 8. Epub 2021 Jun 8.

Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, USA. Electronic address:

Background: The pivotal phase III ASCENT trial demonstrated improved survival outcomes associated with sacituzumab govitecan (SG), an anti-trophoblast cell-surface antigen 2 (anti-Trop-2) antibody-drug conjugate linked with the topoisomerase-inhibitor SN-38, over single-agent chemotherapy treatment of physician's choice (TPC) in previously treated metastatic triple-negative breast cancer (mTNBC). This prespecified, exploratory biomarker analysis from the ASCENT trial evaluates the association between tumor Trop-2 expression and germline BRCA1/2 mutation status with clinical outcomes.

Patients And Methods: Patients with mTNBC refractory to or progressing after two or more prior chemotherapies, with one or more in the metastatic setting, were randomized to receive SG (10 mg/kg intravenously days 1 and 8, every 21 days) or TPC (capecitabine, eribulin, vinorelbine, or gemcitabine) until disease progression/unacceptable toxicity. Read More

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The One-Bone Forearm in Children: Surgical Technique and a Retrospective Review of Outcomes.

J Hand Surg Am 2021 Jun 7. Epub 2021 Jun 7.

Department of Orthopedic Surgery, Shriners Hospitals for Children, Philadelphia, PA.

Purpose: The purpose of this study was to describe a technique of end-to-end rigid fixation of the distal radius to the proximal ulna. The shortening and radioulnar overlap in this technique yield a high union rate, large corrections, and few complications.

Methods: This retrospective chart review from 2 centers was undertaken in 39 patients (40 forearms) who underwent one-bone forearm operations between 2005 and 2019. Read More

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Finding the Sweet Spot in the Management of Early HER2+ Breast Cancer.

Sara A Hurvitz

JCO Oncol Pract 2021 06;17(6):331-333

David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA.

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Realistic boundary conditions in SimVascular through inlet catheter modeling.

BMC Res Notes 2021 May 31;14(1):215. Epub 2021 May 31.

Department of Biomedical Engineering, University of California, Davis, One Shields Ave, Davis, CA, 95616-5270, USA.

Objective: This study aims at developing a pipeline that provides the capability to include the catheter effect in the computational fluid dynamics (CFD) simulations of the cardiovascular system and other human vascular flows carried out with the open-source software SimVascular. This tool is particularly useful for CFD simulation of interventional radiology procedures such as tumor embolization where estimation of a therapeutic agent distribution is of interest.

Results: A pipeline is developed that generates boundary condition files which can be used in SimVascular CFD simulations. Read More

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Distal Radius Physeal Bar and Ulnar Overgrowth: Indications for Treatment.

J Pediatr Orthop 2021 Jul;41(Suppl 1):S6-S13

Department of Orthopedic Surgery, Nationwide Children's Hospital.

Background: Distal radius physeal bar with associated growth arrest can occur because of fractures, ischemia, infection, radiation, tumor, blood dyscrasias, and repetitive stress injuries. The age of the patient as well as the size, shape, and location of the bony bridge determines the deformity and associated pathology that will develop.

Methods: A search of the English literature was performed using PubMed and multiple search terms to identify manuscripts dealing with the evaluation and treatment of distal radius physeal bars and ulnar overgrowth. Read More

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Multitherapeutic nanoplatform based on scintillating anthracene, [email protected], and [email protected] nanoparticles for combined radiation and photodynamic cancer therapies.

Mater Sci Eng C Mater Biol Appl 2021 Jul 23;126:112122. Epub 2021 Apr 23.

Departamento de Física, FFCLRP - Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brazil. Electronic address:

We have synthesized anthracene and [email protected] core-shell nanoparticles to combine radiation (RT) and photodynamic (PDT) therapies. Synthesis of anthracene nanoparticles in the presence of colloidal silver or gold reduced the nanoparticles hydrodynamic radius, caused core-shell nanostructures to grow, and led to plasmon-enhanced fluorescence. Singlet oxygen (O) generation was investigated by electron spin resonance (ESR) and fluorescence spectroscopies. Read More

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