166,430 results match your criteria radiological


Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma.

Eur J Cancer 2021 Sep 15;157:250-258. Epub 2021 Sep 15.

University of Brescia, Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, ASST-Spedali Civili, Brescia, Lombardia, Italy. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) has an overall favourable outcome, except for patients with an advanced stage disease. The programmed death protein-1 (PD-1) inhibitor cemiplimab has been approved for use in advanced cSCC. We report clinical outcomes from the named patient programme-compassionate use of cemiplimab for patients with advanced cSCC in Italy. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Graphene oxide toxicity in W flies.

Sci Total Environ 2021 Sep 11;805:150302. Epub 2021 Sep 11.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China; Institute of Quantitative Biology and College of Life Sciences, Zhejiang University, 310058 Hangzhou, China.

The risk of graphene oxide (GO) exposure to various species has been greatly amplified in recent years due to its booming production and applications in various fields. However, a deep understanding of the GO biosafety lags its wide applications. Herein, we used W flies as a model organism to study GO toxicity at relatively low concentrations. Read More

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September 2021

α Espec-222 as a variant to the radon monitoring method using a solid state nuclear track.

Appl Radiat Isot 2021 Sep 14;178:109948. Epub 2021 Sep 14.

Radioecology Group, Nuclear Energy Department, Center of Technology and Geosciences, Federal University of Pernambuco, Avenida Professor Luiz Freire, 1000, Cidade Universitária, 50740-545, Recife, PE, Brazil. Electronic address:

Radon is important in indoor radiometry, where radiological impact is relevant. The improvement of low-cost methods makes it possible to maximize the monitored areas. Thus, a simple and robust monitoring device based on SSNTD CR-39 was designed. Read More

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September 2021

Human umbilical cord-blood-derived mesenchymal stem cell can improve the clinical outcome and Joint space width after high tibial osteotomy.

Knee 2021 Sep 15;33:31-37. Epub 2021 Sep 15.

Joint Center, Barunsesang Hospital, Seongnam, Gyeonggi-do, South Korea. Electronic address:

Background: There is limited study about the human umbilical cord-blood derived mesenchymal stem cell (hUCB-MSC) cartilage regeneration procedures combined with high tibial osteotomy (HTO). We compared the clinical and radiological results of hUCB-MSC cartilage regeneration procedures combined with HTO to those of microfracture with HTO.

Methods: From August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm on medial femoral condyle (MFC) were enrolled. Read More

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September 2021

Low skeletal muscle mass is a predictor of treatment related toxicity in oncologic patients. A meta-analysis.

Clin Nutr 2021 Sep 3;40(10):5298-5310. Epub 2021 Sep 3.

Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Background & Aims: The purpose of this meta-analysis was to summarize the published data regarding associations between occurrence of severe treatment related toxicity and low skeletal muscle mass (LSMM) in oncologic patients and to perform a meta-analysis based on a large sample.

Methods: MEDLINE, Cochrane, and SCOPUS databases were screened for associations between LSMM and treatment related toxicity in oncologic patients up to June 2021. Overall, 48 studies met the inclusion criteria. Read More

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September 2021

Direct anterior approach vs. SuperPATH vs. conventional approaches in total hip replacement: a network meta-analysis of randomized controlled trials.

Orthop Traumatol Surg Res 2021 Sep 15:103058. Epub 2021 Sep 15.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747 Jena, Germany.

Background: Two minimally invasive approaches showed some advantages in outcomes compared to conventional approaches (CAs) - the direct anterior approach (DAA) and the supercapsular percutaneously assisted approach in THA (SuperPATH). To the best of our knowledge, DAA and SuperPATH have never been compared in clinical studies before. Therefore, we conducted a systematic review and network meta-analysis of randomized controlled trials comparing short-term outcomes of DAA, SuperPATH and CAs in total hip joint arthroplasty (THA), using CAs as common comparator. Read More

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September 2021

Bone-destructive osseous arteriovenous fistula at the jugular bulb mimicking a glomus jugular tumor.

Neurochirurgie 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Some reports have described intraosseous arteriovenous fistulas showing osteolytic changes, but an osseous arteriovenous fistula (AVF) at the jugular bulb showing extensive bone destruction is a very rare disease.

Case Description: A 60-year-old man presented with pulsatile tinnitus and right facial nerve palsy. Radiological imaging showed a large homogenously enhanced osteolytic lesion at the right jugular foramen. Read More

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September 2021

Choice of primary and secondary outcomes in randomised controlled trials evaluating treatment for uterine fibroids: a systematic review.

BJOG 2021 Sep 18. Epub 2021 Sep 18.

Imperial College London, London, UK.

Background: Core outcome sets aim to reduce research heterogenicity and standardise reporting allowing meaningful comparisons between studies.

Objectives: To report on outcomes used in randomised controlled trials(RCTs) investigating uterine fibroid treatments, towards the development of a core outcome set for fibroid research.

Selection Strategy: Database search of MEDLINE, PubMed, EMBASE and CINAHL (inception to July 2021) for all English-language RCTs involving surgical or radiological fibroid treatments. Read More

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September 2021

Genome-Wide Association Study of NAFLD Using Electronic Health Records.

Hepatol Commun 2021 Sep 17. Epub 2021 Sep 17.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edingburgh, Scotland.

Genome-wide association studies (GWAS) have identified several risk loci for nonalcoholic fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and have assessed quantitative traits. We performed a case-control GWAS in the UK Biobank using recorded diagnosis of NAFLD based on diagnostic codes recommended in recent consensus guidelines. Read More

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September 2021

Appendiceal tumours - A correlation of CT features and histopathological diagnosis.

J Med Imaging Radiat Oncol 2021 Sep 17. Epub 2021 Sep 17.

Royal College of Surgeons in Ireland, Dublin, Ireland.

Appendiceal tumours are uncommon neoplasms of the gastrointestinal tract. An understanding of the imaging appearances facilitates an accurate radiological description, which guides surgical and oncological management. In this study, a retrospective review of the CT imaging and histopathology of all cases of appendiceal tumours discussed at the oncology multidisciplinary meetings in a single centre, over an 8-year period (2012-2019) is performed. Read More

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September 2021

Spontaneous Spinal Epidural Hematoma Mimicking Stroke and Its Outcome post Intravenous Thrombolysis.

Cerebrovasc Dis 2021 Sep 15:1-5. Epub 2021 Sep 15.

Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong Kong, China.

Background And Purpose: Spontaneous spinal epidural hematoma (SSEH) is a rare neurological emergency. Its presentation, depending on location of hematoma, could mimic stroke. While intravenous thrombolysis (IVT) is recommended to commence as early as possible in case of acute ischemic stroke, it is likely that it could be given to SSEH patients. Read More

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September 2021

Risk Stratification of Breast Fine-Needle Aspiration Biopsy Specimens Performed without Radiologic Guidance by Application of the International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Cytopathology.

Acta Cytol 2021 Sep 14:1-11. Epub 2021 Sep 14.

Department of Radiation Oncology, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.

Background And Objective: The International Academy of Cytology (IAC) Yokohama system for reporting breast fine-needle aspiration biopsy (FNAB) cytopathology has been proposed to standardize breast FNAB reporting. The aim of this study was to categorize breast FNAB cases performed by palpation without radiological guidance according to the IAC system, establish the risk of malignancy (ROM) for the categories and assess the system's utility, pitfalls, and implications in low-resource/financial constraint settings.

Methods: A retrospective analysis of palpation-guided FNAB of breast lesions performed without radiological guidance between January 2016 and December 2019 was carried out and was correlated with follow-up biopsies wherever available. Read More

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September 2021

Creation and validation of a radiological checklist for functional endoscopic sinonasal surgery. A YO-IFOS initiative.

Acta Otorrinolaringol Esp (Engl Ed) 2021 Sep-Oct;72(5):305-311

Department of Otolaryngology, University of Santiago de Compostela, Spain.

Background: Functional endoscopic sinus surgery might lead to dangerous complications. Studying and analysing preoperative CT scans provides surgeons with a precise knowledge of their patient's anatomy, thus reducing the risk of potential complications. Checklists highlighting key anatomical areas have been published and proven useful. Read More

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Clinical-radiological Correlation in Temporal Bone Fractures.

Acta Otorrinolaringol Esp (Engl Ed) 2021 Sep-Oct;72(5):295-304

Servicio de Otorrinolaringología, Hospital Universitario La Paz, Madrid, Spain; Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain; Centro de Investigación Biomédica en Red para Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.

Introduction: The diagnosis of temporal bone fractures (TBF) is based on radiological imaging. The most widely used classification divides fractures into longitudinal, transverse, and mixed. In recent years, other classifications have emerged to better predict clinical manifestations. Read More

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Comparison of Triple-Rule-Out Prospectively ECG-triggered Systolic and Diastolic Acquisition Protocol in Patients With Acute Chest Pain.

J Thorac Imaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, Santa Maria di Ca' Foncello Hospital, Treviso Department of Radiological, Oncological and Pathological Science, Sant'Andrea Hospital, "La Sapienza" University of Rome, Rome Department of Medicine-DIMED, Institute of Radiology, University of Padova, Padua, Italy.

Purpose: The purpose of this study was to compare image quality and coronary interpretability of triple-rule-out systolic and diastolic protocols in patients with acute chest pain.

Materials And Methods: From March 2016 to October 2017 the authors prospectively enrolled patients with undifferentiated acute chest pain, who were at low to intermediate cardiovascular risk. Those with heart rate >75 bpm underwent a systolic prospectively triggered acquisition (systolic triggering [ST]), and in those with ≤75 bpm, end-diastolic triggering (DT) was instead performed. Read More

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September 2021

Single-subject gray matter networks in temporal lobe epilepsy patients with hippocampal sclerosis.

Epilepsy Res 2021 Sep 13;177:106766. Epub 2021 Sep 13.

Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan; Cyclotron and Drug Discovery Research Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, Fukushima, 963-8052, Japan. Electronic address:

Objective: Previous studies have demonstrated structural brain network abnormalities in patients with temporal lobe epilepsy (TLE) using cortical thickness or gray matter (GM) volume. However, no studies have applied single-subject GM network analysis. Here, we first applied an analysis of similarity-based single-subject GM networks to individual patients with TLE. Read More

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September 2021

A diagnostic tree for differentiation of adult pilocytic astrocytomas from high-grade gliomas.

Eur J Radiol 2021 Sep 8;143:109946. Epub 2021 Sep 8.

Department of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To develop a diagnostic tree analysis (DTA) model based on demographical information and conventional MRI for differential diagnosis of adult pilocytic astrocytomas (PAs) and high-grade gliomas (HGGs; World Health Organization grade III-IV).

Methods: A total of 357 adult patients with pathologically confirmed PA (n = 65) and HGGs (n = 292) who underwent conventional MRI were included. The patients were randomly divided into training (n = 250) and validation (n = 107) datasets to assess the diagnostic performance of the DTA model. Read More

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September 2021

Case report of metastatic breast cancer mimicking ileal Crohn's disease.

Int J Surg Case Rep 2021 Sep 15;87:106408. Epub 2021 Sep 15.

Department of Clinical Surgical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Introduction: Lobular breast cancer (LBC) has an increased risk of gastrointestinal (GI) spread compared with ductal breast carcinoma. Breast cancer commonly metastasises to bone, lung, liver, central nervous system and rarely to the gastrointestinal tract. As the prognosis for breast cancer continues to improve with modern medical practice it is important to be aware of the various clinical presentations and the appropriate management of breast cancer metastases. Read More

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September 2021

The Clinical Implications of Aspergillus Fumigatus Sensitization in Difficult-To-Treat Asthma Patients.

J Allergy Clin Immunol Pract 2021 Sep 14. Epub 2021 Sep 14.

Clinical and Experimental Sciences Department, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK; Asthma, Allergy and Clinical Immunology Department, University Hospital Southampton NHS Foundation Trust, Southampton, UK; The David Hide Asthma & Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, UK. Electronic address:

Background: Fungal sensitivity has been associated with severe asthma outcomes. However, the clinical implication of Aspergillus fumigatus (A.fumigatus) sensitization in difficult-to-treat (or difficult) asthma is unclear. Read More

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September 2021

Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature.

J Acad Consult Liaison Psychiatry 2021 Sep 14. Epub 2021 Sep 14.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences. Electronic address:

Background: Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings among patients with anxiety after TBI. Read More

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September 2021

Tubo-ovarian Abscess: A proposed new scoring system to guide clinical management.

Int J Gynaecol Obstet 2021 Sep 17. Epub 2021 Sep 17.

Department of Obstetrics & Gynaecology, West Middlesex University Hospital, Middlesex, UK.

Objective: To create a risk scoring system comprised of clinical and radiological characteristics that can predict the likelihood of antibiotic treatment failure of tubo-ovarian abscesses. The score should guide clinicians in identifying patients to whom early intervention should be offered instead of a prolonged trial of antibiotics.

Methods: A multicenter retrospective cohort study between 01/01/2013- 30/09/2019 identifying 214 consecutive patients with tubo-ovarian abscess. Read More

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September 2021

Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis.

Curr Opin Oncol 2021 Sep 16. Epub 2021 Sep 16.

Department of Neuroradiology, Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix Sorbonne Université, INSERM, CNRS, Assistance Publique-Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière, boulevard de l'Hôpital, Paris Department of Research & Innovation, Olea Medical, avenue des Sorbiers, La Ciotat, France.

Purpose Of Review: This review aims to cover current MRI techniques for assessing treatment response in brain tumors, with a focus on radio-induced lesions.

Recent Findings: Pseudoprogression and radionecrosis are common radiological entities after brain tumor irradiation and are difficult to distinguish from real progression, with major consequences on daily patient care. To date, shortcomings of conventional MRI have been largely recognized but morphological sequences are still used in official response assessment criteria. Read More

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September 2021

[Accuracy of Alignment of Femoral and Tibial Component of the Oxford Medial Unicompartmental Knee Arthroplasty Using Zimmer Microplasty® Instrumentation].

Acta Chir Orthop Traumatol Cech 2021 ;88(4):291-301

Nemocnice České Budějovice, a.s., Ortopedické oddělení, České Budějovice.

PURPOSE OF THE STUDY The purpose of the study is to verify the correct alignment of components of the Oxford medial unicompartmental knee arthroplasty using the Zimmer Microplasty® instrumentation at the beginning of the learning curve. The implantation of prosthetic components of partial knee arthroplasty in proper alignment has an effect on long-term survival of the prosthesis and should eliminate the occurrence of frequent complications. MATERIAL AND METHODS The study group includes 20 patients, 9 men with the mean age of 68 years (range 62-78 years) and 11 women with the mean age of 69 years (range 52-81 years). Read More

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January 2021

Heterotopic Ossifications after Fractures of the Anterior Pelvic Segment: Overview of Morphology and Clinical Correlations.

Acta Chir Orthop Traumatol Cech 2021 ;88(4):253-259

Centre for Integrated Studies of the Pelvis, Third Faculty of Medicine, Charles University, Prague.

PURPOSE OF THE STUDY In certain patients after treated pelvic fractures, heterotopic ossifications can be observed in the area of the pubic bone, which protrude ventrally, and often also laterally and distally into surrounding soft tissues of the groin or even medially into the proximal thigh. These ossifications are shaped like sharp spikes of various lengths, which is why the authors refer to them as "spicules". In some patients, these ossifications are also associated with pain. Read More

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January 2021

Long-term outcome after surgical treatment of Scheuermann's Kyphosis (SK).

Spine Deform 2021 Sep 17. Epub 2021 Sep 17.

Park Hospital, Nottingham, UK.

Study Design: A retrospective observational cohort study with a minimum follow-up of 10 years of patients who underwent surgery for Scheurmann Kyphosis (SK).

Objective: Evaluate the long-term clinical and radiological outcome of patients with SK who either underwent combined anterior-posterior surgery or posterior instrumented fusion alone. There is paucity of literature for long-term outcome studies on SK. Read More

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September 2021

Role of CT angiography in detecting acute pulmonary embolism associated with COVID-19 pneumonia.

Radiol Med 2021 Sep 17. Epub 2021 Sep 17.

Unit of Emergency Radiology, Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Purpose: Recently coronavirus disease (COVID-19) caused a global pandemic, characterized by acute respiratory distress syndrome (ARDS). The aim of our study was to detect pulmonary embolism (PE) in patients with severe form of COVID-19 infection using pulmonary CT angiography, and its associations with clinical and laboratory parameters.

Methods: From March to December 2020, we performed a prospective monocentric study collecting data from 374 consecutive patients with confirmed SARS-CoV-2 infection, using real-time reverse-transcriptase polymerase-chain-reaction (rRT-PCR) assay of nasopharyngeal swab specimens. Read More

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September 2021

Pulmonary vasculitis in Hughes-Stovin syndrome (HSS): a reference atlas and computed tomography pulmonary angiography guide-a report by the HSS International Study Group.

Clin Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Serviço de Reumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Introduction: Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by widespread venous/arterial thrombosis and pulmonary artery aneurysms (PAAs), which is associated with serious morbidity and mortality. All fatalities reported in HSS resulted from unpredictable fatal suffocating hemoptysis. Therefore, it is necessary to recognize pulmonary complications at an early stage of the disease. Read More

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September 2021

Poor tumor differentiation is an independent adverse prognostic variable in patients with locally advanced oral cavity cancer--Comparison with pathological risk factors according to the NCCN guidelines.

Cancer Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, Republic of China.

Methods: We sought to compare the prognostic impact of tumor differentiation with respect to adverse risk factors (RFs) identified by the National Comprehensive Cancer Network (NCCN) guidelines--including extranodal extension (ENE), positive/close margins, perineural invasion, lymphatic invasion, and vascular invasion--in patients with locally advanced oral cavity squamous cell carcinoma (OCSCC).

Results: Between 1996 and 2018, 1179 consecutive patients with first primary pT3-4 OCSCC were included. A three-level grading system was adopted--in which the final classification was assigned according to the most prevalent tumor grade. Read More

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September 2021

Extracellular vesicles from adipose stromal cells combined with a thermoresponsive hydrogel prevent esophageal stricture after extensive endoscopic submucosal dissection in a porcine model.

Nanoscale 2021 Sep 17;13(35):14866-14878. Epub 2021 Sep 17.

Laboratoire Imagerie de l'Angiogénèse, Plateforme d'Imagerie du Petit Animal, PARCC, INSERM U970, Laboratoire de Recherches Biochirugicales (Fondation Carpentier), Université de Paris, 56 rue Leblanc, 75015, Paris, France.

In this study, we investigated the combination of extracellular (nano) vesicles (EVs) from pig adipose tissue-derived stromal cells (ADSCs) and a thermoresponsive gel, Pluronic® F-127 (PF-127), to prevent stricture formation after endoscopic resection in a porcine model. ADSC EVs were produced at a liter scale by a high-yielding turbulence approach from ADSCs 3D cultured in bioreactors and characterized in terms of size, morphology and membrane markers. The thermoresponsive property of the PF-127 gel was assessed by rheology. Read More

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September 2021