270 results match your criteria radiographs endpoint

Deep learning for classification of pediatric chest radiographs by WHO's standardized methodology.

PLoS One 2021 21;16(6):e0253239. Epub 2021 Jun 21.

Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

Background: The World Health Organization (WHO)-defined radiological pneumonia is a preferred endpoint in pneumococcal vaccine efficacy and effectiveness studies in children. Automating the WHO methodology may support more widespread application of this endpoint.

Methods: We trained a deep learning model to classify pneumonia CXRs in children using the World Health Organization (WHO)'s standardized methodology. Read More

View Article and Full-Text PDF

Accuracy of the Radiographic Assessment of Lung Edema Score for the Diagnosis of ARDS.

Front Physiol 2021 26;12:672823. Epub 2021 May 26.

Department of Intensive Care, Academic Medical Center, Amsterdam, Netherlands.

Bilateral opacities on chest radiographs are part of the Berlin Definition for Acute Respiratory Distress Syndrome (ARDS) but have poor interobserver reliability. The "Radiographic Assessment of Lung Edema" (RALE) score was recently proposed for evaluation of the extent and density of alveolar opacities on chest radiographs of ARDS patients. The current study determined the accuracy of the RALE score for the diagnosis and the prognosis of ARDS. Read More

View Article and Full-Text PDF

How Can We Differentiate Local Recurrence From Heterotopic Ossification After Resection and Implantation of an Oncologic Knee Prosthesis in Patients with a Bone Sarcoma?

Clin Orthop Relat Res 2021 05;479(5):1134-1143

K. Jamshidi, A. Bagherifard, A. Mirzaei, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Heterotopic ossification (HO) is common after total joint arthroplasty and usually does not cause diagnostic problems. However, the occurrence of HO after oncologic prostheses implantation can be troublesome as it may mimic a locally recurrent tumor. Because this distinction could have a profound impact on the surgeon and patient, it is important to distinguish the two entities; to our knowledge, no study has evaluated this after oncologic endoprosthetic reconstruction around the knee after tumor resection. Read More

View Article and Full-Text PDF

Outcomes of the rotating hinge knee in revision total knee arthroplasty with a median follow-up of 6.2 years.

BMC Musculoskelet Disord 2021 Apr 7;22(1):336. Epub 2021 Apr 7.

Coxa Hospital for Joint Replacement, and Faculty of Medicine and Health Technologies, Tampere University, Niveltie 4, 33520, Tampere, Finland.

Background: The purpose of this study was to determine the mid-term clinical, radiographic and health-related quality of life (HRQoL) outcomes and define the survival rate in patients who had undergone revision total knee arthroplasty (TKA) using the single rotating hinged knee (RHK) design.

Methods: Between January 2004 and December 2013, 125 revision TKAs were performed at our institution using the single RHK implant. We conducted both a retrospective analysis of prospectively collected outcome data of these patients and a prospective follow-up study of all 39 living patients (41 knees). Read More

View Article and Full-Text PDF

The Addition of Transdermal Delivery of Neostigmine and Glycopyrrolate by Iontophoresis to Thrice Weekly Bowel Care in Persons with Spinal Cord Injury: A Pilot Study.

J Clin Med 2021 Mar 8;10(5). Epub 2021 Mar 8.

Veterans Affairs Rehabilitation Research and Development Service's National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA.

Persons with spinal cord injury (SCI) have neurogenic bowel disorders characterized by difficulty with evacuation (DWE), fecal incontinence, and discoordination of defecation. Six medically stable in-patients with SCI with a mean age of 57 ± 10 years (range: 39-66 years) and time since injury of 18 ± 17 years (range: 3-47 years) were investigated. Standard of care (SOC) for bowel care was followed by two weeks of SOC plus neostigmine (0. Read More

View Article and Full-Text PDF

Ibandronate Reduces the Surface Bone Resorption of Mandibular Bone Grafts: A Randomized Trial With Internal Controls.

JBMR Plus 2021 Mar 10;5(3):e10468. Epub 2021 Feb 10.

Center for Medical Image Science and Visualization (CMIV) Linköping University Linköping Sweden.

Autologous bone grafts are considered the gold standard for reconstruction of the edentulous alveolar ridges. However, this procedure is associated with unpredictable bone loss caused by physiological bone resorption. Bisphosphonates are antiresorptive drugs that act specifically on osteoclasts, thereby maintaining bone density, volume, and strength. Read More

View Article and Full-Text PDF

Squeaking Is Common and Increases Over Time Among Patients With Long-term Follow-up After Ceramic-on-ceramic THA.

Clin Orthop Relat Res 2021 04;479(4):736-744

K. Taniguchi, M. Quacinella, B. Barlow, Naval Medical Center San Diego, San Diego, CA, USA.

Background: Ceramic-on-ceramic (CoC) is a durable bearing with excellent wear characteristics, but squeaking remains a concern. The proportion of patients who report squeaking varies widely between studies performed at short- and mid-term follow-up.

Questions/purposes: (1) What proportion of patients treated with CoC THA bearings report squeaking at a minimum of 10 years of follow-up? (2) Are patient, implant, or radiographic factors associated with squeaking? (3) Are THAs that squeak more likely to be revised than those that do not? (4) Are patient-reported functional outcome scores lower between THAs that squeak and THAs that do not squeak at long-term follow-up?

Methods: Between January 1, 2003 and August 31, 2008 a total of 80 patients received THAs with third-generation alumina-on-alumina bearings at one center. Read More

View Article and Full-Text PDF

A New Additive-Manufactured Cementless Highly Porous Titanium Acetabular Cup for Primary Total Hip Arthroplasty-Early Two-Year Follow Up.

Surg Technol Int 2021 03 16;38. Epub 2021 Mar 16.

Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Introduction: Additive-manufacturing technologies are increasingly being used, not only to create acetabular components with porous coating architecture very similar to the complex trabecular structure of cancellous bone, but also for producing the entire implant in a single step. The aim of this study is to assess two-year clinical and radiological outcomes of a new additive-manufactured cup in primary total hip arthroplasty (THA).

Materials And Methods: We reviewed 266 primary THAs (254 patients) performed in our institution between December 2016 and December 2018 using a new highly porous titanium acetabulum shell fabricated via additive manufacturing. Read More

View Article and Full-Text PDF

Training physicians in India to interpret pediatric chest radiographs according to World Health Organization research methodology.

Pediatr Radiol 2021 Mar 11. Epub 2021 Mar 11.

Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Chest radiography is the standard for diagnosing pediatric lower respiratory infections in low-income and middle-income countries. A method for interpreting pediatric chest radiographs for research endpoints was recently updated by the World Health Organization (WHO) Chest Radiography in Epidemiological Studies project. Research in India required training local physicians to interpret chest radiographs following the WHO method. Read More

View Article and Full-Text PDF

The Acetabular Wall Index Is Associated with Long-term Conversion to THA after PAO.

Clin Orthop Relat Res 2021 05;479(5):1052-1065

V. M. Stetzelberger, M. Tannast. Department of Orthopaedic Surgery and Traumatology, Hôpital Fribourgeois HFR Cantonal Hospital, University of Fribourg, Fribourg, Switzerland.

Background: Periacetabular osteotomy (PAO) has been shown to be a valuable option for delaying the onset of osteoarthritis in patients with hip dysplasia. Published studies at 30 years of follow-up found that postoperative anterior overcoverage and posterior undercoverage were associated with early conversion to THA. The anterior and posterior wall indices are practical tools for assessing AP coverage on standard AP radiographs of the pelvis pre-, intra-, and postoperatively. Read More

View Article and Full-Text PDF

Clinical results and survivorship of the Mathys Affinis Short, Short Stem Total Shoulder Prosthesis.

Bone Jt Open 2021 Jan 22;2(1):58-65. Epub 2021 Jan 22.

Department of Trauma and Orthopaedics, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK.

Aims: The Mathys Affinis Short is the most frequently used stemless total shoulder prosthesis in the UK. The purpose of this prospective cohort study is to report the survivorship, clinical, and radiological outcomes of the first independent series of the Affinis Short prosthesis.

Methods: From January 2011 to January 2019, a total of 141 Affinis Short prostheses were implanted in 127 patients by a single surgeon. Read More

View Article and Full-Text PDF
January 2021

Cemented acetabular component with femoral neck autograft for acetabular reconstruction in Crowe type III dislocated hips.

Bone Joint J 2021 Feb;103-B(2):299-304

Department of Orthopaedic Surgery, Toyooka Chuou Hospital, Asahikawa, Japan.

Aims: Various surgical techniques have been described for total hip arthroplasty (THA) in patients with Crowe type III dislocated hips, who have a large acetabular bone defect. The aim of this study was to evaluate the long-term clinical results of patients in whom anatomical reconstruction of the acetabulum was performed using a cemented acetabular component and autologous bone graft from the femoral neck.

Methods: A total of 22 patients with Crowe type III dislocated hips underwent 28 THAs using bone graft from the femoral neck between 1979 and 2000. Read More

View Article and Full-Text PDF
February 2021

Short-term Outcomes of 3D-Printed Titanium Metaphyseal Cones in Revision Total Knee Arthroplasty.

Orthopedics 2021 Jan 7;44(1):43-47. Epub 2020 Dec 7.

Recently, 3-dimensional (3D) printing technology has been used in the development of titanium metaphyseal cones to manage severe bone loss in revision total knee arthroplasty (rTKA). This study assessed (1) radiographs; (2) functional outcomes; (3) complications; and (4) 2-year implant survivorship in patients receiving 3D-printed titanium metaphyseal cones for moderate-to-severe tibial and femoral bone loss in rTKA. A single institution, retrospective chart review was performed for patients with large bone defects treated with a 3D-printed femoral or tibial titanium metaphyseal cone between 2015 and 2017 during rTKA (N=54). Read More

View Article and Full-Text PDF
January 2021

Can Chiari Osteotomy Favorably Influence Long-term Hip Degradation in Multiple Epiphyseal Dysplasia and Pseudoachondroplasia?

J Pediatr Orthop 2021 Feb;41(2):e135-e140

Pediatric Orthopedic Department, Necker Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris, France.

Background: Multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH) are congenital skeletal disorders characterized by irregular epiphyses, mild or severe short stature and early-onset osteoarthritis which frequently affect the hips. The current study evaluates the long-term results of the Chiari osteotomy in MED and PSACH patients.

Methods: Twenty patients (14 MED and 6 PSACH) were retrospectively included. Read More

View Article and Full-Text PDF
February 2021

Thirteen-year results of cementless total hip arthroplasty with zirconia heads on highly cross-linked polyethylene.

Mod Rheumatol 2020 Dec 1:1-9. Epub 2020 Dec 1.

Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan.

Objectives: Zirconia ceramic was introduced for femoral heads because of its mechanical strength and fracture toughness. Highly cross-linked polyethylene has been shown to achieve wear reduction compared to conventional polyethylene. The purpose of this study was to investigate the long-term results of cementless total hip arthroplasty with zirconia femoral heads on highly cross-linked polyethylene. Read More

View Article and Full-Text PDF
December 2020

No Clinically Important Differences in Thigh Pain or Bone Loss Between Short Stems and Conventional-length Stems in THA: A Randomized Clinical Trial.

Clin Orthop Relat Res 2021 04;479(4):767-777

S.-H. Won, Y.-K. Lee, K.-H. Koo, Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Short-length stems were developed to reduce bone loss of the proximal femur and potentially decrease the incidence of thigh pain after cementless THA. However, it remains unknown whether short stems indeed reduce bone loss or the frequency of thigh pain.

Questions/purposes: Is there a difference between short- and standard-length stems in terms of: (1) the frequency or severity of thigh pain, (2) modified Harris hip scores, (3) implant loosening, or (4) bone mineral density as measured by dual-energy x-ray absorptiometry?

Methods: Between March 2013 and January 2014, three surgeons performed 205 primary THAs. Read More

View Article and Full-Text PDF

Anterior Cruciate Ligament Deficiency is Not Always a Contraindication for Medial Unicompartmental Knee Arthroplasty: A Retrospective Study in Nondesigner's Japanese Hospital.

J Arthroplasty 2021 02 18;36(2):495-500. Epub 2020 Aug 18.

Department of Orthopedic Surgery and Joint Surgery Center, Takatsuki General Hospital, Takatsuki-city, Osaka, Japan.

Background: An intact anterior cruciate ligament (ACL) is thought to be prerequisite for successful unicompartmental knee arthroplasty (UKA), but recent studies reported successful midterm results of UKA in ACL-deficient (ACLD) knees. We hypothesized that ACLD is not always a contraindication for medial UKA when preoperative radiographs showed typical anteromedial knee patterns.

Methods: From April 2012 to March 2016, 401 Oxford mobile-bearing UKAs in 282 patients were retrospectively identified from our database. Read More

View Article and Full-Text PDF
February 2021

Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children.

Pediatr Pulmonol 2020 11 11;55(11):3197-3208. Epub 2020 Sep 11.

Department of Paediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia.

Background: Whether digitally recorded lung sounds are associated with radiographic pneumonia or clinical outcomes among children in low-income and middle-income countries is unknown. We sought to address these knowledge gaps.

Methods: We enrolled 1 to 59monthold children hospitalized with pneumonia at eight African and Asian Pneumonia Etiology Research for Child Health sites in six countries, recorded digital stethoscope lung sounds, obtained chest radiographs, and collected clinical outcomes. Read More

View Article and Full-Text PDF
November 2020

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study.

Adv Orthop 2020 22;2020:9398274. Epub 2020 Jul 22.

Siracusa No. 51 Col. Lomas Estrella, Mexico City, Mexico.

Objective: Polymerized-type I collagen (polymerized-collagen) is a downregulator of inflammation and a tissue regenerator. The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. . Read More

View Article and Full-Text PDF

Assessing the effect of interventions for axial spondyloarthritis according to the endorsed ASAS/OMERACT core outcome set: a meta-research study of trials included in Cochrane reviews.

Arthritis Res Ther 2020 07 25;22(1):177. Epub 2020 Jul 25.

Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital, University Hospital, Copenhagen F, Denmark.

The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-rheumatic therapy (DC-ART). These include the following domains for all three core sets: "physical function," "pain," "spinal mobility," "spinal stiffness," and "patient's global assessment" (PGA). The core set for clinical record keeping further includes the domains "peripheral joints/entheses" and "acute phase reactants," and the core set for DC-ART further includes the domains "fatigue" and "spine radiographs/hip radiographs. Read More

View Article and Full-Text PDF

Association between the 25-question Geriatric Locomotive Function Scale score and the incidence of certified need of care in the long-term care insurance system: The TOEI study.

J Orthop Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: The Geriatric Locomotive Function Scale is a screening tool to identify the risk of locomotive syndrome in the elderly. We aimed to clarify the association of Geriatric Locomotive Function Scale scores with the incidence of certified need of care in the long-term care insurance system in a prospective longitudinal observational study (the TOEI Study).

Methods: Participants were individuals aged ≥50 years from a mountainous area who had undergone medical check-ups by the National Health Insurance in Toei. Read More

View Article and Full-Text PDF

Interpretation of pediatric chest radiographs by non-radiologist clinicians in Botswana using World Health Organization criteria for endpoint pneumonia.

Pediatr Radiol 2020 06 10;50(7):913-922. Epub 2020 Jun 10.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: In low- and middle-income countries, chest radiographs are most frequently interpreted by non-radiologist clinicians.

Objective: We examined the reliability of chest radiograph interpretations performed by non-radiologist clinicians in Botswana and conducted an educational intervention aimed at improving chest radiograph interpretation accuracy among non-radiologist clinicians.

Materials And Methods: We recruited non-radiologist clinicians at a referral hospital in Gaborone, Botswana, to interpret de-identified chest radiographs for children with clinical pneumonia. Read More

View Article and Full-Text PDF

Can a Novel Scoring System Improve on the Mirels Score in Predicting the Fracture Risk in Patients with Multiple Myeloma?

Clin Orthop Relat Res 2021 03;479(3):521-530

J. A. Bressner, C. D. Morris, L. Fayad, A. S. Levin, Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA.

Background: Stratification of the fracture risk is an important treatment component for patients with multiple myeloma, which is associated with up to an 80% risk of pathologic fracture. The Mirels score, which is commonly used to estimate the fracture risk for patients with osseous lesions, was evaluated in a cohort in which fewer than 15% of lesions were caused by multiple myeloma. The behavior of multiple myeloma lesions often differs from that of lesions caused by metastatic disease, and accurate risk stratification is critical for effective care. Read More

View Article and Full-Text PDF

Results of Cemented Posterior-Stabilized Total Knee Arthroplasty in Obese Patients With an Average 10-Year Follow-Up.

J Arthroplasty 2020 08 11;35(8):2097-2100. Epub 2020 Apr 11.

Department of Orthopaedic Surgery, University of Louisville, Adult Reconstruction Program, Louisville, KY.

Background: Obese and morbidly obese patients undergoing primary total knee arthroplasty (TKA) place significant stress at the bone-cement-implant interface over the life of the patient. The purpose of this study is to evaluate results of cemented, posterior-stabilized TKA in obese and morbidly obese patients at an average follow-up of 10 years.

Methods: Retrospective study of 181 patients who had a cemented, posterior-stabilized TKA between 2000 and 2013 with body mass index >35 at the time of surgery was conducted. Read More

View Article and Full-Text PDF

Long-term Anticoagulation Prevents Progression of Stages I and II Primary Osteonecrosis of the Hip in Patients With Familial Thrombophilia.

Orthopedics 2020 Jul 12;43(4):e208-e214. Epub 2020 Apr 12.

The authors prospectively assessed long-term anticoagulation outcomes (≥3 years) for 9 patients meeting 4 inclusion criteria: pretreatment Ficat stage I or II primary hip osteonecrosis (ON), factor V Leiden or prothrombin G20210A heterozygosity, no contraindication to anticoagulation, and 90-day participation in an initial enoxaparin 60 mg/d protocol. The primary endpoint was prevention of hip collapse (Ficat stage III or IV). The secondary endpoint was pain relief. Read More

View Article and Full-Text PDF

Patients With Modular-Neck Total Hip Arthroplasty: A Brief Five-Year Follow-Up Study.

J Arthroplasty 2020 06 3;35(6S):S268-S272. Epub 2020 Mar 3.

Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA.

Background: We have previously reported the early clinical results of a modular-neck stem identifying an early 2-year revision rate of 13% due to neck-stem corrosion. This report updates our findings to a midterm mean follow-up of 5 years.

Methods: This is a consecutive retrospective review of 186 modular-neck hips in 175 patients with a mean follow-up period was 60. Read More

View Article and Full-Text PDF

Administration of allogeneic mesenchymal stem cells in lengthening phase accelerates early bone consolidation in rat distraction osteogenesis model.

Stem Cell Res Ther 2020 03 20;11(1):129. Epub 2020 Mar 20.

Department of Orthopaedic and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Distraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to accelerate bone formation in DO. However, the optimal time point for cell therapy in DO remains unknown. Read More

View Article and Full-Text PDF

Unique Features of Hospitalized Children with Alveolar Pneumonia Suggest Frequent Viral-Bacterial Coinfections.

Pediatr Infect Dis J 2020 07;39(7):586-590

From the The Pediatric Infectious Disease Unit, Soroka University Medical Center.

Background: The World Health Organization Pneumonia Expert Group (WHO-PEG) defined a standardized radiologic endpoint for childhood community-acquired alveolar pneumonia (RD-CAAP), as the most likely to be pneumococcal, not ruling out other bacteria or coinfecting viruses. We aimed to determine the characteristics associated with hospitalization among children <5 years old presenting to the pediatric emergency room (PER) with RD-CAAP.

Methods: This study was a part of an ongoing prospective population-based surveillance on hospital visits for RD-CAAP. Read More

View Article and Full-Text PDF

Diagnostic pathways in major trauma patients admitted to Italian hospitals: survey and discussion points from the trauma update 2019.

Eur J Emerg Med 2020 Oct;27(5):344-350

Division of Anesthesia, Intensive Care and Prehospital Emergency.

Background: Major trauma is a leading cause of mortality, morbidity, and disability. Severe trauma patients are taken to hospital with multiple suspected injuries and need urgent diagnosis in order to achieve focused and lifesaving interventions. The primary endpoint of this survey was to evaluate the intrahospital diagnostic paths that trauma patients undergo in Italian hospitals. Read More

View Article and Full-Text PDF
October 2020

Thumb Ulnar Collateral Ligament Repair with Suture Tape Augmentation.

J Hand Surg Asian Pac Vol 2020 Mar;25(1):32-38

Department of Orthopaedic Surgery, Lenox Hill Hospital, New York, NY, USA.

The purpose of this study is to describe our technique of thumb ulnar collateral ligament (UCL) repair with suture tape augmentation and to evaluate the short-term outcomes in our initial series of patients treated with this method of repair. Patients with minimum one-year follow up after isolated UCL repair with suture tape augmentation were contacted for clinical evaluation, radiographs, and postoperative outcome questionnaires, including the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire and study-specific questions. Thirteen of 15 (87%) consecutive patients who were treated using this method of repair were available for follow-up, 9 with acute tears and 4 with chronic tears. Read More

View Article and Full-Text PDF