10,108 results match your criteria radical scavenger

SiO-Ag Composite as a Highly Virucidal Material: A Roadmap that Rapidly Eliminates SARS-CoV-2.

Nanomaterials (Basel) 2021 Mar 4;11(3). Epub 2021 Mar 4.

CDMF, LIEC, Federal University of São Carlos-(UFSCar), 13565-905 São Carlos, SP, Brazil.

COVID-19, as the cause of a global pandemic, has resulted in lockdowns all over the world since early 2020. Both theoretical and experimental efforts are being made to find an effective treatment to suppress the virus, constituting the forefront of current global safety concerns and a significant burden on global economies. The development of innovative materials able to prevent the transmission, spread, and entry of COVID-19 pathogens into the human body is currently in the spotlight. Read More

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Environmental Photocatalytic Degradation of Antidepressants with Solar Radiation: Kinetics, Mineralization, and Toxicity.

Nanomaterials (Basel) 2021 Mar 3;11(3). Epub 2021 Mar 3.

Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia.

This work is focused on the kinetics, mineralization, and toxicological assessments of the antidepressant drug amitriptyline hydrochloride (AMI) in UV or solar illuminated aqueous suspensions of ZnO, TiO Degussa P25, and TiO Hombikat. ZnO was proven to be the most effective photocatalyst, and it was used for all further experiments under solar irradiation. The highest reaction rate was observed at 1. Read More

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Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model.

Biomedicines 2021 Mar 10;9(3). Epub 2021 Mar 10.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159 Pr. 100 let Vladivostoku, 690022 Vladivostok, Russia.

Kunitz-type peptides from venomous animals have been known to inhibit different proteinases and also to modulate ion channels and receptors, demonstrating analgesic, anti-inflammatory, anti-histamine and many other biological activities. At present, there is evidence of their neuroprotective effects. We have studied eight Kunitz-type peptides of the sea anemone to find molecules with cytoprotective activity in the 6-OHDA-induced neurotoxicity model on neuroblastoma Neuro-2a cells. Read More

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Improved Oxidative Stability by Embedded Cerium into Graphene Oxide Nanosheets for Proton Exchange Membrane Fuel Cell Application.

Membranes (Basel) 2021 Mar 28;11(4). Epub 2021 Mar 28.

School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Gyeonggi, Korea.

Investigation of the collaborative effect of cerium particles embedded in graphene oxide to enhance the chemical stability of a proton exchange membrane fuel cell (PEMFC) has been carried out. Synthesis of composite membranes (Nafion-GO/Ce-x) with Nafion solution as a polymer is synthesized by a solution casting method where (x = concentration of composite). The developed hybrid material was characterized by FT-IR and X-ray diffraction (XRD) for its phase identification while the chemical structure was characterized by XPS analysis. Read More

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A bioinspired nitrone precursor to a stabilized nitroxide radical.

Free Radic Biol Med 2021 Mar 30;168:110-116. Epub 2021 Mar 30.

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, 05508-000, São Paulo, SP, Brazil. Electronic address:

Nitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional nitrones. Read More

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Efficient isolation of organosolv lignin-carbohydrate complexes (LCC) with high antioxidative activity via introducing LiCl/DMSO dissolving.

Int J Biol Macromol 2021 Mar 30;181:752-761. Epub 2021 Mar 30.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Light Industry and Food Science, Nanjing Forestry University, Nanjing 210037, Jiangsu, PR China. Electronic address:

Lignin-carbohydrate complexes (LCC) have shown great potential as biocompatible antioxidants. But it is difficult to isolate LCC efficiently from lignocellulose by traditional Solid-Liquid Extraction method (SLE), which is blamed to the innate bioimpedance caused by the complex supramolecular structure of the lignocellulose, and a great mass transferring resistance between the extracting solution and solid lignocellulose. To release these restrictions above and improve the efficiency of LCC isolation, a modified isolating method named Liquid-Liquid Extraction (LLE) was proposed, in which ball-milled wheat stalk was dissolved in lithium chloride/dimethyl sulfoxide (LiCl/DMSO) solution, then regenerated by dioxane aqueous to extract LL-LCCs. Read More

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Compartmentally scavenging hepatic oxidants through AMPK/SIRT3-PGC1α axis improves mitochondrial biogenesis and glucose catabolism.

Free Radic Biol Med 2021 Mar 29;168:117-128. Epub 2021 Mar 29.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People's Republic of China. Electronic address:

Early treatment can prevent the occurrence of diabetes; however, there are few pharmacological treatment strategies to date. The liver is a major metabolic organ, and hepatic glucose homeostasis is dysregulated in type 1 and type 2 diabetes mellitus. However, the potential of specifically targeting the liver to prevent diabetes has not been fully exploited. Read More

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Insights into the effects of bromide at fresh water levels on the radical chemistry in the UV/peroxydisulfate process.

Water Res 2021 Mar 15;197:117042. Epub 2021 Mar 15.

Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China. Electronic address:

Bromide (Br) is a typical scavenger to sulfate radical (SO) and hydroxyl radical (HO), which simultaneously forms secondary reactive bromine species (RBS) such as Br and Br. This study investigated the effects of Br at fresh water levels (~μM) on the radical chemistry in the UV/peroxydisulfate (UV/PDS) process by combining the degradation kinetics of probe compounds (nitrobenzene, metronidazole, and benzoate) with kinetic model. Br at 1 - 50 μM promoted the conversion from SO to HO and RBS in the UV/PDS process. Read More

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Accelerated organics degradation by peroxymonosulfate activated with biochar co-doped with nitrogen and sulfur.

Chemosphere 2021 Mar 17;277:130313. Epub 2021 Mar 17.

School of Chemical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia.

Engineered biochar is increasingly regarded as a cost-effective and eco-friendly peroxymonosulfate (PMS) activator. Herein, biochar doped with nitrogen and sulfur moieties was prepared by pyrolysis of wood shavings and doping precursor. The doping precursor consists of either urea, thiourea or 1:1 w/w mixture of urea and thiourea (denoted as NSB-U, NSB-T and NSB-UT, respectively). Read More

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ZIF-8 assisted synthesis of magnetic core-shell FeO@CuS nanoparticles for efficient sulfadiazine degradation via HO activation: Performance and mechanism.

J Colloid Interface Sci 2021 Mar 17;594:502-512. Epub 2021 Mar 17.

Key Laboratory of Building Safety and Energy Efficiency, Ministry of Education, Department of Water Engineering and Science, College of Civil Engineering, Hunan University, Changsha 410082, China. Electronic address:

A novel magnetic core-shell FeO@CuS have been successfully synthesized by chemical etching and cation exchange method using Zeolitic imidazolate frameworks (ZIF) as the template. The morphology and microstructural properties characterization indicated that FeO@CuS nanoparticles were rhombic dodecahedral shape, highly stable, and magnetic with a large specific surface area (772.20 m/g). Read More

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Indole-3-carbinol induces apoptosis-like death in Escherichia coli on different contribution of respective reactive oxygen species.

Life Sci 2021 Mar 24;275:119361. Epub 2021 Mar 24.

School of Life Sciences, BK 21 FOUR KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea. Electronic address:

Aims: Indole-3-carbinol (I3C) is a natural compound derived from brassica vegetables, displaying antibacterial activity. The study aims to elucidate the antibacterial mode of action(s) induced by indole-3-carbionol in Escherichia coli and enhance the understandings on the respective contribution of each reactive oxygen species (ROS), superoxide anion (O), hydrogen peroxide (HO), hydroxyl radical (OH) during the process.

Main Methods: The antibacterial activity of I3C was assessed through kinetic assay. Read More

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Ophthalmological symptoms in a patient with reversible cerebral vasoconstriction syndrome: a case report.

J Med Case Rep 2021 Mar 28;15(1):175. Epub 2021 Mar 28.

Department of Ophthalmology, Saitama Medical Center, Dokkyo Medical University, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.

Background: Reversible cerebral vasoconstriction syndrome is characterized by severe headache with reversible segmental constriction of the cerebral arteries. We present details on a patient with reversible cerebral vasoconstriction syndrome who initially visited an ophthalmologist because of visual symptoms.

Case Presentation: A 34-year-old Japanese woman complained of sustained headache and insomnia starting 2 days after her first childbirth. Read More

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Photocatalytic activation of peroxymonosulfate (PMS) by novel mesoporous Ag/ZnO@NiFeO nanorods, inducing radical-mediated acetaminophen degradation under UVA irradiation.

Chemosphere 2021 Mar 14;277:130271. Epub 2021 Mar 14.

Universidad Politécnica de Madrid, E.T.S. Ingenieros de Caminos, Canales y Puertos, Departamento de Ingeniería Civil: Hidráulica, Energía y Medio Ambiente, Unidad docente Ingeniería Sanitaria, c/ Profesor Aranguren, s/n, ES-28040, Madrid, Spain.

A new mesoporous Ag/ZnO@NiFeO nanorod was prepared by a facile, low-cost, and environmentally friendly strategy from a bimetallic FeNi-MIL-88 metal organic framework (MOF), as an effective catalyst and peroxymonosulfate (PMS) photo-activator. The structural, morphological, optical, and magnetic properties, as well as the material composition were investigated by XRD, FE-SEM, EDX, HR-TEM, XPS, DRS, PL, EIS, VSM, N adsorption-desorption and ICP-AES analysis. 1. Read More

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Synthesis, Structure Characterization, and Antioxidant and Antibacterial Activity Study of Iso-orientin-Zinc Complex.

J Agric Food Chem 2021 Apr 25;69(13):3952-3964. Epub 2021 Mar 25.

Engineering Research Center of High Value Utilization of Western China Fruit Resources, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, People's Republic of China.

Flavonoid-metal complexes possess more effective functional properties than flavonoids. However, the research of iso-orientin (Iso)-metal complex has rarely been reported. In this study, Iso-zinc complex (Iso-Zn, [Zn(CHO)]·4HO) had been synthesized and characterized. Read More

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Making ATRP More Practical: Oxygen Tolerance.

Acc Chem Res 2021 Apr 22;54(7):1779-1790. Epub 2021 Mar 22.

Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.

ConspectusAtom-transfer radical polymerization (ATRP) is a well-known technique for the controlled polymerization of vinyl monomers under mild conditions. However, as with any other radical polymerization, ATRP typically requires rigorous oxygen exclusion, making it time-consuming and challenging to use by nonexperts. In this Account, we discuss various approaches to achieving oxygen tolerance in ATRP, presenting the overall progress in the field. Read More

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Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury.

Cell Prolif 2021 Apr 10;54(4):e13021. Epub 2021 Mar 10.

State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Although the liver is the only organ with regenerative capacity, various injury factors induce irreversible liver dysfunction and end-stage liver disease. Liver resection and liver transplantation (LT) are effective treatments for individuals with liver failure, liver cirrhosis and liver cancers. The remnant or transplanted liver tissues will undergo hepatic ischaemia/reperfusion (IR), which leads to oxidative stress, inflammation, immune injury and liver damage. Read More

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Chalcones and their B-aryl analogues as myeloperoxidase inhibitors: In silico, in vitro and ex vivo investigations.

Bioorg Chem 2021 Mar 2;110:104773. Epub 2021 Mar 2.

Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), 15054-000 São José do Rio Preto, SP, Brazil. Electronic address:

In the present study, a series of chalcones and their B-aryl analogues were prepared and evaluate as inhibitors of myeloperoxidase (MPO) chlorinating activity, using in vitro and ex vivo assays. Among these, B-thiophenyl chalcone (analogue 9) demonstrated inhibition of in vitro and ex vivo MPO chlorinating activity, exhibiting IC value of 0.53 and 19. Read More

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The radical scavenging activity of abietane diterpenoids: Theoretical insights.

J Mol Graph Model 2021 Mar 4;105:107892. Epub 2021 Mar 4.

Faculty of Chemical Technology- Environment, The University of Danang - University of Technology and Education, Danang 550000, Vietnam. Electronic address:

Salvia species are frequently used in traditional medicine and are a source of diterpenoid antioxidants. In this study, the hydroperoxide radical scavenging activity of seven known abietane diterpenoids (ADs), isolated from Salvia barrelieri, are investigated using a quantum chemical approach. The ADs are 7-oxoroyleanone-12-methyl ether (1), 7a-acetoxyroyleanone-12-methyl ether (2), royleanone (3), horminone (4), 7-acetylhorminone (5), cryptojaponol (6), and inuroyleanol (7). Read More

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Glycine alleviates fluoride-induced oxidative stress, apoptosis and senescence in a porcine testicular Sertoli cell line.

Reprod Domest Anim 2021 Mar 19. Epub 2021 Mar 19.

Department of Animals Sciences, College of Animal Sciences, Jilin University, Changchun, China.

Glycine is a well-known free radical scavenger in the cellular antioxidant system that prevents oxidative damage and apoptosis. Excessive fluoride exposure is associated with multiple types of cellular damage in humans and animals. The objective of the present study was to investigate the protective effects of glycine on sodium fluoride (NaF) exposure and the possible underlying mechanisms in a porcine testicular Sertoli cell line model. Read More

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Gellan gum gel tissue phantoms and gel dosimeters with tunable electrical, mechanical and dosimetric properties.

Int J Biol Macromol 2021 Mar 17;180:332-338. Epub 2021 Mar 17.

School of Biomedical Engineering, The University of Western Ontario, London, Canada; Department of Chemical and Biomedical Engineering, The University of Western Ontario, London, Canada. Electronic address:

Gellan gum gels have been proposed as tissue- and water-mimicking materials (phantoms) applied in medical imaging and radiotherapy dosimetry. Phantoms often require ionic additives to induce desirable electrical conductivity, resistance to biological spoilage, and radical scavenging properties. However, gellan gum is strongly crosslinked by the typically used sodium salts, forming difficult-to-work with gels with reduced optical clarity. Read More

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Prompting direct single electron transfer to produce non-radical O/H* by electro-activating peroxydisulfate process with core-shell cathode.

J Environ Manage 2021 Jun 10;287:112294. Epub 2021 Mar 10.

Ministry of Education Key Laboratory of Pollution Control and Ecological Remediation for Industrial Agglomeration Area, College of Environment and Energy, South China University of Technology, Guangzhou, 510006, China; South China Institute of Environmental Sciences, MEE, Guangzhou, 510006, China. Electronic address:

A novel heteroatomic N, P and S co-doped core-shell material (MnFeO@PZS) was synthesized by a simple polycondensation hydro-thermal method, and used as the cathode to cooperate with electron-catalysis to activate persulfate (SO) (E-MnFeO@PZS-PDS) for tetracycline (TTC) degradation. Radical scavenger studies demonstrated that non-radicals including atomic H* and singlet oxygen (O) rather than sulfate and hydroxyl radicals were the crucial reactive oxygen species (ROS). Electrochemical analysis indicated that Mn doping could promote electro-catalytic process via diverting pathway from four/two-electron to one-electron to generate non-radical H*/O at the cathode, including one-electron oxygen reduction reaction (1e-ORR) (O→O), and one-electron hydrogen reduction reaction (1e-HRR) (HO+e→H), as evidenced by the lowest onset potential (0. Read More

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Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia.

Sci Rep 2021 Mar 11;11(1):5722. Epub 2021 Mar 11.

Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan.

Chondrogenesis and angiogenesis drive endochondral ossification. Using the atmospheric scanning electron microscopy (ASEM) without decalcification and dehydration, we directly imaged angiogenesis-driven ossification at different developmental stages shortly after aldehyde fixation, using aqueous radical scavenger glucose solution to preserve water-rich structures. An embryonic day 15. Read More

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Redox treatment ameliorates diabetes mellitus-induced skin flap necrosis via inhibiting apoptosis and promoting neoangiogenesis.

Exp Biol Med (Maywood) 2021 Mar 6;246(6):718-728. Epub 2020 Dec 6.

Department of Otolaryngology, School of Medicine, Ajou University, Suwon 16499, Korea.

Intractable wound healing is the habitual problem of diabetes mellitus. High blood glucose limits wound healing by interrupting inflammatory responses and inhibiting neoangiogenesis. Oxidative stress is commonly thought to be a major pathogenic cause of diabetic complications. Read More

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Identification of a polyphenol and its antioxidant properties from the roasting reaction of alginic acid.

Biosci Biotechnol Biochem 2021 Mar;85(4):957-961

Graduate School of Human Life Science, Osaka City University, Osaka, Japan.

The radical scavenging activity of marine polysaccharides was enhanced by their high-temperature treatment (roasting reaction model). The product obtained from alginic acid exhibited maximum activity, and a radical scavenger, alginetin, was identified in the product. Its antioxidant activities were examined by chemical methods, which confirmed that it possessed a stoichiometrically greater antioxidant capacity than that of Trolox. Read More

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Pharmacology of apocynin: a natural acetophenone.

Drug Metab Rev 2021 Mar 10:1-21. Epub 2021 Mar 10.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Mumbai, India.

Apocynin is a naturally occurring acetophenone, found in the roots of . Various chemical and pharmaceutical modifications have been carried out to enhance the absorption and duration of action of apocynin, like, formulation of chitosan-based apocynin-loaded solid lipid nanoparticles, chitosan-oligosaccharide based nanoparticles, and biodegradable polyanhydride nanoparticles. Apocynin has been subjected to a wide range of experimental screening and has proved to be useful for amelioration of a variety of disorders, like diabetic complications, neurodegeneration, cardiovascular disorders, lung cancer, hepatocellular cancer, pancreatic cancer, and pheochromocytoma. Read More

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Protective Effects of Crocin Against Hepatic Damages in D-galactose Aging Model in Rats.

Iran J Pharm Res 2020 ;19(3):440-450

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Aging is a progressive process which is associated with liver dysfunction and it is due to oxidative stress, inflammation, and cell apoptosis. Long-term D-galactose (D-gal) administration is able to develop an aging model in animals. Crocin as a major active ingredient in saffron has shown anti-inflammatory and hepatoprotective effects via its antioxidant capacity. Read More

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January 2020

Effect on the Antioxidant, Lipoperoxyl Radical Scavenger Capacity, Nutritional, Sensory and Microbiological Traits of an Ovine Stretched Cheese Produced with Grape Pomace Powder Addition.

Antioxidants (Basel) 2021 Feb 17;10(2). Epub 2021 Feb 17.

Dipartimento Scienze Agrarie, Alimentari e Forestali, Ed. 5, Università degli Studi di Palermo, Viale delle Scienze, 90128 Palermo, Italy.

An innovative ovine cheese enriched with red grape pomace powder (GPP) was produced to improve the functional properties of Vastedda cheese typology. Vastedda cheese making was performed adding GPP and four selected strains (Mise36, Mise94, Mise169 and Mise190). For each strain, 40 L of pasteurized ewe's milk was divided into two aliquots representing control and experimental trials. Read More

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February 2021

Changes in Glutathione Content in Liver Diseases: An Update.

Antioxidants (Basel) 2021 Feb 28;10(3). Epub 2021 Feb 28.

Unit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.

Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important thiol reducing agent involved in the modulation of redox processes. It has also been demonstrated that GSH cannot be considered only as a mere free radical scavenger but that it takes part in the network governing the choice between survival, necrosis and apoptosis as well as in altering the function of signal transduction and transcription factor molecules. The purpose of the present review is to provide an overview on the molecular biology of the GSH system; therefore, GSH synthesis, metabolism and regulation will be reviewed. Read More

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February 2021

Highly Dispersed CeO Hybrid Nanoparticles for Perfluorinated Sulfonic Acid Ionomer-Poly(tetrafluoethylene) Reinforced Membranes with Improved Service Life.

Membranes (Basel) 2021 Feb 18;11(2). Epub 2021 Feb 18.

Department of Energy Engineering, Dankook University, Cheonan 31116, Korea.

CeO hybrid nanoparticles were synthesized and evaluated for use as radical scavengers, in place of commercially available Ce(NO) and CeO nanoparticles, to avoid deterioration of the initial electrochemical performance and/or spontaneous aggregation/precipitation issues encountered in polymer electrolyte membranes. When CeO hybrid nanoparticles were used for membrane formation, the resulting membranes exhibited improved proton conductivity (improvement level = 2-15% at 30-90 °C), and thereby electrochemical single cell performance, because the -OH groups on the hybrid nanoparticles acted as proton conductors. In spite of a small amount (i. Read More

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February 2021

Beneficial Effect of Tempol, a Membrane-Permeable Radical Scavenger, on Inflammation and Osteoarthritis in In Vitro Models.

Biomolecules 2021 Feb 25;11(3). Epub 2021 Feb 25.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D׳Alcontres, 31-98166 Messina, Italy.

Osteoarthritis (OA) is one of the most common and widespread diseases which is highly disabling for humans. This makes OA a chronic disease for which it is urgent to find new therapeutic strategies. The inflammatory state in OA contributes to its progression through multiple mechanisms involving the recruitment of phagocytes and leukocytes, inflammatory response, and reactive oxygen species (ROS) production. Read More

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February 2021