72,129 results match your criteria quantitative assessment

Quantitative collateral assessment evaluated by cerebral blood volume measured by CT perfusion in patients with acute ischemic stroke.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105797. Epub 2021 Apr 17.

Department of Neurosurgery, Soka Municipal Hospital, 2-21-1, Soka, Soka city, Saitama 340-8560, Japan.

Objectives: Collateral status (CS) is considered a predictor of clinical outcome after reperfusion therapy (RT) in patients with acute ischemic stroke (AIS). We proposed a quantitative assessment of CS using cerebral blood volume (CBV) measured by computed tomography perfusion (CTP) imaging.

Materials And Methods: This retrospective study was approved by the Institutional Review Board. Read More

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Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain.

J Neuroimaging 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, California, USA.

Background And Purpose: Manual segmentation of white matter (WM) bundles requires extensive training and is prohibitively labor-intensive for large-scale studies. Automated segmentation methods are necessary in order to eliminate operator dependency and to enable reproducible studies. Significant changes in the WM landscape throughout childhood require flexible methods to capture the variance across the span of brain development. Read More

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Responsible product design to mitigate excessive gambling: A scoping review and z-curve analysis of replicability.

PLoS One 2021 20;16(4):e0249926. Epub 2021 Apr 20.

Division on Addiction Cambridge Health Alliance, A Harvard Medical School Teaching Hospital, Malden, MA, United States of America.

Objectives: Systematic mapping of evaluations of tools and interventions that are intended to mitigate risks for gambling harm.

Design: Scoping Review and z-curve analysis (which estimates the average replicability of a body of literature).

Search Strategy: We searched 7 databases. Read More

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Hematocrit-Related Alterations of Circulating microRNA-21 Levels in Heart Failure Patients with Reduced Ejection Fraction: A Preliminary Study.

Genet Test Mol Biomarkers 2021 Apr;25(4):302-306

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia.

Circulating microRNA-21 (miR-21) has been utilized as a diagnostic tool in the assessment of heart failure (HF). Blood constitution may be altered when HF occurs and miR-21 may affect hematopoiesis. Sample hemolysis may influence the determination of circulating miRNAs, challenging the diagnostic use of miRNAs. Read More

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The scope and severity of white-nose syndrome on hibernating bats in North America.

Conserv Biol 2021 Apr 20. Epub 2021 Apr 20.

Bat Conservation International, 500 North Capital of Texas Highway, Building 1, Austin, TX, 78746, U.S.A.

Assessing the scope and severity of threats is necessary for evaluating impacts on populations to inform conservation planning. Quantitative threat assessment often requires monitoring programs that provide reliable data over relevant spatial and temporal scales, yet such programs can be difficult to justify until there is an apparent stressor. Leveraging efforts of wildlife management agencies to record winter counts of hibernating bats, we collated data for 5 species from over 200 sites across 27 U. Read More

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The Effect of Bolus Vitamin D Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial using HR-pQCT.

J Bone Miner Res 2021 Apr 20. Epub 2021 Apr 20.

NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, The Netherlands.

Vitamin D is an important factor in bone metabolism. Animal studies have shown a positive effect of vitamin D supplementation on fracture healing, but evidence from clinical trials is inconclusive. A randomized controlled trial was performed to assess the effect of vitamin D supplementation on fracture healing using high-resolution peripheral quantitative computed tomography (HR-pQCT) based outcome parameters. Read More

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Platelet Deficiency Represents a Modifiable Risk Factor for Periprosthetic Joint Infection in a Preclinical Mouse Model.

J Bone Joint Surg Am 2021 Mar 11. Epub 2021 Mar 11.

Department of Orthopaedic Surgery, University of California Los Angeles, Santa Monica, California.

Background: Well known for their hemostatic function, platelets are increasingly becoming recognized as important immunomodulators. The purpose of the present study was to assess the impact of platelet depletion on antimicrobial host defense in a mouse model of periprosthetic joint infection (PJI).

Methods: Thrombocytopenia (TCP) was induced in C57BL/6 mice with use of a selective antibody against platelet CD41 (anti-CD41). Read More

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DECT in Detection of Vertebral Fracture-associated Bone Marrow Edema: A Systematic Review and Meta-Analysis with Emphasis on Technical and Imaging Interpretation Parameters.

Radiology 2021 Apr 20:203624. Epub 2021 Apr 20.

From the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (F.G.S., H.I.S., S.D.); Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (D.S., M.H.J.); Department of Radiology, NYU Grossman School of Medicine, New York, NY (J.F.); and Department of Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (B.J.S.).

Background Dual-energy CT (DECT) shows promising performance in detecting bone marrow edema (BME) associated with vertebral body fractures. However, the optimal technical and image interpretation parameters are not well described. Purpose To conduct a systematic review and meta-analysis to determine the diagnostic performance of DECT in detecting BME associated with vertebral fractures (VFs), using different technical and image interpretation parameters, compared with MRI as the reference standard. Read More

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Systematic review of factors associated with hope in family carers of persons living with chronic illness.

J Adv Nurs 2021 Apr 20. Epub 2021 Apr 20.

School of Nursing, McMaster University, Hamilton, ON, Canada.

Aims: To identify factors associated with hope in family carers of persons living with chronic illness.

Design: A systematic review of quantitative and mixed method studies on hope in carers of persons living with chronic illness.

Data Sources: Five electronic databases (Medline, Cumulative Index to Nursing and Allied Health Literature, Web of Science, ProQuest Dissertations and PsycINFO) were searched from inception to 13 July 2020. Read More

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Tissue clearing techniques for three-dimensional optical imaging of intact human prostate and correlations with multi-parametric MRI.

Prostate 2021 Apr 20. Epub 2021 Apr 20.

Medical Artificial Intelligence Laboratory Program, The University of Hong Kong, Hong Kong, Hong Kong SAR.

Background: Tissue clearing technologies have enabled remarkable advancements for in situ characterization of tissues and exploration of the three-dimensional (3D) relationships between cells, however, these studies have predominantly been performed in non-human tissues and correlative assessment with clinical imaging has yet to be explored. We sought to evaluate the feasibility of tissue clearing technologies for 3D imaging of intact human prostate and the mapping of structurally and molecularly preserved pathology data with multi-parametric volumetric MR imaging (mpMRI).

Methods: Whole-mount prostates were processed with either hydrogel-based CLARITY or solvent-based iDISCO. Read More

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Toward a socio-spiritual approach? A mixed-methods systematic review on the social and spiritual needs of patients in the palliative phase of their illness.

Palliat Med 2021 Apr 20:2692163211010384. Epub 2021 Apr 20.

Center of Expertise Palliative Care Utrecht, UMC Utrecht, Utrecht, the Netherlands.

Background: Patients express a variety of needs, some of which are labeled social and spiritual. Without an in-depth exploration of patients' expressions of these needs, it is difficult to differentiate between them and allocate appropriate healthcare interventions.

Aim: To gain insight into the social and spiritual needs of patients with a life-limiting illness and the distinction between these needs, as found in the research literature. Read More

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Brucellosis in dairy herds: farm characteristics and practices in relation to likely adoption of three potential Private-Public Partnership (PPP) vaccination control strategies in West and Central Africa.

Transbound Emerg Dis 2021 Apr 20. Epub 2021 Apr 20.

Veterinary Epidemiology, Economics and Public Health Group, Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom.

Brucellosis is regarded as one of the highest burden zoonotic diseases to persist in many regions globally. While sustained vaccination against B. abortus in an endemic setting can markedly reduce the prevalence of large ruminant and human brucellosis and benefit local livelihoods, the implementation of effective and sustainable control programmes has often failed in the worst affected areas. Read More

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Tumor growth rate in pancreatic neuroendocrine tumor patients undergoing PRRT with 177Lu-DOTATATE.

Endocr Connect 2021 Mar 1. Epub 2021 Mar 1.

A Sundin, Department of Radiology and Molecular Imaging, Uppsala University Hospital, Uppsala, Sweden.

Background: Monitoring of pancreatic neuroendocrine tumors (PanNET) undergoing peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE depends on changes in tumor size, which often occur late. Tumor growth rate (TGR) allows for quantitative assessment of the tumor kinetics expressed %/month. We explored how TGR changes before and during/after PRRT and evaluated TGR as a biomarker for progression-free survival (PFS). Read More

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The High Clinical Burden of Erosive Hand Osteoarthritis is Associated with Clinical Findings, Pain, and Radiographic Severity.

Reumatol Clin 2021 Apr 16. Epub 2021 Apr 16.

Departamento de Genética, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico.

Varying reports exist on the clinical impact of erosive hand osteoarthritis (EHOA) in terms of pain and articular function. Few studies have assessed the association of a patient's clinical features with the presence of more severe radiographic disease. The aim was to evaluate clinical and radiographic characteristics in EHOA comparing with non-erosive (NEHOA); to examine pain and functional impairment between EHOA and NEHOA; and correlate functional impairment with clinical findings, pain, and radiographic severity. Read More

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Technology-Based Mental Healthcare Models: A Systematic Review of the Literature.

Rev Colomb Psiquiatr 2021 Apr 16. Epub 2021 Apr 16.

Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia; Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.

Introduction: This systematic review summarises the existing evidence on the implementation of technology-based mental healthcare models in the primary care setting.

Methods: A systematic search was conducted (MEDLINE, Embase, CENTRAL) in August 2019 and studies were selected according to predefined eligibility criteria. The main outcomes were clinical effectiveness, adherence to primary treatment and cost of implementation. Read More

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New Phytol 1986 Dec;104(4):643-651

Department of Pure and Applied Biology, Imperial College, London SW7 2BB, UK.

Undisturbed associations of Peltigera membranacea and associated mosses were held under simulated autumn, winter and spring conditions in a specially constructed, controlled-environment chamber providing an atmosphere enriched with labelled nitrogen. Simulated rainfall via a programmable sprinkler system was incorporated, and the liquid run-off was collected during 4 week experimental periods. Dry weight, total nitrogen and N labelling of the moss, lichen and run-off liquid were determined, and nitrogenase activity of the lichen thalli was estimated by acetylene reduction at the end of the tests. Read More

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December 1986

Elemental mapping using PIXE shows the main pathway of nickel movement is principally symplastic within the fruit of the hyperaccumulator Stackhousia tryonii.

New Phytol 2003 Dec 6;160(3):479-488. Epub 2003 Nov 6.

Primary Industries Research Centre, School of Biological and Environmental Sciences, Central Queensland University, Rockhampton, Qld 4702, Australia.

•  Metal concentrations within reproductive tissues of metallophytes are rarely reported. Here, the spatial distribution of nickel (Ni) within the fruits (seeds) of the Ni hyperaccumulator Stackhousia tryonii was investigated. •  Two microanalytical techniques, energy dispersive x-ray spectrometry (EDXS) and nuclear microprobe (micro-proton-induced x-ray emission spectrometry; micro-PIXE) were employed for qualitative and quantitative assessment, respectively, of localized Ni, within the fruits of S. Read More

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December 2003

EASY score (Eloquent, Age and baseline SYmptoms score) for outcome prediction in patients with acute ischemic stroke.

Clin Neurol Neurosurg 2021 Apr 1;205:106626. Epub 2021 Apr 1.

Department of Neuroradiology, University Hospital of Southampton, Tremona Rd, Southampton, UK.

Objective: A pragmatic tool for the early and reliable prediction of recovery in patients with acute ischemic stroke is needed. We aimed to test the addition of brain eloquent areas involvement in variables predicting poor outcome, using a simple scoring system.

Methods: Retrospective study of patients with anterior circulation acute ischemic stroke treated with best medical treatment and/or endovascular reperfusion. Read More

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In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.

J Biomech 2021 Apr 8;121:110427. Epub 2021 Apr 8.

University of Houston, College of Optometry, Houston, TX 77204, United States. Electronic address:

Reliable and quantitative assessment of corneal biomechanics is important for the detection and treatment of corneal disease. The present study evaluates the repeatability and reproducibility of a novel optical coherence tomography (OCT)-based elastography (OCE) method for in vivo quantification of corneal natural frequency in 20 normal human eyes. Sub-micron corneal oscillations were induced by repeated low-force (13 Pa) microliter air pulses at the corneal apex and were observed by common-path phase-sensitive OCT imaging adjacent to a measurement region of 1-6. Read More

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Excessive ammonia inhalation causes liver damage and dysfunction by altering gene networks associated with oxidative stress and immune function.

Ecotoxicol Environ Saf 2021 Apr 16;217:112203. Epub 2021 Apr 16.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, People's Republic of China; Key Laboratory of Swine Facilities Engineering, Ministry of Agriculture and Rural Affairs, Harbin, People's Republic of China. Electronic address:

Ammonia (NH) is a major gaseous pollutant in livestock production and has adverse effects on production, health and welfare of animals. The liver is one of the target organs of NH, and excessive NH inhalation can induce liver damage. However, the toxicity assessment of NH on pig liver and its mechanism have not been reported yet. Read More

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Emergency upscaling of video consultation during the COVID-19 pandemic: Contrasting user experience with data insights from the electronic health record in a large academic hospital.

Int J Med Inform 2021 Apr 12;150:104463. Epub 2021 Apr 12.

Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, the Netherlands. Electronic address:

Background: Video consultation (VC) has been scaled up at our academic centre attempting to facilitate and accommodate patient-provider interaction in times of social distancing during the recent and ongoing COVID-19 pandemic.

Objectives: This study evaluates qualitative outcomes with data insights from the electronic health record, to contrast satisfaction outcomes with the actual use of VC.

Methods: Healthcare providers and patients using VC during the COVID-19 pandemic at a large academic centre in the Netherlands were surveyed for user satisfaction and experiences with VC. Read More

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Simple quantitative assessment of the outdoor versus indoor airborne transmission of viruses and COVID-19.

Environ Res 2021 Apr 16:111189. Epub 2021 Apr 16.

MERL-Consulting SAS, 21 Rue Sergent Guihard, 35000 Rennes, France.

In this paper we develop a simple model of the inhaled flow rate of aerosol particles of respiratory origin i.e. that have been exhaled by other people. Read More

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The dynamics and prognostic value of FDG PET-metrics in weekly monitoring of (chemo)radiotherapy for NSCLC.

Radiother Oncol 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Purpose: to test if the relative change in FDG-PET SUVmax over the course of treatment was associated with disease progression and overall survival. Additionally, the prognostic values of other first-order PET-metric changes were investigated.

Methods: The study included 38 patients with stage II-III NSCLC, who underwent concurrent chemoradiotherapy. Read More

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Do Inpatients Receive Risk-Based Prophylactic Treatment for Thrombotic Events?

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621995563

568072University Heart Center Freiburg - Bad Krozingen, Department of Cardiology and Angiology I, Faculty of Medicine, University of Freiburg, Germany.

Background: Current guidelines recommend risk-based use of prophylaxis for preventing medical inpatients from venous thromboembolism (VTE). Little is known about the current prescription practice, and even less whether differences between subspecialists like cardiologists, usually treating patients with thrombotic or thromboembolic diseases, and gastroenterologists, treating more patients with gastrointestinal bleeding complications, exist.

Methods: We performed a retrospective chart review of patients on cardiology and gastroenterology wards of our university hospital. Read More

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Protein Corona-Mediated Extraction for Quantitative Analysis of Nanoplastics in Environmental Waters by Pyrolysis Gas Chromatography/Mass Spectrometry.

Anal Chem 2021 Apr 19. Epub 2021 Apr 19.

Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, P. R. China.

There is a growing concern about the effects of nanoplastics on biological safety and human health because of their global ubiquity in the environment. Methodologies for quantitative analysis of nanoplastics are important for the critical evaluation of their possible risks. Herein, a sensitive yet simple and environmentally friendly extraction approach mediated by protein corona is developed and coupled to pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) for nanoplastic determination in environmental waters. Read More

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Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research.

Eur Heart J 2021 Apr 19. Epub 2021 Apr 19.

Columbia University Irving Medical Center/NewYork-Presbyterian Hospital and Cardiovascular Research Foundation, New York, NY, USA.

Aims: The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trials. Rapid evolution of the field, including the emergence of new complications, expanding clinical indications, and novel therapy strategies have mandated further refinement and expansion of these definitions to ensure clinical relevance. This document provides an update of the most appropriate clinical endpoint definitions to be used in the conduct of transcatheter and surgical aortic valve clinical research. Read More

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Establishing the Effectiveness of Interventions Provided to First Responders to Prevent and/or Treat Mental Health Effects of Response to a Disaster: A Systematic Review.

Disaster Med Public Health Prep 2021 Feb 14;15(1):115-126. Epub 2020 Feb 14.

Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Objectives: This review systematically explores the current available evidence on the effectiveness of interventions provided to first responders to prevent and/or treat the mental health effects of responding to a disaster.

Methods: A systematic review of Medline, Scopus, PsycINFO, and gray literature was conducted. Studies describing the effectiveness of interventions provided to first responders to prevent and/or treat the mental health effects of responding to a disaster were included. Read More

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February 2021

Effects of resistance training interventions on muscular strength in adults with intellectual disability: a systematic review and meta-analysis.

Disabil Rehabil 2021 Apr 17:1-14. Epub 2021 Apr 17.

Department of Behavioral Health and Nutrition, University of Delaware, Newark, USA.

Purpose: Muscular strength is critical for adults with an intellectual disability (ID) to promote their mobility, cardiovascular capacity, and performance of daily living/recreational/vocational activities. This article reports the results of the first systematic review and meta-analysis of peer-reviewed clinical trials that evaluated the effects of resistance training (RT) interventions on muscular strength in adults with ID.

Methods: The protocol was registered with PROSPERO (CRD42020184905). Read More

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Diabetes Mellitus Blunts the Symptoms, Physical Function, and Health-Related Quality of Life Benefits of Total Knee Arthroplasty: A Systematic Review With Meta-Analysis of Data From More Than 17,000 Patients.

J Orthop Sports Phys Ther 2021 Apr 19:1-54. Epub 2021 Apr 19.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN.

Objective: To compare physical function, pain, impairments (stiffness, range of motion, and strength), and health-related quality of life (HRQOL) outcomes between patients with and without diabetes mellitus, before and after a total knee arthroplasty (TKA).

Design: Prognosis systematic review.

Literature Search: We searched MEDLINE/PubMed, CINAHL, PsycINFO, and Web of Science to August 2019. Read More

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Interpreting Bibliometric Data.

Front Res Metr Anal 2020 9;5:628703. Epub 2021 Feb 9.

Institute for Scientific Information, Clarivate, London, United Kingdom.

Many academic analyses of good practice in the use of bibliometric data address only technical aspects and fail to account for and appreciate user requirements, expectations, and actual practice. Bibliometric indicators are rarely the only evidence put before any user group. In the present state of knowledge, it is more important to consider how quantitative evaluation can be made simple, transparent, and readily understood than it is to focus unduly on precision, accuracy, or scholarly notions of purity. Read More

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February 2021