10,721 results match your criteria quantify phase

The margin of internal risk volume on atrial septal and ventricular septal based on electrocardiograph gating 4DCT.

Ann Transl Med 2021 May;9(10):842

Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The aim of this study was to quantify the margin of internal risk volume (IRV) on the atrial septum (AS) and ventricular septum (VS) based on electrocardiograph gating (ECG-gating) 4DCT.

Methods: Twenty patients were enrolled and received an ECG-gating 4DCT scan performed in breath-hold, and CT images were reconstructed at 5% intervals of the cardiac cycle for a total of 20 phases (0-95%). The contouring of the AS and VS were delineated in each phase, and the displacements and margin of the AS and VS were calculated. Read More

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Consistent inclusion of continuum solvation in energy decomposition analysis: theory and application to molecular CO reduction catalysts.

Chem Sci 2020 Nov 27;12(4):1398-1414. Epub 2020 Nov 27.

Department of Chemistry, University of California at Berkeley Berkeley CA 94720 USA

To facilitate computational investigation of intermolecular interactions in the solution phase, we report the development of ALMO-EDA(solv), a scheme that allows the application of continuum solvent models within the framework of energy decomposition analysis (EDA) based on absolutely localized molecular orbitals (ALMOs). In this scheme, all the quantum mechanical states involved in the variational EDA procedure are computed with the presence of solvent environment so that solvation effects are incorporated in the evaluation of its energy components. After validation on several model complexes, we employ ALMO-EDA(solv) to investigate substituent effects on two classes of complexes that are related to molecular CO reduction catalysis. Read More

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November 2020

A method to assess glyphosate, glufosinate and aminomethylphosphonic acid in soil and earthworms.

J Chromatogr A 2021 Jun 9;1651:462339. Epub 2021 Jun 9.

Université de Strasbourg, CNRS-UMR 7515, ICPEES, 67087, Strasbourg, France.

A new sensitive and selective analytical methodology to quantify glyphosate (GLY), aminomethylphosphonic acid (AMPA), and glufosinate (GLU) in both soil and earthworms (Allolobophora chlorotica) was developed. The extraction and purification methods were optimized. The samples were extracted with various aqueous solutions (HNO, HO, KOH and borate buffer) and derivatized with 9-Fluorenylmethyl chloroformate (FMOCCl). Read More

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The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response.

NPJ Precis Oncol 2021 Jun 22;5(1):56. Epub 2021 Jun 22.

Department of Gastrointestinal Medical oncology, Harbin Medical University Cancer Hospital, Harbin, PR China.

An emerging body of evidence has recently recognized the coexistence of epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view and survey of the interplay between EMT and immune escape program, and their impact on tumor behavior and clinical outcome across various types of cancer is lacking. Here, we performed comprehensive multi-omics analyses to characterize the landscape of crosstalk between EMT and immune evasion and their clinical relevance across 17 types of solid cancer. Read More

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Estimating the viscosity of volcanic melts from the vibrational properties of their parental glasses.

Sci Rep 2021 Jun 22;11(1):13072. Epub 2021 Jun 22.

Dipartimento di Informatica, Università di Verona, 37134, Verona, Italy.

The numerical modelling of magma transport and volcanic eruptions requires accurate knowledge of the viscosity of magmatic liquids as a function of temperature and melt composition. However, there is growing evidence that volcanic melts can be prone to nanoscale modification and crystallization before and during viscosity measurements. This challenges the possibility of being able to quantify the crystal-free melt phase contribution to the measured viscosity. Read More

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OpenKBP: The open-access knowledge-based planning grand challenge and dataset.

Med Phys 2021 Jun 22. Epub 2021 Jun 22.

Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON, M5S 3G8, Canada.

Purpose: To advance fair and consistent comparisons of dose prediction methods for knowledge-based planning (KBP) in radiation therapy research.

Methods: We hosted OpenKBP, a 2020 AAPM Grand Challenge, and challenged participants to develop the best method for predicting the dose of contoured computed tomography (CT) images. The models were evaluated according to two separate scores: (a) dose score, which evaluates the full three-dimensional (3D) dose distributions, and (b) dose-volume histogram (DVH) score, which evaluates a set DVH metrics. Read More

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Female (Under) Representation in Exercise Thermoregulation Research.

Sports Med Open 2021 Jun 22;7(1):43. Epub 2021 Jun 22.

Institute of Health and Biomedical Innovation, School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Australia.

Background: Despite an increasing rate of women participating in professional sports, emergency services, and military settings where they are exposed to exertional heat stress, our understanding of female thermoregulation and the detrimental effects of heat on women's performance, especially regarding the menstrual cycle, is limited. This review aimed to quantify the representation of women in exercise thermoregulation research between 2010 and 2019 and the frequency that these articles reported details pertaining to female participants' menstrual cycle to determine the volume of novel research that is directly relevant to this growing population.

Methods: Original exercise thermoregulatory studies published in three major sports medicine databases (PubMed, MEDLINE, and SPORTDiscus) between 2010 and 2019 were surveyed. Read More

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Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients.

J Transl Med 2021 Jun 21;19(1):265. Epub 2021 Jun 21.

INSERM UMR1098, Right, EFSBFC, UFC, Laboratoire de Thérapeutique Immuno-Moléculaire Et Cellulaire Des Cancers, 8 rue du Dr Jean François Xavier Girod, 25020, Besançon, France.

Background: Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, are currently approved for treating B cell malignancies. Flow cytometry (FC) remains the standard for monitoring CAR T cells using a recombinant biotinylated target protein. Read More

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Speckle-dependent accuracy in phase-sensitive optical coherence tomography.

Opt Express 2021 May;29(11):16950-16968

Phase-sensitive optical coherence tomography (OCT) is used to measure motion in a range of techniques, such as Doppler OCT and optical coherence elastography (OCE). In phase-sensitive OCT, motion is typically estimated using a model of the OCT signal derived from a single reflector. However, this approach is not representative of turbid samples, such as tissue, which exhibit speckle. Read More

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Quantification of Pharmaceuticals in the Sealant Fluids of Actively Used Waterless Urinals.

Water Environ Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Civil and Environmental Engineering, University of Nevada, Reno, NV, 89557-0258, USA.

Prior measurements at bench-scale revealed that waterless urinal cartridges containing oily sealant fluids are capable of partitioning pharmaceuticals from urine and therefore reducing their concentration in wastewater. We sought to measure pharmaceutical removal from in-use waterless urinals. We developed a method to quantify pharmaceuticals in the sealant phase which resulted in 79 ±30% and 71 ±30% recovery of eight pharmaceuticals from two sealant fluids, respectively. Read More

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Sample Preparation and Analytical Methods for Steroid Hormones in Environmental and Food Samples: An Update Since 2012.

Crit Rev Anal Chem 2021 Jun 21:1-19. Epub 2021 Jun 21.

School of Pharmacy, China Medical University, Shenyang, China.

Steroid hormones (SHs) have been widely used over the past few decades as both human and veterinary drugs to prevent or treat infectious diseases and anti-inflammatory benefits in clinical. Unfortunately, their residues in foodstuffs and environmental samples can produce adverse effects on human and animal life such as disrupting the endocrine system. For these reasons, sensitive, simple and efficient methods have been developed for the determination of these compounds in various matrices. Read More

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Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World: The INCAPS-COVID Study.

JACC Cardiovasc Imaging 2021 Jun 10. Epub 2021 Jun 10.

Technion Israel Institute of Technology, Haifa, Israel.

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.

Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Read More

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A multi-inversion-recovery magnetic resonance fingerprinting for multi-compartment water mapping.

Magn Reson Imaging 2021 Jun 16. Epub 2021 Jun 16.

Department of Diagnostic Radiology, The University of Hong Kong, HKSAR, China. Electronic address:

Purpose: This study aimed at introducing short-T1/T2 compartment to MR fingerprinting (MRF) at 3 T. Water that is bound to myelin macromolecules have significantly shorter T1 and T2 than free water and can be distinguished from free water by multi-compartment analysis.

Methods: We developed a new multi-inversion-recovery (mIR) water mapping-MRF based on an unbalanced steady-state coherent sequence (FISP). Read More

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Disruptions in maternal and child health service utilization during COVID-19: analysis from eight sub-Saharan African countries.

Health Policy Plan 2021 Jun 19. Epub 2021 Jun 19.

Development Research Group, The World Bank, 1818 H St NW, Washington, DC 20433, USA.

The coronavirus-19 pandemic and its secondary effects threaten the continuity of essential health services delivery, which may lead to worsened population health and a protracted public health crisis. We quantify such disruptions, focusing on maternal and child health, in eight sub-Saharan countries. Service volumes are extracted from administrative systems for 63 954 facilities in eight countries: Cameroon, Democratic Republic of Congo, Liberia, Malawi, Mali, Nigeria, Sierra Leone and Somalia. Read More

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Early development of the cortical layers in the human brain.

J Anat 2021 Jun 17. Epub 2021 Jun 17.

Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The cortical plate (CP) first appears at seven postconceptional weeks (pcw), when it splits the preexisting preplate into two layers, the marginal zone and the presubplate (pSP). Although three-dimensional (3D) analysis using fetal magnetic resonance imaging and two-dimensional tissue observations have been reported, there have been no studies analyzing the early development of the layer structure corresponding to the pSP stage in 3D. Here, we reconstructed 3-D models of the brain with a focus on the cortical layers in pSP stage. Read More

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On the interplay of friction and stress relaxation to improve stretch-flangeability of dual phase (DP600) steel.

CIRP J Manuf Sci Technol 2021 Jan;32

Metal Forming Laboratory, Department of Metallurgical and Materials Engineering, IIT Madras, Chennai-600036, India.

Industrial servo presses have been used to successfully demonstrate improved formability when deforming sheet metals. While the time dependent viscoplastic behavior of material is attributed to the observed formability improvement, much less effort has been devoted to understand and quantify the underlying mechanisms. In this context, the hole expansion test (HET) of a dual phase steel was interrupted at pre-defined punch travel heights to understand the time-dependent effects on stretch-flangeability. Read More

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January 2021

A systems pharmacology model for gene therapy in sickle cell disease.

CPT Pharmacometrics Syst Pharmacol 2021 Jun 17. Epub 2021 Jun 17.

Applied BioMath LLC, Concord, Massachusetts, USA.

We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene. These stem cells are expected to produce a lifelong supply of red blood cells (RBCs) containing an anti-sickling hemoglobin. Read More

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Development of outcome measures according to dystrophic phenotypes in canine X-linked muscular dystrophy in Japan.

Exp Anim 2021 Jun 16. Epub 2021 Jun 16.

National Institute of Neuroscience, National Center of Neurology and Psychiatry.

Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disorder characterized by primary muscle degeneration. Therapeutic strategies for DMD have been extensively explored, and some are in the stage of human clinical trials. Along with the development of new therapies, sensitive outcome measures are needed to monitor the effects of new treatments. Read More

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Overcoming stochastic variations in culture variables to quantify and compare growth curve data.

Bioessays 2021 Jun 14:e2100108. Epub 2021 Jun 14.

Molecular & Cellular Biochemistry Department, Indiana University, Bloomington, Indiana, USA.

The comparison of growth, whether it is between different strains or under different growth conditions, is a classic microbiological technique that can provide genetic, epigenetic, cell biological, and chemical biological information depending on how the assay is used. When employing solid growth media, this technique is limited by being largely qualitative and low throughput. Collecting data in the form of growth curves, especially automated data collection in multi-well plates, circumvents these issues. Read More

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HPTLC Method for the Ultrasensitive Detection of Triamterene in Plasma.

J Chromatogr Sci 2021 Jun 14. Epub 2021 Jun 14.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.

A high-performance thin-layer chromatographic (HPTLC) method has developed for the selective detection of a diuretic drug, triamterene (TRIAM), in pure form, tablets and human plasma. The method was based on chromatographic separation of TRIAM using HPTLC plates, precoated with silica gel, and a mobile phase consisted of ethyl acetate: dimethylformamide: ammonia (7.0: 2. Read More

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Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy.

Sci Rep 2021 06 14;11(1):12412. Epub 2021 Jun 14.

Institute of Crystallography, Consiglio Nazionale delle Ricerche CNR, via Salaria Km 29.300, Monterotondo, 00015, Rome, Italy.

The control of Covid 19 epidemics by public health policy in Italy during the first and the second epidemic waves has been driven by using reproductive number R(t) to identify the supercritical (percolative), the subcritical (arrested), separated by the critical regime. Here we show that to quantify the Covid-19 spreading rate with containment measures there is a need of a 3D expanded parameter space phase diagram built by the combination of R(t) and doubling time T(t). In this space we identify the Covid-19 dynamics in Italy and its administrative Regions. Read More

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Development and psychometric testing of a Learning Behaviour Questionnaire among Chinese undergraduate nursing students.

BMJ Open 2021 06 14;11(6):e043711. Epub 2021 Jun 14.

School of Nursing, China Medical University, Shenyang, Liaoning, China

Objective: This study aimed to develop and validate a new Learning Behaviour Questionnaire (LBQ) for the undergraduate nursing students.

Study Design: This study was performed in two phases. Phase 1 of the study focused on questionnaire development to create a pool of items, while phase 2 focused on validity and reliability testing. Read More

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Derivation of the maintenance energy requirements and efficiency of metabolizable energy utilization for dry and lactating Jersey cows.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Animal Science, University of Nebraska-Lincoln, Lincoln 68583. Electronic address:

Maintenance energy is the energy required to conserve the state of an animal when no work is completed. Dietary energy must be supplied to meet maintenance requirements before milk can be produced. The objectives of the current experiment were to quantify the maintenance energy requirement of Jersey cows when lactating or dry. Read More

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The modulation of social behavior and empathy via oral contraceptives and female sex hormones.

Psychoneuroendocrinology 2021 May 9;131:105250. Epub 2021 May 9.

Department of Biological and Clinical Psychology, University of Trier, D54290 Trier, Germany. Electronic address:

Oral contraceptives (OC) and endogenous female sex hormones in naturally cycling women (NC) are related to a wide range of psychological variables (eg, cognition and affect). Little research on social behavior has been done. One study documented a tendency towards more prosocial behavior in NC than OC women, but the underlying neuroendocrine mechanisms remain unknown. Read More

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Quantification of the ion transport mechanism in protective polymer coatings on lithium metal anodes.

Chem Sci 2021 Apr 12;12(20):7023-7032. Epub 2021 Apr 12.

Department of NanoEngineering 9500 Gilman Drive, La Jolla California 92093 USA

Protective Polymer Coatings (PPCs) have been proposed to protect lithium metal anodes in rechargeable batteries to stabilize the Li/electrolyte interface and to extend the cycle life by reducing parasitic reactions and improving the lithium deposition morphology. However, the ion transport mechanism in PPCs remains unclear. Specifically, the degree of polymer swelling in the electrolyte and the influence of polymer/solvent/ion interactions are never quantified. Read More

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On a phase-field approach to model fracture of small intestine walls.

Acta Biomater 2021 Jun 10. Epub 2021 Jun 10.

Institute of Mechanics and Adaptronics, Technische Universität Braunschweig, Braunschweig D-38106, Germany; Chair of Computational and Experimental Solid Mechanics, Technische Universität Dresden, Dresden D-01069, Germany. Electronic address:

We address anisotropic elasticity and fracture in small intestine walls (SIWs) with both experimental and computational methods. Uniaxial tension experiments are performed on porcine SIW samples with varying alignments and quantify their nonlinear elastic anisotropic behavior. Fracture experiments on notched SIW strips reveal a high sensitivity of the crack propagation direction and the failure stress on the tissue orientation. Read More

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Arterial Spin Labeling Reveals Elevated Cerebral Blood Flow with Distinct Clusters of Hypo- and Hyperperfusion after Traumatic Brain Injury.

J Neurotrauma 2021 Jun 10. Epub 2021 Jun 10.

The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. In this study, we used arterial spin labeling (ASL) to quantify cross-sectional and longitudinal changes in cerebral blood flow (CBF) after TBI and correlated changes with clinical outcome. We analyzed magnetic resonance imaging scans from adult participants with TBI requiring hospitalization in the acute (2 weeks post-injury,  = 33) and chronic (6 months post-injury,  = 16) phases, with 13 participants scanned longitudinally at both time points. Read More

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Ectopic cycle length estimation from the quantified distribution patterns of ventricular bigeminy and trigeminy.

Heart Rhythm O2 2021 Apr 10;2(2):138-148. Epub 2021 Mar 10.

Department of Medical Informatics, Kitasato University, Sagamihara City, Japan.

Background: Ectopic cycle length (ECL) and the distribution patterns of ventricular bigeminy and trigeminy, expressed as their postextrasystolic intervals (PEIs) and interectopic intervals (IEIs), have been poorly pursued.

Objective: Based on modulation theory, we hypothesized that the PEIs of bigeminy and trigeminy determine their IEIs and ECL.

Methods: Ambulatory electrocardiograms of 1290 patients with ventricular premature complexes (≥3000/day) were studied. Read More

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Simultaneous quantification of vincristine and its major M1 metabolite from dried blood spot samples of Kenyan pediatric cancer patients by UPLC-MS/MS.

J Pharm Biomed Anal 2021 May 21;203:114143. Epub 2021 May 21.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.

Vincristine (VCR) is an integral part of chemotherapy regimens in the US and in developing countries. There is a paucity of information about its disposition and optimal therapeutic dosing. VCR is preferentially metabolized to its major M1 metabolite by the polymorphic CYP3A5 enzyme, which may be clinically significant as CYP3A5 expression varies across populations. Read More

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μSPE followed by HPLC-MS/MS for the determination of series D and E resolvins in biological matrices.

J Pharm Biomed Anal 2021 May 29;203:114181. Epub 2021 May 29.

University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100, TE, Italy.

The critical role of acute inflammatory processes is recognized in many chronic diseases; a key point in molecular mechanisms of acute inflammation resolution is represented by a new group of pro-resolving lipid mediators that include distinct families of molecules: lipoxins, resolvins, protectins and maresins, collectively termed "specialized pro-resolving mediators" (SPMs). In particular, resolvins are active in the picogram to nanogram dose range, whereby they can directly modulate a plethora of anti-inflammatory responses. The presented method proposes an analytical protocol able to extract and to quantify 6 different resolvins from 3 different matrices (plasma, cells and exudates). Read More

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