Radiology 2021 Jun 15:204320. Epub 2021 Jun 15.
From the Department of Radiology (M.K., D.S.H., M.H., N.M., K.M., K.R.M.), Integrated Brain Imaging Center, Department of Radiology (S.R.L.), Department of Neurologic Surgery (K.R.M.), and Magnetic Resonance Research Laboratory (K.R.M.), University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195; Departments of Radiology (M.K.) and Neurology (K.M.), Toho University Omori Medical Center, Tokyo, Japan; Department of Radiology, Toho University Ohashi Medical Center, Tokyo, Japan (M.H., N.M.); and Department of Pathology, University of Washington School of Medicine, Seattle, Wash (D.A.M., L.F.G.).
Background Linear gadolinium-based contrast agents (GBCAs) are known to be retained at higher levels of gadolinium than macro-cyclic GBCAs. However, very little is known regarding their relative elimination rates and retained fraction of injected gadolinium. Purpose To quantify and compare gadolinium retention and elimination rates in human brain tissue, skin, and bone obtained from cadavers exposed to single-agent administration of either gadoteridol (macrocyclic GBCA) or gadobenate dimeglumine (linear GBCA). Read More