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Benchmarking Various Radiomic Toolkit Features While Applying the Image Biomarker Standardization Initiative toward Clinical Translation of Radiomic Analysis.

J Digit Imaging 2021 Sep 20. Epub 2021 Sep 20.

Department of Radiology, University of Southern California, 1500 San Pablo Street, Los Angeles, CA, 90033, USA.

The image biomarkers standardization initiative (IBSI) was formed to address the standardization of extraction of quantifiable imaging metrics. Despite its effort, there remains a lack of consensus or established guidelines regarding radiomic feature terminology, the underlying mathematics and their implementation across various software programs. This creates a scenario where features extracted using different toolboxes cannot be used to build or validate the same model leading to a non-generalization of radiomic results. Read More

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September 2021

Quantification of 397 pesticide residues in different types of commercial teas: Validation of high accuracy methods and quality assessment.

Food Chem 2021 Aug 31;370:130986. Epub 2021 Aug 31.

Faculty of Environmental and Food Engineering, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam. Electronic address:

Analytical methods with high sensitivity and accuracy were successfully validated for the quantification of 397 pesticides in different types of tea. For the UPLC-MS/MS method, 191 pesticides of 200 ones in total had "soft" matrix effects and could be quantified by calibration curves in the solvent. For the GC-MS/MS method, matrix-matched calibration curves were established on a mixed blank including white, green, oolong and black organic teas. Read More

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Differential Associations of White Matter Brain Age With Language-Related Mechanisms in Word-Finding Ability Across the Adult Lifespan.

Front Aging Neurosci 2021 3;13:701565. Epub 2021 Sep 3.

Molecular Imaging Centre, National Taiwan University, Taipei, Taiwan.

Research on cognitive aging has established that word-finding ability declines progressively in late adulthood, whereas semantic mechanism in the language system is relatively stable. The aim of the present study was to investigate the associations of word-finding ability and language-related components with brain aging status, which was quantified by using the brain age paradigm. A total of 616 healthy participants aged 18-88 years from the Cambridge Centre for Ageing and Neuroscience databank were recruited. Read More

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September 2021

Inhibitory properties of polyphenols in Malus "Winter Red" crabapple fruit on α-glucosidase and α-amylase using improved methods.

J Food Biochem 2021 Sep 18:e13942. Epub 2021 Sep 18.

State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, College of Horticulture, Northwest A&F University, Yangling, China.

To explore the inhibitory activity of polyphenols on α-glucosidase and α-amylase, 16 polyphenols were isolated, identified, and quantified in an edible Malus "Winter Red" crabapple fruit. The limitations of two traditional methods for α-glucosidase and α-amylase activity assay in vitro were assayed. An improved method based on an HPLC assay for α-glucosidase and a colorimetric method coupled with a custom-made mini-column for α-amylase were established. Read More

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September 2021

Coronary Inflammation Assessed by Perivascular Fat Attenuation Index in Patients with Psoriasis: A Propensity Score-Matched Study.

Dermatology 2021 Sep 15:1-9. Epub 2021 Sep 15.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: This study aimed to evaluate coronary inflammation by measuring the perivascular fat attenuation index (FAI) and quantify the atherosclerosis burden in patients with psoriasis and control individuals without psoriasis based on coronary computed tomography angiography (CCTA) images.

Methods: A total of 98 consecutive patients with psoriasis (76 male [77.6%], aged 56. Read More

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September 2021

Consequences of a match made in hell: the harm caused by menthol smoking to the African American population over 1980-2018.

Tob Control 2021 Sep 16. Epub 2021 Sep 16.

Health Management and Policy, University of Michigan, Ann Arbor, Michigan, USA

Background: For many years, national surveys have shown a consistently disproportionately high prevalence of menthol smokers among African Americans compared with the general population. However, to our knowledge, no prior study has quantified the harm that menthol smoking has caused on that population. In this work, we estimate the public health harm that menthol cigarettes have caused to the African American community over the last four decades. Read More

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September 2021

COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):632. Epub 2021 Sep 17.

Centro Hospitalar Universitário de Lisboa Central (CHULC), Lisboa, Portugal.

Background: Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. Read More

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September 2021

Notoginsenoside R2 reduces A25-35-induced neuronal apoptosis and inflammation via miR-27a/SOX8/-catenin axis.

Hum Exp Toxicol 2021 Sep 17:9603271211041996. Epub 2021 Sep 17.

Department of Neurology, 118330The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.

Alzheimer's disease (AD) has affected numerous elderly individuals worldwide. has been shown to ameliorate AD symptoms, and notoginsenoside R2 is a key saponin identified in this plant. In the current study, we aimed to explore whether notoginsenoside R2 could improve the prognosis of AD. Read More

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September 2021

Quantitative 3D microscopy highlights altered von Willebrand factor α-granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms.

Res Pract Thromb Haemost 2021 Aug 14;5(6):e12595. Epub 2021 Sep 14.

Department of Hematology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.

Background: Platelets play a key role in hemostasis through plug formation and secretion of their granule contents at sites of endothelial injury. Defects in von Willebrand factor (VWF), a platelet α-granule protein, are implicated in von Willebrand disease (VWD), and may lead to defective platelet adhesion and/or aggregation. Studying VWF quantity and subcellular localization may help us better understand the pathophysiology of VWD. Read More

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Validation of Cognitive Load During Inquiry-Based Learning With Multimedia Scaffolds Using Subjective Measurement and Eye Movements.

Front Psychol 2021 31;12:703857. Epub 2021 Aug 31.

Physics Education Research Group, Department of Physics, Technische Universität Kaiserslautern, Kaiserslautern, Germany.

Subject-method barriers and cognitive load (CL) of students have a particular importance in the complex learning process of scientific inquiry. In this work, we investigate the valid measurement of CL as well as different scaffolds to reduce it during experimentation. Specifically, we examine the validity of a subjective measurement instrument to assess CL [in extraneous cognitive load (ECL), intrinsic cognitive load, and germane cognitive load (GCL)] during the use of multimedia scaffolds in the phase of the scientific inquiry process based on a theoretical framework of the CL theory. Read More

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Neuromuscular treatment approach for women with chronic pelvic pain syndrome improving pelvic pain and functionality.

Neurourol Urodyn 2021 Sep 16. Epub 2021 Sep 16.

Pelvic Rehabilitation Medicine Clinical Research Foundation, West Palm Beach, Florida, USA.

Aims: Reporting the effects of treating underlying myofascial dysfunction and neuropathic pain in women with chronic pelvic pain syndrome (CPPS).

Methods: Retrospective longitudinal study of 186 women with CPPS treated with ultrasound-guided peripheral nerve blocks and trigger point injections to pelvic floor muscles alongside pelvic floor physical therapy once weekly for 6 weeks in an outpatient setting. Visual Analogue Scale (VAS) and Functional Pelvic Pain Scale (FPPS) questionnaires quantified pain and function in the pelvis. Read More

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September 2021

The impact of spectacle lenses for myopia control on visual functions.

Ophthalmic Physiol Opt 2021 Sep 16. Epub 2021 Sep 16.

College of Optometry, University of Houston, Houston, Texas, USA.

Purpose: Spectacle lenses containing multiple small peripheral elements have been developed for myopia control in children. It is important that their effect on vision be quantified by (i) fixation through the peripheral portion, thereby using foveal vision and (ii) by fixation through the central portion and presentation of peripheral targets.

Methods: The above approaches were used in five studies to evaluate two novel spectacle lens designs: spectacle lenses with Highly Aspherical Lenslets (HAL) and Slightly Aspherical Lenslets (SAL). Read More

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September 2021

Protein signatures of NK cell-mediated melanoma killing predict response to immunotherapies.

Cancer Res 2021 Sep 13. Epub 2021 Sep 13.

Molecular Physiology, Universitätsmedizin Göttingen

Despite impressive advances in melanoma-directed immunotherapies, resistance is common and many patients still succumb to metastatic disease. In this context, harnessing natural killer (NK) cells, which have thus far been sidelined in the development of melanoma immunotherapy, could provide therapeutic benefits for cancer treatment. To identify molecular determinants of NK cell-mediated melanoma killing (NKmK), we quantified NK cell cytotoxicity against a panel of genetically diverse melanoma cell lines and observed highly heterogeneous susceptibility. Read More

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September 2021

Does capsule endoscopy impact clinical management in established Crohn's disease?

Dig Liver Dis 2021 Sep 10. Epub 2021 Sep 10.

Gastroenterology Department, Complejo Hospitalario de Navarra, Calle Irunlarrea 3, Pamplona 31008, Spain.

Background: Capsule endoscopy (SBCE) has developed a relevant role in patients with established Crohn's Disease (CD). However, evaluation of the impact in clinical management has been scarce.

Aims: To evaluate therapeutic impact of SBCE in an 11-year real-life cohort of known CD patients. Read More

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September 2021

Analysis of aristolochic acid I in mouse serum and tissues by using magnetic solid-phase extraction and UHPLC-MS/MS.

Talanta 2021 Dec 8;235:122774. Epub 2021 Aug 8.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, 999077, SAR, Hong Kong, China. Electronic address:

A method combining magnetic solid-phase extraction (MSPE) and ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed for the analysis of aristolochic acids I (AAI) in mouse serum and tissues. The magnetic covalent organic frameworks ([email protected])-based MSPE exhibited high adsorption capacity towards AAI (93.1 mg/g) in optimal conditions. Read More

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December 2021

Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum.

J Pharm Anal 2021 Aug 15;11(4):472-479. Epub 2020 Aug 15.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.

Liquid chromatography tandem mass spectrometry (LC-MS/MS) has gradually become a promising alternative to ligand binding assay for the bioanalysis of biotherapeutic molecules, due to its rapid method development and high accuracy. In this study, we established a new LC-MS/MS method for the determination of the anti-sclerostin monoclonal antibody (SHR-1222) in cynomolgus monkey serum, and compared it to a previous electrochemiluminescence method. The antibody was quantified by detecting the surrogate peptide obtained by trypsin digestion. Read More

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Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study.

J Pharm Anal 2021 Aug 15;11(4):444-457. Epub 2020 Aug 15.

College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory, analgesic, and antipyretic effects. However, the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic (PK) study have yet been investigated. We have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma analysis. Read More

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Predicting outcomes in Dandy-Walker malformation: a retrospective cohort study.

J Neurosurg Pediatr 2021 Sep 10:1-6. Epub 2021 Sep 10.

3University College Dublin, Ireland.

Objective: Dandy-Walker malformation (DWM) is a disorder that most neurologists and neurosurgeons will manage at some point during their careers. It is characterized by partial or complete dysgenesis of the cerebellar vermis. Outcomes are highly variable and range from functionally normal to severely disabled. Read More

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September 2021

Age-related changes in the rhesus macaque eye.

Exp Eye Res 2021 Sep 7:108754. Epub 2021 Sep 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA. Electronic address:

Purpose: To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease.

Methods: Data from eye exams and imaging tests including intraocular pressure (IOP), lens thickness, axial length, and retinal optical coherence tomography (OCT) images were evaluated from 142 individuals and statistically analyzed for age-related changes. Quantitative autofluorescence (qAF) was measured as was the presence of macular lesions as related to age. Read More

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September 2021

A Novel Approach to Automated 3D Spalling Defects Inspection in Railway Tunnel Linings Using Laser Intensity and Depth Information.

Sensors (Basel) 2021 Aug 25;21(17). Epub 2021 Aug 25.

Key Laboratory of Geotechnical and Underground Engineering, Department of Geotechnical Engineering, Tongji University, Siping Road 1239, Shanghai 200092, China.

The detection of concrete spalling is critical for tunnel inspectors to assess structural risks and guarantee the daily operation of the railway tunnel. However, traditional spalling detection methods mostly rely on visual inspection or camera images taken manually, which are inefficient and unreliable. In this study, an integrated approach based on laser intensity and depth features is proposed for the automated detection and quantification of concrete spalling. Read More

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Quantification of phytic acid in baby foods by derivatization with (trimethylsilyl)diazomethane and liquid chromatography-mass spectrometry analysis.

Rapid Commun Mass Spectrom 2021 Sep 8:e9194. Epub 2021 Sep 8.

College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou.

Rationale: Phytic acid (PA) is both a naturally occurring nutrient and a widely-used food additive for conferring antioxidant properties to food. PA can be found in baby foods and it is essential to monitor PA content due to its antinutritional properties when present in excess. Current methods for determining PA content are unsatisfactory because interference from inositol phosphates and inorganic phosphates complicate PA quantification. Read More

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September 2021

Contribution of Tissue Inflammation and Blood-Brain Barrier Disruption to Brain Softening in a Mouse Model of Multiple Sclerosis.

Front Neurosci 2021 23;15:701308. Epub 2021 Aug 23.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Immunology, Berlin, Germany.

Neuroinflammatory processes occurring during multiple sclerosis cause disseminated softening of brain tissue, as quantified by magnetic resonance elastography (MRE). However, inflammation-mediated tissue alterations underlying the mechanical integrity of the brain remain unclear. We previously showed that blood-brain barrier (BBB) disruption visualized by MRI using gadolinium-based contrast agent (GBCA) does not correlate with tissue softening in active experimental autoimmune encephalomyelitis (EAE). Read More

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Association of baseline frailty status and age with postoperative morbidity and mortality following intracranial meningioma resection.

J Neurooncol 2021 Sep 8. Epub 2021 Sep 8.

Department of Neurosurgery, University of New Mexico, Albuquerque, NM, 87106, USA.

Purpose: Although numerous studies have established advanced patient age as a risk factor for poor outcomes following intracranial meningioma resection, large-scale evaluation of frailty for preoperative risk assessment has yet to be examined.

Methods: Weighted discharge data from the National Inpatient Sample were queried for adult patients undergoing benign intracranial meningioma resection from 2015 to 2018. Complex samples multivariable logistic regression models and receiver operating characteristic curve analysis were performed to evaluate adjusted associations and discrimination of frailty, quantified using the 11-factor modified frailty index (mFI), for clinical endpoints. Read More

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September 2021

Weak interaction-alleviated toxicity of aromatic compounds in EPS matrices: Quantifying the noncovalent bonding-to-EPS ecoservice chain.

J Hazard Mater 2021 08 20;416:125824. Epub 2021 Apr 20.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Jiangsu 210095, China. Electronic address:

Extracellular polymeric substances (EPSs) constitute a largely global carbon pool that could participate in geochemical process of organic chemicals. Besides the chemical hydrolysis and redox of chemicals exerted by the EPS, weakly noncovalent interactions with dispersive EPS control the toxicity of numerous organic compounds. Nevertheless, there has been a lack of in-depth research on this issue. Read More

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ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model.

Mol Med Rep 2021 Nov 7;24(5). Epub 2021 Sep 7.

Department of Vascular Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.

An abdominal aortic aneurysm (AAA) is a life‑threatening disease associated with a high mortality rate. At present, surgery or minimally invasive interventions are used in clinical treatment, especially for small aneurysms. However, the benefits of surgical repair are not obvious, and AAA ruptures can be prevented by aneurysm therapy to inhibit the growth of small aneurysms. Read More

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November 2021

[Optimizing experimental conditions of graphite furnace atomic absorption spectrometer using orthogonal design for determination of cobalt in urine].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Aug;39(8):616-618

Henan Institute for Occupational Health, Zhengzhou 450052, China.

To select and optimize the conditions of urine cobalt determination by graphite furnace atomic absorption spectroscopy and establish a method for urine cobalt determination. In April 2020, the matrix modifier and spectrum wavelength were selected by mathematical statistics method, the heating procedure of graphite furnace was optimized, the variance of orthogonal test results was analyzed, and the working curve was quantified by external standard method. The results showed that the diammonium hydrogen phosphate was a matrix modifier with a wavelength of 240. Read More

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The Effect of Particulate Matter Reduction by Indoor Air Filter Use on Respiratory Symptoms and Lung Function: A Systematic Review and Meta-analysis.

Allergy Asthma Immunol Res 2021 Sep;13(5):719-732

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Exposure to particulate matter (PM) is a key public health issue, but effective intervention has not yet been established. A systematic literature review and meta-analysis has been conducted to assess the relationship between the use of air filters, one of the most commonly studied interventions, and respiratory outcomes in patients with chronic respiratory diseases.

Methods: We systematically reviewed intervention studies on PM using PubMed, EMBASE, and Cochrane databases up to September 2019. Read More

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September 2021

Generation and functional characterization of recombinant Porphyromonas gingivalis W83 FimA.

J Biotechnol 2021 Aug 31;340:22-29. Epub 2021 Aug 31.

Institute of Medical Microbiology, Justus-Liebig-University of Giessen, Germany.

Porphyromonas gingivalis (P. gingivalis) is regarded as a keystone pathogen in destructive periodontal diseases. It expresses a variety of virulence factors, amongst them fimbriae that are involved in colonization, invasion, establishment and persistence of the bacteria inside the host cells. Read More

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Double-site recognition of Staphylococcus aureus using a metal-organic framework material with an alkaline hydrolysis property as a sensitive fluorescent probe.

Nanoscale 2021 Aug 20;13(29):12546-12552. Epub 2021 Jul 20.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

A metal-organic framework (MOF) material was prepared from 2-aminoterephthalic acid and aluminum chloride with a solvothermal synthesis protocol. The as-prepared MOF material named NH-MIL-53(Al) emitted a very intensive fluorescent (FL) signal after it was hydrolyzed in alkaline solution for releasing numerous FL ligands NH-HBDC. Thus it can be considered as a sensitive FL probe for studying biorecognition events. Read More

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Clinical value of baseline F-FDG PET/CT in soft tissue sarcomas.

Eur J Hybrid Imaging 2021 Sep 3;5(1):16. Epub 2021 Sep 3.

Nuclear Medicine Department, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.

Background: The use of F-FDG Positron emission tomography/Computed tomography (PET/CT) in the initial staging of many cancers is clearly established. Most soft tissue sarcoma (STS) has a high affinity for F-FDG, which is why F-FDG PET/CT has been proposed as a non-invasive method, useful in diagnosis and follow-up. The standardized uptake value values (SUV), the volume-based metabolic parameters MTV (metabolic tumor volume), and TLG (total lesion glycolysis) determine tumor viability and provide its total volume and the total activity of metabolically active tumor cells. Read More

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September 2021