230,791 results match your criteria quality reviews


High-quality milk exosomes as oral drug delivery system.

Biomaterials 2021 Sep 9;277:121126. Epub 2021 Sep 9.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology of China, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Many drugs must be administered intravenously instead of oral administration due to their poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as high as tens of billions of dollars worldwide. Exosomes are nano-sized (30-150 nm) extracellular vesicles secreted by mammalian cells due to environmental stimulation or self-activation. Read More

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September 2021

A concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa.

Environ Int 2021 Sep 17;157:106880. Epub 2021 Sep 17.

Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium; MYTOX-SOUTH, International Thematic Network, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent, Belgium.

Context: Oesophageal cancer (EC) is among the common causes of illness and death among all cancers worldwide. Advanced EC has a poor prognosis, with worse outcomes observed in low-income settings. Oesophageal squamous cell carcinoma (ESCC) is the most common EC histology reported globally, with the highest ESCC incidence rates in the 'Asian Belt' and the African EC corridor. Read More

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September 2021

Experiences and needs of patients with rectal cancer confronted with bowel problems after stoma reversal: A systematic review and thematic-synthesis.

Eur J Oncol Nurs 2021 Aug 20;54:102018. Epub 2021 Aug 20.

Department of Public Health and Primary Care, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium; Staff Member Nursing Department, Ghent University Hospital, Ghent, Belgium.

Purpose: After the reversal of the temporary stoma, rectal cancer survivors are often confronted with bowel complaints largely impacting on their quality of life. This systematic review aims to identify and synthesise the experiences and needs of patients with rectal cancer confronted with bowel problems after stoma reversal.

Methods: A systematic search was performed through Pubmed, CINAHL and Web of Science. Read More

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How to prevent surgical site infection in vascular surgery: A review of the evidence.

Ann Vasc Surg 2021 Sep 17. Epub 2021 Sep 17.

School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Western Australia, Australia. The University of Western Australia, Mailbox Drop Point 509, 35 Stirling Hwy, Nedlands, WA 6009; Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Western Australia, Australia. Level 6, G Block, QEII Medical Centre, Hospital Avenue, Nedlands, WA 6009; Curtin Medical School, Curtin University, Western Australia, Australia. Faculty of Health Sciences, Level 4 Building 400, Curtin University, GPO Box U1987, Perth, Western Australia 6845; Heart and Vascular Research Institute, Harry Perkins Institute for Medical Research, Western Australia, Australia. Heart and Vascular Research Institute, Level 2 Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, Western Australia, Australia 6009.

Objective: This review aims to identify and review the current evidence for preventing postoperative surgical site infections in abdominal aortic aneurysm surgery or infrainguinal arterial surgery.

Methods: Extended literature review of clinical trials that examined the prevention of postoperative surgical site infections in abdominal aortic aneurysm or infrainguinal arterial surgery. Searches were conducted on Ovid MEDLINE (1950 - 13 March 2020) using key terms for vascular surgery, surgical site infections and specific preventative techniques. Read More

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September 2021

Isatidis Radix and Isatidis Folium: A systematic review on ethnopharmacology, phytochemistry and pharmacology.

J Ethnopharmacol 2021 Sep 17:114648. Epub 2021 Sep 17.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China. Electronic address:

Ethnopharmacological Relevance: Isatidis Radix (called Banlangen, BLG in Chinese) and Isatidis Folium (called Daqingye, DQY in Chinese) are common traditional edible-medicinal herbs in detoxifying for thousands of years, have been traditionally applied in traditional Chinese medicine for centuries. Both of them are bitter in taste, coolness in nature, acting on the heart and stomach channels. They are often used to treat influenza and other viral infectious diseases in clinic, as well as could treat fever, dizziness, and cough and sore throat caused by lung heat. Read More

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September 2021

Comparative efficacy of different methods for difficult biliary cannulation in ERCP: a systematic review and network meta-analysis.

Gastrointest Endosc 2021 Sep 17. Epub 2021 Sep 17.

Center for Advanced Therapeutic Endoscopy (CATE), Porter Adventist Hospital/PEAK Gastroenterology, Denver, Colorado, USA. Electronic address:

Background And Aims: Several methods with variable efficacy have been proposed for difficult biliary cannulation in ERCP. We assessed the comparative efficacy of different strategies for difficult biliary cannulation, through a network meta-analysis combining direct and indirect treatment comparisons.

Methods: We identified 17 randomized controlled trials (RCTs) (2015 patients) that compared the efficacy of different adjunctive methods for difficult biliary cannulation (needle-knife techniques, pancreatic guidewire-assisted technique, pancreatic-assisted technique, and transpancreatic sphincterotomy) either with each other or with persistence with the standard cannulation techniques. Read More

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September 2021

Liver cirrhosis.

Lancet 2021 Sep 17. Epub 2021 Sep 17.

Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C infection, autoimmune diseases, cholestatic diseases, and iron or copper overload. Cirrhosis develops after a long period of inflammation that results in replacement of the healthy liver parenchyma with fibrotic tissue and regenerative nodules, leading to portal hypertension. The disease evolves from an asymptomatic phase (compensated cirrhosis) to a symptomatic phase (decompensated cirrhosis), the complications of which often result in hospitalisation, impaired quality of life, and high mortality. Read More

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September 2021

A silent burden-prolapse, incontinence, and infertility in Australian Aboriginal and Torres Strait Islander women: A systematic search and narrative review.

Int J Gynaecol Obstet 2021 Sep 20. Epub 2021 Sep 20.

Australian National University Medical School, Australian Capital Territory, Canberra, Australia.

Background: Pelvic organ prolapse (POP), urinary incontinence, and infertility are all prevalent conditions associated with considerable reduction in quality of life. As a group, Aboriginal and Torres Strait Islander women may be at higher risk of these conditions, but studies are scarce.

Objectives: To review the literature pertaining to the epidemiology, diagnosis, and management of these conditions in Indigenous Australian women. Read More

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September 2021

Patient-Controlled Sedation Versus Clinician-Administered Sedation for Endoscopic Retrograde Cholangiopancreatography: A Systematic Review.

Anesth Analg 2021 Sep 20. Epub 2021 Sep 20.

Department of Anesthesiology, Queen Mary Hospital, Pokfulam, Hong Kong.

Patient-controlled sedation (PCS) has been explored as a sedation method in endoscopic retrograde cholangiopancreatography (ERCP), yet a comprehensive review article on this topic is lacking. We performed a systematic review to compare PCS against clinician-administered sedation. The primary objectives are to compare the sedative dosage used and the sedation depth, while secondary objectives are to compare sedation failure rates, clinician intervention rates, and patient satisfaction. Read More

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September 2021

Resistance training in heart failure patients: a systematic review and meta-analysis.

Heart Fail Rev 2021 Sep 20. Epub 2021 Sep 20.

School of Science and Technology, University of New England, Armidale, NSW, 2351, Australia.

Aerobic training (AT) has been the primary mode of exercise training in cardiac rehabilitation. Historically, the reason for the prescription of AT was that it was speculated that although RT may be beneficial for some clinical outcomes, it may have an adverse effect on ventricular structure and function. However, RT has now made its way into current cardiac rehabilitation guidelines, including those directed towards patients with HF, albeit differences exist across institutions and guidelines. Read More

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September 2021

[Position paper on required competencies of nonphysician employees in telemedicine centers].

Herzschrittmacherther Elektrophysiol 2021 Sep 20. Epub 2021 Sep 20.

Deutsches Zentrum für Herzinsuffizienz, Universität und Universitätsklinikum Würzburg, und Medizinische Klinik I, Universitätsklinikum Würzburg, Würzburg, Deutschland.

The non-physician employees in telemedicine centers (TMC) play a decisive role in the care and treatment of patients with heart failure. For this reason, a holistic profile consisting of professional and methodological as well as social and personal competences is necessary, which should be built up or promoted in corresponding training concepts. This position paper underlines the urgency of appropriate and standardized further training of non-physician employees for quality assurance in TMCs and summarizes the requirements for the additional qualification of a telemedical assistant across the board. Read More

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September 2021

Paraspinal muscle imaging measurements for common spinal disorders: review and consensus-based recommendations from the ISSLS degenerative spinal phenotypes group.

Eur Spine J 2021 Sep 20. Epub 2021 Sep 20.

Faculty of Health Sciences and Western's Bone and Joint Institute, Western University, London, ON, Canada.

Purpose: Paraspinal muscle imaging is of growing interest related to improved phenotyping, prognosis, and treatment of common spinal disorders. We reviewed issues related to paraspinal muscle imaging measurement that contribute to inconsistent findings between studies and impede understanding.

Methods: Three key contributors to inconsistencies among studies of paraspinal muscle imaging measurements were reviewed: failure to consider possible mechanisms underlying changes in paraspinal muscles, lack of control of confounding factors, and variations in spinal muscle imaging modalities and measurement protocols. Read More

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September 2021

Interventions to Reduce Hospital Length of Stay in High-risk Populations: A Systematic Review.

JAMA Netw Open 2021 Sep 1;4(9):e2125846. Epub 2021 Sep 1.

ECRI Evidence-based Practice Center, Center for Clinical Evidence and Guidelines, Plymouth Meeting, Pennsylvania.

Importance: Many strategies to reduce hospital length of stay (LOS) have been implemented, but few studies have evaluated hospital-led interventions focused on high-risk populations. The Agency for Healthcare Research and Quality (AHRQ) Learning Health System panel commissioned this study to further evaluate system-level interventions for LOS reduction.

Objective: To identify and synthesize evidence regarding potential systems-level strategies to reduce LOS for patients at high risk for prolonged LOS. Read More

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September 2021

Effectiveness of Cognitive Interventions in Older Adults: A Review.

Eur J Investig Health Psychol Educ 2020 Sep 2;10(3):876-898. Epub 2020 Sep 2.

Research Center on Mind, Brain and Behavior (CIMCYC), Campus de Cartuja s/n, University of Granada, 18071 Granada, Spain.

(1) Introduction: With older adults, cognitive intervention programs are most often used for preventing or reversing a decline in cognitive functions, but it has been recently noted that there are insufficient high-quality research studies that report the effects of cognitive intervention on the cognitive functioning of older adults. (2) Objective: To analyze the available evidence concerning the effect of cognitive interventions for improving or maintaining the general cognitive status of older adults who present different cognitive levels. (3) Method: a review of studies published between 2010 and 2019 using the following databases: PubMed, PsycINFO, Cochrane, Google Scholar, ProQuest and Medline. Read More

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September 2020

Impact of Different Types of Physical Activity in Green Urban Space on Adult Health and Behaviors: A Systematic Review.

Eur J Investig Health Psychol Educ 2021 Mar 4;11(1):263-275. Epub 2021 Mar 4.

Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.

This systematic review aimed to investigate the type of physical activity carried out in green urban spaces by the adult population and to value its impact on the population's health. Additionally, another purpose was to examine if the presence of outdoor gyms in green urban spaces can promote participation in physical activity among adults. Searches of electronic databases, with no time restrictions and up to June 2020, resulted in 10 studies meeting the inclusion criteria. Read More

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Toxicities Caused by Head and Neck Cancer Treatments and Their Influence on the Development of Malnutrition: Review of the Literature.

Eur J Investig Health Psychol Educ 2020 Oct 2;10(4):935-949. Epub 2020 Oct 2.

Faculty of Health, University of Canberra, Bruce, 2617 ACT, Australia.

Malnutrition poses a significant problem for oncology patients, resulting in fatalities within this population. Patients with head and neck cancer (HNC) are at high risk, with up to 90% developing malnutrition. Common treatments used for HNC can often lead to adverse side effects, including oral health conditions, gastrointestinal upsets, and several metabolic changes. Read More

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October 2020

Voices from the 'resus room': An integrative review of the resuscitation experiences of nurses.

J Clin Nurs 2021 Sep 20. Epub 2021 Sep 20.

School of Nursing, University of Wollongong, New South Wales, Australia.

Background: Nurses are often the first responders to resuscitations. Understanding their experiences of resuscitation will highlight the resuscitative context nurses work within and identify the conditions that support or hamper their delivery of safe and effective resuscitative care.

Aim: The aim of this integrative review is to develop an understanding of nurses' experience of resuscitation, to gain knowledge of their challenges and identify gaps in evidence. Read More

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September 2021

Continuing professional development for veterinarians in a changing world.

Rev Sci Tech 2021 Aug;40(2):555-566

The veterinary profession has time and again successfully adapted to new challenges and developments, with considerable evolution of the skills needed. Different contexts, production systems and societal requirements continue to shape the profession, resulting in an increasing demand for specialisation, interdisciplinary collaboration along value chains, and preparedness for the omnipresent risk of emerging diseases. To keep up with changes, new insights, advances in research and novel ways to address challenges, continuing professional development (CPD) and the adaptation and updating of the veterinary curriculum have been essential to maintain and enhance the quality and performance of Veterinary Services. Read More

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Predictive Accuracy of Blood-Derived Biomarkers for Amyloid-β Brain Deposition Along with the Alzheimer's Disease Continuum: A Systematic Review.

J Alzheimers Dis 2021 Sep 17. Epub 2021 Sep 17.

IRCCS SDN, Napoli, Italy.

Background: An amyloid-β (Aβ) positron emission tomography (Aβ-PET) scan of the human brain could lead to an early diagnosis of Alzheimer's disease (AD) and estimate disease progression. However, Aβ-PET imaging is expensive, invasive, and rarely applicable to cognitively normal subjects at risk for dementia. The identification of blood biomarkers predictive of Aβ brain deposition could help the identification of subjects at risk for dementia and could be helpful for the prognosis of AD progression. Read More

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September 2021

Pisa syndrome: Pathophysiology, physical rehabilitation and falls risk.

NeuroRehabilitation 2021 Sep 15. Epub 2021 Sep 15.

Institute of Health Sciences, Collegium Medicum, The Jan Kochanowski University, Poland.

Background: Pisa syndrome (PS) is a postural disorder characterised by lateral flexion of the spine (>  10°), predisposing the affected individuals to falls, and contributing to increased mortality in neurodegenerative diseases.

Objective: An overview of currently applied therapeutic management options, primarily focused on specifically structured rehabilitation exercises, in conjunction with falls-risk assessment in the individuals affected by PS.

Methods: A narrative literature review, augmented with the authors' own experience in physical rehabilitation management. Read More

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September 2021

Diagnostic test accuracy of artificial intelligence analysis of cross-sectional imaging in pulmonary hypertension: a systematic literature review.

Br J Radiol 2021 Sep 19:20210332. Epub 2021 Sep 19.

Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.

Objectives: To undertake the first systematic review examining the performance of artificial intelligence (AI) applied to cross-sectional imaging for the diagnosis of acquired pulmonary arterial hypertension (PAH).

Methods: Searches of Medline, Embase and Web of Science were undertaken on July 1 2020. Original publications studying AI applied to cross-sectional imaging for the diagnosis of acquired PAH in adults were identified through two-staged double-blinded review. Read More

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September 2021

Exploring clinical leadership in long term care: An integrative literature review.

J Nurs Manag 2021 Sep 19. Epub 2021 Sep 19.

University of Calgary, Calgary, Alberta, CANADA.

Aim: To understand the concept of clinical leadership and clinical leadership development for nurses working with older adults in long-term care health care facilities.

Background: In Canada, clinical care within long-term care is undertaken by registered nurses and licensed practical nurses working with health care aides. Effective clinical leadership is essential for providing quality nursing care. Read More

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September 2021

Improving rigor and reproducibility in nonhuman primate research.

Am J Primatol 2021 Sep 20:e23331. Epub 2021 Sep 20.

Divisions of Pathobiology and Immunology (JS) and Cardiometabolic Health (CR), Oregon National Primate Research Center, Beaverton, Oregon, USA.

Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Read More

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September 2021

Lung transplantation in South Africa: Indications, outcomes and disease-specific referral guidelines.

Afr J Thorac Crit Care Med 2018 7;24(3). Epub 2018 Sep 7.

Chris Barnard Division of Cardiothoracic Surgery, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.

Lung transplantation (LT) is a robust therapy for advanced lung disease, which offers recipients extended and good-quality survival. In South Africa (SA), patients have historically had limited access to this therapy, particularly if unfunded. LT has been used as a successful therapeutic intervention for a wide variety of end-stage pulmonary parenchymal and vascular diseases, but the most common diseases that lead to LT are chronic obstructive pulmonary disease, interstitial lung disease, cystic fibrosis, alpha-1-antitrypsin deficiency and pulmonary arterial hypertension. Read More

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September 2018

Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A State-of-the-Art Review.

JACC Basic Transl Sci 2021 Sep 15. Epub 2021 Sep 15.

Division of Health Care Delivery and Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.

The vast majority of patients (>99%) with severe acute respiratory syndrome coronavirus 2 survive immediate infection but remain at risk for persistent and/or delayed multisystem. This review of published reports through May 31, 2021, found that manifestations of postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) affect between 33% and 98% of coronavirus disease 2019 survivors and comprise a wide range of symptoms and complications in the pulmonary, cardiovascular, neurologic, psychiatric, gastrointestinal, renal, endocrine, and musculoskeletal systems in both adult and pediatric populations. Additional complications are likely to emerge and be identified over time. Read More

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September 2021

A literature review of microvascular proliferation in arteriovenous malformations of skin and soft tissue.

J Clin Transl Res 2021 Aug 30;7(4):540-557. Epub 2021 Jul 30.

Department of Pathology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background And Aim: Arteriovenous malformations (AVM) are defined as being quiescent vascular masses composed of mature vessels. However, recent studies reported areas of microvascular proliferation (MVP) in AVM, indicating a process of angiogenesis. As this finding questions the previous definition, the primary objective of this review was to evaluate whether angiogenesis occurs in vascular malformations of skin and soft tissue, and second, to identify potential factors involved in MVP. Read More

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Scope and challenges of machine learning-based diagnosis and prognosis in clinical dentistry: A literature review.

J Clin Transl Res 2021 Aug 30;7(4):523-539. Epub 2021 Jul 30.

Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil.

Background: Machine learning (ML) has emerged as a branch of artificial intelligence dealing with the analysis of large amounts of data. The applications of ML algorithms have also expanded to health care, including dentistry. Recent advances in this field point to future improvements in diagnostic techniques and the prognosis of various diseases of the teeth and other maxillofacial structures. Read More

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Surgical Outcomes of Inguinal-, Pubic-, and Adductor-Related Chronic Pain in Athletes: A Systematic Review Based on Surgical Technique.

Orthop J Sports Med 2021 Sep 13;9(9):23259671211023116. Epub 2021 Sep 13.

New York Hip Preservation and Groin Center at Lenox Hill Hospital of Northwell Health, New York, New York, USA.

Background: Controversies remain regarding the surgical treatment of inguinal-, pubic-, and adductor-related chronic groin pain (CGP) in athletes.

Purpose: To investigate the outcomes of surgery for CGP in athletes based on surgical technique and anatomic area addressed.

Study Design: Systematic review; Level of evidence, 4. Read More

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September 2021

Clinical Outcomes of Anterolateral Ligament Reconstruction or Lateral Extra-articular Tenodesis Combined With Primary ACL Reconstruction: A Systematic Review With Meta-analysis.

Orthop J Sports Med 2021 Sep 13;9(9):23259671211023099. Epub 2021 Sep 13.

Department of Orthopedic Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.

Background: Residual rotational instability after isolated anterior cruciate ligament reconstruction (ACLR) has been a challenge for many years. Anterolateral extra-articular procedures (AEAPs), including anterolateral ligament reconstruction (ALLR) or lateral extra-articular tenodesis (LET), are performed as a surgical option for additional rotational stability, but clear evidence for their usefulness is lacking.

Purpose: To conduct a systematic review and meta-analysis of the literature regarding the efficacy of AEAP in primary ACLR. Read More

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September 2021

Scoping Review on the Impact of Outbreaks on Sexual and Reproductive Health Services: Proposed Frameworks for Pre-, Intra-, and Postoutbreak Situations.

Biomed Res Int 2021 8;2021:9989478. Epub 2021 Sep 8.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland.

Introduction: Recent experiences from global outbreaks have highlighted the severe disruptions in sexual and reproductive health services that expose women and girls to preventable health risks. Yet, to date, there is no review studying the possible impact of outbreaks on sexual and reproductive health (SRH). . Read More

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September 2021