158,315 results match your criteria quality improvement

Predictors and moderators of quality of life in patients with major depressive disorder: An AGTs-MDD study report.

J Psychiatr Res 2021 Apr 1;138:96-102. Epub 2021 Apr 1.

Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 201108, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou, 510515, China. Electronic address:

Effective and targeted interventions for improving quality of life (QOL) in addition to achieving 'clinical remission' are imperatives for patients with major depressive disorder (MDD). This study aimed to examine potential predictors and moderators of QOL in depression. Data were obtained from the Algorithm Guided Treatment Strategies for Major Depressive Disorder (AGTs-MDD) study, a multisite, randomized controlled trial composed of 980 depressed patients. Read More

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Sharing and Teaching Electrocardiograms to Minimize Infarction (STEMI): reducing diagnostic time for acute coronary occlusion in the emergency department.

Am J Emerg Med 2021 Mar 25;48:18-32. Epub 2021 Mar 25.

Emergency Department, University Health Network, Toronto, ON, Canada; Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Limits to ST-Elevation Myocardial Infarction (STEMI) criteria may lead to prolonged diagnostic time for acute coronary occlusion. We aimed to reduce ECG-to-Activation (ETA) time through audit and feedback on STEMI-equivalents and subtle occlusions, without increasing Code STEMIs without culprit lesions.

Methods: This multi-centre, quality improvement initiative reviewed all Code STEMI patients from the emergency department (ED) over a one-year baseline and one-year intervention period. Read More

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Development of statistical models for estimating daily nitrate load in Iowa.

Sci Total Environ 2021 Mar 22;782:146643. Epub 2021 Mar 22.

IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, Iowa, USA; Iowa Geological Survey, The University of Iowa, Iowa City, Iowa, USA.

There is an ongoing need to increase our understanding of the sources and timing of stream nitrate loads across agricultural watersheds in Iowa as water quality improvement strategies are implemented. The goal of this study was to model the relationship between nitrate load and the two components of streamflow (i.e. Read More

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Omalizumab response in patients with asthma by number and type of allergen.

Ann Allergy Asthma Immunol 2021 Apr 7. Epub 2021 Apr 7.

University of South Florida, Tampa, Florida.

Background: The anti-IgE therapy omalizumab improves asthma control and reduces exacerbations in patients with moderate-to-severe allergic asthma. However, it has been suggested that omalizumab should be reserved for highly allergic patients with multiple allergen sensitivities or perennial-only sensitivities.

Objective: To examine impact of allergy burden, including number and type of allergen sensitivities, on omalizumab response in a real-world setting. Read More

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Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system.

Neuroimage 2021 Apr 7:118025. Epub 2021 Apr 7.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

The optically pumped magnetometer (OPM) is a viable means to detect magnetic fields generated by human brain activity. Compared to conventional detectors (superconducting quantum interference devices) OPMs are small, lightweight, flexible, and operate without cryogenics. This has led to a step change in instrumentation for magnetoencephalography (MEG), enabling a "wearable" scanner platform, adaptable to fit any head size, able to acquire data whilst subjects move, and offering improved data quality. Read More

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Evaluation of Factors Associated with, and Outcomes for Patients with Non-Home Discharge Destinations Following Carotid Endarterectomy.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Pennsylvania State University, College of Medicine, Hershey, PA. Electronic address:

Introduction: Following a carotid endarterectomy (CEA) procedure, patients are discharged to their homes or other locations than home such as an acute care facility or skilled nursing facility based on their functional status and level of medical attention needed. Decision-making for discharge destination following a CEA to home or non-home locations is important due to the differences in survival and post-operative complications. While primary outcomes such as mortality and occurrence of stroke following CEA have been extensively studied, there is a paucity of information characterizing outcomes of discharge destination and the factors associated. Read More

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Az achondroplasia a fogszabályozás szemszögéből.

Orv Hetil 2021 Apr 10;162(17):683-688. Epub 2021 Apr 10.

3 Heim Pál Országos Gyermekgyógyászati Intézet, Alvásdiagnosztikai és Terápiás Labor, Budapest.

Összefoglaló. Az achondroplasia kialakulásáért az FGFR3-gén mutációja tehető felelőssé, mely a porc növekedési lemezében található chondrocyták érésében okoz zavart. Az esetbemutatásban szereplő lánygyermeknél a születést követő első hónapban a klinikai, laboratóriumi és röntgenvizsgálatok alapján achondroplasia igazolódott. Read More

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Effects of motor imagery training on lower limb motor function of patients with chronic stroke: A pilot single-blind randomized controlled trial.

Int J Nurs Pract 2021 Apr 10:e12933. Epub 2021 Apr 10.

Department of Neurology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Aims: This pilot study aimed to evaluate the effects of motor imagery training on lower limb motor function of stroke patients.

Background: Motor imagery training has played an important role in rehabilitation outcomes of stroke patients.

Methods: In this pilot randomized controlled trial 32 stroke patients were randomly divided into experimental and control groups from January to June 2017. Read More

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The Effect of Tissue Adhesive on Surgical Site Infection Following Elective Bariatric Surgery: a Retrospective Cohort Study.

Obes Surg 2021 Apr 10. Epub 2021 Apr 10.

Division of General Surgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.

Purpose: The reported incidence of surgical site infection (SSI) following bariatric surgery ranges from 1.4 to 30%. The use of skin staples and tissue adhesive was shown to be superior to sutures in reducing SSI in a variety of surgical disciplines; however, this area is under-investigated in elective bariatric surgery. Read More

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Silver Book II: an international framework for urgent care of older people in the first 72 hours from illness or injury.

Age Ageing 2021 Apr 9. Epub 2021 Apr 9.

College of Medicine, University of Saskatchewan, Saskatoon SK S7N 5E5, Canada.

The new edition of the Silver Book, Silver Book II, provides a framework for the urgent care of older people in the first 72 hours from illness or injury. It incorporates principles of geriatric medicine, quality improvement (including patient reported outcome measures) and interdisciplinary care in a balanced, practical and evidence-rich manual on unscheduled and emergent care for older adults. Silver Book II shows how frailty, comprehensive geriatric assessment and shared decision-making can be locally adapted according to national practice and policy across the world. Read More

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Plant Genomics in Africa: Present and prospects.

Plant J 2021 Apr 10. Epub 2021 Apr 10.

Covenant University Bioinformatics Research (CUBRe), Covenant University, Ogun State, Km 10 Idiroko Road, P.M.B, 1023, Ota, Nigeria.

Plants are the world's most consumed goods and they possess high economic and health values. In most countries in Africa, the supply and quality of food will rise to meet the growing population's increasing demand. Genomics and other tools of biotechnology offer the opportunity to improve on subsistence crops and medicinal herbs in the continent. Read More

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The impact of digitisation of a virtual fracture clinic on referral quality, outcomes and assessment times.

Eur J Trauma Emerg Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Trauma and Orthopaedics, Watford General Hospital, West Hertfordshire Hospitals NHS Trust, Watford, WD18 0HB, UK.

Background: Virtual fracture clinics (VFCs) have become widely adopted, aiming to improve efficiency, standardise patient care and reduce clinic appointments for injuries that can be managed conservatively. A variety of means exist to manage VFC referrals and assessment, including paper-based and digital methods. This study assesses VFC referral quality and outcomes before and after implementation of a digital VFC referral and management system. Read More

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Supervised exercise after oesophageal cancer surgery: the PERFECT multicentre randomized clinical trial.

Br J Surg 2021 Apr 10. Epub 2021 Apr 10.

Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: This study investigated whether a supervised exercise programme improves quality of life (QoL), fatigue and cardiorespiratory fitness in patients in the first year after oesophagectomy.

Methods: The multicentre PERFECT trial randomly assigned patients to an exercise intervention (EX) or usual care (UC) group. EX patients participated in a 12-week moderate- to high-intensity aerobic and resistance exercise programme supervised by a physiotherapist. Read More

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'We tend to get pad happy': a qualitative study of health practitioners' perspectives on the quality of continence care for older people in hospital.

BMJ Open Qual 2021 Apr;10(2)

Nursing and Midwifery, University of the West of England Faculty of Health and Applied Sciences, Bristol, UK.

Background: Bladder and bowel control difficulties affect 20% and 10% of the UK population, respectively, touch all age groups and are particularly prevalent in the older (65+ years) population. However, the quality of continence care is often poor, compromising patient health and well-being, increasing the risk of infection, and is a predisposing factor to nursing and residential home placement.

Objective: To identify factors that help or hinder good continence care for patients aged 65 years and over in hospital medical ward settings. Read More

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A comparison of three interactive examination designs in active learning classrooms for nursing students.

BMC Nurs 2021 Apr 9;20(1):59. Epub 2021 Apr 9.

Institute of Health and Care Sciences, Section of Learning and Leadership for Health Care Professionals, University of Gothenburg, Arvid Wallgrens Backe, Box 457, 405 30, Gothenburg, Sweden.

Background: Despite the advantages of using active learning strategies in nursing education, researchers have rarely investigated how such pedagogic approaches can be used to assess students or how interactive examinations can be modified depending on circumstances of practice (e.g., in online education). Read More

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Brassinosteroid signaling integrates multiple pathways to release apical dominance in tomato.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, P.R. China;

The control of apical dominance involves auxin, strigolactones (SLs), cytokinins (CKs), and sugars, but the mechanistic controls of this regulatory network are not fully understood. Here, we show that brassinosteroid (BR) promotes bud outgrowth in tomato through the direct transcriptional regulation of () by the BR signaling component BRASSINAZOLE-RESISTANT1 (BZR1). Attenuated responses to the removal of the apical bud, the inhibition of auxin, SLs or gibberellin synthesis, or treatment with CK and sucrose, were observed in bud outgrowth and the levels of transcripts in the BR-deficient or mutants. Read More

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The Administrative Risk Analysis Index (RAI-A) Does Not Predict Reintervention or Mortality Within 30 Days in Patients Who Undergo Elective Open or Endovascular Abdominal Aortic Aneurysm Repair.

Jeanette Man Jun Xu

J Surg Res 2021 Apr 6;264:179-185. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular Surgery, University of Iowa, Iowa City, Iowa. Electronic address:

Objective: Frailty scores are increasingly utilized to predict postoperative complications. The purpose of this study is to determine whether the administrative risk analysis index (RAI-A) can be used to predict reintervention or mortality within 30 days in patients who undergo elective open or endovascular abdominal aortic aneurysm (AAA) repair.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was used to query data from elective open or endovascular aortic aneurysm repairs from 2011 to 2018. Read More

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Novel Method of Evaluating Liver Transplant Surgery Fellows Using Objective Measures of Operative Efficiency and Surgical Outcomes.

J Am Coll Surg 2021 Apr 6. Epub 2021 Apr 6.

Section of Abdominal Transplant Surgery, Washington University School of Medicine, St Louis, MO. Electronic address:

Background: The majority of liver transplants (LT) in North America are performed by transplant surgery fellows with attending surgeon supervision. While a strict case volume requirement is mandatory for graduating fellows, no guidelines exist on providing constructive feedback to trainees during fellowship.

Study Design: A retrospective review of all adult LTs performed by abdominal transplant surgery fellows at a single ASTS-accredited academic institution from 2005-2019 was conducted. Read More

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Influence of reduction quality on functional outcome and quality of life in the surgical treatment of tibial plateau fractures: a retrospective cohort study.

Orthop Traumatol Surg Res 2021 Apr 6:102922. Epub 2021 Apr 6.

MINTOS - Medical Imaging and Navigation in Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Heidelberg University Hospital, Ludwig-Guttmann-Str. 13, 67071 Ludwigshafen, Germany. Electronic address:

Background: Despite a substantial improvement in the operative treatment of tibial plateau fractures, the surgical procedure remains controversial and is generally challenging, as patients may develop postoperative arthritis and functional impairment of the knee joint.

Hypothesis: In the surgical treatment of tibial plateau fractures the intraoperative reposition quality has the greatest influence on the postoperative outcome, whereby misalignments of >/= 2 mm lead to a worse result.

Patients And Methods: 41 patients with tibial plateau fractures were postoperatively examined. Read More

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Mortality associated with third generation cephalosporin-resistance in infections: a multicenter cohort study in Southern China.

Expert Rev Anti Infect Ther 2021 Apr 9. Epub 2021 Apr 9.

Laboratory of Biostatistics, Division of Social Medicine, School of Medicine, University of Crete, Heraklion, Greece.

Background: Emerging third-generation cephalosporin-resistant (3GCR-EB) pose a global healthcare concern. This study assessed the in-hospital mortality attributed to 3GCR-EB.

Methods: : The study cohort comprised inpatients with a community-onset or healthcare-associated infection caused by in three tertiary-care public hospitals in 2017. Read More

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Use of 1064nm Nd:YAG Laser Biostimulation for Immediate Reversal of a Long-Standing Paresthesia of the Superior Labial Branch of the Infraorbital Nerve Following a Root Coverage Procedure: A Case Report.

Alan M Timko

Clin Adv Periodontics 2021 Apr 9. Epub 2021 Apr 9.

Diplomate of the American Board of Periodontology, Private Practice, 9401 McKnight Rd., Suite 301-A, Pittsburgh, PA, 15237.

Introduction: Paresthesia is a common cause of dental malpractice litigation. Symptoms range from minimal to severely affecting the quality of life. Effective treatments of post-traumatic paresthesias are scarce. Read More

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Comparing the behaviour of dogs before and after enucleation due to glaucoma.

Vet Rec 2021 Apr 24;188(7):e53. Epub 2021 Jan 24.

Queen Mother Hospital for Animals, Royal Veterinary College, North Mymms, Hertfordshire, UK.

Purpose: There is limited literature on owner's attitudes towards enucleation and behavioural changes after enucleation in dogs. The aim of this study is to investigate the owner's perception of canine enucleation as well as gain insight into the behavioural changes of dogs before and after enucleation due to glaucoma.

Methods: This retrospective study involved a questionnaire sent to the owners whose dogs were diagnosed with glaucoma and underwent enucleation at the Queen Mother Hospital for Animals between June 2015 and January 2018. Read More

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Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective.

Curr Heart Fail Rep 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Purpose Of Review: (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. Read More

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Oral nutritional supplements versus a regular diet alone for body weight loss after gastrectomy: a phase 3, multicenter, open-label randomized controlled trial.

Gastric Cancer 2021 Apr 9. Epub 2021 Apr 9.

Osaka University Graduate School of Medicine, Osaka, Japan.

Background: Body weight loss (BWL) after gastrectomy is associated with not only a deteriorated quality of life but also a poor prognosis. Oral nutritional supplements (ONS) may be used to minimize BWL, which is observed in the first 3 months after gastrectomy and becomes stable thereafter, although the results of several randomized trials remain controversial.

Methods: We performed a multicenter, open-label randomized controlled trial including 1003 gastric cancer patients undergoing curative gastrectomy. Read More

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Analytical Method Lifecycle Management in Pharmaceutical Industry: a Review.

AAPS PharmSciTech 2021 Apr 9;22(3):128. Epub 2021 Apr 9.

Analytical Development, R&D, Hovione FarmaCiência S.A, Campus do Lumiar, Edifício R, Estrada do Paço do Lumiar, 1649-038, Lisboa, Portugal.

The adoption of Quality by Design (QbD) and Analytical Method Lifecycle Management (AMLM) concepts to ensure the quality of pharmaceutical products has been applied and proposed over the last few years. These concepts are based on knowledge gained from the application of scientific and quality risk management approaches, throughout method lifecycle to assure continuous improvement and high reliability of analytical results. The overall AMLM starts with the definition of the method's intended use through the Analytical Target Profile definition, including three stages: (1) Method Design, taking advantage of the well-known concept of QbD; (2) Method Performance Qualification; (3) Continued Method Performance Verification. Read More

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Effectiveness of Quality Improvement Processes, Interventions, and Structure in Trauma Systems in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.

World J Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, The University of Auckland, Auckland, New Zealand.

Background: Trauma mortality in low- and middle-income countries (LMICs) remains high compared to high-income countries. Quality improvement processes, interventions, and structure are essential in the effort to decrease trauma mortality.

Methods: A systematic review and meta-analysis of interventional studies assessing quality improvement processes, interventions, and structure in developing country trauma systems was conducted from November 1989 to August 2020 according to the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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EnvRtype: a software to interplay enviromics and quantitative genomics in agriculture.

G3 (Bethesda) 2021 Feb 6. Epub 2021 Feb 6.

Department of Genetics, 'Luiz de Queiroz' Agriculture College, University of São Paulo, São Paulo, Brazil.

Envirotyping is an essential technique used to unfold the nongenetic drivers associated with the phenotypic adaptation of living organisms. Here, we introduce the EnvRtype R package, a novel toolkit developed to interplay large-scale envirotyping data (enviromics) into quantitative genomics. To start a user-friendly envirotyping pipeline, this package offers: (1) remote sensing tools for collecting (get_weather and extract_GIS functions) and processing ecophysiological variables (processWTH function) from raw environmental data at single locations or worldwide; (2) environmental characterization by typing environments and profiling descriptors of environmental quality (env_typing function), in addition to gathering environmental covariables as quantitative descriptors for predictive purposes (W_matrix function); and (3) identification of environmental similarity that can be used as an enviromic-based kernel (env_typing function) in whole-genome prediction (GP), aimed at increasing ecophysiological knowledge in genomic best-unbiased predictions (GBLUP) and emulating reaction norm effects (get_kernel and kernel_model functions). Read More

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February 2021

Risk Assessment in Thyroid Lobectomy and Total Thyroidectomy using Over 100 Thousand Cases.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007219. Epub 2021 Apr 9.

Head and Neck Institute, The Cleveland Clinic, Cleveland, OH, USA.

Objectives: To assess risk factors and non-thyroid specific postoperative complications for thyroid lobectomy compared to total thyroidectomy.

Methods: A retrospective, cross-sectional study of adults undergoing a lobectomy or total thyroidectomy using the National Surgical Quality Improvement Program database between 2005 and 2017. Patients not treated by otolaryngologists or general surgeons and with unknown demographic variables were excluded. Read More

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