179,279 results match your criteria quality evidence


[Pulmonary Rehabilitation in Patients with Chronic Obstructive Airway Diseases].

Pneumologie 2021 Jun 11;75(6):457-473. Epub 2021 Jun 11.

Pulmonary rehabilitation of asthma and COPD patients can improve their physical performance and quality of life, maintain participation in social and professional life and actively promote self-help. In addition, the resources for acute medical treatment can be spared. In case of COPD, rehabilitation directly after exacerbation can also improve the poor survival prognosis and reduce the risk of emergency hospital readmission. Read More

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Analytical validation of a laboratory-development multigene pharmacogenetic assay.

Pharmacogenet Genomics 2021 Jun 9. Epub 2021 Jun 9.

Pharmacogenetic Laboratory, Genetics Department, Hospital Universitario La Paz Experimental Therapies and Novel Biomarkers in Cancer. IdiPAZ Clinical Pharmacology Department, School of Medicine, Hospital Universitario La Paz. IdiPAZ. Universidad Autónoma de Madrid Biostatistics Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.

Objective: The implementation of pharmacogenetics (PGx) in clinical practice is an essential tool for personalized medicine. However, clinical laboratories must validate their procedures before being used to perform PGx studies in patients, in order to confirm that they are adequate for the intended purposes.

Methods: We designed a validation process for our in-house pharmacogenetic PCR-based method assay. Read More

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Does the evidence support brief (≤30-mins), moderate (31-60-mins), or long duration naps (61+ mins) on the night shift? A systematic review.

Sleep Med Rev 2021 May 19;59:101509. Epub 2021 May 19.

University of Pittsburgh, School of Medicine, Department of Emergency Medicine, Pittsburgh, PA, 15261, USA.

We performed a systematic review of four databases to determine if the evidence supports a short or long duration nap during night shifts to mitigate fatigue, and/or improve health, safety, or performance for emergency services and public safety personnel (PROSPERO CRD42020156780). We focused on experimental research and evaluated the quality of evidence with the grading of recommendations, assessment, development, and evaluation (GRADE) framework. We used the Cochrane Collaboration's risk of bias tool to assess bias and reported findings using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Read More

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The effectiveness of smart home technologies to support the health outcomes of community-dwelling older adults living with dementia: A scoping review.

Int J Med Inform 2021 Jun 4;153:104513. Epub 2021 Jun 4.

Menzies Health Institute Queensland, Griffith University, Brisbane, Australia; Australian Aged Care Technologies Collaborative, Griffith University, Brisbane, Australia. Electronic address:

Objectives: To map the current state-of-knowledge about the effectiveness of smart home technologies to support the health outcomes of community-dwelling older adults living with dementia.

Design: A scoping review following the methodological frameworks described by Arksey and O'Malley (2005) and Levac et al. (2010). Read More

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Characterizing the river water quality in China: Recent progress and on-going challenges.

Water Res 2021 May 29;201:117309. Epub 2021 May 29.

Ecological Modelling Laboratory, Department of Physical & Environmental Sciences, University of Toronto, Toronto, ON, M1C 1A4, Canada. Electronic address:

Food production systems, urbanization, and other anthropogenic activities dramatically alter natural hydrological and nutrient cycles, and are primarily responsible for water quality impairments in China's rivers. This study compiled a 16-year (2003-2018) dataset of river water quality (161,337 records from 2424 sites), watershed/landscape features, and meteorological conditions to investigate the spatial water quality patterns and underlying drivers of river impairment (defined as water quality worse than Class V according to China's Environmental Quality Standards for Surface Waters, GB3838-2002) at a national scale. Our analysis provided evidence of a distinct water quality improvement with a gradual decrease in the frequency of prevalence of anoxic conditions, an alleviation of the severity of heavy metal pollution, whereas the cultural eutrophication has only been moderately mitigated between 2003 and 2018. Read More

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Clinical evaluation of in-office tooth whitening with violet LED (405 nm): A double-blind randomized controlled clinical trial.

Photodiagnosis Photodyn Ther 2021 Jun 8:102385. Epub 2021 Jun 8.

Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil. Electronic address:

Background: Although there is little evidence showing the effectiveness of violet LED on in-office tooth whitening, there are some studies which have reported satisfactory results. This double-blind randomized controlled clinical trial aimed to evaluate the effect of a violet light emission diode (LED) (405nm) system, used in-office, on tooth whitening, sensitivity, use of medication after whitening and quality of life.

Methods: Eight patients were randomized into 4 groups (n = 20): G1 - violet LED, G2 - 35% carbamide peroxide (CP) and violet LED, G3 only CP 35% and G4 35% hydrogen peroxide (HP). Read More

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Prospective, Randomized, Double-Blinded Clinical Trial Comparing PEEK and Allograft Spacers in Patients Undergoing Transforaminal Lumbar Interbody Fusion Surgeries.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Boulder Neurosurgical Associates, Boulder, Colorado, USA; Justin Parker Neurological Institute, Boulder, Colorado, USA. Electronic address:

Background Context: Allograft and polyether-ether-ketone (PEEK) radiographic, biomechanical, histological properties have been extensively studied and both spacers have their advantages and shortcomings. There are no comparative randomized or double-blinded spinal fusion clinical trials reported to date.

Purpose: The study's primary objective was to prospectively investigate clinical and radiological outcomes in patients undergoing lumbar interbody fusions and randomized to receive either PEEK or structural bone allografts. Read More

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LOCOMOTION IS IMPACTED DIFFERENTLY ACCORDING TO THE PERINATAL BRAIN INJURY MODEL: META-ANALYSIS OF PRECLINICAL STUDIES WITH IMPLICATIONS FOR CEREBRAL PALSY.

J Neurosci Methods 2021 Jun 8:109250. Epub 2021 Jun 8.

Posgraduate Program in Neuropsychiatry and Behavior Sciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Postgraduate Program in Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Department of Nursing, CAV, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil. Electronic address:

Background: Different approaches to reproduce cerebral palsy (CP) in animals, contribute to the knowledge of the pathophysiological mechanism of this disease and provide a basis for the development of intervention strategies. Locomotion and coordination are the main cause of disability in CP, however, few studies highlight the quantitative differences of CP models, on locomotion parameters, considering the methodologies to cause brain lesions in the perinatal period.

Methods: Studies with cerebral palsy animal models that assess locomotion parameters were systematically retrieved from Medline/PubMed, SCOPUS, LILACS, and Web of Science. Read More

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Efficacy of an autologous blood patch for prolonged air leak, a systematic review.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Thoracic Surgery, Rijnstate Hospital, Arnhem, the Netherlands; Multi-Modality Medical Imaging Group, TechMed Centre, University of Twente, Enschede, The Netherlands.

Background: Prolonged air leak (PAL) following pulmonary surgery remains a clinical challenge and sometimes needs surgical reintervention. An autologous blood patch (ABP) may provide a noninvasive method to cease air leak. Its value, however, is debatable. Read More

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Physiotherapists' perspectives on barriers to implementation of direct access of physiotherapy services in the United Arab Emirates: A cross-sectional study.

PLoS One 2021 11;16(6):e0253155. Epub 2021 Jun 11.

Department of Physiotherapy, College of Health sciences, University of Sharjah, Sharjah, UAE.

Background: There are two primary ways of accessing physiotherapy for service users around the world. The direct access, as opposed to the indirect access which requires a referral from a general physician, has several merits including better quality, timeliness, cost effectiveness of treatment and better probability of preventing acute conditions from turning into chronic ailments. Despite these benefits, several countries including the UAE, do not allow direct access to physiotherapists. Read More

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Inter-rater reliability and predictive accuracy of the Shkuratova Assessment of Falls-risk in Rehabilitation (SAFER) tool.

Int J Rehabil Res 2021 Jun 10. Epub 2021 Jun 10.

Peninsula Health, The Mornington Center Deakin University Geelong, Centre for Quality and Patient Safety Research-Epworth HealthCare Partnership, Melbourne Deakin University Geelong, School of Nursing and Midwifery, Victoria Deakin University Geelong, Centre for Quality and Patient Safety Research-Monash Health Partnership, Monash Health, Clayton, Melbourne, Australia.

Despite the recognised importance of falls prevention in rehabilitation settings, there is limited research focusing on falls risk assessment tools designed to guide both patient screening and therapy. This study evaluated the predictive accuracy and inter-rater reliability of the Shkuratova Assessment of Falls-risk in Rehabilitation settings (SAFER) tool. The study was conducted at a subacute rehabilitation facility in Australia. Read More

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Prehospital Airway Management: A Systematic Review.

Prehosp Emerg Care 2021 Jun 11:1-28. Epub 2021 Jun 11.

Department of Emergency Medicine, Oregon Health & Science University, Portland, OR, USA.

To assess comparative benefits and harms across three airway management approaches (bag valve mask [BVM], supraglottic airway [SGA], and endotracheal intubation [ETI]) used by prehospital emergency medical services (EMS) to treat patients with trauma, cardiac arrest, or medical emergencies, and how they differ based on techniques and devices, EMS personnel and patient characteristics. We searched electronic citation databases (Ovid MEDLINE, CINAHL, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and Scopus) from 1990 to September 2020. We followed Agency for Healthcare Research and Quality Effective Health Care Program Methods guidance. Read More

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Genomic insights into molecular adaptation to intertidal environments in the mangrove Aegiceras corniculatum.

New Phytol 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Biocontrol, Guangdong Key Lab of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.

Mangroves have colonized extreme intertidal environments characterized by high salinity, hypoxia, and other abiotic stresses. Aegiceras corniculatum, a pioneer mangrove species that evolved two specialized adaptive traits (salt secretion and crypto-vivipary), is an attractive ecological model to investigate molecular mechanisms underlying adaptation to intertidal environments. We de novo assembled a high-quality reference genome of A. Read More

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Nurse roles in the advance directive system in Korea.

Int Nurs Rev 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Humanities, Dong-A University College of Medicine, Busan, Korea.

Background: In 2016, the Act on Decisions on Life-Sustaining Treatment for Patients in Hospice and Palliative Care was implemented in Korea, providing a broad framework for end-of-life decision-making for the first time and making advance directives legally recognized documents. This Act can correct long-standing under-recognition of patients as valid decision makers for their own treatment choices. However, limited recognition of patient self-determination, rigid legal forms for documenting patient wishes, and the roles of family under the Act may pose challenges both to patients and nurses. Read More

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Effects of Spaceflight on Musculoskeletal Health: A Systematic Review and Meta-analysis, Considerations for Interplanetary Travel.

Sports Med 2021 Jun 11. Epub 2021 Jun 11.

Human Performance Laboratory, Directorate of Psychology and Sport, University of Salford, Salford, GM, UK.

Background: If interplanetary travel is to be successful over the coming decades, it is essential that countermeasures to minimize deterioration of the musculoskeletal system are as effective as possible, given the increased duration of spaceflight associated with such missions. The aim of this review, therefore, is to determine the magnitude of deconditioning of the musculoskeletal system during prolonged spaceflight and recommend possible methods to enhance the existing countermeasures.

Methods: A literature search was conducted using PubMed, Ovid and Scopus databases. Read More

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Trends in Venous Thromboembolism Anticoagulation in Patients Hospitalized With COVID-19.

JAMA Netw Open 2021 Jun 1;4(6):e2111788. Epub 2021 Jun 1.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor.

Importance: Venous thromboembolism (VTE) is a common complication of COVID-19. It is not well understood how hospitals have managed VTE prevention and the effect of prevention strategies on mortality.

Objective: To characterize frequency, variation across hospitals, and change over time in VTE prophylaxis and treatment-dose anticoagulation in patients hospitalized for COVID-19, as well as the association of anticoagulation strategies with in-hospital and 60-day mortality. Read More

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The therapeutic effects of glucagon-like peptide-1 receptor agonists and metformin on polycystic ovary syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26295

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: Obesity and insulin resistance (IR) are common in polycystic ovary syndrome (PCOS), which contribute to reproductive and metabolic abnormalities. Metformin increases insulin sensitivity, but it is associated with unsatisfied benefits of weight loss. Recent studies have reported that glucagon-like peptide 1 (GLP-1) receptor agonists improve IR and reduce weight in women with PCOS. Read More

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Comparative efficacy and safety of metronomic chemotherapy in breast cancer: A protocol for network meta-analysis protocol.

Medicine (Baltimore) 2021 Jun;100(23):e26255

Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Dongcheng District, Beijing, China.

Background: Metronomic chemotherapy (MC) strategy has been used in breast cancer for more than a decade since it was first proposed. The purpose of this study is to systematically evaluate its efficacy and safety for breast cancer patients at various stages, as well as to clarify the most effective medication strategy when applying MC and discover its most sensitive subpopulation in breast cancer patients.

Method: We will systematically retrieve random controlled trials evaluating the efficacy and safety of MC in breast cancer on PubMed, Cochrane Library, Embase, and web of science to perform this network meta-analysis. Read More

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Effects of brain-computer interface training on upper limb function recovery in stroke patients: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26254

The People's Hospital of Mancheng District, Baoding, Hebei Province, China.

Background: In recent years, with the development of medical technology and the increase of inter-disciplinary cooperation technology, new methods in the field of artificial intelligence medicine emerge in an endless stream. Brain-computer interface (BCI), as a frontier technology of multidisciplinary integration, has been widely used in various fields. Studies have shown that BCI-assisted training can improve upper limb function in stroke patients, but its effect is still controversial and lacks evidence-based evidence, which requires further exploration and confirmation. Read More

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Shaofu Zhuyu decoction for primary dysmenorrhea: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26226

College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Background: Primary dysmenorrhea (PD), one of the common gynecological diseases, is more common in adolescent women. According to epidemiological investigation, the incidence of PD accounts for about 60% of all patients with dysmenorrhea, and its symptoms seriously affect the normal working life of women, so it is important to find a more safe and effective treatment. In recent years, traditional Chinese medicine has made a lot of achievements in the treatment of female PD, among which a number of clinical studies have shown that Shaofu Zhuyu decoction (SFZY) can significantly improve the symptoms of dysmenorrhea and improve the therapeutic effect. Read More

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Tuina for diabetic peripheral neuropathy: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26222

Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Background: Diabetic peripheral neuropathy (DPN) is one of the most common microvascular complications of diabetes mellitus, with an incidence ranging from 60% to 90%. With the change in modern dietary structure, the incidence of diabetes is increasing year by year, and DPN is also on the rise. Tuina therapy has been widely used in the treatment of DPN, but there is no systematic review on the treatment of DPN. Read More

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Effects of respiratory training on pulmonary function, bad mood, and quality of life in patients with COVID-19: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26154

Department of Nephropathy and Rheumatology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, China.

Background: At present, whether respiratory training can improve the lung function, quality of life, and mental health of patients with Coronavirus Disease 2019 (COVID-19) is still controversial. Therefore, in order to provide new evidence-based medicine for clinical treatment, we conducted a systematic review and meta-analysis to evaluate the effects of respiratory training in improving lung function, quality of life, and mental health of patients with COVID-19.

Methods: Relevant publications were searched from clinical trials. Read More

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Efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for acute myeloid leukemia: A protocol for a Bayesian network meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26098

Affiliated Hospital of Shandong University of Traditional Chinese Medicine.

Background: Acute myeloid leukemia (AML) is the most common malignant tumor of the hematopoietic system, which seriously threatens the lives of patients. Most AML patients have acute onset, severe condition, and poor prognosis. The present study aimed to comprehensively evaluate the effectiveness and safety of chemotherapy combined with different doses of interleukin-2 (IL-2) maintenance treatments in AML by Bayesian network meta-analysis (NMA). Read More

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Personality types of patients with glaucoma: A systematic review of observational studies.

Medicine (Baltimore) 2021 Jun;100(23):e25914

Department of Ophthalmology, Maoming People's Hospital, Maoming, Guangdong Province, China.

Objectives: To synthesize recent empirical research on the association between personality and glaucoma among this sub-population.

Methods: PubMed/MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Scopus and ScienceDirect databases were searched to identify eligible studies published between January 1950 and March 2019 in any language. The quality of included observational studies was assessed using an 11-item checklist which was recommended by Agency for Healthcare Research and Quality (AHRQ). Read More

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A comparison of the effects of fire needle and routine acupuncture for myofascitis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e25473

Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China.

Background: Myofascitis is a common disease in clinic. The main cause of the disease is aseptic inflammation of local muscles and connective tissues such as myofascial, which can be manifested as paralysis, distension, and other discomfort, local muscle stiffness, spasm or palpable strain-like nodules. Chinese medicine ascribes it to "bi disease" and "Arthralgia disease," while Western medicine believes that the disease is mainly due to local muscle and fascia edema and exudation caused by trauma or long-term strain, forcing nerves to jam and producing pain and other abnormal feelings. Read More

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Trace elements exposure and risk in age-related eye diseases: a systematic review of epidemiological evidence.

J Environ Sci Health C Toxicol Carcinog 2021 Jun 11:1-47. Epub 2021 Jun 11.

African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, Port Harcourt, Rivers, Nigeria.

This systematic review aimed to evaluate existing evidence on the associations between trace elements exposure and age-related eye diseases. PubMed and Google scholar databases were searched for epidemiological and postmortem studies on the relationship between exposure to trace elements and Age-related eye diseases such as age-related macular degeneration (AMD), cataract, glaucoma and diabetic retinopathy (DR), in population groups aged 40 years and above. Available evidence suggests that cadmium (Cd) exposure may be positively associated with the risks of AMD and cataract. Read More

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EXPRESS: Stroke in India: a systematic review of the incidence, prevalence and case fatality.

Int J Stroke 2021 Jun 11:17474930211027834. Epub 2021 Jun 11.

The George Institute for Global Health, Mental Health, The University of New South Wales, Newtown, New South Wales, Australia.

Background: The burden of stroke is increasing in India; stroke is now the fourth leading cause of death and the fifth leading cause of disability. Previous research suggests that the incidence of stroke in India ranges between 105 and 152/100,000 people per year. However, there is a paucity of available data and a lack of uniform methods across published studies. Read More

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Positive but variable effects of crop diversification on biodiversity and ecosystem services.

Glob Chang Biol 2021 Jun 11. Epub 2021 Jun 11.

UMR MIA 518, INRAE, AgroParisTech, Univsersité Paris-Saclay, Paris, France.

Ecological theory suggests that biodiversity has a positive and stabilizing effect on the delivery of ecosystem services. Yet, the impacts of increasing the diversity of cultivated crop species or varieties in agroecosystems are still under scrutiny. The empirical evidence available is scattered in scope, agronomic and geographical contexts and impacts on ecosystem services may depend on the type of diversification strategy used. Read More

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Notes from the youth mental health field: Using movement towards goals as a potential indicator of service change and quality improvement.

J Clin Psychol 2021 Jun 11. Epub 2021 Jun 11.

Child Outcomes Research Consortium, Anna Freud Centre, London, UK.

The aim of this paper is to report our notes from the field on using movement toward goals at an aggregate level as an inference of service effectiveness. Analysis of routinely collected data from UK youth mental health services was conducted (N = 8,172, age M = 13.8, 67% female, 32% male) to explore the impact of including goal-based outcome data in combined calculations of standardized measures based on the principles of reliable change ("measurable change"). Read More

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Mindfulness-Based Couple Interventions: A Systematic Literature Review.

Fam Process 2021 Jun 11. Epub 2021 Jun 11.

Institute of Medical Psychology, Medical Faculty, Heidelberg University, Heidelberg, Germany.

Over the past decades, mindfulness-based interventions have been shown to improve individual health and well-being in clinical and nonclinical settings. More recently, secular contemplative trainings were adapted to the couple context as research showed satisfying couple relationships to be one of the strongest predictors of physical and mental health. Mindfulness-based interventions hence seem to be a promising treatment in couple counseling and therapy in both clinical and nonclinical settings. Read More

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