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Trends in Single-Level Lumbar Fusions over the Past Decade Using a National Database.

World Neurosurg 2022 Aug 10. Epub 2022 Aug 10.

Department of Orthopaedic Surgery, Rothman Orthopaedic Institute, Thomas Jefferson University, Philadelphia, PA 19107.

Objectives: To 1) compare the rates of different fusion techniques using a nationwide database over the last decade and 2) identify differences in complications and readmissions based on fusion technique.

Methods: All elective, single-level lumbar fusions performed by orthopaedic surgeons from 2011-2020 were identified from the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP). Rates of lumbar fusion technique (posterolateral fusion (PLDF), transforaminal lumbar interbody fusion + PLDF (TLIF), anterior lumbar interbody fusion (ALIF/LLIF), and anterior lumbar interbody fusion + PLDF (ALIF/LLIF+PLDF) were recorded. Read More

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Post COVID-19 condition of the Omicron variant of SARS-CoV-2.

J Infect Chemother 2022 Aug 10. Epub 2022 Aug 10.

Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan; AMR Clinical Reference Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan.

Objectives: To investigate the prevalence of post coronavirus disease (COVID-19) condition of the Omicron variant in comparison to other strains.

Study Design: A single-center cross-sectional study.

Methods: Patients who recovered from Omicron COVID-19 infection (Omicron group) were interviewed via telephone, and patients infected with other strains (control group) were surveyed via a self-reporting questionnaire. Read More

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Adaptive behavior in stroke survivors: A concept analysis.

Asian Nurs Res (Korean Soc Nurs Sci) 2022 Aug 10. Epub 2022 Aug 10.

Department of Nursing, College of Nursing, Chungnam National University, Munwharo 266 Junggu, Daejeon, 35015 Republic of Korea. Electronic address:

Purpose: This study aims to explore a clear and evidence-based definition of adaptive behavior in stroke survivors and establish the antecedents, attributes, consequences, and empirical referents of the concept.

Methods: The concept analysis was performed using the Walker and Avant methods as a framework. Data from 90 publications were collected using various databases (PubMed, EMBASE, CINAHL, RISS, and KISS) and applied in the analysis. Read More

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Monkeypox caused less worry than COVID-19 among the general population during the first month of the WHO Monkeypox alert: Experience from Saudi Arabia.

Travel Med Infect Dis 2022 Aug 10:102426. Epub 2022 Aug 10.

Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco Healthcare, Dhahran, 34465, Saudi Arabia; Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN46202, USA; Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD21218, USA. Electronic address:

Background: Monkeypox re-emerged in May 2022 as another global health threat. This study assessed the public's perception, worries, and vaccine acceptance for Monkeypox and COVID-19 during the first month of WHO announcement.

Methods: A large-scale, cross-sectional survey was conducted between May 27 and June 5, 2022, in Saudi Arabia. Read More

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Amino-functionalized Mesoporous silica nanoparticles (NH-MSiNPs) impair the embryonic development of the sea urchin Paracentrotus lividus.

Environ Toxicol Pharmacol 2022 Aug 10:103956. Epub 2022 Aug 10.

Department of Biology and Biotechnology Charles Darwin, University of Rome Sapienza, 00185 Rome, Italy; CNIS Research Center for Nanotechnology Applied to Engineering, Sapienza University of Rome, 00185 Rome, Italy. Electronic address:

Nanoparticles have found use in a wide range of applications, mainly as carriers of active biomolecules. It is thus necessary to assess their toxicity for human health, as well as for the environment, on which there is still a gap of knowledge. In this work, sea urchin Paracentrotus lividus, a widely used model for embryotoxicity and spermiotoxicity, has been used to assess potential detrimental effects of amino-functionalized mesoporous silica nanoparticles (NH-MSiNPs) on embryonic development. Read More

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Effect of statin on age-related hearing loss via drug repurposing.

Biochim Biophys Acta Mol Cell Res 2022 Aug 10:119331. Epub 2022 Aug 10.

Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea. Electronic address:

Hearing loss in the elderly cause communication difficulties, decreased quality of life, isolation, loneliness and frustration. The aim of our study was to investigate the effect of drug repurposing candidates in aging mouse. The selected candidate drugs for age-related hearing loss (ARHL) included atorvastatin (AS) and sarpogrelate. Read More

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Healthy Eating Index Diet Quality in Randomized Weight Loss Trials: A Systematic Review.

J Acad Nutr Diet 2022 Aug 10. Epub 2022 Aug 10.

Department of Health and Community Systems, School of Nursing, University of Pittsburgh. Electronic address:

Background: - Weight loss interventions focus on dietary and physical activity changes to induce weight loss. Both through weight loss and independent of it, diet quality is important for reducing chronic disease risk. However, if and how diet quality changes over the course of a behavioral intervention is unclear. Read More

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Improving communication about goals of care for hospitalized patients with serious illness: Study protocol for two complementary randomized trials.

Contemp Clin Trials 2022 Aug 10:106879. Epub 2022 Aug 10.

Cambia Palliative Care Center of Excellence at UW Medicine, University of Washington, Seattle, WA, United States of America; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, United States of America.

Background: Although goals-of-care discussions are important for high-quality palliative care, this communication is often lacking for hospitalized older patients with serious illness. Electronic health records (EHR) provide an opportunity to identify patients who might benefit from these discussions and promote their occurrence, yet prior interventions using the EHR for this purpose are limited. We designed two complementary yet independent randomized trials to examine effectiveness of a communication-priming intervention (Jumpstart) for hospitalized older adults with serious illness. Read More

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The relationship between meniscal pathologies, cartilage loss, joint replacement and pain in knee osteoarthritis: a systematic review.

Osteoarthritis Cartilage 2022 Aug 10. Epub 2022 Aug 10.

Leeds Institute of Rheumatic and Musculoskeletal Medicine,University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK. Electronic address:

Objective: We conducted a systematic review in order to understand the relationship between imaging-visualised meniscus pathologies, hyaline cartilage, joint replacement and pain in knee osteoarthritis (OA).

Design: A search of the Medline, EMBASE and Cochrane library databases was performed for original articles reporting association between imaging-detected meniscal pathology (extrusion or tear/damage) and longitudinal and cross-sectional assessments of hyaline articular cartilage loss (assessed on MRI), incident joint replacement and pain (longitudinal and cross-sectional) in knee OA. Each association was qualitatively characterised by a synthesis of data from each analysis, based upon study design and quality scoring (including risk of bias assessment and adequacy of covariate adjustment using Cochrane recommended methodology). Read More

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Association between a low carbohydrate diet, glycemic control, and quality of life in Australian adults living with type 1 diabetes: a pilot study.

Endocr Pract 2022 Aug 10. Epub 2022 Aug 10.

University of Canberra, School of Clinical Science, Faculty of Health, Bruce, ACT, Australia.

Objective: To examine if there is an association between a low carbohydrate diet (LCD), glycemic control, and quality of life (QoL) in Australian adults with type 1 diabetes (T1D).

Methods: This single-group, pre-post, mixed methods (quantitative and qualitative) study was conducted in an outpatient tertiary hospital. Eligible participants: aged ≥18 years, with T1D for ≥1 year, and using multiple daily insulin injections. Read More

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ESMO Expert Consensus Statements on Cancer Survivorship: promoting high-quality survivorship care and research in Europe.

Ann Oncol 2022 Aug 10. Epub 2022 Aug 10.

Department of Oncology and Hemato-Oncology, University of Milan, via Festa del Perdono 7, Milan, 20122, Italy; Applied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS, via Giuseppe Ripamonti 435, Milan, 20141, Italy.

Background: The increased number of cancer survivors and the recognition of physical and psychosocial challenges, present from cancer diagnosis through active treatment and beyond, led to the discipline of cancer survivorship.

Design: and methods: Herein, we reflected on the different components of survivorship care, existing models, and priorities, in order to facilitate the promotion of high-quality European survivorship care and research.

Results: We identified five main components of survivorship care: (1) physical effects of cancer and chronic medical conditions; (2) psychological effects of cancer; (3) social, work and financial effects of cancer (4) surveillance for recurrences and second cancers; and (5) cancer prevention and overall health and well-being promotion. Read More

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Predictive and explanatory themes of NOAEL through a systematic comparison of different machine learning methods and descriptors.

Food Chem Toxicol 2022 Aug 10:113325. Epub 2022 Aug 10.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China. Electronic address:

No observed adverse effect level (NOAEL) is an identified dose level which used as a point of departure to infer a safe exposure limit of chemicals, especially in food additives and cosmetics. Recently, in silico approaches have been employed as effective alternatives to determine the toxicity endpoints of chemicals instead of animal experiments. Several acceptable models have been reported, yet assessing the risk of repeated-dose toxicity remains inadequate. Read More

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Design and manufacture of a lyophilised faecal microbiota capsule formulation to GMP standards.

J Control Release 2022 Aug 10. Epub 2022 Aug 10.

Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. Electronic address:

Faecal microbiota transplant (FMT) is an established and effective treatment for recurrent Clostridioides difficile infection (CDI) and has many other potential clinical applications. However, preparation and quality of FMT is poorly standardised and clinical studies are hampered by a lack of well-defined FMT formulations that meet regulatory standards for medicines. As an alternative to FMT suspensions for administration by nasojejunal tube or colonoscopy, which is invasive and disliked by many patients, this study aimed to develop a well-controlled, standardised method for manufacture of lyophilised FMT capsules and to provide stability data allowing storage for extended time periods. Read More

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The role of patch closure in current-day carotid endarterectomy.

J Vasc Surg 2022 Aug 10. Epub 2022 Aug 10.

Division of Vascular Surgery, Department of Surgery, University of Wisconsin- Madison School of Medicine and Public Health, Madison, WI. Electronic address:

Introduction: It has long been debated whether it is preferable to perform conventional carotid endarterectomy with or without patch closure. While most contemporary surgeons patch, many still do not. Recent small studies have surfaced implying patching is unnecessary. Read More

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Age-related differences in stepping stability following a sudden gait perturbation are associated with lower limb eccentric control of the perturbed limb.

Exp Gerontol 2022 Aug 10:111917. Epub 2022 Aug 10.

Department of Physical Therapy & Rehabilitation Science, University of Maryland School of Medicine, 100 Penn Street, Baltimore, MD 21201, USA. Electronic address:

Introduction: Falls are a leading cause of severe injuries and a major threat to quality of life in older adults. Elderly fallers demonstrate insufficient eccentric quadriceps control during the weight acceptance phase of initial single limb stance. However, the functional role of eccentric control of the perturbed (leading) leg during walking balance recovery and its age-related differences have not yet been studied; thus we investigated age-related differences in eccentric control at the knee of the perturbed leg and its influence on the postural sway and stability of the trailing leg during balance recovery following unexpected surface drop perturbations. Read More

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Discovery of Q-markers of Wenxin Formula based on a Chinmedomics strategy.

J Ethnopharmacol 2022 Aug 10:115576. Epub 2022 Aug 10.

National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, 150040, China. Electronic address:

Ethnopharmacological Relevance: Wenxin Formula (WXF) is a well-known prescription with a significant curative effect in the treatment of cardiac disease. However, the lack of quality control standards caused by unclear quality control components limits the development of new drugs.

Aim Of The Study: The aims of this research were to discover the effective materials and screen the quality markers of WXF through a chinmedomics strategy to aid in efficacy evaluation. Read More

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Bisphenol F induces liver-gut alteration in zebrafish.

Sci Total Environ 2022 Aug 10:157974. Epub 2022 Aug 10.

Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, China. Electronic address:

The unease of consumers with bisphenol A has led to the increased industrial usage of bisphenol F (BPF), which is a new hazard to environmental health. Here, zebrafish were exposed to three BPF concentrations (0.5, 5, and 50 μg/L) from the embryonic stage for 180 days. Read More

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Oxidation and coagulation/adsorption dual effects of ferrate (VI) pretreatment on organics removal and membrane fouling alleviation in UF process during secondary effluent treatment.

Sci Total Environ 2022 Aug 10:157986. Epub 2022 Aug 10.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, PR China.

Ultrafiltration (UF) has been widely used in water and advanced sewage treatment. Unfortunately, membrane fouling is still the main obstacle to further improvement in the system. Fe (III) salt, a type of traditional coagulant, is often applied to mitigate UF membrane fouling. Read More

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The strontium isotope fingerprint of phosphate rocks mining.

Sci Total Environ 2022 Aug 10:157971. Epub 2022 Aug 10.

Nicholas School of the Environment, Duke University, Durham, NC 27708, USA.

High concentrations of metal(loid)s in phosphate rocks and wastewater associated with phosphate mining and fertilizer production operations pose potential contamination risks to water resources. Here, we propose using Sr isotopes as a tracer to determine possible water quality impacts induced from phosphate mining and fertilizers production. We utilized a regional case study in the northeastern Negev in Israel, where salinization of groundwater and a spring have been attributed to historic leaking and contamination from an upstream phosphate mining wastewater. Read More

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Quantifying the post-radiation accelerated brain aging rate in glioma patients with deep learning.

Radiother Oncol 2022 Aug 10. Epub 2022 Aug 10.

Department of Radiation Oncology, UMC Utrecht, 3584 CX Utrecht, The Netherlands. Electronic address:

Background And Purpose: Changes of healthy appearing brain tissue after radiotherapy (RT) have been previously observed. Patients undergoing RT may have a higher risk of cognitive decline, leading to a reduced quality of life. The experienced tissue atrophy is similar to the effects of normal aging in healthy individuals. Read More

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Replacing the greater evil: Can legalizing decentralized waste burning in improved devices reduce waste burning emissions for improved air quality?

Environ Pollut 2022 Aug 10:119897. Epub 2022 Aug 10.

Department of Earth and Environmental Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar, Manauli PO, Punjab, 140306, India. Electronic address:

Open waste burning emissions constitute a significant source of air pollution affecting human health in India. In regions where cleaner fuels have displaced solid biofuel usage, open waste burning is rapidly becoming one of the largest sources of airborne human class-I-carcinogens and particulate matter. As the establishment of waste management infrastructure in rural India is likely to take years, we explore whether health-relevant emissions can be reduced by legalizing the burning of dry non-biodegradable waste in improved devices. Read More

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Wearable system for outdoor air quality monitoring in a WSN with cloud computing: Design, validation and deployment.

Chemosphere 2022 Aug 10:135948. Epub 2022 Aug 10.

Department of Electric Technology, Electronics and Automation, University of Extremadura, Avda. de Elvas S/n, 06006, Badajoz, Spain. Electronic address:

Breathing poor-quality air is a global threat at the same level as unhealthy diets or tobacco smoking, so the availability of affordable instrument for the measurement of air pollutant levels is highly relevant for human and environmental protection. We developed an air quality monitoring platform that comprises a wearable device embedding low-cost metal oxide semiconductor (MOS) gas sensors, a PM sensor, and a smartphone for collecting the data using Bluetooth Low Energy (BLE) communication. Our own developed app displays information about the air surrounding the user and sends the gathered geolocalized data to a cloud, where the users can map the air quality levels measured in the network. Read More

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Comparison of nutritional supplements for glycemic control in type 2 diabetes: A systematic review and network meta-analysis of randomized trials.

Diabetes Res Clin Pract 2022 Aug 10:110037. Epub 2022 Aug 10.

Student Research Committee, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Aims: Direct and indirect evidence were combined in this systematic-review and network meta-analysis (NMA) to assess and compare the effect of nutritional supplements on glycemic control, and rank the supplements accordingly.

Methods: PubMed, Scopus, and Web of Science were searched up to April 2021. We included randomized controlled trials that investigated the effect of vitamins D, C, and E, magnesium, zinc, calcium, selenium, and omega-3 on at least one glycemic marker, including glycated hemoglobin (HbA1c), fasting blood sugar (FBS), homeostasis model assessment-estimated insulin resistance (HOMA-IR), HOMA-B, and insulin, in adults with type 2 diabetes. Read More

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Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.

Prog Neurobiol 2022 Aug 10:102338. Epub 2022 Aug 10.

University of Bristol, School of Physiology, Pharmacology & Neuroscience, University Walk, Bristol BS8 1TD, UK.

Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence, when sleep disruption by delayed chronotypes and societal pressures coincides with our brains preparing for adult life via intense refinement of neural connectivity. These vulnerabilities converge on the prefrontal cortex, one of the last brain regions to mature and a central hub of the limbic-cortical circuits underpinning decision-making, reward processing, social interactions and emotion. Read More

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Agarose hydrogel composite supports microgreen cultivation with enhanced porosity and continuous water supply under terrestrial and microgravitational conditions.

Int J Biol Macromol 2022 Aug 10. Epub 2022 Aug 10.

Food Quality Laboratory, U. S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Beltsville, MD, United States of America.

Hydrogels are attractive soilless media for plant cultivation with strong water and nutrient retention. However, pristine hydrogels contain mostly ultra-micro pores and lack air-filled porosity for root zone aeration. Herein we report a porous hydrogel composite comprising an agarose network and porous growing mix particle (GMP) fillers. Read More

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Bio-nanocomposite edible coatings based on arrowroot starch/cellulose nanocrystals/carnauba wax nanoemulsion containing essential oils to preserve quality and improve shelf life of strawberry.

Int J Biol Macromol 2022 Aug 10. Epub 2022 Aug 10.

Brazilian Agricultural Research Corporation, Embrapa Instrumentation, São Carlos, SP, Brazil.

This study investigated the effects of bio-nanocomposite coatings developed using arrowroot starch (AA), cellulose nanocrystals (CNC), carnauba wax nanoemulsion (CWN), and Cymbopogon martinii and Mentha spicata essential oils (CEO and MEO, respectively) on the physicochemical, microbiological, bioactive, antioxidant, and aromatic characteristics of strawberries cv. 'Oso Grande' in refrigerated storage for 12 days. The coatings improved the shelf life and stability of strawberries, minimizing their weight loss (2. Read More

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Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation.

Int J Biol Macromol 2022 Aug 10. Epub 2022 Aug 10.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau. Electronic address:

Ulcerative colitis (UC) is an autoimmune disease afflicting an increasing number of patients and increasing demands towards the development of efficacious and safe drugs. Recently, with increasing interest in alternative medicines, natural resources have become a hotspot for drug discovery against UC. In addition to being consumed as a food and spice, ginger is also widely used as a well-recognized gastrointestinal herbal medicine. Read More

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Laser Treatment of Burn Scars.

A Altemir P Boixeda

Actas Dermosifiliogr 2022 Aug 10. Epub 2022 Aug 10.

Servicio de Dermatología, Hospital Universitario Ramon y Cajal, Madrid, España.

Burn scars cause high morbidity in the form of contractures, body disfigurement, and itching, and they also have a high emotional impact that adversely affects patient quality of life. Laser therapy has proven effective in this setting. It is superior to topical treatments and can be used in conjunction with surgery, helping to reduce morbidity. Read More

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Measurement of the mixing state of PAHs in individual particles and its effect on PAH transport in urban and remote areas and from major sources.

Environ Res 2022 Aug 10:114075. Epub 2022 Aug 10.

Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution, Jinan University, Guangzhou, 510632, PR China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou, 510632, PR China. Electronic address:

Although recent laboratory simulations have demonstrated that organic matter prevents the degradation of polycyclic aromatic hydrocarbons (PAHs), their role in the long-range transport of PAHs in the real atmosphere remains poorly understood. In this study, we measured the chemical composition and mixing state of PAHs-containing individual particles in aerosols from three sources, one urban area and one remote area. PAHs-containing particles were classified into five types: organic carbon (OC), potassium mixed with organic carbon (KOC), potassium mixed with sodium (KNa), Krich and PAH-rich. Read More

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