Arch Biochem Biophys 2021 05 5;702:108826. Epub 2021 Mar 5.
Department of Biosciences, University of Oslo, Section for Biochemistry and Molecular Biology, P.O. Box 1066, Blindern, NO-0316, Oslo, Norway; Department of Chemistry, University of Oslo, Section for Chemical Life Sciences, University of Oslo, P.O. Box 1033, Blindern, NO-0315, Oslo, Norway. Electronic address:
Structural studies show that enzymes have a limited number of unique folds, although structurally related enzymes have evolved to perform a large variety of functions. In this review, we have focused on enzymes containing the low molecular weight thioredoxin reductase (low M TrxR) fold. This fold consists of two domains, both containing a three-layer ββα sandwich Rossmann-like fold, serving as flavin adenine dinucleotide (FAD) and, in most cases, pyridine nucleotide (NAD(P)H) binding-domains. Read More