938 results match your criteria pyrazole increased

Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice.

Antioxidants (Basel) 2021 Apr 17;10(4). Epub 2021 Apr 17.

Department of Biological Sciences (BK21 Program), University of Ulsan, Ulsan 680-749, Korea.

Loss of ovarian function is closely related to estrogen (E) deficiency, which is responsible for increased osteoclast (OC) differentiation and activity. We aimed to investigate the action mechanism of E to decrease bone resorption in OCs to protect from ovariectomy (OVX)-induced bone loss in mice. In vivo, tartrate-resistant acid phosphatase (TRAP) staining in femur and serum carboxy-terminal collagen crosslinks-1 (CTX-1) were analyzed upon E injection after OVX in mice. Read More

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Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells.

Mol Med Rep 2021 Jun 26;23(6). Epub 2021 Apr 26.

Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.

The present study evaluated indoleamine 2,3‑dioxygenase 1 (IDO) kinetics and how it affects cell survival during the two distinct phases of ischemia‑reperfusion (I‑R) injury. Primary renal proximal tubular epithelial cells (RPTECs) were cultured under anoxia or reoxygenation with or without the IDO inhibitor 1‑DL‑methyltryptophan, the aryl‑hydrocarbon receptor (AhR) inhibitor CH223191 or the ferroptosis inhibitor α‑tocopherol. Using cell imaging, colorimetric assays, PCR and western blotting, it was demonstrated that IDO was upregulated and induced apoptosis during anoxia. Read More

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Recent Progress on Anticancer Agents Incorporating Pyrazole Scaffold.

Mini Rev Med Chem 2021 Mar 25. Epub 2021 Mar 25.

Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar-125001, Haryana. India.

The search of new anticancer agents is considered as a dynamic field of medicinal chemistry. In recent years, the synthesis of compounds with anticancer potential has increased and a large number of structurally varied compounds displaying potent anticancer activities have been published. Pyrazole is an important biologically active scaffold that possessed nearly all types of biological activities. Read More

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17β-Estradiol alleviates cardiac aging induced by d-galactose by downregulating the methylation of autophagy-related genes.

Steroids 2021 Jun 1;170:108829. Epub 2021 Apr 1.

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:

Intrinsic cardiac aging increases cardiovascular mortality and morbidity in the elderly. Estrogen helps reduce the risk of cardiovascular disease in women, with 17β-estradiol (17β-E) activating the autophagy pathway and inhibiting vascular aging, mainly through estrogen receptor alpha (ER α) to prevent atherosclerosis. Abnormal methylation of autophagy-related genes can impact autophagic regulation. Read More

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Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors.

Eur J Med Chem 2021 Mar 1;214:113230. Epub 2021 Feb 1.

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, PR China. Electronic address:

To continue our ongoing studies on discovery of new potent antifungal leads, 43 novel pyrazole-aromatic containing carboxamides were rationally designed and synthesized. Bioassays indicated that most target compounds displayed good in vitro antifungal activities against Botrytis cinerea, Rhizoctonia cerealis and Sclerotinia sclerotiorum and in vivo antifungal activity against R. solani. Read More

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Anti-hyperlipidemic potential of natural product based labdane-pyrroles via inhibition of cholesterol and triglycerides synthesis.

Bioorg Chem 2021 Mar 28;108:104664. Epub 2021 Jan 28.

Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695 019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:

Hyperlipidemia is the clinical condition where blood has an increased level of lipids, such as cholesterol and triglycerides. Therefore controlling hyperlipidemia is considered to be a protective strategy to treat many associated diseases. Thus, a novel natural product derived pyrrole, and pyrazole-(E)-Labda-8(17),12-diene-15,16-dial conjugates with cholesterol and triglycerides synthesis inhibition potential was designed through scaffold hopping approach and synthesized via one-pot selective cycloaddition. Read More

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Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders.

Curr Drug Targets 2021 Jan 20. Epub 2021 Jan 20.

Department of Chemistry, Hallym University, Kangwon-do, Chuncheon. South Korea.

Background: Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase enzyme which controlled the neuronal functions such as neurite outgrowth, synapse formation, neurotransmission, and neurogenesis. The enzyme has two subunits as GSK-3α and GSK-3β. 4ACC, 1Q3D, 3AFG, 1UV5, 1Q5K are the important GSK-3 receptors isolated from Homo sapiens and Mus musculus. Read More

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January 2021

A new synthetic approach for pyrazolo[1,5-a]pyrazine-4(5H)-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line.

Mol Divers 2021 Jan 2. Epub 2021 Jan 2.

Pharmaceutical Chemistry Section, Van Yuzuncu Yil University, 65080, Van, Turkey.

Starting from the 3,5-dimethyl pyrazole ring and acetophenone derivatives, five different N-propargylated C-3 substituted pyrazoles were obtained. These derivatives were reacted with different amine derivatives using CsCO in methanol and 11 different pyrazolo [1,5-a] pyrazine-4(5H)-one derivatives were obtained, which are not found in the literature. The cytotoxic effects of these derivatives in the A549 cell line were investigated. Read More

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January 2021

From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis.

J Med Chem 2021 01 31;64(1):385-403. Epub 2020 Dec 31.

Drug Discovery Unit, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China.

Synthetic cannabinoids, as exemplified by SDB-001 (), bind to both CB1 and CB2 receptors and exert cannabimimetic effects similar to (-)--Δ-tetrahydrocannabinol, the main psychoactive component present in the cannabis plant. As CB1 receptor ligands were found to have severe adverse psychiatric effects, increased attention was turned to exploiting the potential therapeutic value of the CB2 receptor. In our efforts to discover novel and selective CB2 receptor agonists, was selected as a starting point for hit molecule identification and a class of 1-pyrazole-3-carboxamide derivatives were thus designed, synthesized, and biologically evaluated. Read More

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January 2021

Study of the in vivo antiviral activity against TMV treated with novel 1-(t-butyl)-5-amino-4-pyrazole derivatives containing a 1,3,4-oxadiazole sulfide moiety.

Pestic Biochem Physiol 2021 Jan 7;171:104740. Epub 2020 Nov 7.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals of Guizhou University, Guiyang 550025, China. Electronic address:

A series of new 1-tert-butyl-5-amino-4-pyrazole bioxadiazole sulfide derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. The bioactivity results showed that some title compounds exhibited excellent protective activity against TMV and certain insecticidal activity. Among the tested compounds, the EC values of 5d, 5j, 5k and 5l were 165. Read More

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January 2021

Stimulation action of mefenpyr-diethyl on soybean, wheat, and signal grass plants.

J Environ Sci Health B 2021 7;56(2):163-167. Epub 2020 Dec 7.

Department of Plant Production and Breeding, São Paulo State University, Botucatu, São Paulo, Brazil.

Mefenpyr-diethyl is a safener used for protection of cereal plants under applications of ACCase and ALS inhibitor herbicides. Current studies are describing safeners using a new approach, relating these products to stimulation action on plants. The objective of this work was to evaluate the stimulation action of mefenpyr-diethyl on soybean, wheat, and signal grass plants. Read More

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Reaction of phenazone-type drugs and metabolites with chlorine and monochloramine.

Sci Total Environ 2021 Feb 14;757:143770. Epub 2020 Nov 14.

Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R/ Constantino Candeira 5, 15782 Santiago de Compostela, Spain. Electronic address:

This work studies the chlorination and monochloramination reaction kinetics of two phenazone-type drugs (phenazone - Phe and propyphenazone - PrPhe) and three metabolites of phenazone-type drugs (4-formylaminoantipyrine - FAA, 4-aminoantipyrine - AA and 4-acetoamidoantipyrine - AAA). Kinetics were faster with chlorine (apparent second-order constants between 100 and 66,500 times higher) than with monochloramine. For FAA and AAA, no significant reaction was observed during monochloramination. Read More

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February 2021

17β-Estradiol Protects Neural Stem/Progenitor Cells Against Ketamine-Induced Injury Through Estrogen Receptor β Pathway.

Front Neurosci 2020 30;14:576813. Epub 2020 Sep 30.

Department of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Ketamine inhibits neural stem/progenitor cell (NSPC) proliferation and disrupts normal neurogenesis in the developing brain. 17β-Estradiol alleviates neurogenesis damage and enhances behavioral performance after ketamine administration. However, the receptor pathway of 17β-estradiol that protects NSPCs from ketamine-induced injury remains unknown. Read More

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September 2020

An aryl hydrocarbon receptor agonist suppresses the growth of human umbilical vein endothelial cells in vitro: Potent effect with polyunsaturated fatty acids.

Int J Exp Pathol 2020 12 28;101(6):248-263. Epub 2020 Sep 28.

Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

Human umbilical vein endothelial cells (HUVECs) are a pivotal component of the hematopoietic microenvironment linked to the modulation of the immune response, inflammation and carcinogenesis. HUVEC expresses the aryl hydrocarbon receptor (AHR), which regulates gene expression by binding to the xenobiotic-responsive element. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent agonist for AHR signalling. Read More

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December 2020

Bronchospasmolytic and Adenosine Binding Activity of 8- (Proline / Pyrazole)-Substituted Xanthine Derivatives.

Curr Drug Discov Technol 2020 Sep 22. Epub 2020 Sep 22.

Department of Pharmacy, Banasthali Vidyapith, Banasthali-304022, Rajasthan. India.

Background: ABSTRACT: Background: 8-Phenyltheophylline derivatives exhibit prophylactic effects at a specific dose but do not produce the cardiovascular or emetic side effects associated with xanthines, thereby exhibiting unique characteristics of potential therapeutic importance.

Methods: Novel series of 8-(proline/pyrazole)-substituted xanthine analogs has been synthesized. The affinity and selectivity of compounds to adenosine receptors have been assessed by radioligand binding studies. Read More

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September 2020

Aryl hydrocarbon receptor mediates Jak2/STAT3 signaling for non-small cell lung cancer stem cell maintenance.

Exp Cell Res 2020 11 14;396(1):112288. Epub 2020 Sep 14.

Department of Pulmonary Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Cancer stem cells (CSCs) play an important role in shaping the invasive cancer phenotype by contributing to tumor initiation, metastasis, relapse, and therapeutic resistance in non-small cell lung cancer (NSCLC). The Aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which is well known for mediating the toxicity and tumorigenesis of a variety of environmental pollutants, has been extensively recognized as an important mediator in NSCLC development. Here, evidence showed that AhR was overexpressed in NSCLC tissues, and a high AhR protein level was associated with an aggressive tumor phenotype. Read More

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November 2020

A pyrazole-containing selenium compound modulates neuroendocrine, oxidative stress, and behavioral responses to acute restraint stress in mice.

Behav Brain Res 2021 01 21;396:112874. Epub 2020 Aug 21.

Technologic Development Center, Biotechnology Unit, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address:

The contribution of oxidative stress has been described in numerous studies as one of the main pathways involved in the pathophysiology of anxiety and its comorbidities, such as chronic pain. Therefore, in this study, we investigated the anxiolytic-like, antiallodynic, and anti-hyperalgesic effects of 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1H-pyrazole (SePy) in response to acute restraint stress (ARS) in mice through the modulation of oxidative stress and neuroendocrine responses. Mice were restrained for 2 h followed by SePy (1 or 10 mg/kg, intragastrically) treatment. Read More

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January 2021

Estradiol Induces Epithelial to Mesenchymal Transition of Human Glioblastoma Cells.

Cells 2020 08 21;9(9). Epub 2020 Aug 21.

Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, México City CP 11000, Mexico.

The mesenchymal phenotype of glioblastoma multiforme (GBM), the most frequent and malignant brain tumor, is associated with the worst prognosis. The epithelial-mesenchymal transition (EMT) is a cell plasticity mechanism involved in GBM malignancy. In this study, we determined 17β-estradiol (E2)-induced EMT by changes in cell morphology, expression of EMT markers, and cell migration and invasion assays in human GBM-derived cell lines. Read More

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Estrogen Receptor α Agonist is Beneficial for Young Female Rats Against Chronic Unpredicted Mild Stress-Induced Depressive Behavior and Cognitive Deficits.

J Alzheimers Dis 2020 ;77(3):1077-1093

Department of Pathology and Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Disease of National Education Ministry, Institute for Brain Research, Huazhong University of Science and Technology, Wuhan, China.

Background: Women are reported more likely to develop depression and dementia. However, the involved mechanism is poorly understood.

Objective: Here, we clarified the role of estrogen receptor α (ERα) in depression and cognitive deficit in young female rats. Read More

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January 2020

Expression of type I collagen in response to Isoniazid exposure is indirect and is facilitated by collateral induction of cytochrome P450 2E1: An in-vitro study.

PLoS One 2020 31;15(7):e0236992. Epub 2020 Jul 31.

Centre for Liver Research, School of Digestive & Liver Diseases, Institute of Post Graduate Medical Education & Research, Kolkata, India.

We wanted to investigate whether Isoniazid (INH) can directly stimulate activation of hepatic stellate cells (HSCs) and enhance production of collagen. Treatment of human hepatic stellate cell line LX2 with or without 5μM INH for 24 to 72 hours was performed to look into content of cytochrome P450 2E1 (CYP2E1), activity of NADPH oxidase (NOX) and intracellular oxidative stress. Protein level as well as mRNA expression of alpha smooth muscle actin (α-SMA) and collagen1A1 (COL1A1) were assessed by western blot and real time PCR. Read More

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September 2020

Imidazo[1,2-]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells.

Int J Mol Sci 2020 Jul 20;21(14). Epub 2020 Jul 20.

Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, H6726 Szeged, Hungary.

Chemotherapy-induced differentiation of immature myeloid progenitors, such as acute myeloid leukemia (AML) cells or myeloid-derived suppressor cells (MDSCs), has remained a challenge for the clinicians. Testing our imidazo[1,2-]pyrazole-7-carboxamide derivative on HL-60 cells, we obtained ERK phosphorylation as an early survival response to treatment followed by the increase of the percentage of the Bcl-xl and pAkt cells. Following the induction of Vav1 and the AP-1 complex, a driver of cellular differentiation, FOS, JUN, JUNB, and JUND were elevated on a concentration and time-dependent manner. Read More

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Atheroprotective effects of 17β-oestradiol are mediated by peroxisome proliferator-activated receptor γ in human coronary artery smooth muscle cells.

Arch Med Sci Atheroscler Dis 2020 5;5:e118-e126. Epub 2020 Jun 5.

Department of Internal Medicine II, Cardiology, Pneumology, and Angiology, University Hospital Bonn, Bonn, Germany.

Introduction: 17β-oestradiol (E2) mediates vasculoprotection in various preclinical and clinical models of atherosclerosis and neointimal hyperplasia. However, the molecular mechanisms underlying these effects are still not fully elucidated. Previous studies have demonstrated the essential role of the peroxisome-proliferator-activated-receptor-γ (PPARγ) in mediating vasculoprotective effects of E2 . Read More

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Estrogen receptor-α signaling increases allergen-induced IL-33 release and airway inflammation.

Allergy 2021 01 26;76(1):255-268. Epub 2020 Jul 26.

Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: Group 2 innate lymphoid cells (ILC2) are stimulated by IL-33 to increase IL-5 and IL-13 production and airway inflammation. While sex hormones regulate airway inflammation, it remained unclear whether estrogen signaling through estrogen receptor-α (ER-α, Esr1) or ER-β (Esr2) increased ILC2-mediated airway inflammation. We hypothesize that estrogen signaling increases allergen-induced IL-33 release, ILC2 cytokine production, and airway inflammation. Read More

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January 2021

Cooperative Effects of Heterodinuclear Ir-M Complexes on Catalytic H Evolution from Formic Acid Dehydrogenation in Water.

Inorg Chem 2020 Sep 10;59(17):11976-11985. Epub 2020 Jul 10.

Department of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, CREST, Japan Science and Technology Agency (JST), 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, Japan.

Novel heterodinuclear Ir-M complexes (M = Co, Ni, or Cu) with two adjacent reaction sites were synthesized by using 3,5-bis(2-pyridyl)-pyrazole (Hbpp) as a structure-directing ligand and employed as catalysts for H evolution through formic acid dehydrogenation in water. A cooperative effect of the hetero-metal centers was observed in the H evolution in comparison with the corresponding mononuclear Ir and M complexes as the components of the Ir-M complexes. The H evolution rate for the Ir-M complexes was at most 350-fold higher than that of the mononuclear Ir complex. Read More

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September 2020

Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats.

Molecules 2020 Jun 25;25(12). Epub 2020 Jun 25.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Texas at Tyler, Tyler, TX 75799, USA.

Neuronal nicotinic acetylcholine receptor (nAChR)-based therapeutics are sought as a potential alternative strategy to opioids for pain management. In this study, we examine the antinociceptive effects of 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1-pyrazol-4-yl)isoxazole (CMPI), a novel positive allosteric modulator (PAM), with preferential selectivity to the low agonist sensitivity (α4)3(β2)2 nAChR and desformylflustrabromine (dFBr), a PAM for α4-containing nAChRs. We used hot plate and tail flick tests to measure the effect of dFBr and CMPI on the latency to acute thermal nociceptive responses in rats. Read More

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Vinpocetine facilitates the anti-amnesic activity of estrogen-receptor alpha agonist in bilateral ovariectomy-challenged animals.

Behav Brain Res 2020 09 25;393:112789. Epub 2020 Jun 25.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India. Electronic address:

The fluctuation in plasma estrogen level influences the cognitive function in the females. The specific estrogen receptor alpha (ERα) agonist, (4,4',4″-(4-propyl-[1 H] pyrazole-1,3,5-triyl) tris phenol (PPT), is reported to exhibit therapeutic activity similar to that of estrogen replacement therapy. However, the former can also exert cyclic adenosine monophosphate (cAMP)-dependent carcinogenic activity in the uterus of the ovariectomized animals. Read More

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September 2020

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification.

Bioorg Chem 2020 08 8;101:103999. Epub 2020 Jun 8.

Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address:

In this study, we have discovered small druglike molecules as selective inhibitors of human tissue-nonspecific alkaline phosphatase (h-TNAP), an enzyme critical for the regulation of extracellular matrix calcification. The upregulation of h-TNAP is associated with various pathologies particularly the vascular calcification (VC). Selective inhibition of h-TNAP over h-NPP1 may serve as a useful therapeutic strategy against vascular calcification. Read More

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Design, synthesis and pharmacological assessment of new pyrazole compounds.

Inflammopharmacology 2020 Aug 11;28(4):915-928. Epub 2020 Jun 11.

Laboratory of Medicinal Pharmaceutical Chemistry, College of Pharmacy, Federal University of Goiás, Goiâniam, GO, Brazil.

Aims: This study investigated the antinociceptive and anti-inflammatory effects of new pyrazole compounds LQFM011(5), LQFM043(6) and LQFM044(7) as well as the mechanisms of action and acute in vitro toxicity.

Main Methods: The antinociceptive activity was evaluated using the acetic acid-induced abdominal writhing test, formalin-induced pain test and the Randall-Selitto test. The anti-inflammatory activity was evaluated using models of paw oedema and pleurisy induced by carrageenan; cell migration, the levels of tumour necrosis factor α (TNF-α) and myeloperoxidase (MPO) enzyme activity were evaluated. Read More

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Roflumilast attenuates cognitive deficits in estrogen insufficient rats.

Behav Pharmacol 2020 10;31(7):671-687

Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.

Estrogen replacement therapy including specific estrogen receptor alpha (ERα) agonist, 4,4',4″-(4-propyl-[1H] pyrazole-1,3,5-triyl) trisphenol (PPT), improves cognitive function in the females with estrogen insufficiency condition. It is well suggested that the cyclic nucleotides are considered as one of the downstream mediators to ERα receptor activity and they can be hypothesized as a potential target in the management of estrogen insufficiency condition. Roflumilast, a phosphodiesterase-4 inhibitor, increases the level of cyclic adenosine monophosphate (cAMP) in most of the tissues including the brain, and is reported to have procognitive activity in the experimental animals. Read More

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October 2020

Modified pyrazole platinum(II) complex can circumvent albumin and glutathione: Synthesis, structure and cytotoxic activity.

Bioorg Chem 2020 07 13;100:103936. Epub 2020 May 13.

Department of Chemistry, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil. Electronic address:

The synthesis and structural characterization of novel platinum complexes ([Pt(Pz)Cl] - C1, C2 and C3) featuring diphenyl-pyrazole derived ligands: para-fluorophenyl and para-substituted phenyl (CH, F and Cl for L1, L2 and L3, respectively) were reported and it was also evaluated their potential antitumor activity. The elemental, molar conductivity and thermogravimetric analysis combined with FTIR, UV-vis, NMR and mass spectrometry are in agreement with the chemical structure indicated by single-crystal X-ray diffraction. The antiproliferative activities were assessed against tumor (B16F10 and 4T1) and non-tumor (BHK21) cell lines, and the cytotoxicity of the compounds was strongly increased after metal complexation displaying promising activity. Read More

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