Int J Mol Sci 2020 Jul 20;21(14). Epub 2020 Jul 20.
Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, H6726 Szeged, Hungary.
Chemotherapy-induced differentiation of immature myeloid progenitors, such as acute myeloid leukemia (AML) cells or myeloid-derived suppressor cells (MDSCs), has remained a challenge for the clinicians. Testing our imidazo[1,2-]pyrazole-7-carboxamide derivative on HL-60 cells, we obtained ERK phosphorylation as an early survival response to treatment followed by the increase of the percentage of the Bcl-xl and pAkt cells. Following the induction of Vav1 and the AP-1 complex, a driver of cellular differentiation, FOS, JUN, JUNB, and JUND were elevated on a concentration and time-dependent manner. Read More