3,535 results match your criteria pwm

Multivariate approach for longitudinal analysis of brain metabolite levels from ages 5-11 years in children with perinatal HIV infection.

Neuroimage 2021 May 4:118101. Epub 2021 May 4.

Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa. Electronic address:

Treatment guidelines recommend that children with perinatal HIV infection (PHIV) initiate antiretroviral therapy (ART) early in life and remain on it lifelong. As part of a longitudinal study examining the long-term consequences of PHIV and early ART on the developing brain, 89 PHIV children and a control group of 85 HIV uninfected children (HIV-) received neuroimaging at ages 5, 7, 9 and 11 years, including single voxel magnetic resonance spectroscopy (MRS) in three brain regions, namely the basal ganglia (BG), midfrontal gray matter (MFGM) and peritrigonal white matter (PWM). We analysed age-related changes in absolute metabolite concentrations using a multivariate approach traditionally applied to ecological data, the Correlated Response Model (CRM) and compared these to results obtained from a multilevel mixed effect modelling (MMEM) approach. Read More

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Motto: Representing Motifs in Consensus Sequences with Minimum Information Loss.

Genetics 2020 Oct;216(2):353-358

Bioinformatics and Systems Biology, University of California at San Diego, La Jolla, California 92093.

Sequence analysis frequently requires intuitive understanding and convenient representation of motifs. Typically, motifs are represented as position weight matrices (PWMs) and visualized using sequence logos. However, in many scenarios, in order to interpret the motif information or search for motif matches, it is compact and sufficient to represent motifs by wildcard-style consensus sequences (such as [GC][AT]GATAAG[GAC]). Read More

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October 2020

Proliferation of Peripheral Blood Mononuclear Cells From Healthy Piglets After Mitogen Stimulation As Indicators of Disease Resilience.

J Anim Sci 2021 May 4. Epub 2021 May 4.

Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, SK, Canada.

Disease resilience refers to productivity of an animal under disease. Given the high biosecurity of pig nucleus herds, traits that can be measured on healthy pigs and that are genetically correlated with disease resilience, i.e. Read More

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A Separated Reset Waveform Design for Suppressing Oil Backflow in Active Matrix Electrowetting Displays.

Micromachines (Basel) 2021 Apr 27;12(5). Epub 2021 Apr 27.

Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China.

The electrowetting display (EWD) is a kind of reflective paper-like display. Flicker and grayscale distortion are caused by oil backflow, which is one of the important factors restricting the wide application of EWDs. The charge embedding caused by the electric field force in the dielectric layer is the cause of oil backflow. Read More

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The effects of lack of movement in sows during pregnancy period on cortisol, acute phase proteins and lymphocytes proliferation level in piglets in early postnatal period.

Pol J Vet Sci 2021 Mar;24(1):85-92

Nicolaus Copernicus University in Toruń, Institute of Veterinary Medicine, Gagarina 11, 87-100 Toruń, Poland.

Prolonged exposure to stress may cause adverse effects on animal physiology. It is especially important during the gestation period as female physiology can affect the unborn offspring in the form of prenatal stress. Intensive pig farming industry developed gestation crates that enable to keep sows during gestation period in small stalls which do not allow animals to move freely for a maximum of 4 weeks after successful insemination (Council Directive 2008/120/EC). Read More

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Neurometabolic alterations in bipolar disorder with anxiety symptoms: A proton magnetic resonance spectroscopy study of the prefrontal whiter matter.

Psychiatry Res 2021 May 8;299:113859. Epub 2021 Mar 8.

Department of Radiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830000, China.

To identify the pathophysiological mechanism of bipolar disorder (BD) patients with anxiety symptoms, we analyzed the differences of brain biochemical metabolism in BD patients with and without anxiety symptoms. We collected 39 BD patients who had been untreated with drugs in one month and were divided into the anxiety symptoms group (20 cases) and non-anxiety symptoms group (19 cases) according to whether they had anxiety symptoms. We used proton magnetic resonance spectroscopy (H-MRS) to detect the biochemical metabolite ratios of the prefrontal whiter matter (PWM) in all patients. Read More

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Prediction and analysis of multiple protein lysine modified sites based on conditional wasserstein generative adversarial networks.

BMC Bioinformatics 2021 Mar 31;22(1):171. Epub 2021 Mar 31.

Department of Information and Computer Science, University of Science and Technology Beijing, Beijing, 100083, China.

Background: Protein post-translational modification (PTM) is a key issue to investigate the mechanism of protein's function. With the rapid development of proteomics technology, a large amount of protein sequence data has been generated, which highlights the importance of the in-depth study and analysis of PTMs in proteins.

Method: We proposed a new multi-classification machine learning pipeline MultiLyGAN to identity seven types of lysine modified sites. Read More

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Managing plastic packaging waste in emerging economies: The case of EPR in India.

J Environ Manage 2021 Jun 27;288:112405. Epub 2021 Mar 27.

Indian Institute of Management Nagpur, India. Electronic address:

India's large population, rapidly growing economy, and the consequent rising plastic waste, has necessitated the need for an efficient and effective plastic waste management (PWM) system for ensuring an environmentally cleaner and sustainable future. Consequently, PWM policy in India has recently undergone a substantial shift from being an informally organized, largely uncoordinated set of programs towards becoming a formal and integrated system based on the extended producer responsibility (EPR) approach. This paper explicates the evolution, development, implementation, and implications of the Indian EPR framework for PWM by developing an integrative mixed-method case study. Read More

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Experimental evaluation of an OFDM-PWM-based X-ray communication system.

Opt Express 2021 Feb;29(3):3596-3608

We experimentally demonstrate an improved orthogonal frequency division multiplexing (OFDM) into the pulse width modulation (PWM) scheme for the X-ray communication (XCOM). The scheme is insensitive to the nonlinearity of the grid-controlled X-ray tube with switching 'on' and 'off' between two points. The dependence of this system's bit-error-rate (BER) performances on the data rates and the working parameters including the anode voltage and filament current of the grid-controlled X-ray tube are studied. Read More

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February 2021

Clinical utility of brain MRS imaging of patients with adult-onset non-cirrhotic hyperammonemia.

Mol Genet Metab Rep 2021 Jun 13;27:100742. Epub 2021 Mar 13.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Adult-onset non-cirrhotic hyperammonemia (NCH) is a rare, but often fatal condition that can result in both reversible and irreversible neurological defects. Here we present five cases of adult-onset non-cirrhotic hyperammonemia wherein brain magnetic resonance spectroscopy (MRS) scans for cerebral glutamine (Gln) and myo-inositol (mI) levels helped guide clinical management. Specifically, we demonstrate that when combined with traditional brain magnetic resonance imaging (MRI) scans, cerebral Gln and mI MRS can help disentangle the reversible from irreversible neurological defects associated with hyperammonemic crisis. Read More

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Compartmental diffusion and microstructural properties of human brain gray and white matter studied with double diffusion encoding magnetic resonance spectroscopy of metabolites and water.

Neuroimage 2021 Mar 21;234:117981. Epub 2021 Mar 21.

C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Double diffusion encoding (DDE) of the water signal offers a unique ability to separate the effect of microscopic anisotropic diffusion in structural units of tissue from the overall macroscopic orientational distribution of cells. However, the specificity in detected microscopic anisotropy is limited as the signal is averaged over different cell types and across tissue compartments. Performing side-by-side water and metabolite DDE spectroscopic (DDES) experiments provides complementary measures from which intracellular and extracellular microscopic fractional anisotropies (μFA) and diffusivities can be estimated. Read More

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Random forest model to identify factors associated with anabolic-androgenic steroid use.

BMC Sports Sci Med Rehabil 2021 Mar 23;13(1):30. Epub 2021 Mar 23.

Department of Biostatistics, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: One of the types of doping that is commonly used by bodybuilders, is androgenic-anabolic steroids (AAS). The use of AAS besides violating sporting ethics would have serious consequences on physical and mental health statuses. This study aimed to determine the most important factors of using AAS among bodybuilders by prototype willingness model (PWM). Read More

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A qualitative examination of intentions and willingness for heavy drinking among young adult high-intensity drinkers.

Psychol Addict Behav 2021 Mar 18. Epub 2021 Mar 18.

Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University School of Public Health.

Objective: Heavy episodic drinking (HED) and high-intensity drinking (HID) are common in young adulthood but pose unique risks. Quantitative studies have used the Theory of Planned Behavior (TPB) and the Prototype-Willingness Model (PWM) to understand decision-making processes underlying alcohol misuse. However, our understanding of intentions (plans) and willingness (openness) for HED/HID is in its nascent stages. Read More

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Genome-wide scan reveals genomic regions and candidate genes underlying direct and maternal effects of preweaning calf mortality in Nellore cattle.

Genomics 2021 Mar 11;113(3):1386-1395. Epub 2021 Mar 11.

São Paulo State University (Unesp), College of Agricultural and Veterinarian Sciences, Via de Acesso Professor Paulo Donato Castelane Castellane S/N - Vila Industrial, 14884-900 Jaboticabal, SP, Brazil; National Council for Science and Technological Development (CNPq), Brasília, Brazil.

We conducted analysis to estimate genetic parameters and to identify genomic regions and candidate genes affecting direct and maternal effects of preweaning calf mortality (PWM) in Nellore cattle. Phenotypic records of 67,196 animals, and 8443 genotypes for 410,936 SNPs were used. Analysis were performed through the weighted single-step GBLUP approach and considering a threshold animal model via Bayesian Inference. Read More

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Comparing Theoretical Models for the Understanding of Health-Risk Behaviour: Towards an Integrative Model of Adolescent Alcohol Consumption.

Andrea Caputo

Eur J Psychol 2020 Aug 31;16(3):418-436. Epub 2020 Aug 31.

Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Rome, Italy.

The aim of the present manuscript is to test and compare the theory of reasoned action (TRA), theory of planned behaviour (TPB) and prototype-willingness model (PWM) in predicting risky alcohol consumption among adolescents and to build an integrative model to get a more comprehensive understanding of such risky behaviour. A total sample of 518 adolescents (55% females; 13-19 aged) recruited from Italian schools (7th to 12th grade) participated in a cross-sectional research study and completed an online questionnaire. Risky alcohol use assessed through the AUDIT-C was the dependent variable; whereas, variables from the TRA, TPB, and PWM (i. Read More

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Effects of relocation on immunological and physiological measures in female squirrel monkeys (Saimiri boliviensis boliviensis).

PLoS One 2021 26;16(2):e0240705. Epub 2021 Feb 26.

Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, Texas, United States of America.

In the present study, we have quantified the effects of transport, relocation and acclimate/adapt to their new surroundings on female squirrel monkey. These responses are measured in blood samples obtained from squirrel monkeys, at different time points relative to their relocation from their old home to their new home. A group of squirrel monkeys we transported, by truck, for approximately 10 hours. Read More

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February 2021

On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF.

NAR Genom Bioinform 2020 Sep 1;2(3):lqaa046. Epub 2020 Jul 1.

Structural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, University Pompeu Fabra, Barcelona, Catalonia 08005, Spain.

Cis2-His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans. To date, the DNA-binding preferences of many members of this family remain unknown. We have developed a computational method to predict their DNA-binding preferences. Read More

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September 2020

Post-weaning protein malnutrition induces myocardial dysfunction associated with oxidative stress and altered calcium handling proteins in adult rats.

J Physiol Biochem 2021 Feb 8. Epub 2021 Feb 8.

Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria,, ES, Brazil.

Hypercaloric low-protein diet may lead to a state of malnutrition found in the low-income population of Northeastern Brazil. Although malnutrition during critical periods in the early life is associated with cardiovascular diseases in adulthood, the mechanisms of cardiac dysfunction are still unclear. Here we studied the effects of post-weaning malnutrition due to low protein intake induced by a regional basic diet on the cardiac contractility of young adult rats. Read More

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February 2021

Search for SINE repeats in the rice genome using correlation-based position weight matrices.

BMC Bioinformatics 2021 Feb 2;22(1):42. Epub 2021 Feb 2.

Research Center of Biotechnology of the Russian Academy of Sciences, 60 let Oktjabrja pr-t, 7, bld. 1, Moscow, Russia.

Background: Transposable elements (TEs) constitute a significant part of eukaryotic genomes. Short interspersed nuclear elements (SINEs) are non-autonomous TEs, which are widely represented in mammalian genomes and also found in plants. After insertion in a new position in the genome, TEs quickly accumulate mutations, which complicate their identification and annotation by modern bioinformatics methods. Read More

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February 2021

The evaluation of Hashimoto's thyroiditis with event-related potentials and magnetic resonance spectroscopy and its relation to cognitive function.

Sci Rep 2021 Jan 28;11(1):2480. Epub 2021 Jan 28.

Department of Neurology, Wroclaw Medical University, Wroclaw, Poland.

Thyroid dysfunction is very often accompanied by cognitive and affective disorders. The frequency of these disorders in patients with compensated Hashimoto's thyroiditis (HT) is unknown. The aim of the present study was to evaluate brain dysfunction in euthyroid HT patients by means of event-related potentials (ERP) and magnetic resonance spectroscopy (MRS) and to correlate it with cognitive function. Read More

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January 2021

Epigenetic Evolution of ACE2 and IL-6 Genes: Non-Canonical Interferon-Stimulated Genes Correlate to COVID-19 Susceptibility in Vertebrates.

Genes (Basel) 2021 01 25;12(2). Epub 2021 Jan 25.

Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209, USA.

The current novel coronavirus disease (COVID-19) has spread globally within a matter of months. The virus establishes a success in balancing its deadliness and contagiousness, and causes substantial differences in susceptibility and disease progression in people of different ages, genders and pre-existing comorbidities. These host factors are subjected to epigenetic regulation; therefore, relevant analyses on some key genes underlying COVID-19 pathogenesis were performed to longitudinally decipher their epigenetic correlation to COVID-19 susceptibility. Read More

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January 2021

A 10-year trend in piglet pre-weaning mortality in breeding herds associated with sow herd size and number of piglets born alive.

Porcine Health Manag 2021 Jan 4;7(1). Epub 2021 Jan 4.

PigCHAMP Pro Europa S.L., c/Santa Catalina 10, 40003, Segovia, Spain.

Background: Piglet pre-weaning mortality (PWM) is one of the biggest problems regarding sow performance and piglet welfare. Recently, PWM has increased in some countries, but it is not known if there are similar increases in other countries, nor whether increased PWM is related to either increased numbers of piglets born alive (PBA) or to sow herd size. So, the objectives of the present study were 1) to explore the trend in PWM in Spanish sow herds over a recent 10-year period, along with related measurements such as PBA, stillborn piglets, herd productivity and herd size; and 2) to examine the relationships between PWM and the related measurements. Read More

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January 2021

MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection.

Neuroimage Clin 2020 19;28:102505. Epub 2020 Nov 19.

Biomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa; Cape Universities Body Imaging Centre, University of Cape Town, South Africa.

The neurological changes in children living with perinatal HIV (PHIV) on antiretroviral therapy (ART) can be studied at a metabolic level through proton magnetic resonance spectroscopy. While previous studies in children have largely focused on individual metabolite changes, investigating patterns within and across regions of interest can aid in identifying metabolic markers of HIV infection. In this study 76 children with PHIV from the Children with HIV Early AntiRetroviral (CHER) trial, 30 children who were HIV-exposed-uninfected (HEU) and 30 children who were HIV-unexposed (HU), were scanned at the age of 11. Read More

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November 2020

Splitting dynamics of ferrofluid droplets inside a microfluidic T-junction using a pulse-width modulated magnetic field in micro-magnetofluidics.

Soft Matter 2021 Feb;17(5):1317-1329

Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.

Micro-magnetofluidics offers a promising tool for better control over the ferrofluid droplet manipulation which has been vastly utilized in biomedical applications in recent years. In this study, the ferrofluid droplet splitting under an asymmetric Pulse-Width-Modulated (PWM) magnetic field in a T-junction is numerically investigated using a finite volume method and VOF two-phase model. By utilizing the PWM magnetic field, two novel regimes of ferrofluid droplet splitting named as Flowing through the Same Branch (FSB) and Double Splitting (DS) have been observed for the first time. Read More

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February 2021

The characteristic of cognitive impairments in patients with bipolar II depression and its association with N-acetyl aspartate of the prefrontal white matter.

Ann Transl Med 2020 Nov;8(21):1457

Department of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, China.

Background: Cognitive deficit is acknowledged as a core feature of clinical manifestations of bipolar disorder (BD). However, the underlying mechanism of cognitive impairment in bipolar II depression has remained uncertain. We aim to determine the association of cognitive impairments with biochemical metabolism using proton magnetic resonance spectroscopy (H-MRS) and a battery of neuropsychological testing. Read More

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November 2020

A Dual-Output Single-Stage Regulating Rectifier With PWM and Dual-Mode PFM Control for Wireless Powering of Biomedical Implants.

IEEE Trans Biomed Circuits Syst 2020 12 31;14(6):1195-1206. Epub 2020 Dec 31.

This paper presents a reconfigurable, dual-output, regulating rectifier featuring pulse width modulation (PWM) and dual-mode pulse frequency modulation (PFM) control schemes for single-stage ac-to-dc conversion to provide two independently regulated supply voltages (each in 1.5-3 V) from an input ac voltage. The dual-mode PFM controllers feature event-driven regulation as well as frequency division. Read More

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December 2020

Transfer-RNA-Derived Fragments Are Potential Prognostic Factors in Patients with Squamous Cell Carcinoma of the Head and Neck.

Genes (Basel) 2020 Nov 13;11(11). Epub 2020 Nov 13.

Department of Medical Biosciences/Pathology, Umeå University, 90185 Umeå, Sweden.

Transfer-RNA-derived fragments (tRFs) are a class of small non-coding RNAs that are functionally different from their parental transfer RNAs (tRNAs). tRFs can regulate gene expression by several mechanisms, and are involved in a variety of pathological processes. Here, we aimed at understanding the composition and abundance of tRFs in squamous cell carcinoma of the head and neck (SCCHN), and evaluated the potential of tRFs as prognostic markers in this cancer type. Read More

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November 2020

Pasta waste in the feeding of meat quail.

An Acad Bras Cienc 2020 9;92(3):e20180972. Epub 2020 Nov 9.

Universidade Federal Rural de Pernambuco, Departamento de Zootecnia, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.

This study was undertaken to investigate the performance, carcass characteristics, and economic viability of diets including pasta waste in meal form (PWM) for quail. A total of 450 unsexed meat quail (Coturnix coturnix coturnix) were distributed into five treatments (0, 10, 20, 30, and 40% inclusion of PWM) in a completely randomized design with six replicates, each with 15 birds. The following rearing periods were evaluated: Phase 1 - 1 to 21 days; and period of 1 to 42 days. Read More

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November 2020

Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells.

Biomol Ther (Seoul) 2021 03;29(2):154-165

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

This study aimed to investigate whether the antidiabetic drugs dipeptidyl peptidase 4 (DPP4) inhibitors such as evogliptin and sitagliptin affect the membrane DPP4 (mDPP4) enzymatic activity and immune function of T helper1 (Th1) cells in terms of cytokine expression and cell profiles. The mDPP4 enzymatic activity, cytokine expression, and cell profiles, including cell counts, cell viability, DNA synthesis, and apoptosis, were measured in pokeweed mitogen (PWM)-activated CD4CD26 H9 Th1 cells with or without the DPP4 inhibitors, evogliptin and sitagliptin. PWM treatment alone strongly stimulated the expression of mDPP4 and cytokines such as interleukin (IL)-2, IL-10, tumor necrosis factor-alpha, interferon-gamma, IL-13, and granulocyte-macrophage colony stimulating factor in the CD4CD26 H9 Th1 cells. Read More

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A New Approach for Impedance Tracking of Piezoelectric Vibration Energy Harvesters Based on a Zeta Converter.

Sensors (Basel) 2020 Oct 16;20(20). Epub 2020 Oct 16.

Department of Engineering, University of Messina, 98166 Messina, Italy.

Piezoelectric energy harvesters (PEHs) are a reduced, but fundamental, source of power for embedded, remote, and no-grid connected electrical systems. Some key limits, such as low power density, poor conversion efficiency, high internal impedance, and AC output, can be partially overcome by matching their internal electrical impedance to that of the applied resistance load. However, the applied resistance load can vary significantly in time, since it depends on the vibration frequency and the working temperature. Read More

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October 2020